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61. 发明授权

US08486375B2 Foamable compositions 有权
标题翻译：可发泡组合物
公开(公告)号：US08486375B2
公开(公告)日：2013-07-16
申请号：US13400337
申请日：2012-02-20
申请人： Dov Tamarkin , Doron Friedman , Meir Eini
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61K9/00 , A61K9/12 , A61K33/18
CPC分类号： A61K33/18 , A61K9/122 , Y10S514/828 , Y10S514/887 , Y10S514/928 , Y10S514/945
摘要： The present invention is related to a foamable composition of matter comprising iodine, water, a foam adjuvant, a surface-active agent and a gelling agent. This foamable composition, which may be provided in a propellant free foaming device, or alternatively may further comprise a propellant, evolves into foam, which is effective in the topical treatment and prevention of various skin disorders.
摘要翻译：本发明涉及包含碘，水，泡沫助剂，表面活性剂和胶凝剂的可发泡组合物。该可发泡组合物可以以不含推进剂的发泡装置提供，或者可以进一步包含推进剂，演变成泡沫，其在局部治疗和预防各种皮肤病中是有效的。

62. 发明授权

US08435498B2 Penetrating pharmaceutical foam 有权
标题翻译：渗透药物泡沫
公开(公告)号：US08435498B2
公开(公告)日：2013-05-07
申请号：US12752718
申请日：2010-04-01
申请人： Dov Tamarkin , Doron Friedman , Meir Eini
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61K9/12 , A61K9/00 , A61K8/02 , A61K31/19 , A61K31/17
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K8/06 , A61K8/062 , A61K8/31 , A61K8/365 , A61K8/42 , A61K9/0014 , A61K9/107 , A61K9/12 , A61K9/124 , A61K31/167 , A61K31/17 , A61K31/19 , A61K31/196 , A61K31/496 , A61K31/497 , A61K45/00 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/22 , A61K47/24 , A61K47/36 , A61K47/38 , A61K47/44 , A61K2800/75 , A61Q17/02 , A61Q19/00 , A61Q19/08 , A61Q19/10 , Y10S514/945 , A01N53/00
摘要： The invention relates to an alcohol-free cosmetic or pharmaceutical foam composition comprising water, a hydrophobic solvent, a surface-active agent, a gelling agent, an active component selected from the group of urea, hydroxy acid and a therapeutic enhancer and a propellant. The foam further comprises active agents and excipients with therapeutic properties having enhanced skin penetration.
摘要翻译：本发明涉及无水化妆品或药物泡沫组合物，其包含水，疏水性溶剂，表面活性剂，胶凝剂，选自脲，羟基酸和治疗性增强剂和推进剂的活性成分。泡沫还包含具有增强的皮肤渗透性的治疗性质的活性剂和赋形剂。

63. 发明授权

US07700076B2 Penetrating pharmaceutical foam 有权
标题翻译：渗透药物泡沫
公开(公告)号：US07700076B2
公开(公告)日：2010-04-20
申请号：US10922358
申请日：2004-08-20
申请人： Dov Tamarkin , Doron Friedman , Meir Eini
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61K9/12 , A61K9/00 , A61K8/02 , A61K31/19 , A61K31/17
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K8/06 , A61K8/062 , A61K8/31 , A61K8/365 , A61K8/42 , A61K9/0014 , A61K9/107 , A61K9/12 , A61K9/124 , A61K31/167 , A61K31/17 , A61K31/19 , A61K31/196 , A61K31/496 , A61K31/497 , A61K45/00 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/22 , A61K47/24 , A61K47/36 , A61K47/38 , A61K47/44 , A61K2800/75 , A61Q17/02 , A61Q19/00 , A61Q19/08 , A61Q19/10 , Y10S514/945 , A01N53/00
摘要： The invention relates to an alcohol-free cosmetic or pharmaceutical foam composition comprising water, a hydrophobic solvent, a surface-active agent, a gelling agent, an active component selected from the group of urea, hydroxy acid and a therapeutic enhancer and a propellant. The foam further comprises active agents and excipients with therapeutic properties having enhanced skin penetration.
摘要翻译：本发明涉及无水化妆品或药物泡沫组合物，其包含水，疏水性溶剂，表面活性剂，胶凝剂，选自脲，羟基酸和治疗性增强剂和推进剂的活性成分。泡沫还包含具有增强的皮肤渗透性的治疗性质的活性剂和赋形剂。

