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    • 61. 发明申请
    • Primer and Probe for Use in Detection of Mycobacterium Kansasii and Method for Detection of Mycobacterium Kansasii Using the Same
    • 用于检测堪萨斯分枝杆菌的引物和探针及使用其的堪萨斯分枝杆菌检测方法
    • US20090298057A1
    • 2009-12-03
    • US11920234
    • 2006-05-11
    • Tomokazu Ishikawa
    • Tomokazu Ishikawa
    • C12Q1/68C07H21/04G01N27/26
    • C12Q1/04C12Q1/689G01N33/56922G01N2333/35
    • The present invention discloses an oligonucleotide which comprises a part or the entire sequence of the nucleotide sequence depicted in SEQ ID NO: 1, 2, 3 or 4, or a part or the entire sequence of a nucleotide sequence complementary to the nucleotide sequence, wherein the oligonucleotide is capable of hybridizing with the nucleotide sequence of Mycobacterium kansasii; a primer and a probe for use in the detection of Mycobacterium kansasii comprising the oligonucleotide; and a method for detecting Mycobacterium kansasii using the primer and/or probe.The method for detecting Mycobacterium kansasii enables the detection of M. kansasii more rapidly and with higher accuracy compared with a conventional bacterium identification method performed by culture examination on a bacterium. Further, the method can exclude any false positive result for the diagnosis and can also detect and diagnose M. kansasii with higher accuracy compared with a diagnosis method performed by PCR using a conventional primer and/or probe. Still further, the method can quantify a M. kansasii cell.
    • 本发明公开了一种寡核苷酸,其包含SEQ ID NO:1,2,3或4所示核苷酸序列的一部分或全部序列,或与该核苷酸序列互补的核苷酸序列的一部分或全部序列,其中 寡核苷酸能够与堪萨斯分枝杆菌的核苷酸序列杂交; 用于检测包含寡核苷酸的堪萨斯分枝杆菌的引物和探针; 以及使用引物和/或探针检测堪萨斯分枝杆菌的方法。 与通过细菌培养检查进行的常规细菌鉴定方法相比,用于检测堪萨斯分枝杆菌的方法能够更快速地和更准确地检测堪萨斯州。 此外,与通过使用常规的引物和/或探针的PCR进行的诊断方法相比,该方法可以排除诊断中的任何假阳性结果,并且还可以以更高的精度检测和诊断堪萨斯堪萨斯州堪萨斯州。 此外,该方法可以量化堪萨斯统计学(Kansasii)细胞。
    • 62. 发明申请
    • Primer and Probe for Detection of Mycobacterium Intracellulare, and Method for Detection of Mycobacterium Intracellulare by Using the Primer and Probe
    • 用于检测分支杆菌分枝杆菌的引物和探针,以及使用引物和探针检测分支杆菌的分枝杆菌的方法
    • US20090275026A1
    • 2009-11-05
    • US12298525
    • 2007-04-27
    • Tomokazu Ishikawa
    • Tomokazu Ishikawa
    • C12Q1/68C07H21/04
    • C12Q1/689
    • The present invention discloses an oligonucleotide which comprises a part or the entire sequence of the nucleotide sequence shown in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7 or SEQ ID NO: 8, or a part or the entire sequence of a sequence complementary to the nucleotide sequence shown in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7 or SEQ ID NO: 8, wherein the oligonucleotide is capable of hybridizing with a nucleotide sequence of Mycobacterium intracellulare gene; a primer or a probe for the detection of M. intracellulare, which comprises the aforementioned oligonucleotide; and a method for detection of M. intracellulare using the aforementioned primer and/or the probe.According to the detection method of the present invention, any false-positive result in diagnosis can be eliminated and detection or diagnosis of M. intracellulare can be carried out with higher accuracy, more preciseness, and more specifically compared to a conventional diagnostic method employing a cell culture assay or a PCR assay. The method also enables to quantify a microbial cell.
