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61. 发明授权

US08007746B2 Microfluidic devices and methods of using same 有权
标题翻译：微流体装置及其使用方法
公开(公告)号：US08007746B2
公开(公告)日：2011-08-30
申请号：US11929660
申请日：2007-10-30
申请人： Marc Unger , Jiang Huang , Emerson Quan
发明人： Marc Unger , Jiang Huang , Emerson Quan
IPC分类号： B01L3/00
CPC分类号： B01L3/00 , B01L3/0248 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/0642 , B01L2200/142 , B01L2200/147 , B01L2300/0816 , B01L2300/0861 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , C12Q1/686
摘要： An M.times.N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method comprising using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block.
摘要翻译：一种用于执行反应矩阵的M.times.N矩阵微流体装置，该装置具有多个反应池，其通过形成在装置的弹性体块内的通孔与样品入口或试剂入口之一连通。提供的方法包括在微流体装置的弹性体块的弹性体层中平行形成通孔的方法，该方法包括使用图案化的光致抗蚀剂掩模和蚀刻试剂来蚀刻掉弹性体块的弹性体层的区域或部分。

62. 发明授权

US07075162B2 Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes 失效
标题翻译：使用柔性电极的弹性体结构的静电/电致伸缩致动
公开(公告)号：US07075162B2
公开(公告)日：2006-07-11
申请号：US10232997
申请日：2002-08-29
申请人： Marc Unger
发明人： Marc Unger
IPC分类号： H01L29/84
CPC分类号： H01L21/00 , B01L3/0241 , B01L3/5025 , B01L3/502707 , B01L3/502738 , B01L2300/0816 , B01L2300/0887 , B01L2400/0481 , B01L2400/0655 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K99/0051 , F16K99/0053 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008
摘要： A valve structure includes an elastomeric block formed with first and second microfabricated recesses separated by a membrane portion of the elastomeric block. The valve is actuated by positioning a compliant electrode on a first side of the first recess proximate to and in physical communication with the membrane. Where the valve is to be electrostatically actuated, a second electrode is positioned on a second side of the first recess opposite the first side. Application of a potential difference across the electrodes causes the compliant electrode and the membrane to be attracted into the flow channel. Where the valve is to be electrostrictively actuated, a second electrode is positioned on the same side of the recess as the compliant electrode. Application of a potential difference across the electrodes causes the electrodes to be attracted such that elastomer membrane portion material between them is compressed and bows into the flow channel. Either of the electrostrictively or the electrostatically-actuated valve structures may include an electrically-conducting fluid in the second recess to serve as the compliant electrode.
摘要翻译：阀结构包括由弹性块的膜部分隔开的第一和第二微细加工凹部形成的弹性体块。通过将顺应性电极定位在第一凹部的靠近膜并且与膜物理连通的第一侧上来致动阀。在阀被静电致动的地方，第二电极位于与第一侧相对的第一凹槽的第二侧上。在电极之间施加电位差使得柔性电极和膜被吸引到流动通道中。在阀被电致伸缩的情况下，第二电极位于与顺应性电极相同的凹槽侧。在电极之间施加电位差导致电极被吸引，使得它们之间的弹性体膜部分材料被压缩并弯曲到流动通道中。电致伸缩阀或静电致动阀结构中的任何一个可以包括在第二凹槽中用作柔性电极的导电流体。

63. 发明申请

US20050145496A1 Thermal reaction device and method for using the same 审中-公开
公开(公告)号：US20050145496A1
公开(公告)日：2005-07-07
申请号：US10876046
申请日：2004-06-23
申请人： Federico Goodsaid , Marc Unger , Jiang Huang , Emerson Quan
发明人： Federico Goodsaid , Marc Unger , Jiang Huang , Emerson Quan
IPC分类号： B01L3/00 , G01N27/453
CPC分类号： B01L3/00 , B01L3/0248 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/0642 , B01L2200/142 , B01L2200/147 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/123 , B01L2300/1805 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , B01L2400/0655 , C12Q1/686 , G01N27/453
摘要： An M×N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method comprising using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block.

