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61. 发明授权

US4552671A Spin finish compositions for polyester and polyamide yarns 失效
标题翻译：用于聚酯和聚酰胺纱线的纺织成分
公开(公告)号：US4552671A
公开(公告)日：1985-11-12
申请号：US661147
申请日：1984-10-15
申请人： Osamu Ogiso , Hisao Yamamoto , Akira Suzuki
发明人： Osamu Ogiso , Hisao Yamamoto , Akira Suzuki
IPC分类号： C08L71/02 , D06M13/00 , D06M13/02 , D06M13/244 , D06M13/248 , D06M13/256 , D06M13/282 , D06M13/292 , D06M13/51 , D06M13/513 , D06M15/53 , D06M15/643 , D06M15/647 , D06M101/00 , D06M101/12 , D06M101/16 , D06M101/30 , D06M101/32 , D06M101/34 , D06M13/18 , D06M13/50
CPC分类号： D06M15/53 , C08L71/02 , D06M7/00 , D06M2200/40
摘要： Spin finish compositions having as base oil polyether compounds which are .omega.-methoxy-poly (oxyethylene/oxypropylene) ether derivatives of a specified type and containing 0.05 to 10 weight % of polyalkylene oxide modified polysiloxane of another specified type are particularly desirable for application to polyester and polyamide yarns for ultra-high speed texturing because they have the characteristics of preventing fuzz on the yarns, thermally degraded substances and tacky white powder as well as reducing tackiness of such white powder.
摘要翻译：具有特定类型的ω-甲氧基 - 聚（氧乙烯/氧丙烯）醚衍生物的基础油聚醚化合物和含有0.05-10重量％的另一种特定类型的聚环氧烷改性聚硅氧烷的旋涂组合物特别适用于聚酯和用于超高速纹理的聚酰胺纱线，因为它们具有防止纱线上的绒毛，热降解物质和粘性白色粉末以及降低这种白色粉末的粘性的特征。

62. 发明授权

US4387223A Process for preparing 2(1H)-quinazolinone derivatives 失效
标题翻译：制备2（1H） - 喹唑啉酮衍生物的方法
公开(公告)号：US4387223A
公开(公告)日：1983-06-07
申请号：US748145
申请日：1976-12-06
申请人： Michihiro Yamamoto , Shigenari Katayama , Masao Koshiba , Hisao Yamamoto
发明人： Michihiro Yamamoto , Shigenari Katayama , Masao Koshiba , Hisao Yamamoto
IPC分类号： C07D239/78 , C07D239/82 , C07D401/04 , C07D405/04 , C07D409/04 , C07D491/04 , C07D491/056 , C07D413/04 , C07D413/06
CPC分类号： C07D491/04 , C07D239/78 , C07D239/82
摘要： 2(1H)-Quinazolinone and quinazolinethione derivatives having excellent pharmacological activities are produced in high yield with high purity by heating the corresponding 3,4-dihydro-2(1H)-quinazolinone or quinazolinethione derivatives together with sulfur in an inert solvent.
摘要翻译：通过在惰性溶剂中与硫一起加热相应的3,4-二氢-2（1H） - 喹唑啉酮或喹唑啉硫酮衍生物，通过加热相应的3,4-二氢-2（1H） - 喹唑啉酮或喹唑啉硫酮衍生物，以高纯度产生具有优异药理活性的2（1H） - 喹唑啉酮和喹唑啉酮衍生物。

63. 发明授权

US4260774A 5-Carbamoyl imidazoles 失效
标题翻译： 5-氨基甲酰咪唑
公开(公告)号：US4260774A
公开(公告)日：1981-04-07
申请号：US51741
申请日：1979-06-25
申请人： Toshio Atsumi , Yoshiaki Takebayashi , Yuzo Tarumi , Hisao Yamamoto
发明人： Toshio Atsumi , Yoshiaki Takebayashi , Yuzo Tarumi , Hisao Yamamoto
IPC分类号： C07D233/90
CPC分类号： C07D233/90
摘要： There are provided compounds of the formula: ##STR1## wherein R is an adamantyl group, or a phenyl group unsubstituted or substituted with a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a halogen atom, a nitro group, a cyano group, a methylenedioxy group or an acetamido group, useful as anti-transplanted-tumor agents and immunosuppressants.
摘要翻译：提供下式的化合物：其中R是金刚烷基，或未取代或被低级烷基，低级烷氧基，低级烷硫基，卤原子，硝基，氰基，亚甲二氧基或乙酰氨基，可用作抗移植肿瘤剂和免疫抑制剂。