64. 发明申请

US20070292355A1 Anti-infection augmentation foamable compositions and kit and uses thereof 审中-公开
标题翻译：抗感染增加可发泡组合物和试剂盒及其用途
公开(公告)号：US20070292355A1
公开(公告)日：2007-12-20
申请号：US11732547
申请日：2007-04-04
申请人： Dov Tamarkin , Doron Friedman , Meir Eini
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61K9/12 , A61K31/015 , A61K31/415 , A61K31/4164 , A61K31/425 , A61K31/433 , A61K31/44 , A61K31/497 , A61P11/00 , A61P35/00 , A61P31/18 , A61P31/12 , A61P31/10 , A61P27/16 , A61P17/00 , A61K31/505 , A61K31/52 , A61K31/522 , A61K31/551 , A61K31/70 , A61K36/00 , A61K38/00
CPC分类号： A61K9/12 , A01N25/16 , A61K31/015 , A61K31/415 , A61K31/4164 , A61K31/425 , A61K31/433 , A61K31/44 , A61K31/497 , A61K31/505 , A61K31/52 , A61K31/522 , A61K31/551 , A61K31/70 , A61K36/00 , A61K2300/00
摘要： Anti-infective foamable composition and kits include a foamable carrier; a therapeutically safe and effective concentration of an anti-infective agent; an augmenting agent selected from the group consisting of a keratolytic agent and a skin penetration enhancer; and a propellant. The composition is housed in a container and upon release is expandable to form a breakable foam. The foamable carrier is selected to generate a foam of good or excellent quality in the presence of the augmenting agent and anti-infective agent. Methods for treating, alleviating or preventing a disorder of the skin, a body cavity or mucosal surface, wherein the disorder involves a fungal, bacterial or viral infection as one of its etiological factors, is described.
摘要翻译：抗感染性可发泡组合物和试剂盒包括可发泡载体; 治疗安全有效的抗感染剂浓度; 选自由角质分解剂和皮肤渗透增强剂组成的组的增强剂; 和推进剂。将组合物容纳在容器中并且在释放时可膨胀以形成易碎泡沫。选择发泡载体以在增塑剂和抗感染剂的存在下产生良好或优异的质量的泡沫。描述了治疗，缓解或预防皮肤，体腔或粘膜表面疾病的方法，其中所述疾病涉及作为其病因之一的真菌，细菌或病毒感染。

65. 发明申请

US20060275218A1 Foamable vehicle and pharmaceutical compositions thereof 有权
公开(公告)号：US20060275218A1
公开(公告)日：2006-12-07
申请号：US11430599
申请日：2006-05-09
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A61L9/04 , A61K35/64
CPC分类号： A61K47/10 , A01N25/16 , A61K8/046 , A61K9/0014 , A61K9/0034 , A61K9/12 , A61K9/122 , A61K47/14 , A61K47/38 , A61Q19/00 , Y10S514/945 , A01N53/00
摘要： A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

66. 发明申请

US20060269485A1 Antibiotic kit and composition and uses thereof 有权
公开(公告)号：US20060269485A1
公开(公告)日：2006-11-30
申请号：US11448490
申请日：2006-06-07
申请人： Doron Friedman , Alex Besonov , Dov Tamarkin , Meir Eini
发明人： Doron Friedman , Alex Besonov , Dov Tamarkin , Meir Eini
IPC分类号： A61L9/04
CPC分类号： A61K9/107 , A61K47/06 , A61K47/10 , A61K47/14 , Y02A50/473
摘要： The present invention relates to a therapeutic kit to provide a safe and effective dosage of an antibiotic agent, including an aerosol packaging assembly including: a container accommodating a pressurized product; and an outlet capable of releasing the pressurized product as a foam, wherein the pressurized product comprises a foamable composition including: an antibiotic agent; at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, an organic polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight, a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent, water; and liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

