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61. 发明授权

US09087368B2 Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof 有权
标题翻译：用于光学成像或上皮腔内器官的方法和系统通过其束扫描
公开(公告)号：US09087368B2
公开(公告)日：2015-07-21
申请号：US11625135
申请日：2007-01-19
申请人： Guillermo J. Tearney , Milen Shishkov , Brett E. Bouma , Benjamin J. Vakoc , Norman S. Nishioka
发明人： Guillermo J. Tearney , Milen Shishkov , Brett E. Bouma , Benjamin J. Vakoc , Norman S. Nishioka
IPC分类号： A61B5/06 , G06T7/00 , A61B5/00
CPC分类号： A61B5/0084 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/6852 , A61B5/7271 , G06T7/0012 , G06T2207/10056 , G06T2207/10101
摘要： Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.
摘要翻译：提供了布置，装置，系统和系统以获得至少一个管腔或中空样品中的至少一个部分的数据。该装置，系统或装置可以（可通过患者的嘴部或鼻子中的至少一个插入），例如，第一光学装置可以被配置为收发至少一个电磁（例如，可见）第二布置可以至少部分地包围第一布置。此外，第三布置可被配置为被致动以将第一布置定位在管腔或中空样品内的预定位置处，第一布置可以是被配置为补偿由第二布置和/或第三布置引起的至少一个像差（例如，散光），第二布置可以包括使引导布置能够插入到其中的至少一个部分，可以提供另一种布置其被配置为测量所述至少一个部分内的压力，所述数据可以包括所述第一装置的位置和/或取向与r 对于管腔或空心样品。

62. 发明申请

US20120004506A1 APPARATUS AND METHOD FOR DEVICES FOR IMAGING STRUCTURES IN OR AT ONE OR MORE LUMINAL ORGANS 审中-公开
标题翻译：用于在一个或更多个LUMINAL器官上形成结构的设备的装置和方法
公开(公告)号：US20120004506A1
公开(公告)日：2012-01-05
申请号：US13152784
申请日：2011-06-03
申请人： Guillermo J. Tearney , Brett E. Bouma , Michalina Gora , Melissa Suter , Hongki Yoo , Milen Shishkov
发明人： Guillermo J. Tearney , Brett E. Bouma , Michalina Gora , Melissa Suter , Hongki Yoo , Milen Shishkov
IPC分类号： A61B1/00
CPC分类号： A61B1/00082 , A61B1/00064 , A61B1/00071 , A61B1/0008 , A61B1/00165 , A61B1/00179 , A61B5/6852 , A61B5/6853
摘要： In accordance with exemplary embodiments of the present disclosure, device and method can be provided which can facilitate imaging of biological tissues, e.g., luminal organs in vivo, using optical techniques. The exemplary device can include different designs an features of one or more catheters, which can illuminate the tissues, and collect signals from the inside of the lumen. In another exemplary embodiment according to the present disclosure, a balloon-catheter can be provided with the flexible neck, which can absorb most of the bending. According to still another exemplary embodiments of the present disclosure, a balloon-catheter tethered capsule can be provided, and according a yet further exemplary embodiment, a structured balloon design can be provided with one or more protuberances, thus enabling imaging of the structures in close contact, e.g., without compressing of the tissue.
摘要翻译：根据本公开的示例性实施例，可以提供可以使用光学技术来促进生物组织例如体内器官的成像的装置和方法。示例性装置可以包括不同的设计，一个或多个导管的特征可以照亮组织，并从内腔收集信号。在根据本公开的另一示例性实施例中，球囊导管可以设置有柔性颈部，其可以吸收大部分的弯曲。根据本公开的另一示例性实施例，可以提供球囊 - 导管系留胶囊，并且根据另外的示例性实施例，结构化球囊设计可以设置有一个或多个突起，从而能够使结构在近距离成像接触，例如，不压缩组织。