64. 发明授权

US4179560A Imidazo- and pyrimido[2,1-b]quinazolines and preparation thereof 失效
标题翻译：咪唑并嘧啶并[2,3-b]喹唑啉及其制备方法
公开(公告)号：US4179560A
公开(公告)日：1979-12-18
申请号：US553676
申请日：1975-02-27
申请人： Michihiro Yamamoto , Shigeaki Morooka , Masao Koshiba , Shigeho Inaba , Hisao Yamamoto
发明人： Michihiro Yamamoto , Shigeaki Morooka , Masao Koshiba , Shigeho Inaba , Hisao Yamamoto
IPC分类号： A61K31/505 , A61P7/10 , A61P9/12 , A61P25/24 , A61P25/26 , C07D487/04 , C07D491/147 , A61K31/395
CPC分类号： C07D487/04
摘要： Imidazo- and pyrimido[2,1-b]quinazolines of the formula, ##STR1## wherein R.sub.1 and R.sub.2 are independently hydrogen, halogen, trifluoromethyl, nitro, C.sub.1-4 alkyl or C.sub.1-4 alkoxy, or R.sub.1 and R.sub.2 may together represent methylenedioxy; R.sub.3 is hydrogen, C.sub.1-4 alkyl, phenyl or substituted phenyl of the formula, ##STR2## (wherein R is halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy); R.sub.4 is hydrogen, C.sub.1-4 alkyl or aralkyl; and A is C.sub.2-3 alkylene wich may be optionally substituted by one or two C.sub.1-2 alkyl radicals, and pharmaceutically acceptable acid addition salts thereof, are prepared by reacting a compound of the formula, ##STR3## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and A are as defined above; and X is oxygen or sulfur, with a halogenating agent at a temperature of about 30.degree. C. to about 180.degree. C. In the above imidaxo- and pyrimido[2,1-b]quinazolines, those having C.sub.1-4 alkyl, or ##STR4## as R.sub.3 are novel compounds and show antidepressant and/or antihypertensive activities.
摘要翻译：其中R 1和R 2独立地为氢，卤素，三氟甲基，硝基，C 1-4烷基或C 1-4烷氧基，或者R 1和R 2可以一起代表下式的咪唑并 - 嘧啶并[2,3-b]喹唑啉，亚甲二氧基; R 3是氢，C 1-4烷基，苯基或下式的取代的苯基，其中R是卤素，C 1-4烷基或C 1-4烷氧基; R4是氢，C1-4烷基或芳烷基; 并且A是可以任选被一个或两个C 1-2烷基取代的C 2-3亚烷基及其药学上可接受的酸加成盐，其通过使下式化合物，其中R1，R2，R3， R4和A如上所定义; 在上述酰胺基 - 和嘧啶并[2,1-b]喹唑啉中，具有C 1-4烷基的那些，或其中X是氧或硫，与卤化剂在约30℃至约180℃的温度下反应。作为R3是新化合物并显示抗抑郁药和/或抗高血压活性的图像。

