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61. 发明申请

US20100285573A1 Apparatus for processing a sample in a liquid droplet and method of using the same 有权
标题翻译：用于处理液滴中的样品的装置及其使用方法
公开(公告)号：US20100285573A1
公开(公告)日：2010-11-11
申请号：US11984197
申请日：2007-11-14
申请人： Kwong Joo Leck , Nam Yong Kim , Jackie Y. Ying , Li Li , Yong Yeow Lee
发明人： Kwong Joo Leck , Nam Yong Kim , Jackie Y. Ying , Li Li , Yong Yeow Lee
IPC分类号： C12M1/34
CPC分类号： G01N1/31 , B01L3/5088 , B01L2300/0609 , B01L2300/0829 , B01L2300/089 , B01L2300/161 , B01L2400/0415 , C12M25/01 , G01N33/54373 , G01N2035/1037
摘要： The invention provides an apparatus and a method of processing a biological and/or chemical sample in a liquid droplet. The apparatus comprises a processing compartment, which is defined by a reservoir and an immobilisation member. The processing compartment is further adapted to accommodate a medium, which is immiscible with the liquid droplet, and of a lower surface energy than the liquid of the liquid droplet. The reservoir is defined by a circumferential wall and a base. The immobilisation member is arranged within the reservoir and comprises a surface that is patterned in such a way that it comprises at least one predefined immobilisation area. The predefined immobilisation area within the patterned surface is of a higher surface energy than the medium. Furthermore the at least one predefined area is of a higher surface energy than the remaining surface and of a sufficient width in the plane of the surface to allow, in said hydrophobic medium, the immobilisation of the liquid droplet on the hydrophilic area via hydrophilic-hydrophilic or hydrophobic-hydrophobic interactions. The remaining surface is of at most about the same surface energy as the medium. In the method of the invention the medium is disposed into the apparatus, such that the predefined immobilisation area is entirely covered by the medium. The liquid droplet is disposed onto the predefined immobilisation area, whereby the liquid droplet is immobilised thereon via hydrophilic-hydrophilic or hydrophobic-hydrophobic interactions. A process is performed on the biological and/or chemical sample in said liquid droplet.
摘要翻译：本发明提供了一种在液滴中处理生物和/或化学样品的装置和方法。该装置包括由储存器和固定构件限定的处理室。处理室还适于容纳与液滴不混溶的介质和比液滴的液体低的表面能。储存器由圆周壁和底座限定。固定构件布置在储存器内并且包括以使得其包括至少一个预定义的固定区域的方式图案化的表面。图案化表面内的预定义的固定区域具有比介质更高的表面能。此外，至少一个预定义的区域具有比剩余表面更高的表面能并且在表面的平面中具有足够的宽度，以允许在所述疏水介质中通过亲水亲水性将液滴固定在亲水区域上或疏水 - 疏水相互作用。剩余的表面与介质的表面能最多相同。在本发明的方法中，将介质放置在设备中，使得预定义的固定区域被介质完全覆盖。将液滴设置在预定义的固定区域上，由此通过亲水亲水或疏水 - 疏水相互作用将液滴固定在其上。对所述液滴中的生物和/或化学样品进行处理。

