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61. 发明授权

US08093363B2 Tumor necrosis factor-gamma 失效
标题翻译：肿瘤坏死因子-γ
公开(公告)号：US08093363B2
公开(公告)日：2012-01-10
申请号：US12879210
申请日：2010-09-10
申请人： Guo-Liang Yu , Jian Ni , Craig A. Rosen , Jun Zhang
发明人： Guo-Liang Yu , Jian Ni , Craig A. Rosen , Jun Zhang
IPC分类号： C07K16/28 , C07K16/18 , C07K16/22 , C07K16/46 , C07K14/525 , C12N5/00 , G01N33/53
CPC分类号： A61K51/08 , C07K16/241 , Y10S930/144
摘要： Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
摘要翻译：公开了人类TNF-γ-α和TNF-γ-β多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这些多肽抑制细胞生长的方法，例如在肿瘤或癌症中，用于促进伤口愈合，提供抗感染，诱导炎症活性和刺激某些细胞类型的生长以治疗疾病，示例再狭窄。还公开了用于检测TNF-γ-α和TNF-γ-β核酸序列中的突变或TNF-γ-α和/或TNF-γ-β多肽的过表达的诊断方法。还公开了抗这些多肽的拮抗剂及其作为治疗性恶病质，败血性休克，脑疟疾，炎症，关节炎和移植排斥的治疗剂的用途。

62. 发明授权

US07708996B2 DR3 antibodies 失效
标题翻译： DR3抗体
公开(公告)号：US07708996B2
公开(公告)日：2010-05-04
申请号：US12046107
申请日：2008-03-11
申请人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
发明人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
IPC分类号： A61K39/395 , C07K16/18 , C07K16/28
CPC分类号： C07K14/4747 , A61K38/00 , A61K48/00 , C07K14/705 , C07K14/70578 , C07K16/2878 , C07K2317/21 , C12N2799/026
摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are antibodies and fragments thereof that bind to polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新型死亡域含有受体（DR3和DR3-V1）蛋白。特别地，提供编码人DR3和DR3-V1蛋白的分离的核酸分子。还提供DR3和DR3-V1多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。还提供了结合本发明多肽的抗体及其片段。本发明还涉及用于鉴定DR3和DR3-V1活性的激动剂和拮抗剂的筛选方法。

63. 发明授权

US07357927B2 Death domain containing receptors 有权
标题翻译：含有受体的死亡域
公开(公告)号：US07357927B2
公开(公告)日：2008-04-15
申请号：US10189189
申请日：2002-07-05
申请人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
发明人： Guo-Liang Yu , Jian Ni , Reiner L. Gentz , Patrick J. Dillon
IPC分类号： A61K39/395 , A61K39/00 , C07K16/18 , C07K16/28
CPC分类号： C07K14/4747 , A61K38/00 , A61K48/00 , C07K14/705 , C07K14/70578 , C07K16/2878 , C07K2317/21 , C12N2799/026
摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are antibodies and fragments thereof that bind to polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新型死亡域含有受体（DR3和DR3-V1）蛋白。特别地，提供编码人DR3和DR3-V1蛋白的分离的核酸分子。还提供DR3和DR3-V1多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。还提供了结合本发明多肽的抗体及其片段。本发明还涉及用于鉴定DR3和DR3-V1活性的激动剂和拮抗剂的筛选方法。

64. 发明申请

US20070009525A1 Human Endokine Alpha and Methods of Use 失效
标题翻译：人类内含子阿尔法和使用方法
公开(公告)号：US20070009525A1
公开(公告)日：2007-01-11
申请号：US11427956
申请日：2006-06-30
申请人： Guo-Liang Yu , Jian Ni , Craig Rosen
发明人： Guo-Liang Yu , Jian Ni , Craig Rosen
IPC分类号： A61K39/395 , C12P21/02 , C07H21/04 , C07K14/525 , C07K16/24
CPC分类号： C07K14/7151 , A61K38/00 , C07K14/5255 , C07K16/24 , C07K2317/21 , C07K2317/622 , Y10S514/885
摘要： The present invention concerns a novel member of the tumor necrosis factor (TNF) family of cytokines. In particular, isolated nucleic acid molecules are provided encoding the endokine alpha protein. Endokine alpha polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic and therapeutic methods concerning TNF family-related disorders.
摘要翻译：本发明涉及细胞因子的肿瘤坏死因子（TNF）家族的新成员。特别地，提供了分离的核酸分子，其编码内丝蛋白α蛋白。还提供了内含子α多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。还提供了关于TNF家族相关疾病的诊断和治疗方法。

65. 发明申请

US20060147982A1 32 human secreted proteins 审中-公开
标题翻译： 32种人体分泌蛋白
公开(公告)号：US20060147982A1
公开(公告)日：2006-07-06
申请号：US11366001
申请日：2006-03-02
申请人： Steven Ruben , Craig Rosen , Kenneth Carter , Patrick Dillon , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng
发明人： Steven Ruben , Craig Rosen , Kenneth Carter , Patrick Dillon , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/47
CPC分类号： C07K14/47 , A61K38/00 , C07K14/525 , G01N2500/04
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

