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61. 发明授权

US08784338B2 Electrical means to normalize ablational energy transmission to a luminal tissue surface of varying size 有权
标题翻译：电气意味着将消融能量传递归一化到不同大小的管腔组织表面
公开(公告)号：US08784338B2
公开(公告)日：2014-07-22
申请号：US12143404
申请日：2008-06-20
申请人： Michael P. Wallace , Robert Garabedian , Brent C. Gerberding
发明人： Michael P. Wallace , Robert Garabedian , Brent C. Gerberding
IPC分类号： A61B5/00 , A61B5/103 , A61B5/107
CPC分类号： A61B18/18 , A61B5/053 , A61B5/0538 , A61B5/1076 , A61B18/0218 , A61B18/082 , A61B18/14 , A61B18/1492 , A61B18/20 , A61B2018/00017 , A61B2018/00214 , A61B2018/0022 , A61B2018/00488 , A61B2018/00577 , A61B2018/00642 , A61B2018/00714 , A61B2018/00755 , A61B2018/00791 , A61B2018/00875 , A61B2562/0257
摘要： Methods and devices for measuring the size of a body lumen and a method for ablating tissue that uses the measurement to normalize delivery of ablational energy from an expandable operative element to a luminal target of varying circumference are provided. The method includes inserting into the lumen an expandable operative element having circuitry with resistivity or inductance that varies according to the circumference of the operative element, varying the expansion of the operative element with an expansion medium, measuring the resistivity of the circuitry, and relating the resistivity or inductance to a value for the circumference of the operative element. In some embodiments the sizing circuit includes a conductive elastomer wrapped around the operative element. Other embodiments of the method apply to operative elements that include an overlapping energy delivery element support in which the overlap varies inversely with respect to the state of expansion, and which is configured with sizing electrodes that sense the amount of the overlap.
摘要翻译：提供了用于测量体腔尺寸的方法和装置以及用于消融组织的方法和装置，所述方法使用所述测量来将消融能量从可扩张的可操作元件的规则化转变为变化圆周的管腔靶。该方法包括将具有电阻率或电感的电路的可扩展的操作元件插入到内腔中，所述电路或电感根据操作元件的周长而变化，用膨胀介质改变操作元件的膨胀，测量电路的电阻率，电阻率或电感值为操作元件圆周的值。在一些实施例中，施胶电路包括围绕操作元件缠绕的导电弹性体。该方法的其他实施例适用于包括重叠的能量传递元件支撑件的操作元件，其中重叠相对于膨胀状态反向变化，并且其被配置有感测重叠量的尺寸电极。

62. 发明授权

US08641711B2 Method and apparatus for gastrointestinal tract ablation for treatment of obesity 有权
标题翻译：用于治疗肥胖的胃肠道消融的方法和装置
公开(公告)号：US08641711B2
公开(公告)日：2014-02-04
申请号：US12114628
申请日：2008-05-02
申请人： Douglas Kelly , David S. Utley , Robert A. Ganz , Michael P. Wallace , Nathan Every
发明人： Douglas Kelly , David S. Utley , Robert A. Ganz , Michael P. Wallace , Nathan Every
IPC分类号： A61B18/18
CPC分类号： A61B18/04 , A61B18/1492 , A61B18/18 , A61B2018/0022 , A61B2018/0212 , A61B2018/1467
摘要： Devices and methods for ablating tissue in the wall of various organs of the gastrointestinal tract of a patient in order to cure or ameliorate metabolic pathophysiological conditions such as obesity, insulin resistance, or type 2 diabetes mellitus are provided. Ablational treatment of target areas may be fractional or partial, rendering a post-treatment portion of target tissue ablated and another portion that is substantially intact. Fractional ablation is achieved by controlling the delivery of ablational energy across the surface area being treated, and controlling the depth of energy penetration into tissue. Surface area control of energy delivery may controlled by the spatial pattern of distributed ablation elements or by the selective activation of a subset of a dense pattern of ablation elements. Embodiments of the device include an ablational electrode array that spans 360 degrees and an array that spans an arc of less than 360 degrees.
摘要翻译：提供了用于消除患者胃肠道的各种器官的壁中的组织以便治愈或改善代谢病理生理条件如肥胖，胰岛素抵抗或2型糖尿病的装置和方法。目标区域的消融治疗可能是部分或部分，使目标组织的后处理部分消融，另一部分基本上完好无损。通过控制穿过所治疗的表面区域的消融能量的传递并控制能量渗入组织的深度来实现分数消融。能量输送的表面积控制可以由分布式消融元件的空间模式控制，或者通过选择性地激活消融元件的密集图案的子集。该装置的实施例包括跨越360度的消融电极阵列和跨越小于360度的弧的阵列。

