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61. 发明授权

US06846871B2 Antimicrobial resin cured rubber articles and prevulcanized compositions 失效
标题翻译：抗菌树脂固化橡胶制品和预硫化组合物
公开(公告)号：US06846871B2
公开(公告)日：2005-01-25
申请号：US10424025
申请日：2003-04-25
申请人： Bhawan Patel , David L. Morris
发明人： Bhawan Patel , David L. Morris
IPC分类号： C08K3/00 , C08K3/08 , C08K3/22
CPC分类号： C08K3/08 , C08K3/015 , C08K3/22 , C08L21/00
摘要： This invention relates to certain non-silicone resin cured rubber articles that are made from at least a majority by weight of non-silicone vulcanized rubber that include silver-based compounds to provide highly desirable long-term antimicrobial characteristics within the cured rubber articles. Such articles are in either solid or blown (foam or sponge) state (or combinations of both in multilayered forms) and can be utilized in a variety of different applications. This invention encompasses the presence of non-sulfur-based curing systems and agents, such as resin curing, that permit vulcanization and do not irreversibly bind silver ions thereto, thereby resulting in long-term antimicrobial performance of the ultimate rubber article itself. This invention also encompasses certain non-silicone pre-vulcanized raw rubber formulations made from at least a majority by weight of non-silicone rubber that include silver-based components to provide highly desirable long-term antimicrobial characteristics within the ultimate resin cured rubber articles made therefrom.
摘要翻译：本发明涉及由至少大部分重量的非硅氧烷硫化橡胶制成的某些非硅树脂固化橡胶制品，其包括银基化合物，以在固化的橡胶制品内提供高度期望的长期抗菌特性。这样的制品是固体或吹制（泡沫或海绵）状态（或两者的组合形式），可用于各种不同的应用。本发明包括非硫基固化体系和诸如树脂固化的试剂的存在，其允许硫化并且不会不可逆地将银离子结合到其上，从而导致最终橡胶制品本身的长期抗微生物性能。本发明还包括由至少大部分重量的非硅橡胶制成的某些非硅氧烷预硫化生橡胶配方，其包括银基组分，以在最终树脂固化橡胶制品中提供非常期望的长期抗微生物特性由此。

62. 发明授权

US06638993B2 Colored antimicrobial vulcanized rubber articles 有权
公开(公告)号：US06638993B2
公开(公告)日：2003-10-28
申请号：US10015878
申请日：2001-12-12
申请人： Bhawan Patel , David L. Morris , Geoffrey Haas , William O. Burke, III
发明人： Bhawan Patel , David L. Morris , Geoffrey Haas , William O. Burke, III
IPC分类号： C08K509
CPC分类号： C08K3/34 , C08K3/015 , C08K5/0058 , C08L21/00 , C08L23/16
摘要： Certain non-silicone vulcanized rubber articles made from at least a majority by weight of ethylene-propylene-diene modified (terpolymer) rubber (such as, without limitation, EPDM and/or NBR) that include silver-based compounds to provide highly desirable long-term antimicrobial characteristics within the cured rubber articles, at least a portion of which exhibits a color other than black, are provided. Such articles are in either solid or blown (foam or sponge) state (or combinations of both in multilayered forms, either all colored or individual layers colored) that can be utilized in a variety of different applications. As silver-based compounds are deleteriously affected by utilization of standard curing agents and curing accelerators, such as sulfur-based compounds and/or systems, the ability to provide such an effective antimicrobial vulcanized rubber article is rather difficult. However, this invention encompasses the presence of different non-sulfur-based curing systems and agents, such as peroxides, as one example, that permit vulcanization and do not irreversibly bind silver ions thereto, thereby resulting in long-term antimicrobial performance of the ultimate rubber article itself. The rubber articles must also comprise fillers and may also include plasticizers to provide desired characteristics of dimensional stability, stiffness, flexural modulus, tensile strength, abrasion resistance, elongation, and the like, for the ultimate rubber article, while simultaneously and surprisingly both enhancing the control of antimicrobial efficacy of the rubber article and not deleteriously binding to the available silver to permit coloring of the target rubber as well.

