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61. 发明授权

US08481057B2 Chlamydial antigens 失效
标题翻译：衣原体抗原
公开(公告)号：US08481057B2
公开(公告)日：2013-07-09
申请号：US12086571
申请日：2006-12-19
申请人： Guido Grandi , Lehutova Livia
发明人： Guido Grandi , Giulio Ratti
IPC分类号： A61K39/118 , C07K14/295
CPC分类号： A61K39/118
摘要： The invention is in the field of immunology and vaccinology. In particular, it relates to antigens derived from Chlamydia trachomatis that are expressed on the cell surface and so are ideal for use in immunization as well as combinations of these antigens.
摘要翻译：本发明在免疫学和疫苗学领域。特别地，本发明涉及在细胞表面表达的来自沙眼衣原体的抗原，因此是用于免疫的理想用途以及这些抗原的组合。

62. 发明授权

US08133973B2 Immunogenic compositions for Chlamydia trachomatis 失效
标题翻译：沙眼衣原体的免疫原性组合物
公开(公告)号：US08133973B2
公开(公告)日：2012-03-13
申请号：US11920230
申请日：2006-05-12
申请人： Guido Grandi , Giulio Ratti
发明人： Guido Grandi , Giulio Ratti
IPC分类号： C07K14/295 , A61K38/04 , A61K39/118
CPC分类号： C07K14/295 , Y10T436/143333
摘要： The present invention provides variant LcrE sequences and/or combinations of variant LcrE sequences across the Chlamydia trachomatis serovars. Such changes in LcrE genotypes across the Chlamydia trachomatis serovars are likely to correspond with changes in LcrE phenotypes, in particular, with changes in immunogenicity. The present invention also provides peptides surrounding or associated with the amino acid substitutions, in particular, peptides surrounding or associated with high frequency mutated amino acid positions or hypervariable regions, which are likely to be B and/or T cell epitopic regions capable of eliciting Chlamydia specific cell mediated immune responses. The variant LcrE sequences and/or combinations of the variant LcrE sequences and/or epitope regions associated with the variant LcrE sequences are useful as immunogens and/or in the preparation of immunogenic compositions for preventing and/or treating and/or, diagnosing Chlamydia infections.
摘要翻译：本发明提供了穿过沙眼衣原体血清型沙眼衣原体的变体LcrE序列和/或变体LcrE序列的组合。沙眼衣原体血清型的LcrE基因型的这种变化可能与LcrE表型的变化相一致，特别是随着免疫原性的变化。本发明还提供了与氨基酸取代相关的肽，特别是与高频突变的氨基酸位置或高变区相关的肽，其可能是能诱导衣原体的B和/或T细胞表位区特异性细胞介导的免疫应答。与变体LcrE序列相关的变体LcrE序列和/或变体LcrE序列和/或表位区域的变体的变体LcrE序列和/或组合可用作免疫原和/或用于预防和/或治疗和/或诊断衣原体感染的免疫原性组合物。

63. 发明申请

US20110206692A1 CONFORMERS OF BACTERIAL ADHESINS 审中-公开
标题翻译：细菌粘合剂
公开(公告)号：US20110206692A1
公开(公告)日：2011-08-25
申请号：US12304018
申请日：2007-06-11
申请人： Domenico Maione , Nathalie Norais , Guido Grandi , Vincenzo Nardi-Dei
发明人： Domenico Maione , Nathalie Norais , Guido Grandi , Vincenzo Nardi-Dei
IPC分类号： A61K39/40 , C07K14/195 , C07K16/12 , C07K16/46 , A61K39/02 , C07K1/18 , C07K1/14 , A61P31/04 , B01D57/02
CPC分类号： A61K39/092 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/315 , G01N33/56944 , G01N2469/20
摘要： The invention relates to isolated or purified bacterial adhesin conformers, preferably with improved stability and/or immunogenicity. In a preferred aspect, the invention comprises an isolated bacterial adhesin conformer F. Also provided are methods of isolation and/or separation of such adhesin conformers. The compositions may include one or more of the immunogenic polypeptides either alone or with other antigenic components. For example, the immunogenic polypeptides may be combined with other bacterial antigens to provide therapeutic compositions with broader range.
摘要翻译：本发明涉及分离或纯化的细菌粘附素构象异构体，优选具有改善的稳定性和/或免疫原性。在优选的方面，本发明包括分离的细菌粘附素构象体F.还提供了这种粘附素构象异构体的分离和/或分离的方法。组合物可以单独或与其它抗原成分一起包括一种或多种免疫原性多肽。例如，免疫原性多肽可以与其他细菌抗原组合以提供更宽范围的治疗组合物。

