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61. 发明申请

US20120097058A1 Multiplexed Biomolecule Arrays Made By Polymer Pen Lithography 审中-公开
标题翻译：由聚合物笔平版印刷制成的复用生物分子阵列
公开(公告)号：US20120097058A1
公开(公告)日：2012-04-26
申请号：US13263760
申请日：2010-04-23
申请人： Chad A. Mirkin , Fengwei Huo , Zijian Zheng , Louise R. Giam , Weston L. Daniel
发明人： Chad A. Mirkin , Fengwei Huo , Zijian Zheng , Louise R. Giam , Weston L. Daniel
IPC分类号： B41F33/00 , B42D15/00
CPC分类号： B01J19/0046 , B01J2219/00387 , B01J2219/00533 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00626 , B01J2219/00637 , B01J2219/00662 , B01J2219/00725 , B81C1/00206
摘要： Methods of patterning multiple biomolecules on a surface are disclosed. The method includes inking a polymer pen array, where tips are inked with selected inks comprising the biomolecules, and transferring the biomolecules to a surface using a polymer pen lithography technique. Methods of using the multiple patterned biomolecules on a surface are also disclosed.
摘要翻译：公开了在表面上构图多个生物分子的方法。该方法包括着墨聚合物笔阵列，其中尖端用包含生物分子的所选油墨着墨，并使用聚合物笔光刻技术将生物分子转移到表面。还公开了在表面上使用多个图案化的生物分子的方法。

62. 发明申请

US20120006674A1 ENERGY TRANSFER THROUGH SURFACE PLASMON RESONANCE EXCITATION ON MULTISEGMENTED NANOWIRES 审中-公开
标题翻译：通过表面等离子体共振激发在多种纳米级纳米粒子上的能量转移
公开(公告)号：US20120006674A1
公开(公告)日：2012-01-12
申请号：US13037942
申请日：2011-03-01
申请人： Chad A. Mirkin , Wei Wei , Lidong Qin , Can Xue , Jill E. Millstone , Xiaoyang Xu
发明人： Chad A. Mirkin , Wei Wei , Lidong Qin , Can Xue , Jill E. Millstone , Xiaoyang Xu
IPC分类号： C01B21/36 , C01B13/00 , C07D301/03 , C01B31/18 , C01B31/20
CPC分类号： B01J35/004 , B01J23/42 , B01J23/48 , B01J23/50 , B01J23/52 , B01J35/06 , B82Y20/00 , B82Y30/00 , B82Y40/00 , C01B3/042 , Y02E60/364 , Y02P20/134
摘要： Disclosed herein is energy transfer on multisegmented nanowires via surface plasmon resonance excitation of visible light, such as solar energy, absorbed by metals sensitive to visible light and transferred to metals insensitive to visible light. The nanowires are prepared with controllable gap sizes between different segments by on-wire lithography (OWL).
摘要翻译：本文公开的是通过对可见光的表面等离子体共振激发（例如由对可见光敏感的金属吸收的太阳能）转移到对可见光不敏感的金属的多分段纳米线的能量转移。通过在线光刻（OWL）在不同的片段之间制备具有可控的间隙尺寸的纳米线。

63. 发明授权

US08012400B2 Surface and site-specific polymerization by direct-write lithography 失效
标题翻译：通过直写光刻技术进行表面和位点特异性聚合
公开(公告)号：US08012400B2
公开(公告)日：2011-09-06
申请号：US11966764
申请日：2007-12-28
申请人： Chad A. Mirkin , Xiaogang Liu , Shouwu Guo
发明人： Chad A. Mirkin , Xiaogang Liu , Shouwu Guo
IPC分类号： B29C35/08
CPC分类号： G03F7/0002 , G01Q80/00 , G03F7/2049 , H01J2237/31738 , Y10S977/857 , Y10S977/882 , Y10S977/897
摘要： Polymeric microstructures and nanostructures can be prepared with use of a tip to pattern a surface. A tip can be used to pattern a structure which can initiate polymerization. The structure can be then exposed to monomer to induce polymerization at the structure. Alternatively, a tip can be used to pattern a surface with a monomer in which the surface is treated with polymerization catalyst so that polymerization occurs at the patterning site. Ring-opening metathesis polymerization can be carried out with use of the tip to control the polymerization. The tip can be a sharp tip as used in for example an atomic force microscope tip. Norbornene types of monomers can be used. Biological macromolecules can be also prepared.
摘要翻译：可以使用尖端来制备聚合物微结构和纳米结构以对表面进行图案化。尖端可用于图案化可引发聚合的结构。然后将该结构暴露于单体以在结构处引发聚合。或者，可以使用尖端来用表面用聚合催化剂处理的单体对表面进行图案化，使得在图案化位点发生聚合。可以使用尖端进行开环易位聚合以控制聚合。尖端可以是例如原子力显微镜尖端中使用的尖锐尖端。可以使用降冰片烯类型的单体。还可制备生物大分子。

