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61. 发明申请

US20120041317A1 METHOD AND APPARATUS FOR DETECTING ATRIAL FILLING PRESSURE 有权
标题翻译：用于检测心律灌注压的方法和装置
公开(公告)号：US20120041317A1
公开(公告)日：2012-02-16
申请号：US13282143
申请日：2011-10-26
申请人： Abhilash Patangay , Krzysztof Z. Siejko
发明人： Abhilash Patangay , Krzysztof Z. Siejko
IPC分类号： A61B5/0205 , A61B5/0215 , A61B5/02
CPC分类号： A61B5/02028 , A61B7/00 , A61N1/36514 , A61N1/36528
摘要： A cardiac rhythm management system provides for ambulatory monitoring of hemodynamic performance based on quantitative measurements of heart sound related parameters for diagnostic and therapeutic purposes. Monitoring of such heart sound related parameters allows the cardiac rhythm management system to determine a need for delivering a therapy and/or therapy parameter adjustments based on conditions of a heart. This monitoring also allows a physician to observe or assess the hemodynamic performance for diagnosing and making therapeutic decisions. Because the conditions of the heart may fluctuate and may deteriorate significantly between physician visits, the ambulatory monitoring, performed on a continuous or periodic basis, ensures a prompt response by the cardiac rhythm management system that may save a life, prevent hospitalization, or prevent further deterioration of the heart.
摘要翻译：心律管理系统基于用于诊断和治疗目的的心音相关参数的定量测量，提供对血液动力学性能的动态监测。监测这种心脏声音相关参数允许心律管理系统基于心脏的情况来确定递送治疗和/或治疗参数调整的需要。该监测还允许医师观察或评估用于诊断和作出治疗决定的血液动力学性能。由于心脏的状况可能波动，并且可能在医师访问之间显着恶化，所以在连续或周期性的基础上进行的动态监测可确保心律管理系统能够节省生命，预防住院或进一步防止心律失常的迅速反应心脏恶化

62. 发明申请

US20110319778A1 CARDIAC FUNCTION MONITOR USING INFORMATION INDICATIVE OF LEAD MOTION 有权
标题翻译：心脏功能监测器使用信号指示铅运动
公开(公告)号：US20110319778A1
公开(公告)日：2011-12-29
申请号：US13168531
申请日：2011-06-24
申请人： Robert J. Sweeney , Allan C. Shuros , Krzysztof Z. Siejko , David C. Olson , Frank Ingle
发明人： Robert J. Sweeney , Allan C. Shuros , Krzysztof Z. Siejko , David C. Olson , Frank Ingle
IPC分类号： A61B5/0245 , A61N1/365
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods to monitor cardiac function using information indicative of lead motion are described. In an example, a system including an implantable medical device can include a receiver circuit configured to be electrically coupled to conductor comprising a portion of an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The system can include a sensing circuit configured to obtain information indicative of cardiac electrical activity. The system can include a processor circuit configured to construct a template representative of a contraction of the heart, where the template can be constructed using the information indicative of the movement of the implantable lead due at least in part to the motion of the heart during the contraction, and using the information indicative of the cardiac electrical activity sensed during the contraction.
摘要翻译：描述使用指示引导运动的信息来监测心脏功能的系统和方法。在一个示例中，包括可植入医疗装置的系统可以包括被配置为电耦合到导体的接收器电路，该导体包括可植入引线的一部分，并且被配置为获得指示可植入引线的移动的信息，一个心脏的动作。该系统可以包括被配置为获得指示心脏电活动的信息的感测电路。该系统可以包括配置成构造代表心脏收缩的模板的处理器电路，其中可以使用指示可植入导线的运动的信息来构建模板，至少部分地由于心脏的运动并且使用指示在收缩期间感测到的心脏电活动的信息。

63. 发明申请

US20110077707A1 DUAL-USE SENSOR FOR RATE RESPONSIVE PACING AND HEART SOUND MONITORING 审中-公开
标题翻译：用于速率响应的双用途传感器和心脏监听
公开(公告)号：US20110077707A1
公开(公告)日：2011-03-31
申请号：US12955065
申请日：2010-11-29
申请人： Keith R. Maile , Krzysztof Z. Siejko
发明人： Keith R. Maile , Krzysztof Z. Siejko
IPC分类号： A61N1/365
CPC分类号： A61N1/36542 , A61N1/36585
摘要： An implantable medical device includes a dual-use sensor such as a single accelerometer that senses an acceleration signal. A sensor processing circuit processes the acceleration signal to produce an activity level signal and a heart sound signal. The implantable medical device provides for rate responsive pacing in which at least one pacing parameter, such as the pacing interval, is dynamically adjusted based on the physical activity level. The implantable medical device also uses the heart sounds for pacing control purposes or transmits a heart sound signal to an external system for pacing control and/or diagnostic purposes.
摘要翻译：可植入医疗装置包括感测加速度信号的诸如单个加速度计的双重用途传感器。传感器处理电路处理加速度信号以产生活动度信号和心音信号。可植入医疗装置提供速率响应起搏，其中基于身体活动水平动态地调整至少一个起搏参数，例如起搏间隔。可植入医疗装置还使用心脏声音用于起搏控制目的，或者将心音信号发送到外部系统用于起搏控制和/或诊断目的。

