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61. 发明授权

US07171268B1 Implantable cardiac stimulation device providing accelerated defibrillation delivery and method 有权
标题翻译：植入式心脏刺激装置提供加速的除颤输送和方法
公开(公告)号：US07171268B1
公开(公告)日：2007-01-30
申请号：US10746298
申请日：2003-12-24
申请人： Mark W. Kroll , James E. Brewer
发明人： Mark W. Kroll , James E. Brewer
IPC分类号： A61N1/00
CPC分类号： A61N1/3621 , A61N1/3925 , A61N1/3962
摘要： An implantable cardiac stimulation device provides accelerated delivery of defibrillation therapy to a patient's heart. The device includes a sensing circuit that provides right and left heart cardiac activity signals and a detector that detects an accelerated arrhythmia of the patient's heart and establishes a plurality of accelerated cardiac rate zones including a fibrillation rate zone and at least one intermediate rate zone. A classifier responsive to the right and left heart cardiac activity signals classifies an accelerated arrhythmia as one of fibrillation and tachycardia responsive to the detector detecting an accelerated arrhythmia having a cardiac rate within the at least one intermediate rate zones. A therapy circuit applies defibrillation to the heart responsive to the classifier classifying an accelerated arrhythmia as fibrillation and anti-tachycardia pacing to the heart responsive to the classifier classifying an accelerated arrhythmia as tachycardia.
摘要翻译：植入式心脏刺激装置提供加速递送除颤疗法给患者的心脏。该装置包括提供左心心脏活动信号和左心脏心脏活动信号的感测电路和检测患者心脏的加速心律不齐的检测器，并建立包括原纤化速率区和至少一个中间速率区的多个加速心率区。响应于左心心脏活动信号和左心脏心脏活动信号的分类器将加速心律不齐作为对颤动和心动过速之一进行分类，其响应于检测器检测到在至少一个中间速率区域内具有心率的加速心律失常。治疗电路根据分类器对心脏进行除颤，该加速心律失常将加速心律失常归类为心律失常，抗心动过速起搏响应分类器将加速心律失常归类为心动过速。

62. 发明授权

US06484801B2 Flexible joint for well logging instruments 失效
标题翻译：用于测井仪器的柔性接头
公开(公告)号：US06484801B2
公开(公告)日：2002-11-26
申请号：US09810985
申请日：2001-03-16
申请人： James E. Brewer , Borislav Tchakarov , Paul G. Junghans , James C. Hunziker
发明人： James E. Brewer , Borislav Tchakarov , Paul G. Junghans , James C. Hunziker
IPC分类号： E21B1720
CPC分类号： E21B17/028 , E21B17/04 , E21B47/01
摘要： A universal joint between adjacent, electrically connected instrument housings for downhole well operations allow the connected housings to bend longitudinally as required to traverse an arced section of a well bore but does not permit relative elongation or twisting about the longitudinal axis of the housings. In one embodiment, a fluid impermeable open passage space at atmospheric pressure surrounds electrical signal carriers linking the instrument circuitry within the two housings. The passage is constructed as a high-pressure flexible bellows or as a braided or spiral wound high-pressure fluid hose. In another embodiment, a fluid impermeable sheath surrounds the signal carriers and encapsulates the signal carriers by a resilient solid. The articulation structure comprises a Cardan-type of universal joint wherein two fingers project longitudinally from the end of each of the housings. The fingers are meshed and pivotally joined to respective spindles projecting radially from the open center of a ring spyder. The protective bellows, hose or resilient compound filled sheath is secured at opposite ends to bore plugs in the respective instrument housings. Between the instrument housings, the hose, bellows or filled sheath passes through the open center of the spyder ring.
摘要翻译：相邻的电气连接的用于井下井操作的仪器壳体之间的万向接头允许连接的壳体根据需要纵向弯曲以穿过井眼的弧形部分，但不允许围绕壳体的纵向轴线的相对伸长或扭转。在一个实施例中，在大气压下的流体不可渗透的开放通道空间包围连接两个壳体内的仪器电路的电信号载体。通道构造为高压柔性波纹管或编织或螺旋缠绕的高压流体软管。在另一个实施例中，流体不可渗透的护套围绕信号载体并通过弹性固体封装信号载体。铰接结构包括万向节万向接头，其中两个手指从每个壳体的端部纵向突出。指状物被啮合并且枢转地连接到从环形螺旋桨的开放中心径向突出的相应主轴。保护波纹管，软管或弹性复合物填充的护套固定在相对的两端，以在相应的仪器壳体内插入塞子。在仪器外壳之间，软管，波纹管或填充的护套穿过了Spyder环的开放中心。