63. 发明申请

US20110218403A1 SYSTEMS, METHODS AND COMPUTER-ACCESSIBLE MEDIUM WHICH PROVIDE MICROSCOPIC IMAGES OF AT LEAST ONE ANATOMICAL STRUCTURE AT A PARTICULAR RESOLUTION 有权
标题翻译：系统，方法和计算机可访问介质，提供特定解决方案中至少一个解剖结构的微观图像
公开(公告)号：US20110218403A1
公开(公告)日：2011-09-08
申请号：US13042278
申请日：2011-03-07
申请人： Guillermo J. Tearney , Brett E. Bouma , Joseph A. Gardecki , Linbo Liu
发明人： Guillermo J. Tearney , Brett E. Bouma , Joseph A. Gardecki , Linbo Liu
IPC分类号： A61B1/06
CPC分类号： A61B5/0066 , A61B5/0044 , A61B5/0075 , A61B5/0084 , G01B9/02091 , G02B6/32
摘要： Exemplary embodiments of probes, apparatus, systems and methods can be provided which provide at least one electro-magnetic radiation to at least one sample. For example, a plurality of axicon lenses can be provided which are configured to provide the electro-magnetic radiation(s) having at least partially annulus shape. In addition or alternatively, at least one optical arrangement can be provided which is configured to forward at least one radiation to the sample therethrough having at least partially circularly-symmetric pattern. For example, at least one first portion of the radiation transmitted through a circular section of the pattern can have an optical path-length that is different from an optical path-length of at least one second portion of the radiation transmitted through at least one other section of the pattern.
摘要翻译：可以提供探针，装置，系统和方法的示例性实施例，其向至少一个样品提供至少一个电磁辐射。例如，可以提供多个旋转透镜，其构造成提供具有至少部分环形形状的电磁辐射。另外或替代地，可以提供至少一个光学布置，其被配置为将至少一个辐射转发到具有至少部分圆对称图案的样品。例如，透过图案的圆形部分的辐射的至少一个第一部分可以具有不同于透过至少一个其它的辐射的至少一个第二部分的光程长度的光程长度部分图案。

64. 发明申请

US20100210937A1 ENDOSCOPIC BIOPSY APPARATUS, SYSTEM AND METHOD 有权
标题翻译：内窥镜生物仪器，系统和方法
公开(公告)号：US20100210937A1
公开(公告)日：2010-08-19
申请号：US12690686
申请日：2010-01-20
申请人： Guillermo J. Tearney , Brett E. Bouma , Dongkyun Kang , Melissa J. Suter
发明人： Guillermo J. Tearney , Brett E. Bouma , Dongkyun Kang , Melissa J. Suter
IPC分类号： A61B6/00
CPC分类号： A61B5/0066 , A61B5/0068 , A61B5/0075 , A61B5/0086
摘要： Exemplary embodiments of apparatus, method and system for determining a position on or in a biological tissue can be provided. For example, using such exemplary embodiment, it is possible to control the focus of an optical imaging probe. In another exemplary embodiment, it is possible to implement a marking apparatus together with or into an optical imaging probe. According to one exemplary embodiment, it is possible (using one or more arrangements) to receive information associated with at least one image of at least one portion of the biological tissue obtained using an optical imaging technique. Further, it is possible to, based on the information, cause a visible change on or in at least location of the portion(s) using at least one electro-magnetic radiation.
摘要翻译：可以提供用于确定生物组织上或生物组织中的位置的装置，方法和系统的示例性实施例。例如，使用这样的示例性实施例，可以控制光学成像探针的焦点。在另一个示例性实施例中，可以与光学成像探头一起实现标记设备，根据一个示例性实施例，可以（使用一个或多个布置）接收与使用光学成像技术获得的生物组织的至少一部分的至少一个图像相关联的信息。此外，可以基于该信息，使用至少一个电磁辐射在该部分的至少位置上或至少位置处引起可见的变化。

65. 发明授权

US07355716B2 Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands 有权
标题翻译：低相干干涉测量和降噪的装置和方法LCI和光学相干断层扫描OCT信号通过光谱带的并行检测
公开(公告)号：US07355716B2
公开(公告)日：2008-04-08
申请号：US10501276
申请日：2003-01-24
申请人： Johannes F. de Boer , Guillermo J. Tearney , Brett E. Bouma
发明人： Johannes F. de Boer , Guillermo J. Tearney , Brett E. Bouma
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： G01B9/02007 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02008 , G01B9/0201 , G01B9/02032 , G01B9/02044 , G01B9/02045 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Apparatus, method, logic arrangement and storage medium are provided for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source can be split into N spectral bands. The N spectral bands can be individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band may be detected by a separate photo detector and amplified. For each spectral band, the signal can be band p3 filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is likely reduced by a factor equal to the number of spectral bands, while the signal amplitude can remain the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.
摘要翻译：提供装置，方法，逻辑布置和存储介质，用于通过检测光谱带的并行组来提高光学相干断层扫描和低相干干涉测量（“LCI”）信号的检测灵敏度，每个频带是光频率的唯一组合。 LCI宽带宽源可以分为N个光谱带。可以单独地检测和处理N个频谱带，以使信噪比增加N倍。每个频谱带可以由单独的光检测器检测并被放大。对于每个光谱带，信号可以是通过模拟电子装置围绕信号频带滤波的p 3频带，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。结果，对信号的散粒噪声贡献可能降低等于光谱带数的因子，而信号幅度可以保持相同。喷射噪声的降低增加了系统的动态范围和灵敏度。

