专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明授权

US5311484A Method and apparatus for petroleum and gas exploration 失效
标题翻译：石油和天然气勘探方法和装置
公开(公告)号：US5311484A
公开(公告)日：1994-05-10
申请号：US736682
申请日：1991-07-26
申请人： Roger N. Anderson , Wei He
发明人： Roger N. Anderson , Wei He
IPC分类号： G01V1/28 , G01V9/00 , G01V1/00
CPC分类号： G01V9/005 , G01V1/28 , G01V2210/51
摘要： In the exploration for petroleum or natural gas, drilling targets are identified by locating local maxima of horizontal gradient in the top-of-geopressure surface of a region of exploration. The probability of finding hydrocarbon deposits is significantly improved where the drilling targets are local maxima of the horizontal gradient in the top-of-geopressure surface which coincide with local maxima of subsurface heat flow in the region of exploration, particularly where the local maxima in the horizontal gradient of the top-of-geopressured surface is concentrated across major fault offsets and are parallel to the predominant strike directions of the faults. The top-of-geopressure surface may be remotely sensed by performing complex trace analysis on reflection seismic traces gathered for the region of exploration to derive corresponding reflection strength attribute traces. The corresponding reflection strength traces are first smoothed and then subject to further complex trace analysis to derive the envelope amplitudes of the smoothed reflection strength traces, which are referred to as second reflection strength traces. The second reflection strength traces are then analyzed to locate an uppermost distinct subsurface boundary between high and low amplitude components thereof. Such a distinct boundary is then identified as the top-of-geopressure surface for the region of exploration.
摘要翻译：在勘探石油或天然气时，通过在勘探区域顶部地质压力表面定位局部最大水平梯度来确定钻井目标。发现碳氢化合物沉积物的概率显着改善，其中钻井目标是地质压力表面中的水平梯度的局部最大值，其与勘探区域中的地下热流的局部最大值一致，特别是在顶层地表压实表面的水平梯度集中在主要的断层偏移上，并且与断层的主要冲击方向平行。可以通过对为探索区域收集的反射地震迹线执行复杂的轨迹分析来导出相应的反射强度属性轨迹，来远程感测地顶压力表面。首先平滑对应的反射强度迹线，然后进行进一步的复杂轨迹分析，得到平滑的反射强度迹线的包络幅度，这被称为第二反射强度迹线。然后分析第二反射强度迹线以在其高和低幅度分量之间定位最上面的不同的地下边界。然后，将这样一个明确的边界确定为勘探区域的地顶压力表面。

62. 发明申请

US20160200730A1 POLYFLUORINATED COMPOUNDS ACTING AS BRUTON TYROSINE KINASE INHIBITORS 有权
标题翻译：作为BRUTON酪氨酸激酶抑制剂的多氟化合物
公开(公告)号：US20160200730A1
公开(公告)日：2016-07-14
申请号：US15075033
申请日：2016-03-18
申请人： Wei He
发明人： Wei He
IPC分类号： C07D487/04
CPC分类号： A61K31/519 , C07C303/38 , C07C311/08 , C07D487/04 , C07D519/00 , C07F5/025 , C07F5/04
摘要： Described herein is a novel series of multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof. These compounds are Bruton's tyrosine kinase (BTK) inhibitors. These compounds may possess better BTK inhibition selectivity and pharmacokinetic properties. Disclosed herein are the synthesis methods of these compounds. Disclosed herein are novel synthesis methods of the multi-fluoro-substituted benzophenone and substituted phenoxy benzene. Also disclosed are pharmaceutical compositions comprising the BTK inhibitors described herein. The present invention also relates to pharmaceutical formulations comprising the compounds described herein as active ingredients. The present invention also includes the therapeutic methods by administering the BTK inhibitors and their formulations to treat and inhibit autoimmune disease, hypersensitivity disease, inflammatory diseases and cancer.
摘要翻译：本文描述了一系列新的多氟取代的吡唑并嘧啶化合物或其盐。这些化合物是Bruton的酪氨酸激酶（BTK）抑制剂。这些化合物可具有更好的BTK抑制选择性和药代动力学性质。本文公开了这些化合物的合成方法。本文公开了多氟取代的二苯甲酮和取代的苯氧基苯的新型合成方法。还公开了包含本文所述的BTK抑制剂的药物组合物。本发明还涉及包含本文所述的化合物作为活性成分的药物制剂。本发明还包括通过施用BTK抑制剂及其制剂来治疗和抑制自身免疫性疾病，超敏反应性疾病，炎性疾病和癌症的治疗方法。

