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61. 发明授权

US06511504B1 Expandable stents and method for making same 失效
公开(公告)号：US06511504B1
公开(公告)日：2003-01-28
申请号：US09715415
申请日：2000-11-16
申请人： Lilip Lau , William M. Hartigan , John J. Frantzen
发明人： Lilip Lau , William M. Hartigan , John J. Frantzen
IPC分类号： A61F206
CPC分类号： A61F2/86 , A61F2/848 , A61F2/88 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/91533 , A61F2002/9155 , A61F2002/91558 , A61F2002/91575 , A61F2210/0019 , A61M2025/1081 , C23F1/02 , C23F1/04 , Y10S623/901 , Y10S623/903 , Y10S623/921 , Y10T29/49995
摘要： The invention is directed to an expandable stent for implantation in a body lumen, such as an artery, and a method for making it from a single length of tubing. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common axis and interconnected by one or more interconnective elements. The individual radially expandable cylindrical elements consist of ribbon-like material disposed in an undulating pattern. Portions of the expanded stent project outwardly into engagement with the vessel wall to more securely attach the stent.

62. 发明授权

US06361637B1 Method of making a kink resistant stent-graft 有权
公开(公告)号：US06361637B1
公开(公告)日：2002-03-26
申请号：US09376931
申请日：1999-08-13
申请人： Gerald Ray Martin , Lilip Lau , Scott N. Stonebrook , Sharon Lam , Troy Thornton
发明人： Gerald Ray Martin , Lilip Lau , Scott N. Stonebrook , Sharon Lam , Troy Thornton
IPC分类号： A61F206
摘要： A stent-graft including a stent member having an inner surface and an outer surface, a generally tubular graft member and a coupling member that couples the stent member to the graft member. The coupling member, which is the preferred embodiment is in the form of a ribbon, covers only a portion of the inner or outer surface of the stent member and secures the stent member and graft member to one another. Alternatively, the coupling member can be to described as interconnecting less than entirely the inner or outer surface of the graft member to the stent member. With this construction, regions of the stent member do not interfere with the coupling member. Shear stresses between the stent member and the coupling member and the risk of tearing the graft or coupling member or delamination therebetween may be reduced as compared to a fully enveloped stent member. This construction also provides improved flexibility and kink resistance.

63. 发明授权

US06331188B1 Exterior supported self-expanding stent-graft 失效
标题翻译：外支撑自扩张支架移植
公开(公告)号：US06331188B1
公开(公告)日：2001-12-18
申请号：US08871427
申请日：1997-06-09
申请人： Lilip Lau , Charles Maroney
发明人： Lilip Lau , Charles Maroney
IPC分类号： A61F206
CPC分类号： A61F2/92 , A61F2/88 , A61F2/91 , A61F2/915 , A61F2/95 , A61F2/962 , A61F2002/061 , A61F2002/3008 , A61F2002/30093 , A61F2002/30462 , A61F2002/91508 , A61F2002/91516 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2002/9511 , A61F2210/0019 , A61F2210/0076 , A61F2220/0075 , A61F2250/0098 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00137 , A61F2310/00149
摘要： The present invention relates to a stent-graft where the stent is formed from a self-expanding material and is coaxially and slidably coupled to the graft component which contains collagen. At least one flexible linkage is provided for coupling the stent and graft together in the slidable manner.
摘要翻译：支架移植物本发明涉及一种支架，其中支架由自膨胀材料形成并且同轴并可滑动地联接到含有胶原的移植部件上。提供至少一个柔性连接件用于以可滑动的方式将支架和移植物联接在一起。

64. 发明授权

US06309412B1 Expandable stents and method for making same 失效
公开(公告)号：US06309412B1
公开(公告)日：2001-10-30
申请号：US09561098
申请日：2000-04-28
申请人： Lilip Lau , William M. Hartigan , John J. Frantzen
发明人： Lilip Lau , William M. Hartigan , John J. Frantzen
IPC分类号： A61F206
CPC分类号： A61F2/86 , A61F2/848 , A61F2/88 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/91533 , A61F2002/9155 , A61F2002/91558 , A61F2002/91575 , A61F2210/0019 , A61M2025/1081 , C23F1/02 , C23F1/04 , Y10S623/901 , Y10S623/903 , Y10S623/921 , Y10T29/49995
摘要： The invention is directed to an expandable stent for implantation in a body lumen, such as an artery, and a method for making it from a single length of tubing. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common axis and interconnected by one or more interconnective elements. The individual radially expandable cylindrical elements consist of ribbon-like material disposed in an undulating pattern. Portions of the expanded stent project outwardly into engagement with the vessel wall to more securely attach the stent.