63. 发明授权

US4874364A Inspection instrument channel aspirator and pressure neutralizing device 失效
标题翻译：检测仪器通道吸气器和压力中和装置
公开(公告)号：US4874364A
公开(公告)日：1989-10-17
申请号：US171569
申请日：1988-03-22
申请人： David L. Morris , Mihail Filip , Frank D. D'Amelio , Dominick G. Esposito , Robert H. Quint
发明人： David L. Morris , Mihail Filip , Frank D. D'Amelio , Dominick G. Esposito , Robert H. Quint
IPC分类号： A61B1/31
CPC分类号： A61B1/31 , A61B1/00137
摘要： A gas pressure neutralizing device for use with a working channel of an inspection instrument. The device comprises means for providing a first gas pressure buffer, a second gas pressure buffer, a chamber formed therebetween and means for reducing the pressure in the chamber whereby gases are substantially prevented from exiting the instrument through a working inlet of the device at an elevated pressure or high velocity.
摘要翻译：一种与检查仪器的工作通道一起使用的气体压力中和装置。该装置包括用于提供第一气体压力缓冲器，第二气体压力缓冲器和在其间形成的腔室的装置，用于减小腔室中的压力的装置，其中基本上防止气体通过装置的工作入口在升高的压力或高速度。

64. 外观设计

USD291643S Insulated container 失效
公开(公告)号：USD291643S
公开(公告)日：1987-09-01
申请号：US744626
申请日：1985-06-14
申请人： David L. Morris
设计人： David L. Morris

65. 发明授权

US4622293A Iodothyronine immunoassays employing HMS as TBP blocking agent 失效
标题翻译：使用HMS作为TBP阻断剂的碘甲状腺素免疫测定
公开(公告)号：US4622293A
公开(公告)日：1986-11-11
申请号：US510814
申请日：1983-07-05
申请人： Paul B. Ellis , David L. Morris
发明人： Paul B. Ellis , David L. Morris
IPC分类号： G01N33/537 , G01N33/53 , G01N33/542 , G01N33/78 , G01N33/534 , G01N33/535
CPC分类号： G01N33/78 , G01N33/542 , Y10S435/81 , Y10S435/962 , Y10S435/97 , Y10S435/975 , Y10S436/804 , Y10S436/808
摘要： An improved immunoassay method, reagent means, test kit, and test device for determining an iodothyronine, e.g., thyroxine (T-4), in a biological fluid, usually serum or plasma, wherein 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid (HMS), or a salt thereof, is employed as a blocking agent for the binding of iodothyronines to thyroxine binding protein (TBP). The present invention is particularly advantageous as applied to homogeneous competitive binding iodothyronine immunoassays employing labels which are participants in enzyme-catalyzed reactions. Such labels include enzyme substrates, coenzymes, enzyme inhibitors, enzyme prosthetic groups, and enzymes.
摘要翻译：用于测定生物流体（通常为血清或血浆）中的碘甲状腺氨酸（例如甲状腺素（T-4））的改进的免疫测定方法，试剂方法，测试试剂盒和测试装置，其中2-羟基-4-甲氧基二苯甲酮-5-磺酸酸（HMS）或其盐用作结合碘甲腺氨酸与甲状腺素结合蛋白（TBP）的封闭剂。本发明特别有利于应用于使用作为酶催化反应参与者的标记的均相竞争性结合的碘甲状腺原氨酸免疫测定。这样的标记包括酶底物，辅酶，酶抑制剂，酶修补基团和酶。