65. 发明授权

US4148796A .gamma.-Piperidinobutyrophenones 失效
标题翻译： {65-哌啶基丁酰苯
公开(公告)号：US4148796A
公开(公告)日：1979-04-10
申请号：US388561
申请日：1973-08-15
申请人： Hisao Yamamoto , Masaru Nakao , Kikuo Sasajima , Isamu Maruyama , Shigenari Katayama
发明人： Hisao Yamamoto , Masaru Nakao , Kikuo Sasajima , Isamu Maruyama , Shigenari Katayama
IPC分类号： C07D211/48 , C07D401/06 , C07D401/04 , C07D211/50
CPC分类号： C07D401/06 , C07D211/48
摘要： Novel .gamma.-piperidinobutyrophenone derivatives of the formula, ##STR1## wherein R.sup.1 is halogen, amino, alkanoylamino, alkylamino or N-(alkanoyl)alkylamino;R.sup.2 is hydrogen or halogen, provided that when R.sup.1 is halogen, R.sup.2 must be halogen; andZ is a piperidino group having the formula (A), ##STR2## (wherein each of R.sub.a and R.sub.b is hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl; R.sup.3 is hydrogen or hydroxyl; and n is 1 or 2), or a piperidino group having the formula (B), ##STR3## (wherein R.sub.c is hydrogen or lower alkyl; and each of R.sub.d and R.sub.e is hydrogen, halogen, lower alkyl or lower alkoxy), provided that when R.sup.1 is amino and R.sup.2 is hydrogen, Z cannot be represented by the formula (A), and their pharmaceutically acceptable acid addition salts, which are useful as psychotropic, neuroleptic or analgesic agents.
摘要翻译：其中R1是卤素，氨基，烷酰基氨基，烷基氨基或N-（烷酰基）烷基氨基的新颖的γ-哌啶基丁酰苯衍生物， R2是氢或卤素，条件是当R1是卤素时，R2必须是卤素; Z为具有式（A），（A）的哌啶子基，其中R a和R b各自为氢，卤素，低级烷基，低级烷氧基或三氟甲基; R 3为氢或羟基; n为1或 2）或具有式（B）的哌啶子基，其中R c是氢或低级烷基;并且R d和R e各自是氢，卤素，低级烷基或低级烷氧基），条件是当 R1是氨基，R2是氢，Z不能由式（A）表示，它们的药学上可接受的酸加成盐可用作精神药物，精神抑制剂或止痛剂。

66. 发明授权

US4125731A Novel indan derivatives 失效
标题翻译：新的indan衍生物
公开(公告)号：US4125731A
公开(公告)日：1978-11-14
申请号：US748539
申请日：1976-12-08
申请人： Akihiko Sugie , Hiromi Shimomura , Junki Katsube , Hisao Yamamoto
发明人： Akihiko Sugie , Hiromi Shimomura , Junki Katsube , Hisao Yamamoto
IPC分类号： C07C17/32 , C07C33/38 , C07C405/00 , C07D307/93 , C07D309/12 , C07C69/76
CPC分类号： C07D309/12 , C07C17/32 , C07C33/38 , C07C405/00 , C07D307/93 , C07C2102/08 , Y10S514/927
摘要： Novel indan compounds of the formula ##STR1## wherein A and X are each ethylene or vinylene; B is C.sub.2-4 alkylene; R and R.sub.2 are each hydrogen or C.sub.1-4 alkyl; R.sub.1 is C.sub.1-8 alkyl;
摘要翻译：式IMA的新型茚满化合物，其中A和X各自为亚乙烯基或亚乙烯基; B是C 2-4亚烷基; R和R 2各自为氢或C 1-4烷基; R1是C1-8烷基; 及其无毒盐，其可用作抗溃疡剂，胃分泌物抑制剂和假体。