66. 发明授权

US06895137B2 Multi-channel optical coupler for spinning catheter 有权
标题翻译：用于纺丝导管的多通道光耦合器
公开(公告)号：US06895137B2
公开(公告)日：2005-05-17
申请号：US10164721
申请日：2002-06-07
申请人： Andres Zuluaga , Brett E. Bouma
发明人： Andres Zuluaga , Brett E. Bouma
IPC分类号： A61B5/00 , G02B6/36 , G02B6/26 , A61B6/00
CPC分类号： A61B5/0062 , A61B5/0084 , G02B6/3604
摘要： A system for identifying vulnerable plaque includes a catheter having a collection fiber and a delivery fiber extending therethrough. The catheter is engaged to a distal face of a housing configured to spin about an axis. The proximal face of the housing has a central aperture. First and second optical relays extend respectively between the central aperture and a central port on the distal face and between a detector and an eccentric port on the distal face. The central and eccentric ports are in optical communication with the delivery and collection fibers respectively.
摘要翻译：用于识别易损斑块的系统包括具有收集纤维的导管和从其延伸穿过的输送纤维。导管接合到构造成围绕轴线旋转的壳体的远侧面。壳体的近侧面具有中心孔。第一和第二光继电器分别延伸在中心孔和远端面上的中心端口之间以及远端面上的检测器和偏心端口之间。中心和偏心端口分别与输送和收集纤维光学连通。

67. 发明授权

US06485413B1 Methods and apparatus for forward-directed optical scanning instruments 失效
标题翻译：用于前向光学扫描仪器的方法和装置
公开(公告)号：US06485413B1
公开(公告)日：2002-11-26
申请号：US09036283
申请日：1998-03-06
申请人： Stephen A. Boppart , Gary J. Tearney , Brett E. Bouma , Mark E. Brezinski , James G. Fujimoto , Eric A. Swanson
发明人： Stephen A. Boppart , Gary J. Tearney , Brett E. Bouma , Mark E. Brezinski , James G. Fujimoto , Eric A. Swanson
IPC分类号： A61B106
CPC分类号： G01B9/0201 , A61B1/00096 , A61B1/00172 , A61B1/00183 , A61B1/00188 , A61B1/002 , A61B1/043 , A61B1/07 , A61B3/102 , A61B5/0064 , A61B5/0066 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/415 , A61B5/417 , A61B5/418 , A61B5/444 , A61B5/6852 , A61B2562/0242 , G01B9/02022 , G01B9/0205 , G01B9/02063 , G01B9/02091 , G01B11/00 , G01B11/026 , G01B11/12 , G01B11/2441 , G01B2290/65 , G01N21/4795 , G02B5/1828 , G02B27/4227 , G11B7/005 , G11B7/08564 , G11B7/127 , G11B7/1353 , G11B7/24 , G11B2007/0013 , H01S5/141
摘要： An imaging system for performing forward scanning imaging for application to therapeutic and diagnostic devises used in medical procedures. The imaging system includes forward directed optical coherence tomography (OCT), and non-retroreflected forward scanning OCT. Also interferometric imaging and ranging techniques and fluorescent, Raman, two-photon, and diffuse wave imaging can be used. The forward scanning mechanisms include a cam attached to a motor, pneumatic devices, a pivoting device, piezoelectric transducers, electrostatic driven slides for substantially transverse scanning; counter-rotating prisms, and offset lenses are used for arbitrary scanning. The imaging system of the invention is applied to hand held probes including probes integrated with surgical probes, scalpels, scissors, forceps and biopsy instruments. Hand held probes include forward scanning lasers. The imaging system is also applicable to laparoscopes and endoscopes for diagnostc and therapeutic intervention in body orifices, canals, tubes, ducts, vessels and cavities of the body. The imaging system includes application to surgical and high numerical aperture microscopes. An important application of the invention is implantation of the optical probe for periodic or continuous extraction of information from the tissue site where implanted.
摘要翻译：用于执行向前扫描成像以用于医疗程序中使用的治疗和诊断设备的成像系统。成像系统包括前向光学相干断层扫描（OCT）和非逆向前向扫描OCT。还可以使用干涉成像和测距技术以及荧光，拉曼，双光子和漫射波成像。前向扫描机构包括附接到马达的凸轮，气动装置，枢转装置，压电换能器，用于基本上横向扫描的静电驱动滑块; 反向旋转棱镜和偏移透镜用于任意扫描。本发明的成像系统应用于手持式探针，其包括与外科手术探针，解剖刀，剪刀，镊子和活检器械集成的探针。手持式探头包括正向扫描激光器。成像系统还适用于腹腔镜和内窥镜，用于身体孔，运河，管道，管道，血管和身体腔内的诊断和治疗干预。成像系统包括应用于手术和高数值孔径显微镜。本发明的重要应用是植入用于从植入的组织部位周期性或连续地提取信息的光学探针。