64. 发明申请

US20110061647A1 Patient Monitoring, Diagnosis, And/Or Therapy Systems and Methods 审中-公开
标题翻译：患者监测，诊断和/或治疗系统和方法
公开(公告)号：US20110061647A1
公开(公告)日：2011-03-17
申请号：US12872730
申请日：2010-08-31
申请人： Jeffrey E. Stahmann , Kent Lee , Jesse W. Hartley , Quan Ni , John D. Hatlestad , Qingsheng Zhu , Krzysztof Z. Siejko
发明人： Jeffrey E. Stahmann , Kent Lee , Jesse W. Hartley , Quan Ni , John D. Hatlestad , Qingsheng Zhu , Krzysztof Z. Siejko
IPC分类号： A61M16/00
CPC分类号： A61B5/4818 , A61B5/0031 , A61B5/02055 , A61B5/0215 , A61B5/02405 , A61B5/0421 , A61B5/0422 , A61B5/0464 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/053 , A61B5/0809 , A61B5/0836 , A61B5/087 , A61B5/103 , A61B5/1116 , A61B5/113 , A61B5/145 , A61B5/14539 , A61B5/14542 , A61B5/4035 , A61B5/4519 , A61B5/6814 , A61B5/6823 , A61B5/6828 , A61B5/686 , A61B5/6891 , A61B5/7275 , A61B7/00 , A61B2562/0219 , A61M16/0051 , A61M16/026 , A61M16/0666 , A61M16/10 , A61M2016/0021 , A61M2016/0036 , A61M2016/0039 , A61M2016/0042 , A61M2202/0208 , A61M2205/3303 , A61M2205/3306 , A61M2205/3375 , A61M2205/3561 , A61M2205/3592 , A61M2205/52 , A61M2230/04 , A61M2230/10 , A61M2230/202 , A61M2230/205 , A61M2230/30 , A61M2230/432 , A61M2230/435 , A61M2230/50 , A61M2230/60 , A61M2230/63 , A61M2230/65 , A61N1/3601 , A61N1/362 , A61N1/3627 , A61N1/365 , A61N1/36514 , A61N1/36535 , A61N1/36557 , A61N1/36578 , A61N1/36585 , A61N1/36592 , A61N1/37 , G16H20/30 , G16H20/40 , G16H50/20
摘要： Systems and methods involve an implantable device configured to perform at least one cardiac-related function, a patient-external respiratory therapy device, and a communication channel configured to facilitate communication between the implantable device and the respiratory therapy device. The implantable and respiratory therapy devices operate cooperatively via the communication channel to provide one or more of patient monitoring, diagnosis, and therapy. The communication channel may be configured to facilitate communication between an external processing system and at least one of the implantable device and the respiratory therapy device. The processing system is communicatively coupled to at least one of the implantable and respiratory therapy devices via the communication channel to provide one or more of patient monitoring, diagnosis, and therapy.
摘要翻译：系统和方法涉及被配置为执行至少一个心脏相关功能的可植入装置，患者外部呼吸治疗装置和被配置为促进可植入装置和呼吸治疗装置之间的通信的通信信道。可植入和呼吸治疗装置通过通信通道协同工作，以提供患者监测，诊断和治疗中的一个或多个。通信信道可以被配置为促进外部处理系统与至少一个可植入装置和呼吸治疗装置之间的通信。处理系统经由通信信道通信地耦合到可植入和呼吸治疗装置中的至少一个，以提供患者监测，诊断和治疗中的一个或多个。

