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61. 发明申请

US20050142542A1 ABSORBING PATHOGEN-INACTIVATING COMPOUNDS WITH POROUS PARTICLES IMMOBILIZED IN A MATRIX 有权
标题翻译：吸收不稳定化学物质与多元胺在MATRIX中固定化
公开(公告)号：US20050142542A1
公开(公告)日：2005-06-30
申请号：US10016323
申请日：2001-12-10
申请人： Derek Hei , Michael Clarke
发明人： Derek Hei , Michael Clarke
IPC分类号： A61M1/36 , A61L2/00 , A61M1/02 , B01D15/00 , B01D15/08 , B01J20/20 , B01J20/26 , B01J20/28 , C07D219/10 , C07D405/12 , C07D493/04 , C07F9/64 , C12N11/00 , C12N11/08 , C12N11/16 , A01N1/02 , C07H21/04 , C12Q1/68
CPC分类号： B01J20/28026 , A01N1/0205 , A01N1/0236 , A01N1/0242 , A01N1/0278 , A61L2/00 , A61L2/0082 , A61M1/0209 , A61M1/0218 , A61M1/3679 , B01D15/00 , B01J20/20 , B01J20/28004 , B01J20/28019 , B01J20/28028 , B01J20/28057 , B01J20/28078 , C07D219/10 , C07D405/12 , C07D493/04 , C07F9/64 , C12N11/08
摘要： Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition, while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent particles, and the adsorbent particles are immobilized by an inert matrix. The matrix containing the particles is contained in a housing, and the particles range in diameter from about 1 μm to about 200 μm. The matrix can be fibrous, and the particles can have a surface area greater than 750 m2/g and a pore diameter between about 25 and 800 Å. The device can be used to adsorb and remove a pathogen-inactivating compound that is a nucleic acid-binding compound such as psoralen, an acridine derivative or a dye from a biological composition such as a blood product.
摘要翻译：提供的方法和装置用于降低生物组合物中低分子量化合物的浓度，同时基本维持生物组合物的所需生物活性。该装置包括高度多孔的吸附剂颗粒，吸附剂颗粒通过惰性基质固定。含有颗粒的基质包含在壳体中，并且颗粒的直径范围为约1μm至约200μm。基质可以是纤维状的，并且颗粒的表面积可以大于750m 2 / g，孔直径在约25和800之间。该装置可用于从生物组合物如血液制品中吸附和除去作为核酸结合化合物如补骨脂素，吖啶衍生物或染料的病原体灭活化合物。

62. 发明申请

US20050089518A1 Prospective identification and characterization of breast cancer stem cells 审中-公开
标题翻译：乳腺癌干细胞的前瞻性鉴定和表征
公开(公告)号：US20050089518A1
公开(公告)日：2005-04-28
申请号：US10497791
申请日：2002-12-06
申请人： Michael Clarke , Max Wicha , Muhammad Al-Hajj
发明人： Michael Clarke , Max Wicha , Muhammad Al-Hajj
IPC分类号： G01N33/574 , A01K67/027 , A61K31/00 , A61K35/76 , A61K38/00 , A61K38/17 , A61K39/00 , A61K39/395 , A61K45/00 , A61K47/48 , A61P15/00 , A61P35/00 , C07K16/18 , C07K16/28 , C07K16/30
CPC分类号： C07K16/28 , A61K38/1703 , A61K47/6897 , A61K47/6901 , A61K2039/505 , B82Y5/00 , C07K16/3015 , C12N5/0695
摘要： Human breast tumors contain hetrogeneous cancer cells. using an animal xenograft model in which human breast cancer cells were grown in immunocompromised mice we found that only a small minority of breast cancer cells had capacity to form new tumors. The ability to form new tumors was not a slochastic property, rather certain populations of cancer cells were depleted for the ability to form new tumors, while other populations were enriched for the ability to form new tumors. Tumorigenic cells could be distinguished from non-tumorigenic cancer cells based on surface marker expression. We prospectively identified and isolated the tumorigenic cells as CD4430CD24−/lowLINEAGE A few as 100 cells from this population were able to form tumors the animal xenograft model, while tens of thousands of cells from non-tumorigenic populations failed to form tumors. The tumorigenic cells could be serially passaged, each time generating new tumors containing and expanded numbers of CD44+CD24 Lineage tumorigenic cells as well as phenotypically mixed populations of non-tumorigenic cancer cells. This is reminiscent of the ability of normal stem cells to self-renew and differentiate. The expression of potential therapeutic targets also differed between the tumorigenic and non-tumorigenic populations. Notch activation promoted the survival of the tumorigenic cells, and a blocking antibody against Notch 4 induced tumorigenic breast cancer cells to undergo apoptosis.
摘要翻译：人乳腺肿瘤包含巨噬细胞癌细胞。使用动物异种移植模型，其中人类乳腺癌细胞在免疫受损的小鼠中生长，我们发现只有少数乳腺癌细胞具有形成新肿瘤的能力。形成新肿瘤的能力不是一个稀疏性，而是某些癌细胞群能够形成新的肿瘤，而其他的群体却能够形成新的肿瘤。基于表面标志物表达，致瘤细胞可以与非致瘤性癌细胞区分开。我们前瞻性地鉴定并分离了致瘤细胞作为CD44细胞系CD24 - /低序列，从该群体的100个细胞能够形成动物异种移植模型的肿瘤，而数十个来自非致瘤性群体的数千个细胞未能形成肿瘤。致瘤细胞可以连续传代，每次产生含有和扩增数量的CD44 + CD24序列致瘤细胞的新肿瘤以及非致瘤性癌细胞的表型混合群体。这让人想起正常干细胞自我更新和分化的能力。潜在的治疗靶点的表达也在致瘤性和非致瘤性群体之间不同。 Notch激活促进致瘤细胞的存活，并且针对Notch4的阻断抗体诱导致瘤性乳腺癌细胞进行细胞凋亡。

63. 外观设计

USD372740S Arcade game 失效
公开(公告)号：USD372740S
公开(公告)日：1996-08-13
申请号：US18587
申请日：1994-02-10
申请人： Karl D. Lerch , Michael Clarke
设计人： Karl D. Lerch , Michael Clarke

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