67. 发明申请

US20050232869A1 Nonsteroidal immunomodulating kit and composition and uses thereof 有权
标题翻译：非甾体免疫调节试剂盒及其组合物和用途
公开(公告)号：US20050232869A1
公开(公告)日：2005-10-20
申请号：US11078902
申请日：2005-03-11
申请人： Dov Tamarkin , Meir Eini , Doron Friedman
发明人： Dov Tamarkin , Meir Eini , Doron Friedman
IPC分类号： A61K8/04 , A61K8/67 , A61K31/07 , A61K31/203 , A61L9/04 , A61M11/00 , A61Q19/00 , A61K7/42
CPC分类号： A61K9/122 , A61K8/046 , A61K8/671 , A61K9/0014 , A61K9/10 , A61K31/07 , A61K31/203 , A61Q19/00
摘要： A composition and therapeutic kit including an aerosol packaging assembly including a container accommodating a pressurized product and an outlet capable of releasing a foamable composition, including a nonsteroidal immunomodulating agent as a foam. The pressurized product includes a foamable composition including: a) a container accommodating a pressurized product; and b) an outlet capable of releasing the pressurized product as a foam; wherein the pressurized product comprises a foamable composition including: i. a nonsteroidal immunomodulating agent; ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, a polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight; iii. a surface-active agent; iv. about 0.1% to about 5% by weight of a therapeutically active foam adjuvant, selected from the group consisting of a fatty alcohol, a fatty acid, a hydroxyl fatty acid; and mixtures thereof; v. about 0.01 % to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; vi. water; and vii. liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：一种组合物和治疗试剂盒，其包括气溶胶包装组件，其包括容纳加压产品的容器和能够释放可发泡组合物的出口，其包括作为泡沫的非甾体免疫调节剂。加压产品包括可发泡组合物，其包括：a）容纳加压产品的容器; 和b）能够释放作为泡沫的加压产品的出口; 其中所述加压产品包括可发泡组合物，其包含：i。非甾体免疫调节剂; ii。选自浓度为约2％至约50％重量的至少一种选自疏水性有机载体，极性溶剂，软化剂及其混合物的有机载体; iii。表面活性剂; iv。约0.1重量％至约5重量％的治疗活性泡沫佐剂，其选自脂肪醇，脂肪酸，羟基脂肪酸; 及其混合物; 约0.01重量％至约5重量％的至少一种选自生物粘附剂，胶凝剂，成膜剂和相变剂的聚合物添加剂; vi。水; 和vii。液化或压缩气体推进剂的浓度为总组合物重量的约3％至约25％。

