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61. 发明授权

US07371761B2 Lactam-containing compounds and derivatives thereof as factor Xa inhibitors 有权
标题翻译：含有内酰胺的化合物及其衍生物作为因子Xa抑制剂
公开(公告)号：US07371761B2
公开(公告)日：2008-05-13
申请号：US11623367
申请日：2007-01-16
申请人： Donald J. P. Pinto , Mimi L. Quan , Michael J. Orwat , Yun-Long Li , Wei Han , Jennifer X. Qiao , Patrick Y. S. Lam , Stephanie L Koch
发明人： Donald J. P. Pinto , Mimi L. Quan , Michael J. Orwat , Yun-Long Li , Wei Han , Jennifer X. Qiao , Patrick Y. S. Lam , Stephanie L Koch
IPC分类号： C07D471/02 , C07D491/02 , A61K31/44 , A61P7/02
CPC分类号： C07D413/14 , A61K31/4365 , A61K31/616 , A61K45/06 , C07D211/40 , C07D211/76 , C07D213/64 , C07D213/75 , C07D213/81 , C07D213/82 , C07D239/10 , C07D241/08 , C07D265/10 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14 , C07D471/04 , C07D495/04 , A61K2300/00
摘要： The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4-P-M-M4I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
摘要翻译：本申请描述了含有内酰胺的化合物及其式I的衍生物：<？in-line-formula description =“In-line Formulas”end =“lead”→> P 其中环P（如果存在的话）是5-7元碳环或其可药用盐形式，其中环P 杂环和环M是5-7元碳环或杂环。本发明的化合物可用作胰蛋白酶样丝氨酸蛋白酶的抑制剂，特别是因子Xa。

62. 发明授权

US07312218B2 Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors 有权
公开(公告)号：US07312218B2
公开(公告)日：2007-12-25
申请号：US11611195
申请日：2006-12-15
申请人： Wei Han , Zilun Hu , Timur Gungor
发明人： Wei Han , Zilun Hu , Timur Gungor
IPC分类号： C07D241/36 , C07D471/02 , C07D217/06 , C07D401/00 , C07D207/00
CPC分类号： C07D401/04 , C07D207/38 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula Ia-If: or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

63. 发明申请

US20070129361A1 LACTAM-CONTAINING DIAMINOALKYL, Beta-AMINOACIDS, Alpha-AMINOACIDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS 审中-公开
标题翻译：含乳酸的二氨基甲酸，β-氨基酸，α-氨基酸及其作为因子XA抑制剂的衍生物
公开(公告)号：US20070129361A1
公开(公告)日：2007-06-07
申请号：US11622484
申请日：2007-01-12
申请人： Jennifer Qiao , Wei Han
发明人： Jennifer Qiao , Wei Han
IPC分类号： A61K31/538 , A61K31/517 , A61K31/4706 , A61K31/4745 , A61K31/502 , A61K31/381 , A61K31/325
CPC分类号： C07D213/64 , C07D211/76 , C07D213/75 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The present application describes lactam-containing diaminoalkyl, β-aminoacids, α-aminoacids and derivatives thereof of Formula I: P-M-M1 Ior pharmaceutically acceptable salt forms thereof, wherein M is a linear core. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
摘要翻译：本申请描述了式I的含内酰胺的二氨基烷基，β-氨基酸，α-氨基酸及其衍生物：<？in-line-formula description =“In-line Formulas”end =“lead”？> PMM 1 其中M是线性核心，其中M是线性核心。本发明的化合物可用作胰蛋白酶样丝氨酸蛋白酶的抑制剂，特别是因子Xa。

64. 发明授权

US07213681B2 Acoustic stimulation tool with axial driver actuating moment arms on tines 有权
标题翻译：声刺激工具，带有轴向驱动器，在齿上启动力矩臂
公开(公告)号：US07213681B2
公开(公告)日：2007-05-08
申请号：US11059214
申请日：2005-02-16
申请人： James R. Birchak , Thomas E. Ritter , Ali I. Mese , Diederik van Batenburg , William Trainor , Wei Han , Kwang Yoo , Daniel P. Kusmer , Mark A. Proett , Ferdinand van der Bas , Peter van der Sman , Jeroen Groenenboom , Pedro Zuiderwijk
发明人： James R. Birchak , Thomas E. Ritter , Ali I. Mese , Diederik van Batenburg , William Trainor , Wei Han , Kwang Yoo , Daniel P. Kusmer , Mark A. Proett , Ferdinand van der Bas , Peter van der Sman , Jeroen Groenenboom , Pedro Zuiderwijk
IPC分类号： G01V1/02 , G01V1/112 , G01V1/143
CPC分类号： G01V1/04 , B06B1/02 , B06B1/0611 , E21B37/00 , E21B37/08
摘要： An apparatus for generating acoustic waves, the apparatus having: a support structure; two tines extending from the support structure so that proximal ends of the two tines are attached to the support structure so that distal ends of the two tines are positioned with standoffs relative to a dimension of the support structure and the distal ends of the two tines are uninhibited, wherein the two tines each comprise a moment arm; and an oscillator in mechanical communication with the two tines.
摘要翻译：一种用于产生声波的装置，所述装置具有：支撑结构; 两个齿从支撑结构延伸，使得两个尖齿的近端附接到支撑结构，使得两个齿的远端相对于支撑结构的尺寸定位，并且两个齿的远端是不受限制地，其中两个齿各自包括力臂; 以及与两个齿的机械通信的振荡器。