63. 发明申请

US20130345617A1 METHODS AND DEVICES FOR REMOVAL OF TISSUE, BLOOD CLOTS AND LIQUIDS FROM THE PATIENT 审中-公开
标题翻译：从患者身上清除组织，血液和液体的方法和装置
公开(公告)号：US20130345617A1
公开(公告)日：2013-12-26
申请号：US13962646
申请日：2013-08-08
申请人： Michael P. Wallace
发明人： Michael P. Wallace
IPC分类号： A61B17/22
CPC分类号： A61B17/2202 , A61B17/22004 , A61B17/22012 , A61B2017/22014 , A61B2017/22015 , A61B2017/22018 , A61B2017/22039 , A61B2017/22082 , A61B2017/22088 , A61B2017/22098 , A61B2017/320088 , A61B2018/00029
摘要： The present invention provides methods and devices for removal of tissue, blood clots and liquids from the patient that are located inside or outside of the patient's endovascular system using vibrational energy. One or more therapeutic agents or bubbles/microbubbles may be delivered to the treatment location to further facilitate the removal process.
摘要翻译：本发明提供了使用振动能量从病人血管内系统内部或外部去除患者组织，血块和液体的方法和装置。一种或多种治疗剂或气泡/微泡可以被递送到治疗位置以进一步促进移除过程。

64. 发明授权

US08449532B2 Detachable aneurysm neck bridge 有权
公开(公告)号：US08449532B2
公开(公告)日：2013-05-28
申请号：US13194730
申请日：2011-07-29
申请人： Richard Murphy , Michael P. Wallace , Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Robert M. Abrams , Harold F. Carrison
发明人： Richard Murphy , Michael P. Wallace , Tri Tran , Kim Nguyen , Hanh Ho , My Doan , Robert M. Abrams , Harold F. Carrison
IPC分类号： A61B17/00
CPC分类号： A61B17/12113 , A61B17/12022 , A61B17/1214 , A61B17/12168 , A61B17/12172 , A61B90/39 , A61B2017/1205 , A61B2017/12063
摘要： A device for bridging a neck of an aneurysm, comprises a junction region, one or more radially extending array elements secured to the junction region, each array element having an unfolded shape and a delivery shape; and a cover attached to the junction region, and extending over the delivery shape of the array elements, wherein each array element is attached at one end to the junction region and the array elements are constructed and arranged to unfold the cover when assuming their unfolded shape, and wherein the device further comprises a tip, and each array element is attached at another end to the tip, the tip comprising an opening through which a vaso-occlusive device or occlusion fluid may be delivered.

65. 发明授权

US08412348B2 Intravascular self-anchoring integrated tubular electrode body 失效
标题翻译：血管内自我锚定一体化管状电极体
公开(公告)号：US08412348B2
公开(公告)日：2013-04-02
申请号：US10841069
申请日：2004-05-06
申请人： Michael P. Wallace , Robert J. Garabedian , John Eric Peckham
发明人： Michael P. Wallace , Robert J. Garabedian , John Eric Peckham
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/3787 , A61N2001/0585
摘要： An expandable intravascular medical device is provided. The medical device comprises an expandable tubular body that includes an integrated resilient support structure that forms a plurality of electrically conductive regions to which the lead(s) is coupled. The tubular body further includes at least one electrically insulative element disposed between the conductive regions. In one embodiment, the support structure is skeletal in nature, e.g., it can be formed of a mesh, braid, or coil. The conductive regions can be variously formed by the support structure. For example, the support structure may comprise electrically conductive sub-structures that form the conductive regions. In this case, the sub-structures may be mechanically linked together by the insulative element(s), or they can be directly linked together, and the insulative element(s) can take the form of insulative layer(s) disposed on one or more of the conductive sub-structures. As another example, the support structure can have a conductive core and insulative material disposed over portions of the conductive core. In this case, the exposed core portions form the conductive regions, and the unexposed core portions form the insulative element(s).
摘要翻译：提供可扩张血管内医疗装置。医疗装置包括可扩张的管状体，其包括形成多个导电区域的集成的弹性支撑结构，引线与该多个导电区域相连。管状体还包括设置在导电区域之间的至少一个电绝缘元件。在一个实施例中，支撑结构本质上是骨架的，例如，其可以由网，编织物或线圈形成。导电区域可以由支撑结构各种形成。例如，支撑结构可以包括形成导电区域的导电子结构。在这种情况下，子结构可以通过绝缘元件机械地连接在一起，或者它们可以直接连接在一起，并且绝缘元件可以采取设置在一个或多个绝缘元件上的绝缘层的形式，更多的导电子结构。作为另一示例，支撑结构可以具有设置在导电芯的部分上方的导电芯和绝缘材料。在这种情况下，露出的芯部形成导电区域，未曝光的芯部形成绝缘元件。