63. 发明授权

US08960769B2 Fairing for a truck cab-trailer gap 有权
标题翻译：一个卡车驾驶室 - 拖车间隙的整流罩
公开(公告)号：US08960769B2
公开(公告)日：2015-02-24
申请号：US14348087
申请日：2011-10-12
申请人： Wei He , Mathew Frederick Heinecke
发明人： Wei He , Mathew Frederick Heinecke
IPC分类号： B62D35/00
CPC分类号： B62D35/001
摘要： A truck for pulling a semi-trailer includes an operator cab positioned on a frame and a fifth wheel mounted on the frame for receiving an underside of the semi-trailer. The trailer when attached to the truck defines a gap between a forward most portion of the semi-trailer and rearward most portion of the operator cab. A fairing can be located on the frame, aft of the operator cab and forward of at least a portion of the fifth wheel. The fairing can block at least a portion of the air flow attempting to enter the gap from below the frame.
摘要翻译：用于牵引半挂车的卡车包括位于框架上的操作者驾驶室和安装在框架上的用于接收半挂车下侧的第五轮。拖车当连接到卡车时，定义了半挂车的最前部分和驾驶室后方最大部分之间的间隙。整流罩可以位于框架上，操作员驾驶室的后部和第五轮的至少一部分的前方。整流罩可以阻挡试图从框架下方进入间隙的空气流的至少一部分。

64. 发明申请

US20130245051A1 CYCLIC UREA INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 有权
标题翻译： 11BETA-羟基脱氢酶脱氢酶的循环尿素抑制剂1
公开(公告)号：US20130245051A1
公开(公告)日：2013-09-19
申请号：US13873574
申请日：2013-04-30
申请人： David A. Claremon , Linghang Zhuang , Colin M. Tice , Yuanjie Ye , Wei He , Suresh B. Singh , Zhenrong Xu , Salvacion Cacatian , Wei Zhao
发明人： David A. Claremon , Linghang Zhuang , Colin M. Tice , Yuanjie Ye , Wei He , Suresh B. Singh , Zhenrong Xu , Salvacion Cacatian , Wei Zhao
IPC分类号： C07D239/10
CPC分类号： C07D239/10 , C07D239/42 , C07D265/10 , C07D401/12 , C07D413/12
摘要： This invention relates to novel compounds of the Formula (I), (Ia) and (Ib), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, j which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell Or the inhibition of the conversion of cortisone to Cortisol in a cell.
摘要翻译：本发明涉及式（I），（Ia）和（Ib）的新化合物，其药学上可接受的盐及其药物组合物，j可用于治疗与调节或抑制11β相关的疾病 -HSD1在哺乳动物。本发明进一步涉及新化合物的药物组合物及其用于还原或控制细胞中皮质醇生产的方法或抑制细胞中可的松转化为皮质醇。

65. 发明授权

US08440658B2 Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 失效
标题翻译： 11β-羟基类固醇脱氢酶的环状脲抑制剂1
公开(公告)号：US08440658B2
公开(公告)日：2013-05-14
申请号：US12747391
申请日：2008-12-10
申请人： David A. Claremon , Linghang Zhuang , Colin M. Tice , Yuanjie Ye , Wei He , Suresh B. Singh , Zhenrong Xu , Salvacion Cacatian , Wei Zhao
发明人： David A. Claremon , Linghang Zhuang , Colin M. Tice , Yuanjie Ye , Wei He , Suresh B. Singh , Zhenrong Xu , Salvacion Cacatian , Wei Zhao
IPC分类号： C07D413/10 , C07D413/14 , A61K31/5355
CPC分类号： C07D239/10 , C07D239/42 , C07D265/10 , C07D401/12 , C07D413/12
摘要： Disclosed is a compound represented by Formula (I): or a pharmaceutically acceptable salt, monohydrate, enantiomer or diastereomer thereof. Also disclosed are pharmaceutical compositions comprising the compound of Formula (I) or a pharmaceutically acceptable salt, monohydrate, enantiomer or diastereomer thereof and methods of inhibiting 11β-HSD1 activity comprising the step of administering to a mammal in need of such treatment an effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt, monohydrate, enantiomer or diastereomer thereof. Values for the variables in Formula (I) are defined herein.
摘要翻译：公开了由式（I）表示的化合物或其药学上可接受的盐，一水合物，对映体或非对映体。还公开了包含式（I）化合物或其药学上可接受的盐，一水合物，对映异构体或非对映体的药物组合物和抑制11beta-HSD1活性的方法，其包括向需要这种治疗的哺乳动物施用有效量的式（I）的化合物或其药学上可接受的盐，一水合物，对映体或非对映异构体。式（I）中的变量的值在本文中定义。