65. 发明申请

US20070099922A1 SULFONYLAMINOVALEROLACTAMS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS 有权
标题翻译：作为因子XA抑制剂的磺酰氨基戊酸酯衍生物及其衍生物
公开(公告)号：US20070099922A1
公开(公告)日：2007-05-03
申请号：US11611195
申请日：2006-12-15
申请人： Wei Han , Zilun Hu , Timur Gungor
发明人： Wei Han , Zilun Hu , Timur Gungor
IPC分类号： A61K31/517 , A61K31/502 , A61K31/498 , A61K31/4709 , A61K31/4015 , C07D403/02
CPC分类号： C07D401/04 , C07D207/38 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D495/04
摘要： The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula Ia-If: or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
摘要翻译：本申请描述了式Ia-If的磺酰氨基戊内酰胺及其衍生物：或其药学上可接受的盐形式，其中环G是单环或双环碳环或杂环。本发明的化合物可用作胰蛋白酶样丝氨酸蛋白酶的抑制剂，特别是因子Xa。

66. 发明申请

US20070067274A1 Hybrid push-down/pull-up of unions with expensive operations in a federated query processor 审中-公开
标题翻译：在联合查询处理器中使用昂贵的操作的工会的混合下推/上拉
公开(公告)号：US20070067274A1
公开(公告)日：2007-03-22
申请号：US11228888
申请日：2005-09-16
申请人： Wei Han , Inderpal Narang , Vijayshankar Raman
发明人： Wei Han , Inderpal Narang , Vijayshankar Raman
IPC分类号： G06F17/30
CPC分类号： G06F16/2456
摘要： Disclosed are a method and a system for executing a query that requires an expensive process, such as a join, between two or more datasets. If each dataset has multiple partitions that are located at multiple sources, then each of the multiple partitions for each dataset must be unioned prior to completing execution of the query. The method and system develop both a query execution plan and at least one alternative query execution plan to indicate when the process should be pushed down below the unions and when the process should be pulled up above the unions based on collocation of partitions. The query execution plan and the alternative query execution plan(s) are embedded in a composite query execution plan which is evaluated and re-evaluated at run time to determine which of the query execution plan and the alternative query execution plan is currently the most efficient plan and the query is executed, accordingly.
摘要翻译：公开了一种执行查询的方法和系统，该查询需要在两个或更多个数据集之间的昂贵的处理，诸如连接。如果每个数据集具有位于多个源的多个分区，则在完成执行查询之前，必须对每个数据集的每个分区进行联合。该方法和系统开发查询执行计划和至少一个替代查询执行计划，以指示何时将流程推送到工会下方，以及何时应该根据分区的搭配将工作提升到工会以上。查询执行计划和替代查询执行计划嵌入在复合查询执行计划中，该计划在运行时进行评估和重新评估，以确定查询执行计划和备用查询执行计划中的哪一个当前是最有效的相应地执行计划并执行查询。

67. 发明申请

US20070064539A1 Generating acoustic waves 审中-公开
标题翻译：产生声波
公开(公告)号：US20070064539A1
公开(公告)日：2007-03-22
申请号：US11213484
申请日：2005-08-26
申请人： Wei Han , Robert Birchak , William Trainor , Thomas Ritter , Kwang Yoo , Diederik Batenburg , Dan Kusmer
发明人： Wei Han , Robert Birchak , William Trainor , Thomas Ritter , Kwang Yoo , Diederik Batenburg , Dan Kusmer
IPC分类号： G01V1/155
CPC分类号： G01V1/40 , G01V1/02
摘要： An example method for generating acoustic waves is disclosed. The example method includes activating at least one driver, transmitting force from the at least one driver to at least one moment arm, and transferring force from the at least one moment arm to at least one plate, thereby causing the at least one plate to vibrate and generate acoustic waves.
摘要翻译：公开了一种用于产生声波的示例性方法。该示例性方法包括激活至少一个驱动器，将力从至少一个驾驶员传递到至少一个力矩臂，以及将力从至少一个力矩臂传递到至少一个板，从而使至少一个板振动并产生声波。

