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61. 发明授权

US07906284B2 Arrays of optical confinements and uses thereof 有权
标题翻译：光学限制阵列及其用途
公开(公告)号：US07906284B2
公开(公告)日：2011-03-15
申请号：US11925607
申请日：2007-10-26
申请人： Stephen Turner , Jonas Korlach
发明人： Stephen Turner , Jonas Korlach
IPC分类号： C12Q1/68
CPC分类号： G01N21/77 , C12Q1/6806 , C12Q1/6869 , G01N21/00 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N2021/6439 , G01N2021/6463 , G01N2021/7786 , G01N2201/06113
摘要： The present invention relates to optical confinements, methods of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis.
摘要翻译：本发明涉及光学限制，其制备方法和使用它们分析分子和/或监测化学反应的方法。本发明中体现的装置和方法对于高通量和低成本的单分子分析特别有用。

62. 发明申请

US20100221716A1 Classification of Nucleic Acid Templates 有权
标题翻译：核酸模板分类
公开(公告)号：US20100221716A1
公开(公告)日：2010-09-02
申请号：US12635618
申请日：2009-12-10
申请人： Benjamin Flusberg , Stephen Turner , Jessica Lee , Lei Jia , Jonas Korlach , Jon Sorenson , Dale Webster , John Lyle , Kevin Travers , Jeremiah Hanes
发明人： Benjamin Flusberg , Stephen Turner , Jessica Lee , Lei Jia , Jonas Korlach , Jon Sorenson , Dale Webster , John Lyle , Kevin Travers , Jeremiah Hanes
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6837 , C12Q1/6858 , C12Q2561/113 , C12Q2537/164 , C12Q2527/113 , C12Q2521/101 , C12Q2525/307 , C12Q2525/117
摘要： Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.
摘要翻译：提供了方法，组合物和系统用于表征修饰的核酸。在某些优选实施方案中，提供单分子测序方法用于鉴定核酸序列内的修饰的核苷酸。通过本文提供的方法可检测的修饰物包括化学修饰的碱基，酶修饰的碱基，脱碱基位点，非天然碱基，二级结构和与模板核酸结合的试剂。

63. 发明申请

US20100143466A1 MODIFIED RELEASE IBUPROFEN DOSAGE FORM 有权
标题翻译：改良释放IBUPROFEN剂型
公开(公告)号：US20100143466A1
公开(公告)日：2010-06-10
申请号：US12706429
申请日：2010-02-16
申请人： Michael Hite , Cathy Federici , Alan Brunelle , Stephen Turner
发明人： Michael Hite , Cathy Federici , Alan Brunelle , Stephen Turner
IPC分类号： A61K9/20 , A61K31/192
CPC分类号： A61K9/2054 , A61K9/2009 , A61K9/2013 , A61K9/2031 , A61K9/2059 , A61K31/192 , A61K47/02 , A61K47/183 , A61K47/38
摘要： The present invention is a solid dosage form for oral administration of ibuprofen comprising a modified release formulation of ibuprofen which provides an immediate burst effect and thereafter a sustained release of sufficient ibuprofen to maintain blood levels at least 6.4 μg/ml over an extended period of at least 8 hours following administering of a single dose.
摘要翻译：本发明是用于口服施用布洛芬的固体剂型，其包含布洛芬的改良释放制剂，其提供立即的爆发作用，然后持续释放足够的布洛芬以在长时间内维持血液水平至少为6.4μg/ ml 在给予单次剂量后至少8小时。

64. 发明申请

US20090325166A1 SUBSTRATES FOR PERFORMING ANALYTICAL REACTIONS 有权
标题翻译：执行分析反应的基质
公开(公告)号：US20090325166A1
公开(公告)日：2009-12-31
申请号：US12341556
申请日：2008-12-22
申请人： Mathieu Foquet , Paul Peluso , Stephen Turner , Daniel Bernardo Roitman , Geoffrey Otto
发明人： Mathieu Foquet , Paul Peluso , Stephen Turner , Daniel Bernardo Roitman , Geoffrey Otto
IPC分类号： C12Q1/68
CPC分类号： G02B6/10 , G01N21/648 , G01N2021/7713
摘要： Substrates, including zero mode waveguide substrates that have been fabricated to provide additional functional elements and/or components including increased volumes for positioning of active surfaces and/or components for the mitigation of negative electrochemical properties of the underlying substrates.
摘要翻译：衬底，包括零模式波导衬底，其已经被制造成提供额外的功能元件和/或组件，包括用于定位活性表面和/或组件的增加的体积以减轻底层衬底的负电化学性质。

65. 发明申请

US20090105094A1 Error-free amplification of DNA for clonal sequencing 有权
标题翻译：用于克隆测序的无错扩增DNA
公开(公告)号：US20090105094A1
公开(公告)日：2009-04-23
申请号：US12286119
申请日：2008-09-26
申请人： Cheryl Heiner , Stephen Turner , Kevin Travers
发明人： Cheryl Heiner , Stephen Turner , Kevin Travers
IPC分类号： C40B50/06
CPC分类号： C12Q1/6806 , C12Q1/6869 , C12Q2563/179 , C12Q2563/155 , C12Q2525/307
摘要： Methods of preparing nucleic acid templates and providing the nucleic acid templates to low copy number reaction volumes are provided. Related compositions of nucleic acid templates are also provided.
摘要翻译：提供了制备核酸模板并将核酸模板提供给低拷贝数反应体积的方法。还提供了核酸模板的相关组合物。

66. 发明申请

US20080176316A1 Mitigation of photodamage in analytical reactions 有权
公开(公告)号：US20080176316A1
公开(公告)日：2008-07-24
申请号：US11981626
申请日：2007-10-31
申请人： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
发明人： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
IPC分类号： C12M1/40 , C12M1/34
CPC分类号： A61K38/446 , A61K38/063 , A61K38/443 , G01N33/582
摘要： Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.