64. 发明申请

US20100183674A1 COMPOSITIONS COMPRISING YERSINIA PESTIS ANTIGENS 审中-公开
标题翻译：包含YERSINIA PESTIS抗原的组合物
公开(公告)号：US20100183674A1
公开(公告)日：2010-07-22
申请号：US12733488
申请日：2008-09-04
申请人： Renata Maria Grifantini , Guido Grandi , Maria Scarselli , Erika Bartolini , Elisabetta Frigimelica
发明人： Renata Maria Grifantini , Guido Grandi , Maria Scarselli , Erika Bartolini , Elisabetta Frigimelica
IPC分类号： A61K39/02 , C07K16/12 , A61P31/04 , A61P37/04
CPC分类号： A61K39/025 , A61K39/00 , Y02A50/407
摘要： Disclosed are several Y. pestis antigens that are particularly suitable for immunisation purposes, particularly when used in combinations.
摘要翻译：公开了几种特别适用于免疫目的的鼠疫菌，特别是组合使用时。

65. 发明授权

US07538207B2 Polyepitope carrier protein 失效
标题翻译：多表皮载体蛋白
公开(公告)号：US07538207B2
公开(公告)日：2009-05-26
申请号：US11030635
申请日：2005-01-06
申请人： Rino Rappuoli , Guido Grandi
发明人： Rino Rappuoli , Guido Grandi
IPC分类号： C07H21/04 , C12N15/09 , C12N15/00
CPC分类号： C07K14/005 , A01K2217/05 , A61K38/00 , A61K39/00 , C07K14/22 , C07K14/235 , C07K14/33 , C07K14/34 , C07K14/445 , C07K2319/00 , C12N2730/10122 , C12N2760/16222 , Y02A50/412 , Y10S424/831 , Y10S424/832 , Y10S530/806 , Y10S530/807 , Y10S530/822 , Y10S530/825 , Y10S530/826
摘要： The invention relates to polyepitope carrier proteins that comprise at least five CD4+T cell epitopes, for conjugation to capsular polysaccharides. The carrier proteins are use useful as components of vaccines that can elicit a T-cell dependent immune response. These vaccines are particularly useful to confer protection against infection from encapsulated bacteria in infants between the ages of 3 months and about 2 years.
摘要翻译：本发明涉及包含至少五个CD4 + T细胞表位的多表位载体蛋白，用于与荚膜多糖缀合。载体蛋白可用作可引发T细胞依赖性免疫应答的疫苗的组分。这些疫苗特别适用于在3个月至2年之间的婴儿中赋予防止包囊细菌感染的保护作用。

66. 发明申请

US20080220010A1 Immunogenic Compositions for Streptococcus Agalactiae 有权
标题翻译：无乳链球菌的免疫原性组成
公开(公告)号：US20080220010A1
公开(公告)日：2008-09-11
申请号：US10568422
申请日：2004-09-15
申请人： John L. Telford , Guido Grandi , Immaculada Margarit Y Ros , Domenico Maione
发明人： John L. Telford , Guido Grandi , Immaculada Margarit Y Ros , Domenico Maione
IPC分类号： A61K39/02 , A61K39/09 , A61K39/00
CPC分类号： A61K39/09 , Y10S530/825
摘要： This application relates to Group B Streptococcus (“GBS”) vaccines comprising combinations of GBS polypeptide antigens where the polypeptides contribute to the immunological response in a recipient. Preferably, the compositions of the invention comprise a combination of two or more GBS antigens, wherein said combination includes GBS 80 or a fragment thereof. In one embodiment, the combination may consist of two to thirteen GBS antigens selected from an antigen group consisting of GBS 80, GBS 91, GBS 104, GBS 184, GBS 276, GBS 305, GBS 322, GBS 330, GBS 338, GBS 361, GBS 404, GBS 690, and GBS 691.
摘要翻译：本申请涉及包含GBS多肽抗原组合的B组链球菌（“GBS”）疫苗，其中多肽有助于接受者的免疫应答。优选地，本发明的组合物包含两种或更多种GBS抗原的组合，其中所述组合包括GBS 80或其片段。在一个实施方案中，该组合可以由选自GBS 80，GBS 91，GBS 104，GBS 184，GBS 276，GBS 305，GBS 322，GBS 330，GBS 338，GBS 361的抗原组中的两至十三个GBS抗原组成，GBS 404，GBS 690和GBS 691。

67. 发明申请

US20070116726A1 Immunisation against Chlamydia pneumoniae 审中-公开
标题翻译：免疫肺炎衣原体
公开(公告)号：US20070116726A1
公开(公告)日：2007-05-24
申请号：US11414403
申请日：2006-05-01
申请人： Guilio Ratti , Guido Grandi
发明人： Guilio Ratti , Guido Grandi
IPC分类号： A61K39/118 , C07H21/04 , C12N15/74 , C12N1/21 , C07K14/295
CPC分类号： C07K14/295 , A61K39/00 , A61K2039/53
摘要： The published genomic sequence of Chlamydia pneumoniae reveals over 1000 putative encoded proteins but does not itself indicate which of these might be useful antigens for immunisation and vaccination or for diagnosis. This difficulty is addressed by the invention, which provides a number of C. pneumoniae protein sequences suitable for vaccine production and development and/or for diagnostic purposes.
摘要翻译：公布的肺炎衣原体的基因组序列揭示超过1000个推定编码的蛋白质，但本身并不表明其中哪些可能是免疫接种或疫苗接种或诊断的有用抗原。本发明解决了这个困难，本发明提供了许多适用于疫苗生产和开发和/或用于诊断目的的肺炎衣原体蛋白序列。

