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61. 发明授权

US5200196A Improvement in pulsed drug therapy 失效
标题翻译：改善脉冲药物治疗
公开(公告)号：US5200196A
公开(公告)日：1993-04-06
申请号：US640469
申请日：1991-01-11
申请人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
发明人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
摘要翻译：一种剂型，其包含（1）立即可用的有效药物剂量，然后是药物的定时延迟剂量，或（2）定时延迟剂量的药物。

62. 发明授权

US5169383A Control membrane for electrotransport drug delivery 失效
标题翻译：电转运药物控制膜
公开(公告)号：US5169383A
公开(公告)日：1992-12-08
申请号：US571577
申请日：1990-09-07
申请人： J. Richard Gyory , Ronald P. Haak , Felix Theeuwes
发明人： J. Richard Gyory , Ronald P. Haak , Felix Theeuwes
IPC分类号： A61J1/20 , A61M37/00 , A61N20060101 , A61N1/30
CPC分类号： A61N1/0444 , A61N1/044
摘要： A membrane capable of controlling the rate at which an agent is released from an iontophoretic delivery device is provided. The membrane inhibits agent release from the delivery device when no electrical current is flowing and yet provides minimal impedance to electrically-assisted agent delivery. The membrane is useful both as a control membrane in an iontophoretic agent delivery device and as a test membrane for testing the performance characteristics of an iontophoretic agent delivery device in vitro.
摘要翻译： PCT No.PCT / US89 / 04318 Sec。 371 1990年9月7日第 102（e）1990年9月7日PCT PCT 1989年10月2日PCT公布。出版物WO90 / 0382500 日本1990年04月19日提供了能够控制药剂从离子电渗输送装置中释放的速率的膜。当没有电流流动时，该膜抑制剂量从输送装置释放，并且对电辅助剂递送提供最小的阻抗。膜可用作离子电渗剂递送装置中的对照膜以及用于在体外测试离子电渗疗法递送装置的性能特征的测试膜。

63. 发明授权

US5156850A Dosage form for time-varying patterns of drug delivery 失效
标题翻译：用于药物递送时间变化的剂型
公开(公告)号：US5156850A
公开(公告)日：1992-10-20
申请号：US576042
申请日：1990-08-31
申请人： Patrick S. Wong , Felix Theeuwes , Atul D. Ayer , Anthony L. Kuczynski
发明人： Patrick S. Wong , Felix Theeuwes , Atul D. Ayer , Anthony L. Kuczynski
IPC分类号： A61K9/00 , A61K9/22 , A61K31/155 , A61K31/275 , A61K31/435 , A61K31/55
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed that comprises means inside the dosage form for providing a substantially drug-free interval before the dosage form delivers a drug from inside the dosage form. The dosage form in an embodiment comprises a drug on the exterior of the dosage form, which drug is available for immediate delivery.
摘要翻译：公开了一种剂型，其包含剂型内的装置，用于在剂型从剂型内部递送药物之前提供基本上无药物的间隔。在一个实施方案中的剂型包含在剂型外部的药物，该药物可用于立即递送。

64. 发明授权

US5110597A Multi-unit delivery system 失效
标题翻译：多单元交付系统
公开(公告)号：US5110597A
公开(公告)日：1992-05-05
申请号：US701927
申请日：1991-05-17
申请人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
发明人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
IPC分类号： A61K9/00 , A61K9/48 , A61M31/00
CPC分类号： A61K9/0004 , A61K9/4808 , A61M31/002
摘要： A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
摘要翻译：用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多个离散的含药单元。

65. 发明授权

US5045059A Intravenous system for delivering a beneficial agent 失效
标题翻译：用于递送有益药物的静脉内系统
公开(公告)号：US5045059A
公开(公告)日：1991-09-03
申请号：US568457
申请日：1990-08-15
申请人： Felix Theeuwes , Su I. Yum
发明人： Felix Theeuwes , Su I. Yum
IPC分类号： A61M5/14
CPC分类号： A61M5/1407
摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber has a fluid inlet and a fluid outlet for maintaining a flow of IV fluid through the chamber. A portion of the chamber wall is comprised of a window material which allows the drug to diffuse therethrough but which prevents convective loss of the IV fluid. A flow distributor is provided within the chamber for distributing the flow of IV fluid along the interior surface of the window. A transdermal-type drug delivery device is adhered to the exterior surface of the window. Drug is delivered by the delivery device through the window and into the flowing IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery from the device into the IV fluid is controlled by either the window itself or by a membrane layer in the drug delivery device. A plurality of drug delivery devices may be adhered to the window to deliver a plurality of drugs or to deliver a single drug at a higher dosage rate. A similar window may be placed in an IV bag to deliver a drug into the IV fluid therein.
摘要翻译：提供了用于静脉内给药组的药物制剂室。静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。药物制剂室具有流体入口和流体出口，用于维持IV流体流过腔室的流动。室壁的一部分由允许药物扩散通过但防止IV流体的对流损失的窗口材料构成。在室内提供流动分配器，用于沿着窗口的内表面分配IV流体流。透皮型药物输送装置粘附在窗户的外表面上。药物由输送装置通过窗口输送到流动的IV流体中。该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。从装置向IV流体的药物递送速率由窗口本身或药物递送装置中的膜层控制。多个药物递送装置可以粘附到窗户以递送多种药物或以更高的剂量率递送单一药物。类似的窗口可以放置在IV袋中以将药物递送到其中的IV流体中。