67. 发明申请

US20080161194A1 ARRAYS OF OPTICAL CONFINEMENTS AND USES THEREOF 有权
公开(公告)号：US20080161194A1
公开(公告)日：2008-07-03
申请号：US11925650
申请日：2007-10-26
申请人： Stephen Turner , Jonas Korlach
发明人： Stephen Turner , Jonas Korlach
IPC分类号： C40B20/04 , C40B60/12 , C40B30/10
CPC分类号： G01N21/77 , C12Q1/6806 , C12Q1/6869 , G01N21/00 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N2021/6439 , G01N2021/6463 , G01N2021/7786 , G01N2201/06113
摘要： The present invention relates to optical confinements, methods of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost single-molecular analysis.

68. 发明申请

US20070231804A1 Methods, systems and compositions for monitoring enzyme activity and applications thereof 有权
标题翻译：用于监测酶活性的方法，系统和组合物及其应用
公开(公告)号：US20070231804A1
公开(公告)日：2007-10-04
申请号：US11394637
申请日：2006-03-31
申请人： Jonas Korlach , Stephen Turner
发明人： Jonas Korlach , Stephen Turner
IPC分类号： C12Q1/68 , C12Q1/66
CPC分类号： C12Q1/66 , C12Q1/42 , G01N33/573
摘要： Methods of monitoring enzyme mediated reactions, and particularly nucleic acid synthesis reactions such as pyrosequencing methods that employ enzymatic reporter systems. The methods and systems provide elevated signal levels as compared to conventional pyrosequencing processes, and/or mediate de-phasing of sequencing analyses employing pyrosequencing or other “sequencing by synthesis” methods.
摘要翻译：监测酶介导的反应的方法，特别是使用酶报告系统的核酸合成反应，如焦磷酸测序方法。与常规焦磷酸测序方法相比，该方法和系统提供升高的信号水平，和/或介导使用焦磷酸测序或其他“合成测序”方法的测序分析的脱相。

69. 发明申请

US20070206189A1 Optical analysis of molecules 有权
标题翻译：分子的光学分析
公开(公告)号：US20070206189A1
公开(公告)日：2007-09-06
申请号：US11626610
申请日：2007-01-24
申请人： Stephen Turner , Jonas Korlach
发明人： Stephen Turner , Jonas Korlach
IPC分类号： G01N21/47 , G02B6/00
CPC分类号： G01N21/77 , C12Q1/6806 , C12Q1/6869 , G01N21/00 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N2021/6439 , G01N2021/6463 , G01N2021/7786 , G01N2201/06113
摘要： The present invention relates to optical confinements, methods of preparing and methods of using them for analyzing molecules and/or monitoring chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughout and low-cost single-molecular analysis.
摘要翻译：本发明涉及光学限制，其制备方法和使用它们分析分子和/或监测化学反应的方法。本发明中体现的装置和方法对于高整体和低成本的单分子分析特别有用。

70. 发明申请

US20070185657A1 Graphic design of combinatorial material libraries 审中-公开
标题翻译：组合材料库的平面设计
公开(公告)号：US20070185657A1
公开(公告)日：2007-08-09
申请号：US11732408
申请日：2007-04-02
申请人： Steven Lacy , Eric McFarland , Adam Safir , Stephen Turner , Lynn Erden , Pei Wang
发明人： Steven Lacy , Eric McFarland , Adam Safir , Stephen Turner , Lynn Erden , Pei Wang
IPC分类号： C40B30/02
CPC分类号： G16C20/60 , G16B35/00
摘要： Computer-implemented methods, programs and apparatus for generating a library design for a combinatorial library of materials. A library design includes a set of sources representing components to be used in preparing the combinatorial library, destinations representing arrangements of cells and mappings, defining one or more distribution patterns for assigning components to cells in the destination arrangement or arrangements. Mappings include gradients and sets of user-defined equations, and are used to calculate the amount of one or more components to be assigned to a cell or cells in an arrangement. A library design can also include one or more process parameters defined to vary over time or across a plurality of destination cells. The invention outputs a data file defining the library design, including electronic data representing the sources, the destinations and the mapping, in a format suitable for implementing manually or using automated material handling apparatus.
摘要翻译：用于生成材料组合库的图书馆设计的计算机实现的方法，程序和装置。图书馆设计包括一组代表用于准备组合库的组件的源，表示单元格和映射的目的的目的地，定义用于将组件分配给目的地布置或布置中的单元的一个或多个分布模式。映射包括梯度和用户定义方程组，并且用于计算要分配给单元或单元的一个或多个组件的数量。库设计还可以包括一个或多个过程参数，其定义为随时间变化或跨多个目的地小区而变化。本发明以适合手动实现或使用自动化材料处理装置的格式输出定义库设计的数据文件，包括表示源，目的地和映射的电子数据。

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