63. 发明授权

US5968080A Method for determining the second phase of external defibrillator devices 失效
标题翻译：用于确定外部除颤器装置的第二相的方法
公开(公告)号：US5968080A
公开(公告)日：1999-10-19
申请号：US886736
申请日：1997-07-01
申请人： James E. Brewer , Gary B. Stendahl , Kenneth F. Olson
发明人： James E. Brewer , Gary B. Stendahl , Kenneth F. Olson
IPC分类号： A61N1/39
CPC分类号： A61N1/3937
摘要： A method for determining an optimal transchest external defibrillation waveform which, when applied through a plurality of electrodes positioned on a patient's torso will produce a desired response in the patient's cardiac cell membranes. The method includes the steps of providing a quantitative model of a defibrillator circuit for producing external defibrillation waveforms, the quantitative model of a patient includes a chest component, a heart component, a cell membrane component and a quantitative description of the desired cardiac membrane response function. Finally, a quantitative description of a transchest external defibrillation waveform that will produce the desired cardiac membrane response function is computed. The computation is made as a function of the desired cardiac membrane response function, the patient model and the defibrillator circuit model.
摘要翻译：一种用于确定最佳交织外部除颤波形的方法，当通过位于患者躯体上的多个电极施加时，其将在患者的心脏细胞膜中产生期望的响应。该方法包括提供用于产生外部除颤波形的除颤器电路的定量模型的步骤，患者的定量模型包括胸部组分，心脏组分，细胞膜组分和所需心脏膜响应函数的定量描述。最后，计算将产生期望的心脏膜响应函数的经外科除颤波形的定量描述。作为所需心脏膜响应函数，患者模型和除颤器电路模型的函数进行计算。

64. 发明授权

US5891173A Method of designing external defibrillator waveforms 失效
标题翻译：设计外部除颤器波形的方法
公开(公告)号：US5891173A
公开(公告)日：1999-04-06
申请号：US837224
申请日：1997-04-10
申请人： James E. Brewer
发明人： James E. Brewer
IPC分类号： A61N1/39
CPC分类号： A61N1/39 , A61N1/3906 , A61N1/3912 , A61N1/3925
摘要： A method for determining an optimal transchest external defibrillation waveform which, when applied through a plurality of electrodes positioned on a patient's torso will produce a desired response in the patient's cardiac cell membranes. The method includes the steps of providing a quantitative model of a defibrillator circuit for producing external defibrillation waveforms, the quantitative model of a patient includes a chest component, a heart component, a cell membrane component and a quantitative description of the desired cardiac membrane response function. Finally, a quantitative description of a transchest external defibrillation waveform that will produce the desired cardiac membrane response function is computed. The computation is made as a function of the desired cardiac membrane response function, the patient model and the defibrillator circuit model.
摘要翻译：一种用于确定最佳交织外部除颤波形的方法，当通过位于患者躯体上的多个电极施加时，其将在患者的心脏细胞膜中产生期望的响应。该方法包括提供用于产生外部除颤波形的除颤器电路的定量模型的步骤，患者的定量模型包括胸部组分，心脏组分，细胞膜组分和所需心脏膜响应函数的定量描述。最后，计算将产生期望的心脏膜响应函数的经外科除颤波形的定量描述。作为所需心脏膜响应函数，患者模型和除颤器电路模型的函数进行计算。

65. 发明授权

US5709215A R-wave detection method for implantable cardioverter defibrillators 失效
标题翻译：用于植入式心律转复除颤器的R波检测方法
公开(公告)号：US5709215A
公开(公告)日：1998-01-20
申请号：US524391
申请日：1995-09-06
申请人： Joseph S. Perttu , Dennis A. Brumwell , James E. Brewer , Theodore P. Adams
发明人： Joseph S. Perttu , Dennis A. Brumwell , James E. Brewer , Theodore P. Adams
IPC分类号： A61B5/0456 , A61N1/39
CPC分类号： A61B5/0456 , A61B5/7207 , A61N1/3931
摘要： An ICD detection method for sensing the occurrence of an R-wave improves the ability to distinguish R-waves from noise through the use of variable declining sensitivity thresholds. The method includes the consideration of the amplitude of at least the previous most recent R-wave to determine a declining threshold of sensitivity used to recognize a subsequent electrical signal as an R-wave. In the method, the amplitude of the previous R-wave may be classified, based upon amplitude, and based upon the classification, a desirable time constant for the declining threshold of sensitivity is provided as an exponential or reverse exponential decay. Alternatively, a piece wise use of various decay formulas may be combined and used to avoid false recognition of noise as an R-wave.
摘要翻译：用于感测R波的发生的ICD检测方法通过使用可变下降的灵敏度阈值来提高区分R波与噪声的能力。该方法包括考虑至少先前最近的R波的振幅，以确定用于将后续电信号识别为R波的灵敏度下降阈值。在该方法中，先前R波的振幅可以基于振幅进行分类，并且基于分类，灵敏度下降阈值的期望时间常数被提供为指数或反指数衰减。或者，可以组合并且使用各种衰减公式的分段使用来避免作为R波的噪声的错误识别。