65. 发明授权

US6113607A Method of delivering a stent 失效
标题翻译：输送支架的方法
公开(公告)号：US6113607A
公开(公告)日：2000-09-05
申请号：US119344
申请日：1998-07-20
申请人： Lilip Lau , William M. Hartigan , Farhad Khosravi , Kurt R. Klemm , Ulrich Sigwart
发明人： Lilip Lau , William M. Hartigan , Farhad Khosravi , Kurt R. Klemm , Ulrich Sigwart
IPC分类号： A61F2/82 , A61F2/06 , A61F2/84 , A61M25/00 , A61M25/01 , A61F11/00
CPC分类号： A61F2/97 , A61F2/958 , A61F2002/9517 , A61M2025/0183 , A61M2025/1081
摘要： The invention is directed to a stent delivery method and system which generally includes an elongated delivery sheath and a catheter disposed within an outer lumen of the sheath having an expandable member on its distal extremity. An expandable stent is mounted on the expandable member of the catheter. The distal portion of the sheath tapers down and is tucked within an elastic cone during transport of the stent to a stenotic region. A manipulating device is provided on the proximal end of the delivery system to effect relative axial movement between the sheath and the catheter so as to expose the stent mounted on the expandable member on the catheter within a body lumen such as a coronary artery and allow the expansion of the stent by the expansion of the expandable member. The elastic cone thereby disengages from the sheath and collapses about the distal end of the catheter. The delivery sheath has a first port in its distal end and a second port in the sheath wall proximally disposed from the distal end of the sheath. The catheter likewise has a first port in its distal end and a second port proximally disposed from the distal end of the catheter. An inner lumen extends within the distal portion of the catheter between the first and second ports and slidably receives a guiding member such as a guidewire. This system allows the stent to be delivered over a guidewire previously advanced to the desired location within a body lumen.
摘要翻译：本发明涉及一种支架输送方法和系统，其通常包括细长的输送护套和设置在护套的外腔内的导管，其在其远端上具有可扩张构件。可扩张支架安装在导管的可扩张构件上。护套的远端部分在将支架运送到狭窄区域期间逐渐变细并且被折叠在弹性锥体内。操纵装置设置在输送系统的近端上以实现护套和导管之间的相对轴向移动，以便将安装在可扩张构件上的支架暴露在诸如冠状动脉的体腔内的导管上，并允许通过可扩张构件的膨胀来扩张支架。因此弹性锥体与护套分离并围绕导管的远端塌陷。输送护套在其远端具有第一端口，并且护套壁中的第二端口从护套的远端向近侧设置。导管同样具有其远端中的第一端口和从导管的远端向近侧设置的第二端口。内腔在第一和第二端口之间的导管的远端部分内延伸，并且可滑动地容纳诸如导丝的引导构件。该系统允许支架在先前推进到体腔内的期望位置的导丝上传送。