67. 发明授权

US4110376A Cyclopropylmethylamine derivatives 失效
标题翻译：环丙基甲胺衍生物
公开(公告)号：US4110376A
公开(公告)日：1978-08-29
申请号：US605012
申请日：1975-08-15
申请人： Atsuyuki Kojima , Junki Katsube , Yoshito Kameno , Shigeho Inaba , Hisao Yamamoto
发明人： Atsuyuki Kojima , Junki Katsube , Yoshito Kameno , Shigeho Inaba , Hisao Yamamoto
IPC分类号： A61K31/135 , A61K31/13 , C07C20060101 , C07C67/00 , C07C209/00 , C07C209/50 , C07C211/26 , C07C87/32
CPC分类号： C07D401/12
摘要： Novel cyclopropylmethylamine compounds of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each hydrogen or halogen and R.sup.3 is hydrogen or methyl, and their non-toxic salts, which possess various useful pharmacological activities and can be produced by reduction of the corresponding compounds of the formula: ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are each as defined above or their non-toxic salts, or by condensation of the corresponding compounds of the formula: ##STR3## wherein R.sup.1 and R.sup.2 are each defined above, and X is a conventional interchangeable group such as halogen or sulfonyloxy with methylamine or dimethylamine.
摘要翻译：下式的新型环丙基甲胺化合物：其中R 1和R 2各自为氢或卤素，R 3为氢或甲基，及其无毒盐，其具有各种有用的药理活性，可通过还原相应化合物其中R 1，R 2和R 3各自如上所定义，或其无毒盐，或通过下式的相应化合物的缩合：其中R 1和R 2各自如上所定义，X为常规的可互换基团如卤素或磺酰氧基与甲胺或二甲胺。

68. 发明授权

US4085210A Novel morpholine derivatives and the treatment of mental depression 失效
标题翻译：新型吗啉衍生物和精神抑郁症的治疗
公开(公告)号：US4085210A
公开(公告)日：1978-04-18
申请号：US646908
申请日：1976-01-06
申请人： Junki Katsube , Atsuyuki Kojima , Makoto Sunagawa , Yoshinori Takashima , Yoshito Kameno , Hisao Yamamoto
发明人： Junki Katsube , Atsuyuki Kojima , Makoto Sunagawa , Yoshinori Takashima , Yoshito Kameno , Hisao Yamamoto
IPC分类号： C07D265/30 , C07D267/10 , C07D409/06 , A61K31/535 , C07D405/06
CPC分类号： C07D265/30 , C07D267/10
摘要： Novel morpholine compounds of the formula: ##STR1## wherein R.sub.1 represents hydrogen or C.sub.1 -C.sub.4 alkyl, R.sub.2 represents hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.5 alkenyl, C.sub.3 -C.sub.5 alkynyl, aryl-(C.sub.1 -C.sub.4)alkyl, (C.sub.3 -C.sub.6)cycloalkyl(C.sub.1 -C.sub.4)alkyl, polyhalo(C.sub.2 -C.sub.4)alkyl or hydroxy(C.sub.2 -C.sub.4)alkyl, A represents straight or branched C.sub.2 -C.sub.4 alkylene, B represents a divalent radical selected from the group consisting of --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, ##STR2## --CH.sub.2 --O--, --CH.sub.2 --S--, --S-- and --O--, >D --E-- represents a trivalent radical selected from the group consisting of >CH--CH.sub.2 -- and >C.dbd.CH-- and C.sub.1 and C.sub.2 each represent 1,2-phenylene optionally substituted with one or more substituents selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy, and their non-toxic salts, which are useful as antidepressants and can be produced by various methods.
摘要翻译：式中：R1代表氢或C1-C4烷基，R2代表氢，C1-C4烷基，C3-C5烯基，C3-C5炔基，芳基 - （C1-C4）烷基，（C3 -C 6）环烷基（C 1 -C 4）烷基，多卤代（C 2 -C 4）烷基或羟基（C 2 -C 4）烷基，A表示直链或支链C 2 -C 4亚烷基，B表示选自-CH 2 -CH 2 - ， - CH = CH-， -CH 2 -O-，-CH 2 -S-，-S-和-O-，> D-E-代表选自下组的三价基团：CH -CH 2 - 和> C = CH-且C 1和C 2各自表示任选被一个或多个选自卤素，C 1 -C 4烷基和C 1 -C 4烷氧基的取代基取代的1,2-亚苯基，它们的无毒盐，其可用作抗抑郁药并且可以通过各种方法制备。