66. 发明申请

US20120203300A1 Method and Apparatus for Ablation of Benign, Pre-Cancerous and Early Cancerous Lesions That Originate Within the Epithelium and are Limited to the Mucosal Layer of the Gastrointestinal Tract 审中-公开
标题翻译：用于消除起源于上皮内并且限于胃肠道粘膜层的良性，癌前和早期癌性病变的方法和装置
公开(公告)号：US20120203300A1
公开(公告)日：2012-08-09
申请号：US13438652
申请日：2012-04-03
申请人： David S. Utley , Michael P. Wallace
发明人： David S. Utley , Michael P. Wallace
IPC分类号： A61B18/12
CPC分类号： A61B18/1492 , A61B18/02 , A61B18/18 , A61B2018/0016 , A61B2018/00285 , A61B2018/00291 , A61B2018/00482 , A61B2018/00642 , A61B2018/00702 , A61B2018/00779 , A61B2018/00791 , A61B2018/00875 , A61B2018/044 , A61B2018/1467 , A61B2018/1497 , A61B2090/064 , A61B2218/007
摘要： Devices and methods are provided for ablating areas of the gastrointestinal tract affected with certain benign, pre-cancerous, or early cancerous lesions that originate within the epithelium and are limited to the mucosal layer of the gastrointestinal tract wall. Examples of such lesions include benign conditions such as cervical inlet patch (ectopic gastric mucosa in the upper esophagus), as well as pre-cancerous and cancerous conditions such as intestinal metaplasia/intra-epithelial neoplasia/early cancer of the stomach, squamous intra-epithelial neoplasia and early cancer of the esophagus, oral and pharyngeal leukoplakia, flat colonic polyps, anal intra-epithelial neoplasia (AIN), and early cancers of the anal canal. Ablation, as provided in an embodiment of the invention, commences at the epithelial layer of the gastrointestinal wall and penetrates deeper into the gastrointestinal wall in a controlled manner to achieve a successful patient outcome.
摘要翻译：提供了装置和方法，用于消融受到某些良性，癌前或早期癌性病变影响的胃肠道区域，这些病变起源于上皮内，并限于胃肠道壁的粘膜层。这种病变的实例包括诸如宫颈入口贴片（上食管中的异位胃粘膜）的良性病症，以及癌前和癌症状况如肠化生/上皮内瘤变/胃癌早期癌，鳞状内膜炎，食道上皮性肿瘤和早期癌症，口腔和咽部白斑，扁平结肠息肉，肛门上皮内瘤变（AIN）和肛管早期癌症。如本发明的一个实施方案中所提供的消融从胃肠壁的上皮层开始，并以受控的方式深入胃肠壁以达到成功的患者结果。

67. 发明申请

US20120123294A1 FLEXIBLE NEURAL LOCALIZATION DEVICES AND METHODS 有权
标题翻译：灵活的神经定位设备和方法
公开(公告)号：US20120123294A1
公开(公告)日：2012-05-17
申请号：US13340363
申请日：2011-12-29
申请人： Benjamin Kao-Shing Sun , Michael P. Wallace , Christopher D. Summa
发明人： Benjamin Kao-Shing Sun , Michael P. Wallace , Christopher D. Summa
IPC分类号： A61B5/05
CPC分类号： A61N1/0551 , A61B5/04001 , A61B5/0488 , A61B5/1107 , A61B5/4519 , A61B5/4893 , A61B5/6852 , A61B5/6855 , A61B17/149 , A61B17/1671 , A61B17/1757 , A61B17/7092 , A61B17/8897 , A61B2562/0209 , A61B2562/0261 , A61B2562/043 , A61B2562/046 , A61N1/0553
摘要： Methods for determining if a nerve is nearby a device. The neural stimulation tools described herein are configured to be flexible and low-profile, so that they can be used within body regions that may be tortuous or difficult to reach, such as within a compressed or partially occluded neural foramen. In most cases, these tools described herein are ribbon-shaped and adapted to be manipulated bimanually, applying force to the ends of the devices from separate locations outside of the patient's body. Thus, the distal end region of the device may be configured to couple to the proximal end of a guidewire. One or more surfaces of the devices may include an electrode or multi-polar network of electrodes configured to stimulate only nerves within a predetermined distance of a particular face of the device. Methods of using these devices are described.
摘要翻译：确定神经是否在设备附近的方法。本文所述的神经刺激工具被配置为柔性和低轮廓，使得它们可以在可能曲折或难以到达的身体区域内使用，例如在压缩或部分闭塞的神经孔内。在大多数情况下，这里描述的这些工具是带状的并且适于双向操纵，从患者身体外部的分离位置向装置的端部施加力。因此，装置的远端区域可以被配置为联接到导丝的近端。器件的一个或多个表面可以包括电极或多极电极网络，其被配置为仅在装置的特定面部的预定距离内刺激神经。描述使用这些装置的方法。