66. 发明授权

US5023088A Multi-unit delivery system 失效
标题翻译：多单元交货系统
公开(公告)号：US5023088A
公开(公告)日：1991-06-11
申请号：US495825
申请日：1990-03-19
申请人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
发明人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff , Steven D. Larsen , Hoa T. Huynh
IPC分类号： A61K9/00 , A61K9/48 , A61M31/00
CPC分类号： A61M31/002 , A61K9/0004 , A61K9/4808
摘要： A dispenser for use in a fluid environment which is capable of delivery of a plurality of discrete drug-containing units in any desired delivery pattern or profile.
摘要翻译：用于流体环境中的分配器，其能够以任何期望的递送模式或轮廓递送多个离散的含药单元。

67. 发明授权

US4969872A Intravenous system for delivering a beneficial agent with delivery rate control via permeable surface area variance 失效
标题翻译：用于通过渗透性表面积差异递送有效药物的输送速率控制的静脉内系统
公开(公告)号：US4969872A
公开(公告)日：1990-11-13
申请号：US320732
申请日：1989-03-08
申请人： John Urquhart , Felix Theeuwes
发明人： John Urquhart , Felix Theeuwes
IPC分类号： A61M39/00 , A61M5/14
CPC分类号： A61M5/1409
摘要： A drug formulation chamber for an intravenous administration set is provided. The intravenous administration set includes a container of an IV fluid, a drip chamber, a drug formulation chamber, and an adapter-needle assembly. The drug formulation chamber houses a diffusional or an osmotically driven drug delivery device. The osmotically driven delivery device has a semipermeable, microporous or diffusional wall which surrounds a compartment containing the drug. Drug is delivered through an orifice in the semipermeable/microporous wall or through the diffusional wall itself, into the IV fluid. The device delivers drug into the IV fluid at a rate that is independent of the flow rate of IV fluid through the formulation chamber. The rate of drug delivery is controlled by variably adjusting the surface area of the semipermeable/microporous/diffusional wall that is exposed to the IV fluid flowing through the drug formulation chamber.
摘要翻译：提供了用于静脉内给药组的药物制剂室。静脉内给药组包括IV液体的容器，滴液室，药物制剂室和适配器 - 针组件。药物制剂室容纳扩散或渗透驱动的药物递送装置。渗透驱动的输送装置具有围绕包含药物的隔室的半透性，微孔或扩散壁。药物通过半透膜/微孔壁中的孔口或通过扩散壁本身输送到IV液体中。该装置以与通过制剂室的IV流体的流速无关的速率将药物递送到IV流体中。通过可变地调节暴露于流过药物制剂室的IV液体的半透性/微孔/扩散壁的表面积来控制药物递送的速率。

68. 发明授权

US4859470A Dosage form for delivering diltiazem 失效
标题翻译：用于给予地尔硫卓的剂型
公开(公告)号：US4859470A
公开(公告)日：1989-08-22
申请号：US201519
申请日：1988-06-02
申请人： George V. Guittard , Patrick S. L. Wong , Felix Theeuwes , Richard Cortese
发明人： George V. Guittard , Patrick S. L. Wong , Felix Theeuwes , Richard Cortese
IPC分类号： A61K9/22 , A61K9/00 , A61K9/52 , A61K31/55 , A61K47/00 , A61K47/30 , A61K47/32 , A61K47/38 , A61P9/08 , A61P9/10
CPC分类号： A61K9/0004 , A61K31/55
摘要： A device is disclosed for delivering diltiazem at a controlled and substantially zero order rate over a prolonged period of time.
摘要翻译：公开了一种用于在长时间段内以受控且基本为零级速率输送硫氮的装置。

69. 发明授权

US4851231A System for delivering drug in selected environment of use 失效
标题翻译：在选定的使用环境中输送药物的系统
公开(公告)号：US4851231A
公开(公告)日：1989-07-25
申请号：US026427
申请日：1987-03-16
申请人： John Urquhart , Felix Theeuwes
发明人： John Urquhart , Felix Theeuwes
IPC分类号： A61K9/20 , A61K9/22
CPC分类号： A61K9/2081
摘要： A delivery system is disclosed for delivering an agent to a selected environment of use having a pH of greater than 3.5.
摘要翻译：公开了用于将试剂递送到pH大于3.5的所选择的使用环境的递送系统。

70. 发明授权

US4842867A Pulsed drug delivery of doxylamine 失效
标题翻译：脉冲药物递送多西拉敏
公开(公告)号：US4842867A
公开(公告)日：1989-06-27
申请号：US861188
申请日：1986-05-09
申请人： Atul D. Ayer , Felix Theeuwes , Patrick S. Wong
发明人： Atul D. Ayer , Felix Theeuwes , Patrick S. Wong
IPC分类号： A61K31/445 , A61K9/00 , A61K9/22 , A61K9/58
CPC分类号： A61K9/0004
摘要： A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
摘要翻译：一种剂型，其包含（1）立即可用的有效药物剂量，然后是药物的定时延迟剂量，或（2）定时延迟剂量的药物。

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