62. 发明申请

US20100248245A1 INTEGRATED APPARATUS FOR CONDUCTING AND MONITORING CHEMICAL REACTIONS 有权
标题翻译：用于导电和监测化学反应的综合装置
公开(公告)号：US20100248245A1
公开(公告)日：2010-09-30
申请号：US12746510
申请日：2008-11-06
申请人： Jackie Y. Ying , Tseng-Ming Hsieh , Jeremy Ming Hock Loh , Chunyan Zhang
发明人： Jackie Y. Ying , Tseng-Ming Hsieh , Jeremy Ming Hock Loh , Chunyan Zhang
IPC分类号： C12Q1/68 , C12M1/34 , C12M1/38
CPC分类号： B01L3/50851 , B01J2219/00283 , B01J2219/00306 , B01J2219/00495 , B01J2219/00576 , B01J2219/00585 , B01J2219/00704 , B01J2219/00722 , B01L7/52 , B01L2300/0654 , B01L2300/1822 , B01L2300/1827 , G01N21/03 , G01N2021/0346
摘要： Apparatus for conducting and monitoring chemical reactions comprises a base and a thermal cycler mounted on the base. A plurality of heat-conducting receptacles are mounted on the thermal cycler and in heat-communication therewith. Each receptacle comprises an opaque body defining a bore having an open end, a first window, and a second window. A cartridge is removably mounted on the receptacles. The cartridge comprises a plurality of light-transmitting reaction vessels, and conduits connected to the reaction vessels for processing and transferring fluid. The reaction vessels are received in the bores of the receptacles through the open ends of the bores. A light emitter is mounted on the base for illuminating the reaction vessels through the first windows of the reaction vessels. A light detector is mounted on the base for selectively receiving and detecting light emitted from the reaction vessels through the second windows of the receptacles.
摘要翻译：用于进行和监测化学反应的装置包括安装在基座上的底座和热循环仪。多个导热容器安装在热循环仪上并与其热连通。每个容器包括限定具有开口端，第一窗口和第二窗口的孔的不透明体。容器可拆卸地安装在容器上。盒包括多个透光反应容器和连接到反应容器的管道，用于处理和传送流体。反应容器通过孔的开口端容纳在容器的孔中。光发射器安装在基座上，用于通过反应容器的第一窗口照亮反应容器。光检测器安装在基座上，用于通过容器的第二窗口选择性地接收和检测从反应容器发射的光。

63. 发明申请

US20100240117A1 THREE DIMENSIONAL FABRICATION OF BIOCOMPATIBLE STRUCTURES IN ANATOMICAL SHAPES AND DIMENSIONS FOR TISSUE ENGINEERING AND ORGAN REPLACEMENT 审中-公开
标题翻译：用于组织工程和组织替代的解剖形状和尺寸中生物化学结构的三维制造
公开(公告)号：US20100240117A1
公开(公告)日：2010-09-23
申请号：US12749831
申请日：2010-03-30
申请人： Jackie Y. Ying , Shyi Herng Kan , Jeremy Ming Hock Loh , Karl Schumacher , Tseng-Ming Hsieh
发明人： Jackie Y. Ying , Shyi Herng Kan , Jeremy Ming Hock Loh , Karl Schumacher , Tseng-Ming Hsieh
IPC分类号： C12M3/00 , C12M1/00
CPC分类号： A61L27/38 , A61L27/56 , B33Y80/00 , C12N5/0068 , C12N2533/30
摘要： Methods and apparatuses involving biocompatible structures for tissue engineering and organ replacement and, more specifically, biocompatible structures formed by three-dimensional fabrication, are described. In some embodiments, the biocompatible structures are scaffolds for cells that can be used as tissue engineering templates and/or as artificial organs. The structures may be three-dimensional and can mimic the shapes and dimensions of tissues and/or organs, including the microarchitecture and porosities of the tissues and organs. Pores in the structure may allow delivery of molecules across the structure, and may facilitate cell migration and/or generation of connective tissue between the structure and its host environment. Structures of the invention can be implanted into a mammal and/or may be used ex vivo as bioartificial assist devices.
摘要翻译：描述了涉及用于组织工程和器官置换的生物相容性结构的方法和装置，更具体地，涉及通过三维制造形成的生物相容性结构。在一些实施方案中，生物相容性结构是可用作组织工程模板和/或作为人造器官的细胞的支架。结构可以是三维的并且可以模拟组织和/或器官的形状和尺寸，包括组织和器官的微结构和孔隙率。结构中的孔可以允许跨结构传递分子，并且可以促进细胞迁移和/或结构与其宿主环境之间的结缔组织的产生。本发明的结构可以植入哺乳动物和/或作为生物人造辅助装置离体使用。