65. 发明申请

US20110004264A1 Systems and Methods for Ranking and Selection of Pacing Vectors 有权
标题翻译：用于起搏向量排序和选择的系统和方法
公开(公告)号：US20110004264A1
公开(公告)日：2011-01-06
申请号：US12822487
申请日：2010-06-24
申请人： Krzysztof Z. Siejko , Shibaji Shome , Jiang Ding
发明人： Krzysztof Z. Siejko , Shibaji Shome , Jiang Ding
IPC分类号： A61N1/08
CPC分类号： A61N1/3704 , A61N1/056 , A61N1/36185 , A61N1/36514 , A61N1/36542 , A61N1/36585 , A61N1/368 , A61N1/3686 , A61N1/371
摘要： Approaches to rank potential left ventricular (LV) pacing vectors are described. Early elimination tests are performed to determine the viability of LV cathode electrodes. Some LV cathodes are eliminated from further testing based on the early elimination tests. LV cathodes identified as viable cathodes are tested further. Viable LV cathode electrodes are tested for hemodynamic efficacy. Cardiac capture and phrenic nerve activation thresholds are then measured for potential LV pacing vectors comprising a viable LV cathode electrode and an anode electrode. The potential LV pacing vectors are ranked based on one or more of the hemodynamic efficacy of the LV cathodes, the cardiac capture thresholds, and the phrenic nerve activation thresholds.
摘要翻译：描述了评估潜在的左心室（LV）起搏向量的方法。执行早期消除测试以确定LV阴极的可行性。基于早期消除测试，一些LV阴极被进一步测试消除。确定为阴极的LV阴极被进一步测试。测试可行的LV阴极电极的血液动力学效能。然后测量包含可行的LV阴极电极和阳极电极的潜在LV起搏向量的心脏捕获和膈神经激活阈值。潜在的LV起搏向量基于LV阴极的血液动力学功效，心脏捕获阈值和膈神经激活阈值中的一种或多种进行排名。

66. 发明授权

US07844334B2 Dual-use sensor for rate responsive pacing and heart sound monitoring 有权
标题翻译：双用传感器用于速率响应起搏和心脏声音监测
公开(公告)号：US07844334B2
公开(公告)日：2010-11-30
申请号：US11778527
申请日：2007-07-16
申请人： Keith R. Maile , Krzysztof Z. Siejko
发明人： Keith R. Maile , Krzysztof Z. Siejko
IPC分类号： A61N1/00
CPC分类号： A61N1/36542 , A61N1/36585
摘要： An implantable medical device includes a dual-use sensor such as a single accelerometer that senses an acceleration signal. A sensor processing circuit processes the acceleration signal to produce an activity level signal and a heart sound signal. The implantable medical device provides for rate responsive pacing in which at least one pacing parameter, such as the pacing interval, is dynamically adjusted based on the physical activity level. The implantable medical device also uses the heart sounds for pacing control purposes or transmits a heart sound signal to an external system for pacing control and/or diagnostic purposes.
摘要翻译：可植入医疗装置包括感测加速度信号的诸如单个加速度计的双重用途传感器。传感器处理电路处理加速度信号以产生活动度信号和心音信号。可植入医疗装置提供速率响应起搏，其中基于身体活动水平动态地调整至少一个起搏参数，例如起搏间隔。可植入医疗装置还使用心脏声音用于起搏控制目的，或者将心音信号发送到外部系统用于起搏控制和/或诊断目的。

67. 发明申请

US20090247889A1 DETERMINING A PATIENT'S POSTURE FROM MECHANICAL VIBRATIONS OF THE HEART 有权
标题翻译：从心脏的机械振动中确定患者的姿势
公开(公告)号：US20090247889A1
公开(公告)日：2009-10-01
申请号：US12484108
申请日：2009-06-12
申请人： Keith R. Maile , Krzysztof Z. Siejko
发明人： Keith R. Maile , Krzysztof Z. Siejko
IPC分类号： A61B5/02
CPC分类号： A61N1/36542 , A61B7/00 , A61N1/36535 , A61N1/36578
摘要： A system for determining a patient's posture by monitoring heart sounds. The system comprises an implantable medical device that includes a sensor operable to produce an electrical signal representative of heart sounds, a sensor interface circuit coupled to the sensor to produce a heart sound signal, and a controller circuit coupled to the sensor interface circuit. The heart sounds are associated with mechanical activity of a patient's heart and the controller circuit is operable to detect a posture of the patient from a heart sound signal.
摘要翻译：通过监测心脏声音来确定患者姿势的系统。该系统包括可植入医疗装置，其包括可操作以产生表示心脏声音的电信号的传感器，耦合到传感器以产生心音信号的传感器接口电路，以及耦合到传感器接口电路的控制器电路。心脏声音与患者心脏的机械活动相关联，并且控制器电路可操作以从心脏声音信号检测患者的姿势。