66. 发明授权

US4318983A Fad-labeled specific binding assay monitored with apoglutathione reductase or apolipoamide dehydrogenase 失效
标题翻译：用谷抑肽酶还原酶或载脂蛋白脱氢酶监测Fad标记的特异性结合分析
公开(公告)号：US4318983A
公开(公告)日：1982-03-09
申请号：US203525
申请日：1980-11-03
申请人： William E. Hornby , David L. Morris
发明人： William E. Hornby , David L. Morris
IPC分类号： C12N9/96 , G01N33/535 , G01N33/542 , G01N33/78 , G01N33/54
CPC分类号： G01N33/78 , C12N9/96 , G01N33/535 , G01N33/542 , Y10S435/81 , Y10S435/96 , Y10S435/975
摘要： A specific binding assay for determining a ligand in a liquid medium employing an organic prosthetic group residue, such as a residue of flavin adenine dinucleotide, flavin mononucleotide, or heme, as a label component in the labeled conjugate. Preferably, the label component is the prosthetic group residue alone or is a holoenzyme residue comprising such prosthetic group residue combined with an apoenzyme in the form of a holoenzyme complex. In the former case, the label component preferably is monitored in the assay by adding an apoenzyme after the binding reaction has been initiated and measuring the resultant holoenzyme activity. In the latter case, the label component is monitored simply by measuring holoenzyme activity. The assay method may follow conventional homogeneous and heterogeneous schemes. Preferred apoenzymes for use in the assay are apoglucose oxidase and apoperoxidase. The assay offers the advantages of colorimetric read-out and of being readily adaptable to automated techniques. Also disclosed are prosthetic group-labeled and enzyme-labeled conjugates for use in the assay, as well as a method for preparing the latter conjugates.
摘要翻译：使用有机修饰基团残基（例如黄素腺嘌呤二核苷酸残基，黄素单核苷酸或血红素）作为标记缀合物中的标记成分来测定液体培养基中配体的特异性结合测定。优选地，标记组分是单独的修饰基团残基，或者是包含与全酶复合物形式的脱辅基酶组合的这种假基团残基的全酶残基。在前一种情况下，优选在测定中通过在结合反应开始后加入脱辅基酶并测量所得的全酶活性来监测标记组分。在后一种情况下，通过测量全酶活性来简单地监测标签组分。测定方法可以遵循常规的均相和异构方案。用于测定的优选的脱辅基酶是糖苷氧化酶和过氧化物酶。该测定提供比色读出的优点并且易于适应于自动化技术。还公开了用于测定中的假体基团标记和酶标记的缀合物，以及制备后缀合物的方法。

67. 发明授权

US4268631A Apoglucose oxidase preparation 失效
标题翻译：葡萄糖氧化酶制剂
公开(公告)号：US4268631A
公开(公告)日：1981-05-19
申请号：US45191
申请日：1979-06-04
申请人： Paul B. Ellis , David L. Morris
发明人： Paul B. Ellis , David L. Morris
IPC分类号： C12Q1/26 , C12N9/04 , G01N33/542
CPC分类号： C12N9/0006 , G01N33/542 , Y10S435/815
摘要： An apoglucose oxidase preparation having a residual glucose oxidase activity of less than 0.05%, and preferably less than 0.005%. The preparation is obtained by incubation of glucose oxidase in aqueous solution at a pH of less than about 2 and in the presence of about 20 to about 40, preferably about 30, percent by volume glycerol, and separating resulting dissociated prosthetic group, flavin adenine dinucleotide, from apoglucose oxidase by column chromatography, preferably on cross-linked dextran gel. The purified apoglucose oxidase is useful as a reagent in specific binding assays employing flavin adenine dinucleotide as a label.
摘要翻译：具有小于0.05％，优选小于0.005％的残留葡萄糖氧化酶活性的糖苷氧化酶制剂。通过将葡萄糖氧化酶在小于约2的pH和约20至约40，优选约30体积％甘油的存在下在水溶液中温育获得制备，并分离所得的解离的假体基团，黄素腺嘌呤二核苷酸，通过柱色谱从糖葡萄糖氧化酶，优选在交联的葡聚糖凝胶上。在使用黄素腺嘌呤二核苷酸作为标记的特异性结合测定中，纯化的糖苷氧化酶可用作试剂。

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