66. 发明授权

US6015431A Endolumenal stent-graft with leak-resistant seal 失效
标题翻译：腔内支架移植物具有防漏密封
公开(公告)号：US6015431A
公开(公告)日：2000-01-18
申请号：US773479
申请日：1996-12-23
申请人： Troy Thornton , Lilip Lau
发明人： Troy Thornton , Lilip Lau
IPC分类号： A61F2/00 , A61F2/06
CPC分类号： A61F2/07 , A61F2/97 , A61F2/848 , A61F2/89 , A61F2/954 , A61F2002/067 , A61F2002/075 , A61F2002/9511 , A61F2220/0075 , A61F2230/0054 , A61F2230/0078 , A61F2250/0039
摘要： An implantable medical device has a tubular member and a sealing member secured to an outer surface of the tubular member. The tubular member is expandable to engage an endolumenal wall and has a lumen for providing an artificial conduit for flow through an endolumenal space defined by that wall. The seal member occludes flow around the tubular member between the outer surface and the endolumenal wall. One suitable tubular member for use in the present invention is a stent-graft which may be bifurcated for use in protecting vascular wall malformations adjacent to vascular bifurcations against endolumenal pressure and flow. The seal member may be a flange that is oriented on the outer surface at one end of the tubular member as a one-way valve against flow. Multiple seal members may be used, either on opposite ends of the tubular member or in series at one end thereof. Where anchors are used to secure the tubular member to the endolumenal wall, the seal member is positioned to protect against flow through leakage paths formed at localized areas of deformation in the tubular wall adjacent to the anchors. One or more seal members may also be used with two or more tubular members to prevent flow through endolumenal spaces that remain open to flow due to gaps between the multiple, parallel tubular members.
摘要翻译：可植入医疗装置具有管状构件和固定到管状构件的外表面的密封构件。管状构件可扩张以接合内腔壁，并具有内腔，用于提供用于流过由该壁限定的腔室空间的人造管道。密封构件在外表面和内腔壁之间封闭管状构件周围的流动。用于本发明的一种合适的管状构件是支架移植物，其可以分叉用于保护邻近血管分叉的血管壁畸形以抵抗内腔内压力和流动。密封构件可以是在管状构件的一端的外表面上定向为防止流动的单向阀的凸缘。可以在管状构件的相对端上或在其一端串联使用多个密封构件。在使用锚固件将管状构件固定到内腔壁的情况下，密封构件被定位成防止流过形成在与锚固件相邻的管状壁中的局部变形区域处的泄漏路径。一个或多个密封构件也可以与两个或多个管状构件一起使用，以防止由于多个平行的管状构件之间的间隙而保持开放的内腔空间的流动。

67. 发明授权

US5766238A Expandable stents and method for making same 失效
公开(公告)号：US5766238A
公开(公告)日：1998-06-16
申请号：US823434
申请日：1997-03-24
申请人： Lilip Lau , William M. Hartigan , John J. Frantzen
发明人： Lilip Lau , William M. Hartigan , John J. Frantzen
IPC分类号： A61F2/00 , A61F2/86 , A61F2/88 , C23F1/02 , C23F1/04 , A61F2/06 , B44C1/22
CPC分类号： A61F2/86 , A61F2/88 , A61F2/89 , A61F2/91 , A61F2/915 , C23F1/02 , C23F1/04 , A61F2/848 , A61F2/958 , A61F2002/91533 , A61F2002/9155 , A61F2002/91558 , A61F2002/91575 , A61F2210/0019 , A61M2025/1081 , Y10S623/901 , Y10S623/903 , Y10S623/921 , Y10T29/49995
摘要： The invention is directed to an expandable stent for implantation in a body lumen, such as an artery, and a method for making it from a single length of tubing. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common axis and interconnected by one or more interconnective elements. The individual radially expandable cylindrical elements consist of ribbon-like material disposed in an undulating pattern. Portions of the expanded stent project outwardly into engagement with the vessel wall to more securely attach the stent.

68. 发明授权

US5735893A Expandable stents and method for making same 失效
标题翻译：可扩展支架及其制作方法
公开(公告)号：US5735893A
公开(公告)日：1998-04-07
申请号：US783097
申请日：1997-01-14
申请人： Lilip Lau , William M. Hartigan , John J. Frantzen
发明人： Lilip Lau , William M. Hartigan , John J. Frantzen
IPC分类号： A61F2/00 , A61F2/86 , A61F2/88 , C23F1/02 , C23F1/04 , A61F2/06
CPC分类号： A61F2/86 , A61F2/88 , A61F2/89 , A61F2/91 , A61F2/915 , C23F1/02 , C23F1/04 , A61F2/848 , A61F2/958 , A61F2002/91533 , A61F2002/9155 , A61F2002/91558 , A61F2002/91575 , A61F2210/0019 , A61M2025/1081 , Y10S623/901 , Y10S623/903 , Y10S623/921 , Y10T29/49995
摘要： The invention is directed to an expandable stent for implantation in a body lumen, such as an artery, and a method for making it from a single length of tubing. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common axis and interconnected by one or more interconnective elements. The individual radially expandable cylindrical elements consist of ribbon-like material disposed in an undulating pattern. Portions of the expanded stent project outwardly into engagement with the vessel wall to more securely attach the dtent.
摘要翻译：本发明涉及用于植入体腔（例如动脉）中的可扩张支架，以及用于从单一管道制造它的方法。支架由多个径向可扩张的圆柱形元件组成，其大致在公共轴线上对准并且由一个或多个互连元件相互连接。各个可径向扩张的圆柱形元件由以波浪形图案布置的带状材料组成。扩张的支架的一部分向外突出地与血管壁接合，以更牢固地附接该凹陷。

