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61. 发明授权

US09808557B2 Tubular silk compositions and methods of use thereof 有权
公开(公告)号：US09808557B2
公开(公告)日：2017-11-07
申请号：US12672521
申请日：2008-08-11
申请人： Michael L. Lovett , Xianyan Wang , Christopher M. Cannizzaro , Gordana Vunjak-Novakovic , David L. Kaplan
发明人： Michael L. Lovett , Xianyan Wang , Christopher M. Cannizzaro , Gordana Vunjak-Novakovic , David L. Kaplan
IPC分类号： A61F2/06 , A61L27/36 , A61L27/22 , A61F2/08 , A61L27/26 , A61F2/07 , A61F2/82
CPC分类号： A61L27/227 , A61F2/07 , A61F2/08 , A61F2/82 , A61L27/26 , A61L27/3604 , D10B2211/22 , Y10T428/13 , C08L89/00
摘要： Described are tubular silk fibroin compositions and methods for their manufacture and use. Tubular compositions as described herein can be produced in a range of high burst strengths, can easily be made in a range of inner diameters, can be derivatized with functional moieties, and can be produced in a range of permeabilities suitable for particularized uses. In one aspect, the tubular compositions can be used in the repair or replacement of damaged or diseased blood vessels, including, but not limited to vessels smaller than about 6 mm.

62. 发明授权

US09603971B2 Silk-based ionomeric compositions 有权
公开(公告)号：US09603971B2
公开(公告)日：2017-03-28
申请号：US13582903
申请日：2011-03-04
申请人： David L. Kaplan , Monica A. Serban
发明人： David L. Kaplan , Monica A. Serban
IPC分类号： A61L27/52 , A61K9/08 , A61K9/50 , A61L15/26 , A61L15/32 , A61L27/18 , A61L27/22 , A61L27/26 , A61L27/50 , A61L27/54 , A61L15/42
CPC分类号： A61L27/52 , A61K9/5063 , A61L15/26 , A61L15/32 , A61L15/42 , A61L27/18 , A61L27/227 , A61L27/26 , A61L27/50 , A61L27/54 , A61L2300/00 , Y10T428/2982 , C08L77/04
摘要： Disclosed herein are pH-dependent silk fibroin-based ionomeric compositions and colloids, and methods of making the same. The state of the silk fibroin ionomeric compositions is reversible and can transform from a gel-like colloid to a more fluid-like solution, or vice versa, upon an environmental stimulus, e.g., pH. Thus, the silk-based ionomeric compositions and colloids can be applied in various industries, ranging from electronic applications to biomedical applications, such as sensors, gel diodes, absorbent materials, drug delivery systems, tissue implants and contrast agents.

63. 发明授权

US09585830B2 Vitamin C composition for use in the prevention and treatment of stretch marks, radiation dermatitis, and other skin conditions and methods of using the same 有权
标题翻译：用于预防和治疗妊娠纹，放射性皮炎和其他皮肤病症的维生素C组合物及其使用方法
公开(公告)号：US09585830B2
公开(公告)日：2017-03-07
申请号：US13738125
申请日：2013-01-10
申请人： David L. Kaplan
发明人： David L. Kaplan
IPC分类号： A01N43/08 , A61K31/34 , A61K8/67 , A61K9/00 , A61K47/10 , A61Q19/06 , A61K31/341 , A61Q19/00
CPC分类号： A61K8/676 , A61K9/0014 , A61K31/34 , A61K31/341 , A61K47/10 , A61Q19/004 , A61Q19/06
摘要： A formulation for a stable ascorbic acid composition which, in a simplified form, is comprised of ascorbic acid in solution with a hygroscopic compound (i.e., a substance with the ability to attract water molecules from the surrounding environment through either absorption or adsorption). Also disclosed herein are methods for the production of such compounds and methods of using such compounds in the prevention, inhibition and treatment of striae gravidarum, radiation dermatitis, rhytids, lentigoes, dyschromia, sun-damage induced hyperpigmentation, cellulite, scars and purpura, among other skin diseases or conditions.
摘要翻译：用于稳定的抗坏血酸组合物的制剂，其以简单的形式由溶液中的抗坏血酸与吸湿性化合物（即具有通过吸收或吸附从周围环境吸引水分子的能力的物质）组成。本文还公开了生产这些化合物的方法和使用这些化合物在预防，抑制和治疗妊娠纹，放射性皮炎，ids ids，，，es，dys ia ia ia，，，damage damage ite，among among among among among among among among among among among among among among among among among among 其他皮肤病或病症。