68. 发明授权

US6134003A Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope 失效
标题翻译：使用光纤成像导丝，导管或内窥镜执行光学测量的方法和装置
公开(公告)号：US6134003A
公开(公告)日：2000-10-17
申请号：US607787
申请日：1996-02-27
申请人： Guillermo Tearney , Stephen A. Boppart , Brett E. Bouma , Mark Brezinski , Eric A. Swanson , James G. Fujimoto
发明人： Guillermo Tearney , Stephen A. Boppart , Brett E. Bouma , Mark Brezinski , Eric A. Swanson , James G. Fujimoto
IPC分类号： G01B11/00 , A61B1/00 , A61B3/10 , A61B3/12 , A61B5/00 , A61B5/103 , A61B8/12 , A61B10/00 , A61M25/00 , G01B9/02 , G01B11/02 , G01B11/12 , G01B11/24 , G01J1/00 , G01N21/17 , G01N21/35 , G01N21/47 , G02B5/18 , G02B27/44 , G11B7/00 , G11B7/005 , G11B7/125 , G11B7/24 , H01S5/14
CPC分类号： B82Y15/00 , A61B1/00096 , A61B1/00172 , A61B1/00183 , A61B3/102 , A61B5/0064 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/445 , A61B5/6852 , G01B11/00 , G01B11/026 , G01B11/12 , G01B11/2441 , G01B9/02002 , G01B9/02004 , G01B9/02007 , G01B9/0201 , G01B9/0205 , G01B9/02091 , G01J1/00 , G01N21/4795 , G02B5/1828 , G11B7/005 , G11B7/127 , A61B2562/0242 , A61B3/1005 , G01B2290/65 , G01B2290/70 , G11B2007/0013 , G11B7/24 , H01S5/141
摘要： An imaging system for performing optical coherence tomography includes an optical radiation source; a reference optical reflector; a first optical path leading to the reference optical reflector; and a second optical path coupled to an endoscopic unit. The endoscopic unit preferably includes an elongated housing defining a bore; a rotatable single mode optical fiber having a proximal end and a distal end positioned within and extending the length of the bore of the elongated housing; and an optical system coupled to the distal end of the rotatable single mode optical fiber, positioned to transmit the optical radiation from the single mode optical fiber to the structure and to transmit reflected optical radiation from the structure to the single mode optical fiber. The system further includes a beam divider dividing the optical radiation from the optical radiation source along the first optical path to the reflector and along the second optical path; and a detector positioned to receive reflected optical radiation from the reflector transmitted along the first optical path and reflected optical radiation transmitted from the structure along the second optical path. The detector generates a signal in response to the reflected optical radiation from the reference reflector and the reflected optical radiation from the structure, and a processor generating a image of the structure in response to the signal from the detector. The system provides both rotational and longitudinal scanning of an image.
摘要翻译：用于执行光学相干断层摄影的成像系统包括光辐射源; 参考光学反射器; 通向参考光反射器的第一光路; 以及耦合到内窥镜单元的第二光路。内窥镜单元优选地包括限定孔的细长壳体; 可旋转的单模光纤，其具有定位在所述细长壳体的所述孔的长度内并延伸所述细长壳体的所述孔的长度的近端和远端; 以及耦合到可旋转单模光纤的远端的光学系统，定位成将光辐射从单模光纤传输到结构，并将反射的光辐射从结构传输到单模光纤。该系统还包括一个光束分配器，将沿着第一光路的光辐射源的光辐射分成沿着第二光路; 以及检测器，其被定位成接收来自沿着第一光路传输的反射器的反射光辐射以及沿着第二光路从结构传输的反射光辐射。检测器响应于来自参考反射器的反射光辐射和来自结构的反射光辐射产生信号，以及响应于来自检测器的信号产生结构图像的处理器。该系统提供图像的旋转和纵向扫描。