69. 发明授权

US4083981A Analgetic composition 失效
标题翻译：笔画组成
公开(公告)号：US4083981A
公开(公告)日：1978-04-11
申请号：US773936
申请日：1977-03-03
申请人： Hisao Yamamoto , Toshiya Inukai , Yoshihiko Koga
发明人： Hisao Yamamoto , Toshiya Inukai , Yoshihiko Koga
IPC分类号： C07D209/28 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/435 , A61K31/445 , A61K31/485 , A61P25/04 , C07D211/64 , C07D221/28
CPC分类号： A61K31/485 , A61K31/435 , A61K31/445
摘要： An analgetic composition which comprises, as an active ingredient, a therapeutically effective amount of a synergistic mixture of an indole-3-acetic acid derivative of the formula, ##STR1## wherein R is a halobenzoyl, piperonylcyl or cinnamoyl group and R.sub.1 is a 5-methoxy or 5,6-methylenedioxy group; and a narcotic or anti-narcotic analgesic selected from the group consisting of a compound of the formula, ##STR2## wherein R.sub.2 and R.sub.3 are each a C.sub.1 - C.sub.3 alkyl group and R.sub.4 is a 4-(4-fluorophenyl)-4-oxobutyl, cyclopropylmethyl or 3-methyl-2-butenyl group; a compound of the formula, ##STR3## wherein R.sub.5 is a hydrogen atom or a C.sub.1 - C.sub.3 alkyl group; a compound of the formula, ##STR4## and a compound of the formula, ##STR5## wherein R.sub.6 is a C.sub.1 - C.sub.3 alkyl group; and a pharmaceutically acceptable carrier or diluent and its preparation and a method of obtaining analgesia which comprises administering the same to a patient.
摘要翻译：一种止痛组合物，其包含作为活性成分的治疗有效量的下式的吲哚-3-乙酸衍生物，其中R是卤代苯甲酰基，胡烷基或肉桂酰基的吲哚-3-乙酸衍生物，R 1为5 - 甲氧基或5,6-亚甲二氧基; 以及选自由下式化合物组成的组的麻醉或抗麻醉止痛剂，其中R2和R3各自为C1-C3烷基，R4为4-（4-氟苯基）-4-氧代丁基，环丙基甲基或3-甲基-2-丁烯基; 下式的化合物，其中R 5是氢原子或C 1 -C 3烷基; 下式的化合物和下式的化合物，其中R 6是C 1 -C 3烷基; 和药学上可接受的载体或稀释剂及其制备方法和获得镇痛的方法，其包括将其施用于患者。

70. 发明授权

US4075346A CNS depressant .gamma.-(secondary amino)-ortho-nitro-butyrophenones 失效
标题翻译： CNS DEPRESSANT“ - （二级氨基） - 硝基 - 丁基
公开(公告)号：US4075346A
公开(公告)日：1978-02-21
申请号：US705840
申请日：1976-07-16
申请人： Kikuo Sasajima , Keiichi Ono , Yasuo Motoike , Shigeho Inaba , Hisao Yamamoto
发明人： Kikuo Sasajima , Keiichi Ono , Yasuo Motoike , Shigeho Inaba , Hisao Yamamoto
IPC分类号： C07D211/08 , C07D211/14 , C07D211/18 , C07D211/36 , C07D211/48 , C07D211/52 , C07D295/04 , C07D295/108 , C07D295/12 , C07D307/33 , C07D317/16 , C07D401/04 , C07D471/10 , C07D211/28 , A61K31/445
CPC分类号： C07D295/108 , C07C205/45 , C07D211/14 , C07D211/18 , C07D211/52 , C07D307/33 , C07D317/16
摘要： Novel compounds of the formula: ##STR1## wherein R is a hydrogen or fluorine atom, W is an oxygen atom or an ethylenedioxy or ethylenedithio group and Z is a certain secondary amino group, which are useful as central nervous system depressants, can be prepared by the reaction of a compound of the formula: ##STR2## wherein X is a halogen atom and R and W are each as defined above with a secondary amine of the formula: H--Z wherein Z is as defined above, in case of W being ethylenedioxy or ethylenedithio, optionally followed by hydrolysis and can be reduced to give a compound of the formula: ##STR3## wherein R and Z are each as defined above, which are useful as antipsychotic and/or analgesic agents.

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