68. 发明授权

US07404802B2 Trending of systolic murmur intensity for monitoring cardiac disease with implantable device 有权
标题翻译：用植入式装置监测心脏病的收缩期杂音强度的趋势
公开(公告)号：US07404802B2
公开(公告)日：2008-07-29
申请号：US11122749
申请日：2005-05-05
申请人： Krzysztof Z. Siejko , Richard Fogoros
发明人： Krzysztof Z. Siejko , Richard Fogoros
IPC分类号： A61B5/02
CPC分类号： A61N1/36514 , A61B7/023 , A61N1/3627
摘要： Described is an implantable device configured to monitor for changes in the intensity and/or duration of a systolic murmur such as mitral regurgitation by means of an acoustic sensor. Such changes may be taken to indicate a change in a patient's heart failure status. Upon detection of a worsening in the patient's heart failure statue, the device may be programmed to alert clinical personnel over a patient management network and/or make appropriate adjustments to pacing therapy.
摘要翻译：描述了被配置为通过声学传感器监测收缩期杂音如二尖瓣反流的强度和/或持续时间的变化的可植入装置。可以采取这种改变来指示患者心力衰竭状态的变化。当检测到患者的心力衰竭雕像恶化时，该装置可以被编程以通过患者管理网络警告临床人员和/或对起搏治疗进行适当的调整。

69. 发明申请

US20080058872A1 CONTROLLED TITRATION OF NEUROSTIMULATION THERAPY 有权
标题翻译：控制神经病治疗方法
公开(公告)号：US20080058872A1
公开(公告)日：2008-03-06
申请号：US11468143
申请日：2006-08-29
申请人： Marina V. Brockway , Imad Libbus , Krzysztof Z. Siejko , Robert J. Sweeney
发明人： Marina V. Brockway , Imad Libbus , Krzysztof Z. Siejko , Robert J. Sweeney
IPC分类号： A61N1/00
CPC分类号： A61N1/3727 , A61B5/02405 , A61B5/4035 , A61B5/4839 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N1/362 , A61N1/37264
摘要： Described herein are methods and devices that utilize electrical neural stimulation to treat heart failure by modulating a patient's autonomic balance in a manner that inhibits sympathetic activity and/or augments parasympathetic activity. Because other therapies for treating heart failure may also affect a patient's autonomic balance, a device for delivering neural stimulation is configured to appropriately titrate such therapy in either an open-loop or closed-loop fashion.
摘要翻译：本文描述了利用电神经刺激来以抑制交感神经活动和/或增加副交感神经活动的方式调节患者的自主神经平衡来治疗心力衰竭的方法和装置。因为用于治疗心力衰竭的其它治疗也可能影响患者的自主平衡，用于递送神经刺激的装置被配置为以开环或闭环方式适当地滴定这种治疗。

70. 发明授权

US08886313B2 Systems and methods for ranking and selection of pacing vectors 有权
标题翻译：起搏向量的排序和选择的系统和方法
公开(公告)号：US08886313B2
公开(公告)日：2014-11-11
申请号：US12822487
申请日：2010-06-24
申请人： Krzysztof Z. Siejko , Shibaji Shome , Jiang Ding
发明人： Krzysztof Z. Siejko , Shibaji Shome , Jiang Ding
IPC分类号： A61N1/05 , A61N1/365 , A61N1/36 , A61N1/368 , A61N1/37
CPC分类号： A61N1/3704 , A61N1/056 , A61N1/36185 , A61N1/36514 , A61N1/36542 , A61N1/36585 , A61N1/368 , A61N1/3686 , A61N1/371
摘要： Approaches to rank potential left ventricular (LV) pacing vectors are described. Early elimination tests are performed to determine the viability of LV cathode electrodes. Some LV cathodes are eliminated from further testing based on the early elimination tests. LV cathodes identified as viable cathodes are tested further. Viable LV cathode electrodes are tested for hemodynamic efficacy. Cardiac capture and phrenic nerve activation thresholds are then measured for potential LV pacing vectors comprising a viable LV cathode electrode and an anode electrode. The potential LV pacing vectors are ranked based on one or more of the hemodynamic efficacy of the LV cathodes, the cardiac capture thresholds, and the phrenic nerve activation thresholds.
摘要翻译：描述了评估潜在的左心室（LV）起搏向量的方法。执行早期消除测试以确定LV阴极的可行性。基于早期消除测试，一些LV阴极被进一步测试消除。确定为阴极的LV阴极被进一步测试。测试可行的LV阴极电极的血液动力学效能。然后测量包含可行的LV阴极电极和阳极电极的潜在LV起搏向量的心脏捕获和膈神经激活阈值。潜在的LV起搏向量基于LV阴极的血液动力学功效，心脏捕获阈值和膈神经激活阈值中的一种或多种进行排名。

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