68. 发明申请

US20050205086A1 Retinoid immunomodulating kit and composition and uses thereof 审中-公开
标题翻译：类视黄醇免疫调节试剂盒及其组合物和用途
公开(公告)号：US20050205086A1
公开(公告)日：2005-09-22
申请号：US11078948
申请日：2005-03-11
申请人： Dov Tamarkin , Meir Eini , Doron Friedman
发明人： Dov Tamarkin , Meir Eini , Doron Friedman
IPC分类号： A61K8/04 , A61K8/67 , A61K31/07 , A61K31/203 , A61L9/04 , A61M11/00 , A61Q19/00
CPC分类号： A61Q19/00 , A61K8/046 , A61K8/671 , A61K9/0014 , A61K9/122 , A61K31/07 , A61K31/203
摘要： A composition and therapeutic kit including an aerosol packaging assembly including a container accommodating a pressurized product and an outlet capable of releasing a foamable composition, including a retinoid as a foam. The pressurized product includes a foamable composition including: a container accommodating a pressurized product; and an outlet capable of releasing the pressurized product as a foam; wherein the pressurized product comprises a foamable composition including: i. a retinoid; ii. at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, a polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight; iii. a surface-active agent; iv. about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; v. water; and vi. liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition. The composition further may include a therapeutically active foam adjuvant, selected from the group consisting of a fatty alcohol, a fatty acid, a hydroxyl fatty acid; and mixtures thereof.
摘要翻译：一种组合物和治疗试剂盒，其包括气溶胶包装组件，其包括容纳加压产品的容器和能够释放可发泡组合物的出口，其包含类视黄醇作为泡沫。加压产品包括可发泡组合物，其包括：容纳加压产品的容器; 以及能够释放作为泡沫的加压产品的出口; 其中所述加压产品包括可发泡组合物，其包含：i。类视黄醇 ii。选自浓度为约2％至约50％重量的至少一种选自疏水性有机载体，极性溶剂，软化剂及其混合物的有机载体; iii。表面活性剂; iv。约0.01重量％至约5重量％的至少一种选自生物粘附剂，胶凝剂，成膜剂和相变剂的聚合物添加剂; v。水和vi。液化或压缩气体推进剂的浓度为总组合物重量的约3％至约25％。组合物还可以包括治疗活性的泡沫佐剂，其选自脂肪醇，脂肪酸，羟基脂肪酸; 及其混合物。

69. 发明申请

US20050075407A1 Foam incorporating eutetic mixture 审中-公开
标题翻译：泡沫混合可溶性混合物
公开(公告)号：US20050075407A1
公开(公告)日：2005-04-07
申请号：US10922555
申请日：2004-08-20
申请人： Dov Tamarkin , Doron Friedman , Meir Eini
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61K8/04 , A61K8/365 , A61K8/42 , A61K9/12 , A61K31/167 , A61K31/196 , A61K31/496 , A61Q19/00 , C08J9/00
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K8/342 , A61K8/37 , A61K8/39 , A61K8/731 , A61K9/0014 , A61K47/10 , A61K2800/91 , A61Q19/00 , A01N53/00
摘要： The invention relates to an alcohol-free cosmetic or pharmaceutical foam carrier comprising water, a surface-active agent a gelling agent and a combination of active agents, which creates, upon admixing, a eutectic mixture. The foam carrier further comprises active agents and excipients with therapeutic properties.
摘要翻译：本发明涉及一种无醇化妆品或药物泡沫载体，其包含水，表面活性剂，胶凝剂和活性剂的组合，其在混合时产生共晶混合物。泡沫载体还包含具有治疗性质的活性剂和赋形剂。

70. 发明申请

US20050031547A1 Oleaginous pharmaceutical and cosmetic foam 有权
标题翻译：油性药用和化妆品泡沫
公开(公告)号：US20050031547A1
公开(公告)日：2005-02-10
申请号：US10835505
申请日：2004-04-28
申请人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
发明人： Dov Tamarkin , Doron Friedman , Meir Eini , Alex Besonov
IPC分类号： A61K9/00 , A61L9/04 , A61Q90/00
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K9/0034 , A61K9/107 , A61K9/12 , A61K31/351 , A61K31/436 , A61K31/496 , A61K31/522 , A61K31/573 , A61K38/13 , A61K47/10 , A61K47/14 , A61Q19/00
摘要： The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition; at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition; a therapeutically effective amount of at least one active agent; and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition.
摘要翻译：本发明涉及含有某些活性剂的稳定的含油化妆品或治疗性泡沫组合物，其具有独特的治疗性质和使用这种组合物的治疗方法。可发泡组合物包括至少一种选自疏水性溶剂，硅油，软化剂，共溶剂及其混合物的溶剂，其中溶剂的浓度为约70重量％至约96.5重量％总组合物，至少一种非离子表面活性剂，其浓度为总组合物重量的约0.1％至小于约10％; 浓度为总组合物重量的约0.1％至约5％的至少一种胶凝剂; 治疗有效量的至少一种活性剂; 和至少一种液化或压缩气体推进剂，其浓度为总组合物重量的约3％至约25％。

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