64. 发明申请

US20100197920A1 N-HETEROCYCLIC CARBENE METALLACYCLE CATALYSTS AND METHODS 有权
标题翻译： N-杂环碳酸盐金属催化剂和方法
公开(公告)号：US20100197920A1
公开(公告)日：2010-08-05
申请号：US12452204
申请日：2007-06-20
申请人： Jackie Y. Ying , Eric Assen B. Kantchev
发明人： Jackie Y. Ying , Eric Assen B. Kantchev
IPC分类号： C07F15/00
CPC分类号： C07F15/006
摘要： The present invention generally relates to materials and methods for catalytic reactions, including transition metal-catalyzed cross-coupling reactions. The materials may be stable metal complexes that do not require special handling or processing conditions. In some cases, materials of the invention advantageously may be synthesize in one synthetic step without the need for isolation of intermediate compounds. Also, materials of the invention may be synthesized from inexpensive and readily available starting materials, under relatively mild reaction conditions that do not require the exclusion of air, water, and the like. In some embodiments, the material is a N-heterocyclic carbene metallacycle complex. Such materials and methods may be useful in the production of fine chemicals, advanced materials and specialty polymers.
摘要翻译：本发明一般涉及催化反应的材料和方法，包括过渡金属催化的交叉偶联反应。这些材料可以是不需要特殊处理或加工条件的稳定的金属络合物。在一些情况下，本发明的材料有利地可以在一个合成步骤中合成，而不需要分离中间体化合物。此外，本发明的材料可以在不需要排除空气，水等的相对温和的反应条件下由廉价且易于获得的原料合成。在一些实施方案中，该材料是N-杂环卡宾金属环络合物。这些材料和方法可用于生产精细化学品，先进材料和特种聚合物。

65. 发明申请

US20100126880A1 DNA COMPLEXING AGENTS 审中-公开
标题翻译： DNA复合物
公开(公告)号：US20100126880A1
公开(公告)日：2010-05-27
申请号：US12514299
申请日：2007-11-09
申请人： Hsiao-Hua Yu , Jackie Y. Ying , Natalia C. Tansil , Eric Assen B. Kantchev
发明人： Hsiao-Hua Yu , Jackie Y. Ying , Natalia C. Tansil , Eric Assen B. Kantchev
IPC分类号： C07D471/04 , C07F15/00 , C08F26/06 , G01N27/00 , G01N27/26
CPC分类号： C07F15/0026 , C07D519/00
摘要： The invention provides a compound of structure (I): wherein X is S, O or NRN, where RN is H or alkyl; L is a linker group; Q is a group capable of binding with dsDNA; G and G′ are, independently, absent or have between 1 and 20 main chain atoms; FG is a functional moiety comprising at least one O or N atom or a transition metal complex; and R is selected from the group consisting of H, alkyl, alkoxy or OCRaRb coupled to an atom in L so as to form a six-membered ring. Ra and Rb are independently H or optionally substituted alkyl.
摘要翻译：本发明提供结构（I）的化合物：其中X是S，O或NRN，其中RN是H或烷基; L是连接基团; Q是能够与dsDNA结合的基团; G和G'独立地不存在或具有1至20个主链原子; FG是包含至少一个O或N原子或过渡金属络合物的官能部分; 并且R选自与L中的原子偶联的H，烷基，烷氧基或OCRaRb，以形成六元环。 Ra和Rb独立地为H或任选取代的烷基。