66. 发明申请

US20130072543A1 Compounds and Compositions for Nucleic Acid Formulation and Delivery 审中-公开
标题翻译：用于核酸配方和递送的化合物和组合物
公开(公告)号：US20130072543A1
公开(公告)日：2013-03-21
申请号：US13541891
申请日：2012-07-05
申请人： John Frederick Boylan , Wei He
发明人： Michael J. Bennett , John Frederick Boylan , Wei He
IPC分类号： A61K47/22
CPC分类号： A61K47/22 , A61K9/1271 , A61K9/5123 , A61K31/7105 , C12N15/88 , Y10S977/773
摘要： The invention relates to compositions containing compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R, R1, R2, R3, and n are defined in the detailed description and claims. In addition, the present invention relates to novel formulations containing compounds of formula I for improved delivery of nucleic acids such as siRNA to the cytoplasm of target cells. In particular embodiments these formulations comprise compounds of formula I, phospholipids, cholesterol, and pegylated lipids. The present invention also relates to methods of manufacturing and using such compounds and compositions.
摘要翻译：本发明涉及包含式I化合物及其药学上可接受的盐的组合物，其中R，R 1，R 2，R 3和n在详细描述和权利要求书中定义。此外，本发明涉及含有式I化合物的新型制剂，用于将核酸如siRNA转移至靶细胞的细胞质。在具体实施方案中，这些制剂包含式I化合物，磷脂，胆固醇和聚乙二醇化脂质。本发明还涉及制备和使用这些化合物和组合物的方法。

67. 外观设计

USD678235S1 Handheld electronic device 有权
公开(公告)号：USD678235S1
公开(公告)日：2013-03-19
申请号：US29419776
申请日：2012-05-01
申请人： Wei He , Todd Andrew Wood , Anders Fahrendorff , Cortez Corley , Lesli Ann Mie Agcaoili
设计人： Wei He , Todd Andrew Wood , Anders Fahrendorff , Cortez Corley , Lesli Ann Mie Agcaoili

68. 发明授权

US08394809B2 Phenoxy-substituted pyrimidines as opioid receptor modulators 有权
标题翻译：苯氧基取代的嘧啶作为阿片受体调节剂
公开(公告)号：US08394809B2
公开(公告)日：2013-03-12
申请号：US12913948
申请日：2010-10-28
申请人： Steven J. Coats , Yue-Mei Zhang , Shu-Chen Lin , Li Liu , Tamara A. Miskowski , Scott L. Dax , Henry Breslin , Bart L. De Corte , Wei He
发明人： Steven J. Coats , Yue-Mei Zhang , Shu-Chen Lin , Li Liu , Tamara A. Miskowski , Scott L. Dax , Henry Breslin , Bart L. De Corte , Wei He
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D239/52 , A61K31/506 , C07D239/28 , C07D239/34 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, Y, R2, R3, and Ra are defined herein.
摘要翻译：公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。这样的化合物由式I表示如下：其中R1，Y，R2，R3和Ra在本文中定义。

69. 发明授权

US08383629B2 Inhibitors of 11β-hydroxysteroid dehydrogenase type 1 失效
标题翻译： 11＆bgr-羟基类固醇脱氢酶抑制剂1型
公开(公告)号：US08383629B2
公开(公告)日：2013-02-26
申请号：US12919370
申请日：2009-02-26
申请人： David A. Claremon , Colin M. Tice , Yuanjie Ye , Suresh B. Singh , Wei He , Wei Zhao , Robert D. Simpson
发明人： David A. Claremon , Colin M. Tice , Yuanjie Ye , Suresh B. Singh , Wei He , Wei Zhao , Robert D. Simpson
IPC分类号： A61K31/497 , A61K31/44 , C07D241/04 , C07D401/04
CPC分类号： C07D471/10 , C07D221/20
摘要： This invention relates to novel compounds of the Formulae I or II and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD 1 in mammals. Formula (I).
摘要翻译：本发明涉及式I或II的新化合物及其药学上可接受的盐及其药物组合物，其可用于治疗与哺乳动物中11β-HSD1的调节或抑制相关的疾病的治疗。式（I）。

70. 外观设计

USD675182S1 Handheld electronic device 有权
公开(公告)号：USD675182S1
公开(公告)日：2013-01-29
申请号：US29412411
申请日：2012-02-02
申请人： Wei He , Todd Andrew Wood , Anders Fahrendorff , Cortez Corley , Lesli Ann Mie Agcaoili
设计人： Wei He , Todd Andrew Wood , Anders Fahrendorff , Cortez Corley , Lesli Ann Mie Agcaoili

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式