68. 发明申请

US20120109234A1 METHOD OF STIMULATING FASTIGIUM NUCLEUS TO TREAT NEUROLOGICAL DISORDERS 有权
标题翻译：刺激核仁治疗神经病变的方法
公开(公告)号：US20120109234A1
公开(公告)日：2012-05-03
申请号：US13347434
申请日：2012-01-10
申请人： Michael P. Wallace , James Carl Makous
发明人： Michael P. Wallace , James Carl Makous
IPC分类号： A61N1/36 , A61M37/00
CPC分类号： A61N1/36082 , A61N1/36103
摘要： A method of treating a neurological disorder comprises introducing an electrical stimulation lead within a patient's head, locating the stimulation lead within the 4th ventricle of the patient's head, and placing the stimulation lead adjacent the fastigium nucleus of the patient's brain. The method may further comprise stimulating the fastigium nucleus with the stimulation lead to treat the neurological disorder, for example, by increasing the flow of blood within the patient's brain.
摘要翻译：治疗神经障碍的方法包括在患者头部内引入电刺激引线，将刺激引线置于患者头部的第四脑室内，并将刺激引线放置在患者大脑的快速核附近。该方法可以进一步包括用刺激引线刺激快镰核，以治疗神经障碍，例如通过增加患者脑内血液的流动。

69. 发明授权

US08016852B2 Bioactive components for incorporation with vaso-occlusive members 有权
标题翻译：用于与血管闭塞成员并入的生物活性成分
公开(公告)号：US08016852B2
公开(公告)日：2011-09-13
申请号：US10409796
申请日：2003-04-09
申请人： Hanh Ho , Kenneth W. Quan, Jr. , Clifford Teoh , Robert M. Abrams , Joseph C. Eder , Paul C. Slaikeu , Michael P. Wallace , James Barry
发明人： Hanh Ho , Kenneth W. Quan, Jr. , Clifford Teoh , Robert M. Abrams , Joseph C. Eder , Paul C. Slaikeu , Michael P. Wallace , James Barry
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61B17/12172 , A61B17/12177 , A61B90/39 , A61B2017/00004 , A61B2017/12063 , A61F2/0077 , A61L31/044 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2430/36 , C08L67/04 , C08L65/04
摘要： A vaso-occlusive device is disclosed. The device includes a vaso-occlusive member having a coating disposed thereon. In accordance with one embodiment, the coating comprises a polyacrylic material. In accordance with another embodiment, the coating comprises a polyvinyl alcohol-based material. In accordance with other embodiments, various other materials and coatings are applied to at least a portion of a vaso-occlusive device.
摘要翻译：公开了一种血管闭塞装置。该装置包括其上设置有涂层的血管闭塞构件。根据一个实施方案，涂层包含聚丙烯酸材料。根据另一个实施方案，涂层包含聚乙烯醇基材料。根据其他实施例，各种其它材料和涂层被应用于血管闭塞装置的至少一部分。

70. 发明授权

US07997278B2 Precision ablating method 有权
标题翻译：精密烧蚀法
公开(公告)号：US07997278B2
公开(公告)日：2011-08-16
申请号：US11286444
申请日：2005-11-23
申请人： David S. Utley , Robert Garabedian , Michael P. Wallace
发明人： David S. Utley , Robert Garabedian , Michael P. Wallace
IPC分类号： A61B18/12
CPC分类号： A61B18/1492 , A61B18/02 , A61B18/1815 , A61B90/50 , A61B2017/00296 , A61B2018/00285 , A61B2018/00482 , A61B2018/046 , A61B2018/1495
摘要： Methods of ablating tissue in an alimentary tract are provided. The methods include advancing an ablation structure into an alimentary tract while supporting the ablation structure with an endoscope. The methods further include a step of moving at least part of the ablation structure with respect to the endoscope and toward a tissue surface, before activating the ablation structure to ablate a tissue surface.
摘要翻译：提供了在消化道中消融组织的方法。所述方法包括将消融结构推进消化道，同时用内窥镜支持消融结构。所述方法还包括在激活消融结构以消融组织表面之前相对于内窥镜移动至少部分消融结构并朝向组织表面的步骤。

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