66. 发明申请

US20100116682A1 ELECTROCHEMICAL SENSOR WITH INTERDIGITATED MICROELECTRODES AND CONDUCTED POLYMER 审中-公开
标题翻译：电化学传感器与介电微电子和导电聚合物
公开(公告)号：US20100116682A1
公开(公告)日：2010-05-13
申请号：US12310957
申请日：2007-09-13
申请人： Pavel Neuzil , Hsiao-Hua Yu , Jackie Y. Ying
发明人： Pavel Neuzil , Hsiao-Hua Yu , Jackie Y. Ying
IPC分类号： G01N27/26 , C25B3/00 , G01N27/403
CPC分类号： H01L51/0006 , G01N27/403 , H01L51/0035 , H01L51/0036
摘要： The present invention generally relates to electronic devices and methods. In some cases, the invention provides a sensor device comprising a pair of interdigitated microelectrodes (60), coated with an electrically conducting polymer material (70). The microelectrodes (60) may be surrounded by a first electrode (22), a second electrode (40), and a hydrophobic wall (50).
摘要翻译：本发明一般涉及电子设备和方法。在一些情况下，本发明提供一种传感器装置，其包括涂覆有导电聚合物材料（70）的一对叉指式微电极（60）。微电极（60）可以被第一电极（22），第二电极（40）和疏水壁（50）围绕。

67. 发明申请

US20100059391A1 METHOD FOR DETECTING BIOMOLECULES AND USE THEREOF 审中-公开
标题翻译：检测生物分子的方法及其用途
公开(公告)号：US20100059391A1
公开(公告)日：2010-03-11
申请号：US12540669
申请日：2009-08-13
申请人： Jackie Y. Ying , Jie Zhang , Zhiqiang Gao , Boon Ping Ting
发明人： Jackie Y. Ying , Jie Zhang , Zhiqiang Gao , Boon Ping Ting
IPC分类号： G01N27/26
CPC分类号： G01N33/5438
摘要： Biomolecule-specific probe is immobilized on an electrode surface to form a modified electrode. The modified electrode is exposed to target biomolecule. The biomolecule is captured by the probe whereby a first complex with the biomolecule is formed. Subsequently, the biomolecule is exposed to electroactive label having binding affinity to the biomolecule. The biomolecule adsorbs the electroactive label to the modified electrode to form a working electrode whereby a second complex comprising the first complex with the biomolecule and the bound electroactive label is formed. The working electrode is placed in an electrolyte medium and electrochemical measurement between the working electrode and a reference electrode is taken wherein the electrochemical measurement comprises the measurement of electrical signal resulting from a solid-state electrochemical process involving the electroactive labels. The magnitude of the electrochemical measurement corresponds to the concentration of the biomolecule present in the sample.
摘要翻译：将生物分子特异性探针固定在电极表面上以形成修饰电极。将修饰的电极暴露于靶生物分子。通过探针捕获生物分子，由此形成与生物分子的第一复合物。随后，将生物分子暴露于对生物分子具有结合亲和力的电活性标记。生物分子将电活性标记物吸附到修饰电极上以形成工作电极，由此形成包含与生物分子和结合的电活性标记物的第一配合物的第二络合物。将工作电极放置在电解质介质中，并且在工作电极和参考电极之间进行电化学测量，其中电化学测量包括由涉及电活性标记的固态电化学过程产生的电信号的测量。电化学测量的大小对应于样品中存在的生物分子的浓度。

68. 发明申请

US20100048815A1 Electrically Conducting Polymers 失效
标题翻译：导电聚合物
公开(公告)号：US20100048815A1
公开(公告)日：2010-02-25
申请号：US12440484
申请日：2006-09-26
申请人： Jackie Y. Ying , Hsiao-Hua Yu , Emril Mohamed Ali , Eric Assen B. Kantchev
发明人： Jackie Y. Ying , Hsiao-Hua Yu , Emril Mohamed Ali , Eric Assen B. Kantchev
IPC分类号： C08G61/12 , C08F2/58 , C08F2/52 , C08G73/06 , C08G75/00
CPC分类号： C08G61/123 , C08G61/124 , C08G61/125 , C08G61/126 , H01B1/127 , H01L51/0037
摘要： The present invention provides a polymer for use in detecting or quantifying an analyte Exposure of the polymer to the analyte is capable of causing a shift in the onset potential for conductivity or semiconductivity of the polymer. A sensor for an analyte comprising the polymer is also described.
摘要翻译：本发明提供用于检测或定量分析物的聚合物聚合物对分析物的暴露能够导致聚合物的导电性或半导电性的起始电位的偏移。还描述了用于包含聚合物的分析物的传感器。