64. 发明申请

US20050084421A1 Microfluidic devices and methods of using same 有权
标题翻译：微流体装置及其使用方法
公开(公告)号：US20050084421A1
公开(公告)日：2005-04-21
申请号：US10837885
申请日：2004-05-02
申请人： Marc Unger , Jiang Huang , Emerson Quan
发明人： Marc Unger , Jiang Huang , Emerson Quan
IPC分类号： B01L3/00
CPC分类号： B01L3/00 , B01L3/0248 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/0642 , B01L2200/142 , B01L2200/147 , B01L2300/0816 , B01L2300/0861 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , C12Q1/686
摘要： An M×N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method comprising using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block.
摘要翻译：一种用于执行反应矩阵的MxN矩阵微流体装置，所述装置具有多个反应池，其通过形成在所述装置的弹性体块内的通孔与样品入口或试剂入口之一连通。提供的方法包括在微流体装置的弹性体块的弹性体层中平行形成通孔的方法，该方法包括使用图案化的光致抗蚀剂掩模和蚀刻试剂来蚀刻掉弹性体块的弹性体层的区域或部分。

65. 发明授权

US06818395B1 Methods and apparatus for analyzing polynucleotide sequences 有权
标题翻译：分析多核苷酸序列的方法和装置
公开(公告)号：US06818395B1
公开(公告)日：2004-11-16
申请号：US09707737
申请日：2000-11-06
申请人： Stephen Quake , Marc Unger
发明人： Stephen Quake , Marc Unger
IPC分类号： C12Q168
CPC分类号： C12Q1/68 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2200/10 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2400/0481 , B01L2400/0655 , C12Q1/6869 , C12Q1/6874 , F04B43/043 , F15C5/00 , F16K99/0001 , F16K99/0015 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , F16K2099/0094 , G01N33/549 , C12Q2535/125 , C12Q2565/629 , C12Q2533/101
摘要： Methods for high speed, high throughput analysis of polynucleotide sequences, and apparatuses with which to carry out the methods are provided in the invention.
摘要翻译：在本发明中提供了用于多核苷酸序列的高速，高通量分析的方法以及用于实施所述方法的装置。

66. 发明授权

US09157116B2 Combinatorial amplification and detection of nucleic acids 有权
标题翻译：核酸的组合扩增和检测
公开(公告)号：US09157116B2
公开(公告)日：2015-10-13
申请号：US12866018
申请日：2009-02-09
申请人： Kenneth J. Livak , Marc Unger
发明人： Kenneth J. Livak , Marc Unger
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/6834 , C12Q2565/629
摘要： High throughput methods are used that combine the features of using a matrix-type microfluidic device, labeled nucleic acid probes, and homogenous assays to detect and/or quantify nucleic acid analytes. The high throughput methods are capable of detecting nucleic acid analyes with high PCR and probe specificity, producing a low fluorescence background and therefore, a high signal to noise ratio. Additionally, the high throughput methods are capable of detecting low copy number nucleic acid analyte per cell.
摘要翻译：使用高通量方法，其结合使用基质型微流体装置，标记的核酸探针和均质测定的特征来检测和/或定量核酸分析物。高通量方法能够以高PCR和探针特异性检测核酸分析，产生低荧光背景，因此具有高的信噪比。此外，高通量方法能够检测每个细胞的低拷贝数核酸分析物。

67. 发明授权

US07867454B2 Thermal reaction device and method for using the same 有权
标题翻译：热反应装置及其使用方法
公开(公告)号：US07867454B2
公开(公告)日：2011-01-11
申请号：US11929370
申请日：2007-10-30
申请人： Federico Goodsaid , Marc Unger , Jiang Huang , Emerson Quan
发明人： Federico Goodsaid , Marc Unger , Jiang Huang , Emerson Quan
IPC分类号： B01L3/00
CPC分类号： B01L3/00 , B01L3/0248 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/0642 , B01L2200/142 , B01L2200/147 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/123 , B01L2300/1805 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , B01L2400/0655 , C12Q1/686 , G01N27/453
摘要： An M.times.N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method comprising using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block.
摘要翻译：一种用于执行反应矩阵的M.times.N矩阵微流体装置，该装置具有多个反应池，其通过形成在装置的弹性体块内的通孔与样品入口或试剂入口之一连通。提供的方法包括在微流体装置的弹性体块的弹性体层中平行形成通孔的方法，该方法包括使用图案化的光致抗蚀剂掩模和蚀刻试剂来蚀刻掉弹性体块的弹性体层的区域或部分。