    • 本发明公开了包含SEQ ID NO:1,SEQ ID NO:2,SEQ ID NO:3,SEQ ID NO:4,SEQ ID NO:5所示核苷酸序列的部分或全部序列的寡核苷酸, SEQ ID NO:6,SEQ ID NO:7或SEQ ID NO:8,或与SEQ ID NO:1,SEQ ID NO:2,SEQ ID NO所示的核苷酸序列互补的序列的部分或全部序列 3,SEQ ID NO:4,SEQ ID NO:5,SEQ ID NO:6,SEQ ID NO:7或SEQ ID NO:8,其中所述寡核苷酸能够与胞内分枝杆菌基因的核苷酸序列杂交; 用于检测胞内分枝杆菌的引物或探针,其包含上述寡核苷酸; 以及使用上述引物和/或探针检测胞内分枝杆菌的方法。 根据本发明的检测方法,可以消除诊断中的任何假阳性结果,并且可以以更高的精度,更精确的方式进行胞内分枝杆菌的检测或诊断,并且更具体地与使用 细胞培养测定或PCR测定。 该方法还能够定量微生物细胞。
    • 63. 发明申请
    • ENERGY SHAPING APPARATUS AND ENERGY SHAPING METHOD
    • 能量成形装置和能量成形方法
    • US20090234657A1
    • 2009-09-17
    • US12065378
    • 2006-08-31
    • Yoshiaki TakagiKok Seng ChongTakeshi NorimatsuShuji MiyasakaAkihisa KawamuraKojiro OnoTomokazu Ishikawa
    • Yoshiaki TakagiKok Seng ChongTakeshi NorimatsuShuji MiyasakaAkihisa KawamuraKojiro OnoTomokazu Ishikawa
    • G10L21/00
    • G10L19/26G10L19/008G10L19/0204H04S2420/03
    • A temporal processing apparatus (energy shaping apparatus) (600a) includes: a splitter (601) splitting an audio signal, included in the sub-band domain, which are obtained through a hybrid time and frequency transformation into diffuse signals indicating reverberating components and direct signals indicating non-reverberating components; a downmix unit (604) generating a downmix signal by downmixing the direct signals; BPFs (605 and 606) respectively generating a bandpass downmix signal and bandpass diffuse signals, by performing bandpass processing on the downmix signal and the diffuse signals on a sub-band-to-sub-band basis, which are split on the sub-band basis; normalization processing units (607 and 608) respectively generating a normalized downmix signal and normalized diffuse signals by normalizing the bandpass downmix signal and the bandpass diffuse signals with regard to respective energy; a scale computation processing unit (609) computing, on a predetermined time slot basis, a scale factor indicating the magnitude of energy of the normalized downmix signal with respect to energy of the normalized diffuse signals; a calculating unit (611) generating scale diffuse signals by multiplying the normalized diffuse signals by the scale factor; a HPF (612) generating high-pass diffuse signals by performing high-pass processing on the scale diffuse signals; an adding unit (613) generating addition signals by adding the high-pass diffuse signals and the direct signals; and a synthesis filter bank (614) performing synthesis filter processing on the addition signals and transforming the addition signals into the time domains
    • 时间处理装置(能量整形装置)(600a)包括:分离器(601),将包括在子带域中的音频信号(通过混合时间和频率变换获得)分解成指示混响分量的漫射信号,并且直接 表示非混响分量的信号; 下混合单元(604),通过将所述直接信号进行下混合来产生下混合信号; BPF(605和606)分别产生带通下混合信号和带通扩散信号,通过对分频在子带上的下混信号和扩频信号进行带通处理,分散在子带 基础; 归一化处理单元(607和608),分别通过相对于各自的能量归一化带通下混合信号和带通漫射信号来产生归一化的下混合信号和归一化的扩散信号; 比例计算处理单元(609)在预定时隙的基础上计算指示归一化的下混合信号相对于归一化扩散信号的能量的能量的大小的比例因子; 计算单元(611),通过将归一化扩散信号乘以比例因子来生成缩放漫射信号; HPF(612)通过对刻度扩散信号进行高通处理来产生高通漫反射信号; 加法单元(613),通过加上高通漫反射信号和直接信号来产生加法信号; 以及合成滤波器组(614)对加法信号执行合成滤波处理,并将加法信号转换成时域
    • 66. 发明授权
    • Compiler, compiler apparatus and compilation method
    • 编译器,编译器和编译方法
    • US07284241B2
    • 2007-10-16
    • US10630705
    • 2003-07-31
    • Taketo HeishiToshiyuki SakataHajime OgawaRyoko MiyachiShuji MiyasakaTomokazu Ishikawa
    • Taketo HeishiToshiyuki SakataHajime OgawaRyoko MiyachiShuji MiyasakaTomokazu Ishikawa
    • G06F9/45
    • G06F8/443G06F8/425G06F8/427G06F8/4441
    • An operator definition file 102 and the like included in a source program 101 and a compiler 100 that translates the source program 101 into a machine language program 105 are provided. The operator definition file 102 includes definitions of various fixed point type operators by class definitions. The compiler 100 can generate effectively advanced and specific instructions that a processor executes and make improvements through expanding functions and the like without repeating frequently upgrading of the version of the compiler itself. The compiler 100 is made up of an intermediate code generation unit 121 that generates intermediate codes, a machine language instruction substitution unit 122 that substitutes the intermediate codes referring to classes defined by the operator definition file 102 with machine language instructions and an optimization unit 130 that performs optimization targeting the intermediate codes including the substituted machine language instructions.
    • 提供包括在源程序101中的操作者定义文件102等以及将源程序101转换为机器语言程序105的编译器100。 操作者定义文件102包括通过类定义的各种定点类型操作符的定义。 编译器100可以生成有效的高级特定指令,处理器执行并通过扩展功能等进行改进,而不会重复频繁升级编译器本身的版本。 编译器100由生成中间代码的中间代码生成单元121构成,机器语言指令替换单元122,其使用机器语言指令代替参考由操作者定义文件102定义的类别的中间代码和优化单元130, 执行针对包括替代机器语言指令的中间代码的优化。