64. 发明授权

US09566365B2 Silk fibroin and polyethylene glycol-based biomaterials 有权
标题翻译：丝素蛋白和聚乙二醇基生物材料
公开(公告)号：US09566365B2
公开(公告)日：2017-02-14
申请号：US13820440
申请日：2011-09-01
申请人： David L. Kaplan , Monica A. Serban
发明人： David L. Kaplan , Monica A. Serban
IPC分类号： A61L24/10 , C08L77/04 , C08L71/02 , C08L89/00 , A61L27/26 , A61L27/52 , A61L27/54 , A61L24/00
CPC分类号： A61L24/108 , A61L24/0094 , A61L27/26 , A61L27/52 , A61L27/54 , A61L2300/406 , C08L71/02 , C08L77/04 , C08L89/00 , C08L89/06
摘要： This invention relates to methods and compositions for preparation of silk-PEGs based biomaterials through crosslinking by chemically reacting active polyethylene glycols (PEGs) possessing different chemical groups (e.g., thiols and maleimides functionalized PEGs) that are additionally stabilized by the beta-sheet formation of silk fibroin. The crosslinked silk-PEGs biomaterials present strong adhesive properties, which are comparable to or better than the current leading PEG-based sealant, depending on the silk concentration in the silk-PEGs biomaterials. In addition, the silk-PEGs based biomaterials are cytocompatible, show decreased swelling behavior and longer degradation times, which make them suitable for hemostatic applications where the current available tissue sealant products can be contraindicated.
摘要翻译：本发明涉及通过化学反应具有不同化学基团的活性聚乙二醇（PEG）（例如硫醇和马来酰亚胺官能化的PEG）进行交联而制备基于丝-PEG的生物材料的方法和组合物，其通过β- 丝素蛋白交联的丝-PEGs生物材料具有强大的粘合性能，其与当前领先的PEG基密封剂相当或更好，这取决于丝-PEG生物材料中的丝浓度。此外，基于丝-PEG的生物材料是细胞相容性的，显示出降低的溶胀行为和更长的降解时间，这使得它们适用于当前可用的组织密封剂产品可以禁忌的止血应用。

65. 发明授权

US09427499B2 Surface modification of silk fibroin matrices with poly(ethylene glycol) useful as anti-adhesion barriers and anti-thrombotic materials 有权
标题翻译：用聚乙二醇作为抗粘连屏障和抗血栓形成材料的丝素蛋白基质的表面改性
公开(公告)号：US09427499B2
公开(公告)日：2016-08-30
申请号：US13129738
申请日：2009-11-17
申请人： Charu P. Vepari , David L. Kaplan
发明人： Charu P. Vepari , David L. Kaplan
IPC分类号： A61L27/14 , A61L27/28 , A61L27/22 , A61L31/10 , A61L33/06 , A61L31/00
CPC分类号： A61L31/005 , A61L31/10 , A61L33/068 , C08L71/02
摘要： The present invention provides compositions and methods for the production of silk fibroin matrices surface-PEGylated on one or more surfaces. Such surface-PEGylated silk fibroin matrices can be used in biomedical applications, such as anti-adhesive and anti-thrombosis materials. Silk matrices may be surface-PEGylated, for example, by a reaction with a functional group-activated PEG. Controlling the degree of PEGylation on surface of silk fibroin matrix can regulate both the degradation rate of the silk matrix, and the differentiated adhesion of cells or differentiated adsorption of proteins on the surface of the silk matrix. The present invention also provides for silk fibroin matrices having one or more surfaces possessing differentiated adhesion properties, which allows for tissue integration on the adherent side and inhibition of tissue adhesion to the opposing tissues or organs. Embedding active agents in silk fibroin matrices provides more benefits, such as promoting tissue ingrowth on the adherent side of the matrix.
摘要翻译：本发明提供了用于生产在一个或多个表面上表面聚乙二醇化的丝素蛋白基质的组合物和方法。这种表面聚乙二醇化的丝素蛋白基质可用于生物医学应用，例如抗粘连和抗血栓形成的材料。丝质基质可以被表面聚乙二醇化，例如通过与官能团活化的PEG的反应。控制丝素蛋白基质表面聚乙二醇化程度可以调节蚕丝基质的降解速率，分化细胞粘附或蛋白质在丝质基质表面的分化吸附。本发明还提供具有一个或多个具有分化的粘附性质的表面的丝素蛋白基质，其允许组合物在粘附层上的整合并抑制组织对相对组织或器官的粘附。在丝素蛋白基质中包埋活性剂提供了更多的益处，例如促进组织向上生长在基质的粘着面上。

