专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 外观设计

USD291674S Truck cab 失效
公开(公告)号：USD291674S
公开(公告)日：1987-09-01
申请号：US736641
申请日：1985-05-21
申请人： Robert E. Smith
设计人： Robert E. Smith

62. 发明授权

US4528443A Bar code reading system and method 失效
标题翻译：条码阅读系统及方法
公开(公告)号：US4528443A
公开(公告)日：1985-07-09
申请号：US585365
申请日：1984-03-02
申请人： Robert E. Smith
发明人： Robert E. Smith
IPC分类号： G06K7/016 , G06K7/10
CPC分类号： G06K7/0166
摘要： A bar code reading system having a wand that detects variations in light reflected by bars and spaces of the label produces a sequence of corresponding pulses and intervals as the wand scans the label. The entire sequence of pulses and intervals is input to a microprocessor system which produces corresponding digital duration numbers. The microprocessor system computes a reference number for a first character of the label and compares each digital duration number of the character to the reference number to compute a binary number with bits that are a "one" or a "zero" according to whether corresponding digital internal numbers exceed or are less than the reference number. If the number of "ones" in the binary number is too low or too high, the microprocessor decreases or increases the reference time, compares the digital duration number with the adjusted reference number, and re-determines if the resulting value of the binary number has the correct number of "ones". This compensates for variations in scan speed over different characters of the label.
摘要翻译：具有用于检测由标签的条和空间反射的光的变化的条形码读取系统的条形码读取系统在该条纹扫描标签时产生相应脉冲和间隔的序列。脉冲和间隔的整个序列被输入到产生相应的数字持续时间数的微处理器系统。微处理器系统计算标签的第一个字符的参考号，并将字符的每个数字持续时间数与参考号进行比较，以根据相应数字的数字计算具有位为“一”或“零”的二进制数内部数字超过或小于参考号。如果二进制数的“1”数太低或太高，则微处理器减小或增加参考时间，将数字持续时间数与调整的参考号进行比较，并重新确定二进制数的结果值具有正确数量的“一”。这可以补偿标签不同字符上扫描速度的变化。

63. 发明授权

US4275153A Analytical fluorogenic substrates for proteolytic enzymes 失效
标题翻译：用于蛋白水解酶的分析荧光底物
公开(公告)号：US4275153A
公开(公告)日：1981-06-23
申请号：US930826
申请日：1978-08-03
申请人： Robert J. Gargiulo , Gary A. Mitchell , Patricia M. Hudson , Sharon P. Pochron , Rolf M. Huseby , Robert E. Smith
发明人： Robert J. Gargiulo , Gary A. Mitchell , Patricia M. Hudson , Sharon P. Pochron , Rolf M. Huseby , Robert E. Smith
IPC分类号： C07K5/083 , C07K5/087 , C07K5/093 , C07K5/097 , C07K5/103 , C12Q1/37 , C12Q1/56 , C12Q1/36 , C07G7/00 , C12Q1/38
CPC分类号： C07K5/0823 , C07K5/0804 , C07K5/0812 , C07K5/0819 , C07K5/1013 , C12Q1/37 , C12Q1/56 , C12Q2337/10 , C12Q2337/30 , G01N2333/968 , G01N2333/974 , G01N2400/40 , Y10S530/802 , Y10S930/28
摘要： Fluorogenic substrates for proteolytic enzymes having the formula: ##STR1## or acid salts thereof wherein: R.sub.1 is hydrogen-L, hydrogen-D, benzoyl, benzenesulfonyl, glutaryl, pyroglutamyl, carbobenzoxy, D-serine, or carbobenzoxy-serine;R.sub.2 is hydrogen, phenyl, a straight, branched or cyclic alkyl having 1 to 4 carbons, or propionic acid;R.sub.3 is hydrogen, straight or branched or cyclic alkyl having 1 to 4 carbons, 4-aminobutane, or 3-guanidylpropane;R.sub.4 is methyl, 4-aminobutane, or 3-guanidylpropane;R.sub.5 is a fluorogenic moiety, severable from said compound by a proteolytic enzyme and having different fluorescent property when severed from said compound than when forming part of said compound.The enzymes, when reacting with the substrate, remove the fluorogenic group R.sub.5 producing an increase in its fluorescence. The increase of the fluorescence is an indication of the activity of the enzyme present. Specific enzymes thusly detectable include plasmin, thrombin, the factors X.sub.a, XI.sub.a, & XII.sub.a, kallikrein, trypsin, elastase, urokinase, and cathepsin B.sub.1.
摘要翻译：用于具有下式的蛋白水解酶的荧光底物：其中：R 1是氢-L，氢-D，苯甲酰基，苯磺酰基，戊二酰基，焦谷氨酰基，苄氧羰基，D-丝氨酸或苄氧羰基丝氨酸; R2是氢，苯基，具有1-4个碳原子的直链，支链或环状烷基或丙酸; R3是氢，具有1至4个碳的直链或支链或环状烷基，4-氨基丁烷或3-胍基丙烷; R4是甲基，4-氨基丁烷或3-胍基丙烷; R5是荧光部分，当与所述化合物形成一部分时，所述化合物与蛋白水解酶可从所述化合物中分离，并且在从所述化合物切断时具有不同的荧光特性。