66. 发明授权

US5705812A Compaction monitoring instrument system 失效
标题翻译：压实监测仪系统
公开(公告)号：US5705812A
公开(公告)日：1998-01-06
申请号：US656503
申请日：1996-05-31
申请人： James E. Brewer , Richard R. Pemper , Izhar Ahmad , Randy Gold
发明人： James E. Brewer , Richard R. Pemper , Izhar Ahmad , Randy Gold
IPC分类号： E21B47/00 , E21B47/01 , E21B47/09 , E21B49/00 , G01V5/04 , G01V5/00
CPC分类号： E21B49/006 , E21B47/00 , E21B47/01 , E21B47/0905 , E21B49/00
摘要： An apparatus and method for detecting the location of subsurface markers in a formation proximate to a borehole. The apparatus includes marker detectors in a housing having at least two housing sections attached in an initial orientation. The distance between the detectors is measured under controlled conditions with a calibration bar. The initial attached orientation between the housing sections is identified with a calibrator, and deviations from the initial attached orientation are identified by the calibrator after the housing sections are detached and reattached. The calibrator permits well site corrections to be made to the housing sections without recalibration. Gauges permit corrections for temperature and pressure fluctuations, and the corrected distances between the housing detectors is computed. Detectors in the housing generate signals when each detector is proximate to a marker in the formation, and such signals can be processed to identify the elevation of a marker in the borehole, or the distance between markers in the borehole, to determine formation compaction or settlement. In an apparatus having two detectors separated by a spacer, flexible retainers can be positioned between each detector and the spacer to permit thermal expansion or contraction of the detectors relative to the spacer.
摘要翻译：一种用于检测靠近钻孔的地层中地下标记的位置的装置和方法。该装置包括在壳体中的标记检测器，其具有以初始取向附接的至少两个壳体部分。检测器之间的距离在受控条件下用校准条进行测量。在壳体部分之间的初始附接取向由校准器识别，并且在拆卸和重新连接壳体部分之后，通过校准器识别与初始附接取向的偏差。校准器允许在不重新校准的情况下对外壳部分进行良好的现场校正。仪表允许校正温度和压力波动，并且计算外壳检测器之间的校正距离。当每个检测器接近地层中的标记物时，壳体中的探测器产生信号，并且可以处理这些信号以识别井眼中的标记物的高度或井眼中的标记之间的距离，以确定地层压实或沉降。在具有由隔离物隔开的两个检测器的设备中，柔性保持器可以位于每个检测器和间隔件之间，以允许检测器相对于间隔件的热膨胀或收缩。

67. 发明授权

US5643323A System and method inducing fibrillation using an implantable defibrillator 失效
标题翻译：使用可植入除颤器诱导原纤维颤动的系统和方法
公开(公告)号：US5643323A
公开(公告)日：1997-07-01
申请号：US486761
申请日：1995-06-07
申请人： Mark W. Kroll , James E. Brewer
发明人： Mark W. Kroll , James E. Brewer
IPC分类号： A61N1/38 , A61N1/362
CPC分类号： A61N1/385
摘要： A method and apparatus for inducing fibrillation generates a continuous fibrillation waveform from the internal battery source of an implantable cardioverter defibrillator. The continuous fibrillation waveform has a voltage of at least 5 volts and not more than 50 volts and a duration of not less than 500 milliseconds and is applied though the at least two implantable electrodes so as to induce fibrillation in the heart of the human patient.
摘要翻译：用于诱导原纤维颤动的方法和装置从可植入式心律转复除颤器的内部电池源产生连续原纤颤波形。连续原纤化波形具有至少5伏且不大于50伏特的电压，并且持续时间不少于500毫秒，并且通过至少两个可植入电极施加，以便在人类患者的心脏中诱发原纤维颤动。