68. 发明申请

US20050267097A1 Lactam-containing compounds and derivatives thereof as factor xa inhibitors 有权
标题翻译：含有内酰胺的化合物及其衍生物作为因子xa抑制剂
公开(公告)号：US20050267097A1
公开(公告)日：2005-12-01
申请号：US11198801
申请日：2005-08-05
申请人： Donald Pinto , Mimi Quan , Michael Orwat , Yun-Long Li , Wei Han , Jennifer Qiao , Patrick Lam , Stephanie Koch
发明人： Donald Pinto , Mimi Quan , Michael Orwat , Yun-Long Li , Wei Han , Jennifer Qiao , Patrick Lam , Stephanie Koch
IPC分类号： C07D401/10 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/506 , A61K31/517 , A61K31/55 , A61K31/553 , A61P7/02 , A61P9/00 , C07D401/12 , C07D401/14 , C07D413/14 , C07D471/04 , C07D471/16
CPC分类号： C07D471/04 , A61J1/00 , A61J1/03 , A61J1/05 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/513 , A61K31/55 , A61K45/06 , B65D81/3216 , C07D213/75 , C07D213/81 , C07D213/82 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/14 , C07D417/14
摘要： The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P-M-M4 I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
摘要翻译：本申请描述了含有内酰胺的化合物及其式I的衍生物：<？in-line-formula description =“In-line Formulas”end =“lead”→> P 其中环P（如果存在的话）是5-7元碳环或其可药用盐形式，其中环P 杂环和环M是5-7元碳环或杂环。本发明的化合物可用作胰蛋白酶样丝氨酸蛋白酶的抑制剂，特别是因子Xa。

69. 发明授权

US06967208B2 Lactam-containing compounds and derivatives thereof as factor Xa inhibitors 有权
标题翻译：含有内酰胺的化合物及其衍生物作为因子Xa抑制剂
公开(公告)号：US06967208B2
公开(公告)日：2005-11-22
申请号：US10245122
申请日：2002-09-17
申请人： Donald J. P. Pinto , Mimi L. Quan , Michael J. Orwat , Yun-Long Li , Wei Han , Jennifer X. Qiao , Patrick Y. S. Lam , Stephanie L. Koch
发明人： Donald J. P. Pinto , Mimi L. Quan , Michael J. Orwat , Yun-Long Li , Wei Han , Jennifer X. Qiao , Patrick Y. S. Lam , Stephanie L. Koch
IPC分类号： A61K31/4439 , A61K31/4709 , A61K31/4745 , A61K31/502 , A61K31/513 , A61K31/538 , C07D211/40 , C07D213/75 , C07D213/81 , C07D213/82 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D413/02 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/16 , A61K31/437 , A61P7/02
CPC分类号： C07D413/14 , A61K31/4365 , A61K31/616 , A61K45/06 , C07D211/40 , C07D211/76 , C07D213/64 , C07D213/75 , C07D213/81 , C07D213/82 , C07D239/10 , C07D241/08 , C07D265/10 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14 , C07D471/04 , C07D495/04 , A61K2300/00
摘要： The present application describes lactam-containing compounds and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
摘要翻译：本申请描述了含有式I的化合物及其衍生物或其药学上可接受的盐形式，其中环P（如果存在）为5-7元碳环或杂环，且环M为5-7元碳环或杂环。本发明的化合物可用作胰蛋白酶样丝氨酸蛋白酶的抑制剂，特别是因子Xa。

70. 发明申请

US20050124602A1 Lactam-containing compounds and derivatives thereof as factor Xa inhibitors 有权
标题翻译：含有内酰胺的化合物及其衍生物作为因子Xa抑制剂
公开(公告)号：US20050124602A1
公开(公告)日：2005-06-09
申请号：US10970781
申请日：2004-10-20
申请人： Donald Pinto , Mimi Quan , Michael Orwat , Yun-Long Li , Wei Han , Jennifer Qiao , Patrick Lam , Stephanie Koch
发明人： Donald Pinto , Mimi Quan , Michael Orwat , Yun-Long Li , Wei Han , Jennifer Qiao , Patrick Lam , Stephanie Koch
IPC分类号： A61K31/4439 , A61K31/4709 , A61K31/4745 , A61K31/502 , A61K31/513 , A61K31/538 , C07D211/40 , C07D213/75 , C07D213/81 , C07D213/82 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D413/02 , C07D413/14 , C07D417/14 , C07D471/04 , C07D417/02 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D43/02
CPC分类号： C07D413/14 , A61K31/4365 , A61K31/616 , A61K45/06 , C07D211/40 , C07D211/76 , C07D213/64 , C07D213/75 , C07D213/81 , C07D213/82 , C07D239/10 , C07D241/08 , C07D265/10 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/14 , C07D471/04 , C07D495/04 , A61K2300/00
摘要： The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4-P-M-M4 I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
摘要翻译：本申请描述了含有内酰胺的化合物及其式I的衍生物：<？in-line-formula description =“In-line Formulas”end =“lead”→> P 其中环P（如果存在的话）是5-7元碳环或其可药用盐形式，其中环P 杂环和环M是5-7元碳环或杂环。本发明的化合物可用作胰蛋白酶样丝氨酸蛋白酶的抑制剂，特别是因子Xa。

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