64. 发明授权

US4155916A Fluorescence method for enzyme analysis which couples aromatic amines with aromatic aldehydes 失效
标题翻译：芳香族胺与芳族醛结合的酶分析荧光法
公开(公告)号：US4155916A
公开(公告)日：1979-05-22
申请号：US828394
申请日：1977-08-29
申请人： Robert E. Smith , Frank A. Dolbeare
发明人： Robert E. Smith , Frank A. Dolbeare
IPC分类号： C07D311/20 , C12Q1/00 , C07C119/00
CPC分类号： C07D311/20 , C12Q1/00
摘要： Analysis of proteinases is accomplished using conventional amino acid containing aromatic amine substrates. Aromatic amines such as 4-methoxy-2-naphthylamine (4M2NA), 2-naphthylamine, aminoisophthalic acid dimethyl ester, p-nitroaniline, 5-methoxy-1-aminofluorene and coumarin derivatives resulting from enzymatic hydrolysis of the substrate couples with aromatic aldehydes such as 5-nitrosalicylaldehyde (5-NSA), benzaldehyde and p-nitrobenzaldehyde to produce Schiff-base complexes which are water insoluble. Certain Schiff-base complexes produce a shift from blue to orange-red (visible) fluorescence. Such complexes are useful in the assay of enzymes.
摘要翻译：使用常规含氨基酸的芳香族胺底物进行蛋白酶分析。芳基胺如4-甲氧基-2-萘胺（4M2NA），2-萘胺，氨基间苯二甲酸二甲酯，对硝基苯胺，5-甲氧基-1-氨基芴和由底物的酶水解产生的香豆素衍生物与芳族醛偶联作为5-硝基水杨醛（5-NSA），苯甲醛和对硝基苯甲醛以产生水不溶性的席夫碱配合物。某些席夫碱配合物产生从蓝色到橙红色（可见）荧光的转变。这样的复合物在酶的测定中是有用的。

65. 发明授权

US4066217A Tail end grip mechanism 失效
标题翻译：尾端机构
公开(公告)号：US4066217A
公开(公告)日：1978-01-03
申请号：US704009
申请日：1976-07-09
申请人： Robert E. Smith , Frank S. Chytil , George Feldstein , Dorman J. Swartz
发明人： Robert E. Smith , Frank S. Chytil , George Feldstein , Dorman J. Swartz
IPC分类号： B65H63/02 , B65H65/00 , B65H75/28
CPC分类号： B65H75/28 , B65H63/02 , B65H65/005
摘要： An apparatus which grips the tail end of a rapidly traversing metal filament that has been wound onto a winding reel. The apparatus comprises a triggering means, which when actuated, pivots a grip lever that is mounted on the rotating reel support and locks the end of the advancing filament to the winding reel without interrupting the movement of either the filament or reel.

66. 发明申请

US20110236867A1 PROMPTING SYSTEM FOR CPR DELIVERY 审中-公开
标题翻译： CPR交付提供系统
公开(公告)号：US20110236867A1
公开(公告)日：2011-09-29
申请号：US13105768
申请日：2011-05-11
申请人： Ronald E. Stickney , Robert E. Smith , James M. Owen , Alidene Doherty
发明人： Ronald E. Stickney , Robert E. Smith , James M. Owen , Alidene Doherty
IPC分类号： G09B23/28
CPC分类号： G09B23/288 , A61B5/046 , A61B5/0535 , A61B5/742 , A61N1/39 , A61N1/3993
摘要： A method of providing instruction on the performance of chest compressions includes providing a series of signals of a first type corresponding to the desired rhythm of delivery of chest compressions in a chest compression series, and providing signals of a second type which indicate a desired point in the first series. The desired point may be a point near the end of the chest compression series. The signals of the second type may be a voiced countdown to the end of the compression series. The signals of the first type may be a series of identical sounds delivered in the desired rhythm for chest compressions, and the signals of the second type may be sounds distinct from those of the first type which correspond to the rhythm of the last N compressions in the series. The desired point in the first series may include a first point at a desired interval from the first compression, where the interval is measured in number of compressions or elapsed time. A protocol may be chosen between a protocol for a patient with a secured airway and one for a patient with an unsecured airway.
摘要翻译：提供关于胸部按压的表现的指导的方法包括提供与胸部按压序列中胸部按压的期望节奏对应的第一类型的一系列信号，以及提供第二类型的信号，其指示所需的点第一个系列。所需要的点可以是接近胸部压缩系列末端的点。第二类型的信号可以是压缩序列结束时的有声倒计时。第一类型的信号可以是用于胸部按压的期望节奏中递送的一系列相同的声音，并且第二类型的信号可以是与第一类型的声音不同的声音，其对应于最后N次按压的节奏该系列。第一系列中的期望点可以包括以第一压缩的期望间隔的第一点，其中间隔以压缩次数或经过的时间被测量。在具有安全气道的患者的协议之间可以选择协议，一个用于具有不安全气道的患者。