69. 发明申请

US20100048755A1 POROUS POLYMERIC MATERIAL WITH CROSS-LINKABLE WETTING AGENT 审中-公开
标题翻译：具有交联润湿剂的多孔聚合材料
公开(公告)号：US20100048755A1
公开(公告)日：2010-02-25
申请号：US12515264
申请日：2007-11-17
申请人： Edwin Pei Yong Chow , Jackie Y. Ying
发明人： Edwin Pei Yong Chow , Jackie Y. Ying
IPC分类号： C08G63/00 , C08J9/00 , C08G73/06
CPC分类号： C08J9/283 , A61F9/0008 , A61L27/16 , A61L27/50 , A61L27/56 , C08B37/0021 , C08B37/0072 , C08F290/10 , C08J2207/10 , C08J2333/06 , C08L51/02 , G02B1/043 , C08L2666/02
摘要： A porous material is provided which comprises a transparent polymer matrix defining interconnected pores and a wetting agent. At least a portion of the wetting agent is cross-linked with the polymer matrix. A process for forming a porous polymeric material is also provided. A bicontinuous microemulsion comprising water, a wetting agent, a monomer, and a surfactant copolymerizable with the monomer is polymerized, to form a polymer defining interconnected pores. The wetting agent comprises a cross-linkable wetting agent such that after polymerization, at least a portion of the cross-linkable wetting agent is cross-linked with the polymer. The wetting agent may comprise acrylated hyaluronic acid (AHA) such as methacrylated hyaluronic acid (MeHA). The wetting agent may also comprise a hyaluronic acid (HA). The wetting agent may include an unbonded portion that this releasable from the material. A contact lens may be made from the porous material.
摘要翻译：提供一种多孔材料，其包括限定互连孔的透明聚合物基质和润湿剂。润湿剂的至少一部分与聚合物基质交联。还提供了一种形成多孔聚合物材料的方法。将包含水，润湿剂，单体和可与单体共聚的表面活性剂的双连续微乳液聚合，形成限定互连孔的聚合物。润湿剂包括可交联的润湿剂，使得在聚合后，至少一部分可交联润湿剂与聚合物交联。润湿剂可以包括丙烯酸酯化透明质酸（AHA），例如甲基丙烯酸酯化透明质酸（MeHA）。润湿剂还可以包含透明质酸（HA）。润湿剂可以包括可从材料中释放的未粘合部分。隐形眼镜可以由多孔材料制成。

70. 发明授权

US07589041B2 Mesostructured zeolitic materials, and methods of making and using the same 有权
标题翻译：介孔结构的沸石材料及其制造和使用方法
公开(公告)号：US07589041B2
公开(公告)日：2009-09-15
申请号：US10830714
申请日：2004-04-23
申请人： Jackie Y. Ying , Javier Garcia Martinez
发明人： Jackie Y. Ying , Javier Garcia Martinez
IPC分类号： B01J29/06
CPC分类号： B01J29/40 , B01J20/18 , B01J20/186 , B01J29/005 , B01J29/0308 , B01J29/041 , B01J29/084 , B01J29/106 , B01J29/18 , B01J29/80 , B01J2229/62 , B82Y30/00 , C01B39/02 , C01B39/023 , C01B39/026 , C01B39/04 , C10G1/086 , C10G11/02 , C10G11/05 , C10G11/18 , C10G45/04 , C10G47/02 , C10G2300/1033 , C10G2300/1074 , C10G2300/1096 , C10G2400/02 , C10G2400/20 , Y10T428/26
摘要： One aspect of the present invention relates to mesostructured zeolites. The invention also relates to a method of preparing mesostructured zeolites, as well as using them as cracking catalysts for organic compounds and degradation catalysts for polymers.
摘要翻译：本发明的一个方面涉及介孔结构的沸石。本发明还涉及一种制备介孔结构的沸石的方法，以及它们用作有机化合物的裂化催化剂和聚合物的降解催化剂。

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