66. 发明授权

US09074302B2 Methods of making drawn silk fibers 有权
标题翻译：制作拉丝丝纤维的方法
公开(公告)号：US09074302B2
公开(公告)日：2015-07-07
申请号：US13498722
申请日：2010-09-28
申请人： Tim Jia-Ching Lo , Gary G. Leisk , David L. Kaplan
发明人： Tim Jia-Ching Lo , Gary G. Leisk , David L. Kaplan
IPC分类号： C08L89/00 , D01D5/40 , D01F4/00 , D01F4/02 , D01D1/02 , D01D5/00 , G02B6/02
CPC分类号： D01F4/02 , D01D1/02 , D01D5/00 , G02B6/02033
摘要： The present invention relates to compositions and method for drawing egel silk fibroin fibers. The resulting fibers can transmit light and hence can be used as optical fiber. Silk fibroin fiber is produced by a method comprising applying an electric field to a solubilized silk fibroin solution to create a silk fibroin gel; converting the silk fibroin gel to a viscous silk liquid; and drawing a silk fiber from the viscous silk liquid. The silk fiber of the invention can be used in materials such as textile, medical sutures, and tissue materials, as well as conferring optical properties into these materials.
摘要翻译：本发明涉及丝绒丝素纤维的组合物和方法。所得到的纤维可以透射光，因此可以用作光纤。丝素蛋白纤维通过包括向溶解的丝素蛋白溶液施加电场以产生丝素蛋白凝胶的方法产生; 将丝素蛋白凝胶转化为粘稠的丝液; 并从粘性丝液中抽出丝纤维。本发明的丝纤维可以用于纺织品，医用缝合线和组织材料等材料，并且可以赋予这些材料光学特性。

67. 发明授权

US09016875B2 All-protein implantable, resorbable reflectors 有权
标题翻译：全蛋白可植入，可吸收反射体
公开(公告)号：US09016875B2
公开(公告)日：2015-04-28
申请号：US13386388
申请日：2010-07-20
申请人： Fiorenzo Omenetto , David L. Kaplan
发明人： Fiorenzo Omenetto , David L. Kaplan
IPC分类号： G02B5/124 , A61B5/00 , A61L27/22
CPC分类号： A61B5/0059 , A61K49/0004 , A61L27/227
摘要： The invention provides for compositions and process for fabricating an optical reflector constructed from biocompatible and bioresorbable silk fibroin proteins. For example, the silk retroreflectors may be built based on millimeter size microprism arrays to rotate the image plane of imaged cortical layers, thus enhancing the amount of photons that are detectable in the reflected direction when inserted in a sample to be analyzed, and ultimately increasing in contrast ratio in multiphoton microscopy. Such device can be used as a label-free, biocompatible, bioresorbable, implantable device for various applications ranging from medical imaging/diagnostics, drug/therapeutic delivery, to food chain safety and environmental monitoring.
摘要翻译：本发明提供了用于制造由生物相容性和生物可再吸收的丝素蛋白构成的光反射体的组合物和方法。例如，丝绸后向反射器可以基于毫米尺寸的微棱镜阵列构建，以旋转成像的皮质层的图像平面，从而增加当插入待分析的样品中时在反射方向上可检测的光子的量，并且最终增加在多光子显微镜中的对比度。这种装置可用作用于各种应用的无标签，生物相容性，生物可再吸收的可植入装置，从医学成像/诊断，药物/治疗递送，食品链安全和环境监测。