67. 发明授权

US07835419B2 Optimized graphite electrode pin configuration 有权
标题翻译：优化石墨电极引脚配置
公开(公告)号：US07835419B2
公开(公告)日：2010-11-16
申请号：US11489772
申请日：2006-07-20
申请人： Robert E. Smith , Lionel D. Burton Batty , Philip D. Coleman
发明人： Robert E. Smith , Lionel D. Burton Batty , Philip D. Coleman
IPC分类号： H05B7/06 , H05B7/09 , H05B7/14
CPC分类号： H05B7/085 , H05B7/14 , Y02P10/256 , Y02P10/259
摘要： A pin for use in connecting graphite electrodes into a joint, where the pin has at least one male tang having a tang factor, defined as the ratio of male tang length to diameter of the electrode into which hit is to be threaded, of at least about 0.60.
摘要翻译：用于将石墨电极连接到接头中的销，其中所述销具有至少一个具有相角的凸形柄柄，其定义为至少要被击打的电极的公头长度与直径的比率约0.60。

68. 发明申请

US20080203672A1 PRESSURE-ENERGIZED SHAFT SEAL 审中-公开
标题翻译：压力可靠的轴封
公开(公告)号：US20080203672A1
公开(公告)日：2008-08-28
申请号：US11680158
申请日：2007-02-28
申请人： Robert E. Smith
发明人： Robert E. Smith
IPC分类号： B61F15/22 , F16J15/34
CPC分类号： F16J15/028
摘要： A generally cylindrical shaft seal with an axial opening is disclosed having annular “lips” or “legs” on one or both ends that are separated by a fluid-filled cavity. The seal is adapted to seal between a support or housing holding the seal and a generally cylindrical shaft passing axially through the seal. Fluid, under pressure, may enter the cavity and urge the lips or legs in a radial direction which enhances the sealing engagement of the seal member to the shaft and the housing. In certain embodiments, the seal has a concave inner surface to minimize the contact area (and hence the friction) between the seal and the movable shaft. The outer circumference of the seal may be equipped with one or more O-ring seals for sealing to the housing or support. The seal may be fabricated from natural or synthetic polymers, metal or composite materials.
摘要翻译：公开了一种具有轴向开口的大致圆柱形的轴封，在一端或两端具有由流体填充空腔分开的环形“唇”或“腿”。密封件适于在保持密封件的支撑件或壳体和轴向穿过密封件的大致圆柱形的轴之间进行密封。在压力下的流体可以进入空腔并沿径向推动唇或腿，这增强了密封构件与轴和壳体的密封接合。在某些实施例中，密封件具有凹入的内表面以最小化密封件和可动轴之间的接触面积（并因此最小化摩擦）。密封件的外周可以配备有一个或多个O形圈密封件，用于密封到壳体或支撑件。密封件可以由天然或合成聚合物，金属或复合材料制成。