69. 发明授权

US07310150B2 Apparatus and method for low coherence ranging 有权
标题翻译：低相干范围的装置和方法
公开(公告)号：US07310150B2
公开(公告)日：2007-12-18
申请号：US10501268
申请日：2003-01-10
申请人： Tearney J. Guillermo , Brett E. Bouma
发明人： Tearney J. Guillermo , Brett E. Bouma
IPC分类号： G01B9/02
CPC分类号： G01B9/02035 , G01B9/02028 , G01B9/02036 , G01B9/02091 , G01N21/4795
摘要： A system, apparatus and method for performing low coherence ranging of a sample with high transverse resolution and large depth of focus can be provided. For example, an optical ranging system including a light source can be used. Certain exemplary arrangement can be provided, e.g., a first arrangement for directing light from the light source to the sample, a second arrangement for directing reflected light from the sample to a detector, at least one detector, and a third arrangement for processing light data received by the detector and which generates an image can be utilized. Further, for example, an optical element can be provided which can have a transverse resolution defined as .Δris less than or equal to about μ5 m, and a depth of focus Δz of at least about 50 μm.
摘要翻译：可以提供用于执行具有高横向分辨率和大的焦深的样品的低相干范围的系统，装置和方法。例如，可以使用包括光源的光学测距系统。可以提供某些示例性布置，例如用于将来自光源的光引导到样品的第一布置，用于将来自样品的反射光引导到检测器的第二布置，至少一个检测器和用于处理光数据的第三布置可以利用检测器接收并产生图像的图像。此外，例如，可以提供可以具有定义为小于或等于约5μm的横向分辨率和至少约50μm的聚焦深度Deltaz的光学元件。

70. 发明授权

US06282011B1 Grating based phase control optical delay line 失效
公开(公告)号：US06282011B1
公开(公告)日：2001-08-28
申请号：US09603806
申请日：2000-06-26
申请人： Guillermo Tearney , Brett E. Bouma , James G. Fujimoto
发明人： Guillermo Tearney , Brett E. Bouma , James G. Fujimoto
IPC分类号： G02F111
CPC分类号： B82Y15/00 , A61B1/00096 , A61B1/00172 , A61B1/00183 , A61B3/1005 , A61B3/102 , A61B5/0064 , A61B5/0066 , A61B5/0084 , A61B5/441 , A61B5/6852 , A61B2562/0242 , G01B9/02002 , G01B9/02091 , G01B11/00 , G01B11/002 , G01B11/026 , G01B11/12 , G01B11/2441 , G01B2290/20 , G01B2290/35 , G01J1/00 , G01N21/4795 , G02B5/1828 , G02B26/06 , G02B27/4233 , G02B27/4244 , G02B27/4255 , G11B7/005 , G11B7/08564 , G11B7/127 , G11B7/1353 , G11B7/24 , G11B2007/0013 , H01S5/141
摘要： An apparatus for performing high speed scanning of an optical delay and its application for performing optical interferometry, ranging, and imaging, including cross sectional imaging using optical coherence tomography, is disclosed. The apparatus achieves optical delay scanning by using diffractive optical elements in conjunction with imaging optics. In one embodiment a diffraction grating disperses an optical beam into different spectral frequency or wavelength components which are collimated by a lens. A mirror is placed one focal length away from the lens and the alteration of the grating groove density, the grating input angle, the grating output angle, and/or the mirror tilt produce a change in optical group and phase delay. This apparatus permits the optical group and phase delay to be scanned by scanning the angle of the mirror. In other embodiments, this device permits optical delay scanning without the use of moving parts.

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