68. 发明申请

US20070003566A1 Polyepitope carrier protein 失效
标题翻译：多表皮载体蛋白
公开(公告)号：US20070003566A1
公开(公告)日：2007-01-04
申请号：US11030635
申请日：2005-01-06
申请人： Rino Rappuoli , Guido Grandi
发明人： Rino Rappuoli , Guido Grandi
IPC分类号： A61K39/12 , A61K39/02 , A61K39/005 , C07K14/74 , C07K14/44 , C07K14/195 , C07K14/005
CPC分类号： C07K14/005 , A01K2217/05 , A61K38/00 , A61K39/00 , C07K14/22 , C07K14/235 , C07K14/33 , C07K14/34 , C07K14/445 , C07K2319/00 , C12N2730/10122 , C12N2760/16222 , Y02A50/412 , Y10S424/831 , Y10S424/832 , Y10S530/806 , Y10S530/807 , Y10S530/822 , Y10S530/825 , Y10S530/826
摘要： The invention relates to polyepitope carrier proteins that comprise at least five CD4+T cell epitopes, for conjugation to capsular polysaccharides. The carrier proteins are use useful as components of vaccines that can elicit a T-cell dependent immune response. These vaccines are particularly useful to confer protection against infection from encapsulated bacteria in infants between the ages of 3 months and about 2 years.
摘要翻译：本发明涉及包含至少五个CD4 + T细胞表位的多表位载体蛋白，用于与荚膜多糖缀合。载体蛋白可用作可引发T细胞依赖性免疫应答的疫苗的组分。这些疫苗特别适用于在3个月至2年之间的婴儿中赋予防止包囊细菌感染的保护作用。

69. 发明授权

US5674712A Recombinant vector and use thereof for exocellular preparation of antibodies in single molecule form from Bacillus subtilis 失效
标题翻译：重组载体及其用于从枯草芽孢杆菌单分子形式的细胞外抗体制备
公开(公告)号：US5674712A
公开(公告)日：1997-10-07
申请号：US207169
申请日：1994-03-08
申请人： Guido Grandi , Francesca De Ferra , Claudio Tosi , Ornella Tortora , Anna Cuzzoni
发明人： Guido Grandi , Francesca De Ferra , Claudio Tosi , Ornella Tortora , Anna Cuzzoni
IPC分类号： C07K7/06 , A61K38/00 , C07K7/08 , C07K14/00 , C07K14/195 , C07K14/41 , C07K16/00 , C07K16/46 , C12N1/21 , C12N15/02 , C12N15/09 , C12N15/13 , C12N15/75 , C12P21/02 , C12P21/08 , C12R1/125 , C12N15/63
CPC分类号： C07K16/468 , C12N15/75 , A61K38/00 , C07K2319/00 , C07K2319/036 , Y10S435/839 , Y10S530/808 , Y10S530/867
摘要： A recombinant vector for the expression and secretion of antibodies in single molecule form (scFv) from B. subtilis, where said vector comprises the promoter of the gene for neutral protease, a new secretion sequence (I) and a DNA sequence coding a scFv antibody of interest, a strain of B. subtilis transformed with said recombinant vector, and a process for the exocellular production of scFv antibodies by culturing said strain of B. subtilis are described. The recombinant vector allows the expression of scFv in a completely soluble form and its secretion in high yields.
摘要翻译：一种用于从枯草芽孢杆菌分离形式（scFv）表达和分泌抗体的重组载体，其中所述载体包含用于中性蛋白酶的基因的启动子，新的分泌序列（I）和编码scFv抗体的DNA序列描述了用所述重组载体转化的枯草芽孢杆菌菌株，以及通过培养所述枯草芽孢杆菌菌株来细胞外产生scFv抗体的方法。重组载体允许以完全可溶形式表达scFv，并以高产率分泌其表达。

70. 发明授权

US5252478A Thermostable mutants of neutral protease and means for their preparation 失效
标题翻译：中性蛋白酶的热稳定突变体及其制备方法
公开(公告)号：US5252478A
公开(公告)日：1993-10-12
申请号：US658908
申请日：1991-02-22
申请人： Immaculada Margarit y Ros , Susanna Campagnoli , Roberto Gianna , Salvatore Toma , Guido Grandi
发明人： Immaculada Margarit y Ros , Susanna Campagnoli , Roberto Gianna , Salvatore Toma , Guido Grandi
IPC分类号： C12N1/21 , C12N9/50 , C12N9/56 , C12N15/57 , C12N15/00 , C12N15/75
CPC分类号： C12N9/54 , C12N9/50
摘要： The mutants of neutral protease (NP) described can retain their enzymatic activities at temperatures at which wild-type neutral protease becomes inactive, the mutants being characterised in that the Gly 189 and/or Gly 147 residues of the aminoacid sequence of NP are replaced by different residues selected from the natural aminoacids.Mutagenised genes of neutral protease which code for the mutants, recombinant plasmids containing the genes, and strains of Bacillus transformed by the plasmids are also described. The mutants of neutral protease having the characteristics described above are particularly useful in the food sector.

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