66. 发明申请

US20060025574A1 32 human secreted proteins 有权
公开(公告)号：US20060025574A1
公开(公告)日：2006-02-02
申请号：US11226657
申请日：2005-09-15
申请人： Steven Ruben , Craig Rosen , Kenneth Carter , Patrick Dillon , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng
发明人： Steven Ruben , Craig Rosen , Kenneth Carter , Patrick Dillon , Gregory Endress , Guo-Liang Yu , Jian Ni , Ping Feng
IPC分类号： C07H21/04 , C12P21/06 , C12N5/06 , C07K16/44
CPC分类号： C07K14/47 , A61K38/00 , C07K16/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

67. 发明授权

US06951735B2 Death domain containing receptors 有权
标题翻译：含有受体的死亡域
公开(公告)号：US06951735B2
公开(公告)日：2005-10-04
申请号：US09314889
申请日：1999-05-19
申请人： Guo-Liang Yu , Jian Ni , Vishva Dixit , Reiner L. Gentz , Patrick J. Dillon
发明人： Guo-Liang Yu , Jian Ni , Vishva Dixit , Reiner L. Gentz , Patrick J. Dillon
IPC分类号： C12N15/09 , A61K38/00 , A61P29/00 , A61P31/04 , A61P31/12 , A61P35/00 , A61P37/00 , A61P43/00 , C07H21/04 , C07K14/705 , C07K14/715 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/19 , C12R1/91 , C12N15/63
CPC分类号： C07K14/70578 , A61K38/00
摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新型死亡域含有受体（DR3和DR3-V1）蛋白。特别地，提供编码人DR3和DR3-V1蛋白的分离的核酸分子。还提供DR3和DR3-V1多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。本发明还涉及用于鉴定DR3和DR3-V1活性的激动剂和拮抗剂的筛选方法。

68. 发明授权

US06743625B2 Death domain containing receptor 5 有权
标题翻译：含有受体5的死亡域
公开(公告)号：US06743625B2
公开(公告)日：2004-06-01
申请号：US09874138
申请日：2001-06-06
申请人： Jian Ni , Reiner L. Gentz , Guo-Liang Yu , Craig A. Rosen
发明人： Jian Ni , Reiner L. Gentz , Guo-Liang Yu , Craig A. Rosen
IPC分类号： C07K14705
CPC分类号： C07K14/7151 , A61K38/00 , A61K39/395 , C07K14/70578 , C07K2319/00 , C07K2319/30 , A61K2300/00
摘要： The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity.
摘要翻译：本发明涉及作为肿瘤坏死因子（TNF）受体家族的成员的新的含有死亡域的受体-5（DR5）蛋白，现在已经显示结合TRAIL。特别地，提供编码人DR5蛋白的分离的核酸分子。还提供了DR5多肽，载体，宿主细胞以及用于制备它们的重组方法。本发明还涉及用于鉴定DR5活性的拮抗剂和拮抗剂的筛选方法。

69. 发明授权

US06599719B2 Nucleic acid molecules encoding tumor necrosis factor-gamma-alpha 失效
标题翻译：编码肿瘤坏死因子-γ-α的核酸分子
公开(公告)号：US06599719B2
公开(公告)日：2003-07-29
申请号：US09131237
申请日：1998-08-07
申请人： Guo-Liang Yu , Jian Ni , Craig A. Rosen
发明人： Guo-Liang Yu , Jian Ni , Craig A. Rosen
IPC分类号： C12N1528
CPC分类号： C07K14/525 , A61K38/00 , A61K48/00 , Y10S930/14
摘要： Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory acitvities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexperession of the TNF-gamma-alpha and TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
摘要翻译：公开了人类TNF-γ-α和TNF-γ-β多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。还公开了利用这些多肽抑制细胞生长的方法，例如在肿瘤或癌症中，用于促进伤口愈合，提供抗感染，诱导炎性活性和刺激某些细胞类型的生长以治疗疾病，示例再狭窄。还公开了用于检测TNF-γ-α和TNF-γ-β核酸序列中的突变或TNF-γ-α和TNF-γ-β多肽的过度表达的诊断方法。还公开了抗这些多肽的拮抗剂及其作为治疗性恶病质，败血性休克，脑疟疾，炎症，关节炎和移植排斥的治疗剂的用途。

70. 发明授权

US06448044B2 DNA encoding human natural killer cell activating factor II 失效
标题翻译：编码人类天然杀伤细胞活化因子II的DNA
公开(公告)号：US06448044B2
公开(公告)日：2002-09-10
申请号：US08832488
申请日：1997-04-03
申请人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner L. Gentz
发明人： Jian Ni , Haodong Li , Guo-Liang Yu , Reiner L. Gentz
IPC分类号： C12P2102
CPC分类号： C07K16/28 , A61K38/00 , C07K14/52
摘要： The invention relates to NKAF II polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.
摘要翻译：本发明涉及NKAF II多肽，编码多肽的多核苷酸，产生多肽的方法，特别是通过表达多核苷酸，多肽的激动剂和拮抗剂。本发明还涉及用于应用的这些多核苷酸，多肽，激动剂和拮抗剂的方法，其部分涉及研究，诊断和临床领域。

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