69. 发明授权

US5546646A Method for mounting an intravascular stent on a catheter 失效
标题翻译：将血管内支架安装在导管上的方法
公开(公告)号：US5546646A
公开(公告)日：1996-08-20
申请号：US390096
申请日：1995-02-17
申请人： Michael S. Williams , Lilip Lau , Farhad Khosravi , William Hartigan , Avegel Hernando
发明人： Michael S. Williams , Lilip Lau , Farhad Khosravi , William Hartigan , Avegel Hernando
IPC分类号： A61B17/00 , A61F2/06 , A61F2/84 , B29C63/18 , B29C65/56 , B23P11/00
CPC分类号： A61F2/958 , B29C63/18 , B29C65/56 , B29C66/534 , B29C66/5344 , B29C66/8322 , A61F2002/9522 , B29L2031/7542 , Y10T29/49776 , Y10T29/49927 , Y10T29/53657 , Y10T29/53987
摘要： The method for mounting an intravascular stent on the distal end of a catheter. The stent-loading device includes at least two substantially flat surfaces, that are parallel to each other, and that have relative sliding movement while remaining parallel. A stent is placed on the distal end of a catheter and positioned between the substantially flat surfaces which are then moved in an orthogonal direction relative to each other while simultaneous compressive force is applied to the stent. The stent is progressively crimped onto the catheter.
摘要翻译：用于在导管的远端安装血管内支架的方法。支架装载装置包括彼此平行的至少两个基本平坦的表面，并且具有相对滑动运动同时保持平行。将支架放置在导管的远端上并定位在基本上平坦的表面之间，然后在相对于彼此的正交方向上移动，同时对支架施加压缩力。支架逐渐卷曲到导管上。

70. 发明授权

US5507768A Stent delivery system 失效
公开(公告)号：US5507768A
公开(公告)日：1996-04-16
申请号：US85959
申请日：1993-07-06
申请人： Lilip Lau , William M. Hartigan , Farhad Khosravi , Kurt R. Klemm , Ulrich Sigwart
发明人： Lilip Lau , William M. Hartigan , Farhad Khosravi , Kurt R. Klemm , Ulrich Sigwart
IPC分类号： A61F2/82 , A61F2/06 , A61F2/84 , A61M25/00 , A61M25/01 , A61M29/00
CPC分类号： A61F2/97 , A61F2/958 , A61F2002/9517 , A61M2025/0183 , A61M2025/1081
摘要： The invention is directed to a stent delivery method and system which generally includes an elongated delivery sheath and a catheter disposed within an outer lumen of the sheath having an expandable member on its distal extremity. An expandable stent is mounted on the expandable member of the catheter. The distal portion of the sheath tapers down and is tucked within an elastic cone during transport of the stent to a stenotic region. A manipulating device is provided on the proximal end of the delivery system to effect relative axial movement between the sheath and the catheter so as to expose the stent mounted on the expandable member on the catheter within a body lumen such as a coronary artery and allow the expansion of the stent by the expansion of the expandable member. The elastic cone thereby disengages from the sheath and collapses about the distal end of the catheter. The delivery sheath has a first port in its distal end and a second port in the sheath wall proximally disposed from the distal end of the sheath. The catheter likewise has a first port in its distal end and a second port proximally disposed from the distal end of the catheter. An inner lumen extends within the distal portion of the catheter between the first and second ports and slidably receives a guiding member such as a guidewire. This system allows the stent to be delivered over a guidewire previously advanced to the desired location within a body lumen.

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