68. 发明授权

US5534015A Method and apparatus for generating biphasic waveforms in an implantable defibrillator 失效
标题翻译：用于在可植入除颤器中产生双相波形的方法和装置
公开(公告)号：US5534015A
公开(公告)日：1996-07-09
申请号：US321540
申请日：1994-10-11
申请人： Mark W. Kroll , James E. Brewer
发明人： Mark W. Kroll , James E. Brewer
IPC分类号： A61N1/39 , H01M2/10 , H01M16/00
CPC分类号： A61N1/3956 , A61N1/3906 , A61N1/3912 , H01M16/00 , H01M2/1066
摘要： An implantable defibrillator system for generating biphasic waveforms comprises a self-contained human implantable housing containing a capacitor system for storing an electrical charge, a power supply for charging the capacitor system, and a controller for selectively discharging the electrical charge as a biphasic countershock to be delivered through at least two electrodes in response to a sensing of a cardiac dysrhythmia in the human patient. The controller includes a system for controlling a first duration of a first phase of the biphasic countershock such that the discharge of the electrical charge is of a first polarity and the first duration is variable and a system for controlling a second duration of a second phase of the biphasic countershock such that the discharge of the electrical charge is of a second polarity that is opposite from the first polarity and the second duration is fixed.
摘要翻译：用于产生双相波形的可植入除颤器系统包括：包含用于存储电荷的电容器系统的独立人类可植入壳体，用于对电容器系统充电的电源以及用于将电荷选择性地放电为两相反相的控制器响应于人类患者心脏心律失常的感测，通过至少两个电极递送。控制器包括用于控制双相反冲的第一相位的第一持续时间的系统，使得电荷的放电具有第一极性，并且第一持续时间是可变的，并且用于控制第二相的第二持续时间的系统两相反相，使得电荷的放电具有与第一极性相反的第二极性，并且第二持续时间是固定的。

69. 发明授权

US5255324A Digitally controlled audio amplifier with voltage limiting 失效
标题翻译：带电压限制的数字音频放大器
公开(公告)号：US5255324A
公开(公告)日：1993-10-19
申请号：US633919
申请日：1990-12-26
申请人： James E. Brewer , Peter S. Abowd , Frank W. Raffaeli
发明人： James E. Brewer , Peter S. Abowd , Frank W. Raffaeli
IPC分类号： H03G9/02 , H03G11/00 , H03G3/00 , H03G9/00
CPC分类号： H03G9/005 , H03G11/00 , H03G9/02
摘要： An audio system employs a microcontroller to supervise the operation of an audio system including a digitally controlled audio processor which controls at least a wideband and a narrowband gain for the audio signal. The narrowband gain may preferably comprise a bass boost to the audio signal. Clipping distortion of the audio signal is avoided by sensing clipping in a power amplifier and reducing the digital commands for the wideband gain and the narrowband gain according to a method which reduces narrowband gain in preference to the wideband gain. After the narrowband gain is reduced to a predetermined gain, the wideband gain may be reduced if clipping persists. When clipping ceases, the narrowband gain is likewise restored to its original gain in preference to restoring of the wideband gain.
摘要翻译：音频系统采用微控制器来监督音频系统的操作，包括数字控制的音频处理器，该音频处理器至少控制音频信号的宽带和窄带增益。窄带增益可以优选地包括对音频信号的低音提升。通过感测功率放大器中的限幅并且根据减小窄带增益优先于宽带增益的方法减少用于宽带增益和窄带增益的数字命令来避免音频信号的剪切失真。在窄带增益减小到预定增益之后，如果削波持续，则宽带增益可能会降低。当削波停止时，窄带增益同样恢复到其原始增益，优于恢复宽带增益。

70. 发明授权

US5188116A Electrocardiographic method and device 失效
标题翻译：电磁学方法与装置
公开(公告)号：US5188116A
公开(公告)日：1993-02-23
申请号：US662578
申请日：1991-02-28
申请人： Mark R. Pommrehn , James E. Brewer , Mark W. Kroll
发明人： Mark R. Pommrehn , James E. Brewer , Mark W. Kroll
IPC分类号： A61B5/0452 , A61B5/0456
CPC分类号： A61B5/04525 , A61B5/0456
摘要： A method and apparatus for detecting heart disease from an electrocardiogram (ECG) is disclosed. The method comprises the steps of acquiring the ECG signals, correcting for signal variability caused by breathing, and calculating the level of remaining variability due to myocardial function. The apparatus comprises a signal input system, a storage system, a microprocessor and an output system. The microprocessor has program logic for processing signal data in accordance with the above method.
摘要翻译：公开了一种从心电图（ECG）检测心脏病的方法和装置。该方法包括以下步骤：获取ECG信号，校正由呼吸引起的信号变异性，以及计算由于心肌功能引起的剩余变异性水平。该装置包括信号输入系统，存储系统，微处理器和输出系统。微处理器具有根据上述方法处理信号数据的程序逻辑。

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