69. 发明授权

US06190865B1 Method for characterizing nucleic acid molecules 失效
标题翻译：表征核酸分子的方法
公开(公告)号：US06190865B1
公开(公告)日：2001-02-20
申请号：US08534799
申请日：1995-09-27
申请人： Jerome J. Jendrisak , Leslie M. Hoffman , Robert E. Smith
发明人： Jerome J. Jendrisak , Leslie M. Hoffman , Robert E. Smith
IPC分类号： C12Q168
CPC分类号： C12Q1/6869 , C12Q1/6848 , C12Q2525/119 , C12Q2525/117 , C12Q2521/531 , C12Q2525/101
摘要： A method of characterizing a nucleic acid molecule is disclosed. The method comprises synthesizing DNA in the presence of a reaction mixture comprising a nucleic acid template, a primer molecule, an enzyme that extends the primer so that a DNA molecule may be synthesized, four canonical deoxynucleoside triphosphates and at least one non-canonical deoxynucleoside triphosphate. The non-canonical deoxynucleoside triphosphate is incorporated into the synthesized DNA in place of a portion of only one canonical deoxynucleoside triphosphate. The synthesized DNA is treated with an N-glycosylase that excises a base portion of the non-canonical deoxynucleoside triphosphate from the synthesized DNA. The DNA is then treated in such a manner that the phosphodiester backbone of the DNA is broken at the abasic site, thus creating at least two DNA fragments. The fragments are separated according to size.
摘要翻译：公开了表征核酸分子的方法。该方法包括在包含核酸模板，引物分子，延伸引物以使得可以合成DNA分子的酶的反应混合物存在下合成DNA，四种典型脱氧核苷三磷酸和至少一种非标准脱氧核苷三磷酸。将非标准脱氧核苷三磷酸引入合成的DNA中代替仅一个典型脱氧核苷三磷酸的一部分。合成的DNA用从合成的DNA中切除非标准脱氧核苷三磷酸的碱基的N-糖基化酶处理。然后以这样的方式处理DNA，使得DNA的磷酸二酯骨架在脱碱基位点断裂，从而产生至少两个DNA片段。碎片根据大小分离。

70. 发明授权

US6147188A .alpha.- (1,3- or 1, 2- dicarbonylenol ether methyl ketones as cysteine protease inhibitors 失效
标题翻译： α-（1,3-或1,2-二羰基酚醚甲基酮作为半胱氨酸蛋白酶抑制剂）
公开(公告)号：US6147188A
公开(公告)日：2000-11-14
申请号：US17276
申请日：1998-02-02
申请人： Mary P. Zimmerman , Robert E. Smith , Mark Becker
发明人： Mary P. Zimmerman , Robert E. Smith , Mark Becker
IPC分类号： C07D239/88 , A61K31/34 , A61K31/341 , A61K31/35 , A61K31/365 , A61K31/37 , A61K31/38 , A61K31/381 , A61K31/382 , A61K31/40 , A61K31/44 , A61K31/4406 , A61K31/443 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/517 , A61K31/535 , A61K31/5355 , A61K31/5375 , A61K38/00 , A61K47/48 , A61P1/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/02 , A61P25/28 , A61P27/02 , A61P27/12 , A61P27/14 , A61P29/00 , A61P31/00 , A61P31/12 , A61P33/02 , A61P35/00 , A61P37/08 , A61P43/00 , C07D207/16 , C07D213/64 , C07D213/65 , C07D213/80 , C07D215/22 , C07D215/26 , C07D217/22 , C07D235/26 , C07D239/34 , C07D295/215 , C07D307/58 , C07D307/60 , C07D307/62 , C07D309/32 , C07D309/38 , C07D309/40 , C07D311/16 , C07D311/18 , C07D311/46 , C07D333/64 , C07D333/68 , C07D335/02 , C07D405/12 , C07D487/04 , C07K5/062 , C07K5/065 , C07K14/81 , C07K5/00 , C07K7/00
CPC分类号： C07D405/12 , A61K31/34 , A61K31/341 , A61K31/35 , A61K31/40 , A61K31/44 , A61K31/443 , A61K31/505 , A61K31/5375 , A61K47/48238 , C07D207/16 , C07D213/64 , C07D213/80 , C07D239/34 , C07D295/215 , C07D307/58 , C07D307/60 , C07D307/62 , C07D309/38
摘要： Cysteine protease inhibitors which deactivate the protease by covalently bonding to the cysteine protease and releasing the enolate of a 1,3-dicarbonyl (or its enolic form). The cysteine protease inhibitors of the present invention accordingly comprise a first portion which targets a desired cysteine protease and positions the inhibitor near the thiolate anion portion of the active site of the protease, and a second portion which covalently bonds to the cysteine protease and irreversibly deactivates that protease by providing a carbonyl or carbonyl-equivalent which is attacked by the thiolate anion of the active site of the cysteine protease to sequentially cleave a .beta.-dicarbonyl enol ether leaving group.
摘要翻译：半胱氨酸蛋白酶抑制剂，其通过共价键合到半胱氨酸蛋白酶并释放1,3-二羰基（或其烯醇形式）的烯醇化物而使蛋白酶失活。因此，本发明的半胱氨酸蛋白酶抑制剂包含第一部分，其靶向所需的半胱氨酸蛋白酶，并将抑制剂置于蛋白酶活性位点的硫醇酸阴离子部分附近，第二部分与半胱氨酸蛋白酶共价结合并不可逆地失活该蛋白酶通过提供被半胱氨酸蛋白酶的活性位点的硫醇盐阴离子攻击的羰基或羰基等价物来顺序地裂解β-二羰基烯醇醚离去基团。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式