68. 发明申请

US20100120038A1 ASSAY METHODS FOR INCREASED THROUGHPUT OF SAMPLES AND/OR TARGETS 有权
标题翻译：用于增加样品和/或目标物的测定方法
公开(公告)号：US20100120038A1
公开(公告)日：2010-05-13
申请号：US12548132
申请日：2009-08-26
申请人： Alain Mir , Ramesh Ramakrishnan , Marc Unger , Bernhard G. Zimmermann
发明人： Alain Mir , Ramesh Ramakrishnan , Marc Unger , Bernhard G. Zimmermann
IPC分类号： C12Q1/68 , G01N33/48
CPC分类号： C12Q1/686 , C12N15/1065 , C12Q1/6853 , Y10T436/143333 , C12Q2537/143 , C12Q2525/161
摘要： The present invention provides assay methods that increase the number of samples and/or target nucleic acids that can be analyzed in a single assay.
摘要翻译：本发明提供了增加可以在单次测定中分析的样品和/或靶核酸数量的测定方法。

69. 发明申请

US20080292504A1 Thermal Reaction Device and Method for Using the Same 有权
标题翻译：热反应装置及其使用方法
公开(公告)号：US20080292504A1
公开(公告)日：2008-11-27
申请号：US11929370
申请日：2007-10-30
申请人： Federico Goodsaid , Marc Unger , Jiang Huang , Emerson Quan
发明人： Federico Goodsaid , Marc Unger , Jiang Huang , Emerson Quan
IPC分类号： G01N21/64 , B01J19/00
CPC分类号： B01L3/00 , B01L3/0248 , B01L3/5025 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L7/52 , B01L2200/0642 , B01L2200/142 , B01L2200/147 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/123 , B01L2300/1805 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , B01L2400/0655 , C12Q1/686 , G01N27/453
摘要： An M.times.N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for forming vias in parallel in an elastomeric layer of an elastomeric block of a microfluidic device, the method comprising using patterned photoresist masks and etching reagents to etch away regions or portions of an elastomeric layer of the elastomeric block.
摘要翻译：一种用于执行反应矩阵的M.times.N矩阵微流体装置，该装置具有多个反应池，其通过形成在装置的弹性体块内的通孔与样品入口或试剂入口之一连通。提供的方法包括在微流体装置的弹性体块的弹性体层中平行形成通孔的方法，该方法包括使用图案化的光致抗蚀剂掩模和蚀刻试剂来蚀刻掉弹性体块的弹性体层的区域或部分。

70. 发明授权

US07291512B2 Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes 有权
标题翻译：使用柔性电极的弹性体结构的静电/电致伸缩致动
公开(公告)号：US07291512B2
公开(公告)日：2007-11-06
申请号：US11316282
申请日：2005-12-21
申请人： Marc Unger
发明人： Marc Unger
IPC分类号： H01L21/00
CPC分类号： H01L21/00 , B01L3/0241 , B01L3/5025 , B01L3/502707 , B01L3/502738 , B01L2300/0816 , B01L2300/0887 , B01L2400/0481 , B01L2400/0655 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K99/0051 , F16K99/0053 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008
摘要： A valve structure comprises an elastomeric block formed with first and second microfabricated recesses separated by a membrane portion of the elastomeric block. The valve is actuated by positioning a compliant electrode on a first side of the first recess proximate to and in physical communication with the membrane. Where the valve is to be electrostatically actuated, a second electrode is positioned on a second side of the first recess opposite the first side. Application of a potential difference across the electrodes causes the compliant electrode and the membrane to be attracted into the flow channel. Where the valve is to be electrostrictively actuated, a second electrode is positioned on the same side of the recess as the compliant electrode. Application of a potential difference across the electrodes causes the electrodes to be attracted such that elastomer membrane portion material between them is compressed and bows into the flow channel. Either of the electrostrictively or the electrostatically-actuated valve structures may include an electrically-conducting fluid in the second recess to serve as the compliant electrode.
摘要翻译：阀结构包括由弹性体块的膜部分分开的第一和第二微细加工凹部形成的弹性体块。通过将顺应性电极定位在第一凹部的靠近膜并且与膜物理连通的第一侧上来致动阀。在阀被静电致动的地方，第二电极位于与第一侧相对的第一凹槽的第二侧上。在电极之间施加电位差使得柔性电极和膜被吸引到流动通道中。在阀被电致伸缩的情况下，第二电极位于与顺应性电极相同的凹槽侧。在电极之间施加电位差导致电极被吸引，使得它们之间的弹性体膜部分材料被压缩并弯曲到流动通道中。电致伸缩阀或静电致动阀结构中的任何一个可以包括在第二凹槽中用作柔性电极的导电流体。

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