68. 发明授权

US08666471B2 Implantable biomedical devices on bioresorbable substrates 有权
标题翻译：可植入生物医学装置在生物可吸收底物上
公开(公告)号：US08666471B2
公开(公告)日：2014-03-04
申请号：US12892001
申请日：2010-09-28
申请人： John A. Rogers , Dae-Hyeong Kim , Fiorenzo Omenetto , David L. Kaplan , Brian Litt , Jonathan Viventi , Yonggang Huang , Jason Amsden
发明人： John A. Rogers , Dae-Hyeong Kim , Fiorenzo Omenetto , David L. Kaplan , Brian Litt , Jonathan Viventi , Yonggang Huang , Jason Amsden
IPC分类号： A61B5/04 , A61N1/05
CPC分类号： A61B5/04 , A61B5/05 , A61B5/6867 , A61B2562/0285 , A61L31/047 , A61L31/148 , A61N1/0529 , A61N1/0551 , B82Y15/00 , H01L2924/0002 , H05K1/0283 , H05K3/20 , H01L2924/00
摘要： Provided herein are implantable biomedical devices, methods of administering implantable biomedical devices, methods of making implantable biomedical devices, and methods of using implantable biomedical devices to actuate a target tissue or sense a parameter associated with the target tissue in a biological environment. Each implantable biomedical device comprises a bioresorbable substrate, an electronic device having a plurality of inorganic semiconductor components supported by the bioresorbable substrate, and a barrier layer encapsulating at least a portion of the inorganic semiconductor components. Upon contact with a biological environment the bioresorbable substrate is at least partially resorbed, thereby establishing conformal contact between the implantable biomedical device and the target tissue in the biological environment.
摘要翻译：本文提供了植入式生物医学装置，可植入生物医学装置的施用方法，制造可植入生物医学装置的方法，以及使用可植入生物医学装置致动靶组织或感测与生物环境中的靶组织相关的参数的方法。每个可植入的生物医学装置包括生物可再吸收的基底，具有由生物可再吸收的基底支撑的多个无机半导体组分的电子器件，以及封装至少一部分无机半导体组分的阻挡层。在与生物环境接触时，生物可再吸收底物至少部分吸收，从而在生物环境中建立可植入生物医学装置与靶组织之间的共形接触。

69. 发明授权

US08530625B2 Silk-based drug delivery system 有权
标题翻译：丝绸药物输送系统
公开(公告)号：US08530625B2
公开(公告)日：2013-09-10
申请号：US13443264
申请日：2012-04-10
申请人： David L. Kaplan , Lorenz Meinel
发明人： David L. Kaplan , Lorenz Meinel
IPC分类号： A61K38/17 , A61K9/22
CPC分类号： A61K47/42 , A61K9/0002 , A61K9/7007 , A61K38/17 , A61K47/46
摘要： The present invention provides for novel sustained release silk-based delivery systems. The invention further provides methods for producing such formulations. In general, a silk fibroin solution is combined with a therapeutic agent to form a silk fibroin article. The article is then treated in such a way as to alter its conformation. The change in conformation increases its crytallinity or liquid crystallinity, thus controlling the release of a therapeutic agent from the formulation. This can be accomplished as single material carriers or in a layer-by-layer fashion to load different therapeutic agents or different concentrations of these agents in each layer.
摘要翻译：本发明提供了新颖的持续释放的基于丝的递送系统。本发明还提供了生产这种制剂的方法。通常，将丝素蛋白溶液与治疗剂组合以形成丝素蛋白制品。然后对该文章进行处理，以改变其构象。构象的变化增加其胆固醇或液体结晶度，从而控制治疗剂从制剂中的释放。这可以作为单一材料载体或以逐层方式实现，以在每个层中加载不同的治疗剂或不同浓度的这些试剂。

70. 发明授权

US08459716B2 Removable tailgate gap cover 有权
标题翻译：可拆卸后挡板间隙盖
公开(公告)号：US08459716B2
公开(公告)日：2013-06-11
申请号：US13328375
申请日：2011-12-16
申请人： David L. Kaplan
发明人： David L. Kaplan
IPC分类号： B62D33/03
CPC分类号： B62D33/0273
摘要： A removable tailgate gap cover for preventing ingress of debris in a tailgate gap. The gap cover comprises an elongated cover plate having a top surface, a bottom surface, two longitudinal edges and an elongated support bar having an upper end and a lower end, wherein the upper end is fixedly attached to and substantially centrally aligned with the lengthwise direction of the bottom surface. The elongated support bar comprises a magnetic attaching means disposed along the lower end of the elongated support bar for attaching the gap cover to the floor of the end portion of the truck bed.
摘要翻译：可拆卸的后挡板间隙盖，用于防止尾门间隙中的碎屑进入。间隙盖包括细长的盖板，其具有顶表面，底表面，两个纵向边缘和具有上端和下端的细长支撑杆，其中上端固定地附接到长度方向的底面。细长的支撑杆包括沿着细长支撑杆的下端设置的磁性附接装置，用于将间隙盖附接到卡车车厢底部的底部。

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