64. 发明申请

US20110165341A1 BLOCK COPOLYMER-ASSISTED NANOLITHOGRAPHY 审中-公开
标题翻译：嵌段共聚物辅助纳米尺度
公开(公告)号：US20110165341A1
公开(公告)日：2011-07-07
申请号：US12959105
申请日：2010-12-02
申请人： Chad A. Mirkin , Jinan Chai , Fengwei Huo , Zijian Zheng , Louise R. Giam
发明人： Chad A. Mirkin , Jinan Chai , Fengwei Huo , Zijian Zheng , Louise R. Giam
IPC分类号： B05D5/00 , B05D1/28 , B05D3/10 , B82Y40/00 , B82Y99/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00
摘要： In accordance with an embodiment of the disclosure, a method for forming submicron size nanostructures on a substrate surface includes contacting a substrate with a tip coated with an ink comprising a block copolymer matrix and a nanostructure precursor to form a printed feature comprising the block copolymer matrix and the nanostructure precursor on the substrate, and reducing the nanostructure precursor of the printed feature to form a nanostructure having a diameter (or line width) of less than 1 μm.
摘要翻译：根据本公开的实施例，用于在衬底表面上形成亚微米级纳米结构的方法包括使基底与涂覆有包含嵌段共聚物基质和纳米结构前体的油墨的末端接触，以形成包含嵌段共聚物基质和纳米结构前体，并且还原印刷特征的纳米结构前体以形成直径（或线宽）小于1μm的纳米结构。

65. 发明申请

US20110165329A1 Force Feedback Leveling of Tip Arrays for Nanolithography 有权
标题翻译：用于纳米光刻的尖端阵列的力反馈调平
公开(公告)号：US20110165329A1
公开(公告)日：2011-07-07
申请号：US12960439
申请日：2010-12-03
申请人： Chad A. Mirkin , Xing Liao , Adam B. Braunschweig
发明人： Chad A. Mirkin , Xing Liao , Adam B. Braunschweig
IPC分类号： B05D5/00 , B05D1/28 , G01L1/06 , B82Y99/00
CPC分类号： G03F7/0002
摘要： A method of leveling a polymer pen array includes contacting a pen array with a surface and measuring a total force exerted on the surface by the pen array, the pen array being disposed at a first angle with respect to a first axis of the surface and a second angle with respect to a second axis of the surface; tilting one or both of the pen array and the surface to vary the first and second angles of the pen array with respect to the surface; measuring the total force exerted by the tilted pen array on the surface; and repeating the tilting and measuring steps until a global maximum of the total force exerted on the surface by the pen array is measured, thereby determining first and second angles which correspond to a leveled position of the pen array with respect to the surface.
摘要翻译：调整聚合物笔阵列的方法包括使笔阵列与表面接触并且通过笔阵列测量施加在表面上的总力，笔阵列相对于表面的第一轴线以第一角度设置，相对于表面的第二轴线的第二角度; 倾斜笔阵列和表面中的一个或两个以改变笔阵列相对于表面的第一和第二角度; 测量由倾斜笔阵列施加在表面上的总力; 并且重复倾斜和测量步骤，直到测量由笔阵列施加在表面上的总力的全局最大值，从而确定对应于笔阵列相对于表面的调平位置的第一和第二角度。

66. 发明授权

US07951334B2 Direct write nanolithographic deposition of nucleic acids from nanoscopic tips 有权
标题翻译：从纳米尖端直接写入纳米光刻的核酸
公开(公告)号：US07951334B2
公开(公告)日：2011-05-31
申请号：US12044738
申请日：2008-03-07
申请人： Chad A. Mirkin , Linette Demers , David S. Ginger
发明人： Chad A. Mirkin , Linette Demers , David S. Ginger
IPC分类号： B01L3/02
CPC分类号： G03F7/0002 , G01Q80/00 , Y10T436/2575
摘要： The use of direct-write nanolithography to generate anchored, nanoscale patterns of nucleic acid on different substrates is described, including electrically conductive and insulating substrates. Modification of nucleic acid, including oligonucleotides, with reactive groups such as thiol groups provides for patterning with use of appropriate scanning probe microscopic tips under appropriate conditions. The reactive groups provide for chemisorption or covalent bonding to the substrate surface. The resulting nucleic acid features, which exhibit good stability, can be hybridized with complementary nucleic acids and probed accordingly with use of, for example, nanoparticles functionalized with nucleic acids. Patterning can be controlled by selection of tip treatment, relative humidity, and nucleic acid structure.
摘要翻译：描述了使用直写式纳米光刻技术在不同基底上产生锚定的纳米级核酸图案，包括导电和绝缘基底。含有反应性基团如硫醇基团的核酸（包括寡核苷酸）的修饰使得在合适的条件下使用合适的扫描探针显微镜尖端进行图案化。反应性基团提供化学吸附或共价结合到基底表面。所得到的表现出良好稳定性的核酸特征可与互补核酸杂交，并使用例如用核酸官能化的纳米颗粒进行相应的探测。可以通过选择尖端处理，相对湿度和核酸结构来控制图案化。

67. 发明申请

US20110033940A1 CLICK CHEMISTRY, MOLECULAR TRANSPORT JUNCTIONS, AND COLORIMETRIC DETECTION OF COPPER 审中-公开
标题翻译：点击化学，分子运输和铜色检测
公开(公告)号：US20110033940A1
公开(公告)日：2011-02-10
申请号：US12696638
申请日：2010-01-29
申请人： Chad A. Mirkin , Xiaodong Chen , Adam B. Braunschweig , Michael J. Wiester , Xiaoyang Xu , Weston L. Daniel
发明人： Chad A. Mirkin , Xiaodong Chen , Adam B. Braunschweig , Michael J. Wiester , Xiaoyang Xu , Weston L. Daniel
IPC分类号： G01N33/50 , H01B1/12
CPC分类号： G01N33/5308 , G01N33/54346
摘要： Click chemistry is used to construct molecular transport junctions (MTJs) through assembly of a molecular wire across a nanogap formed between two electrodes. Also disclosed are methods of using click chemistry and oligonucleotide-modified nanoparticles to detect the presence of copper in a sample.
摘要翻译：点击化学被用于通过在两个电极之间形成的纳米隙组装分子线来构建分子转运结（MTJ）。还公开了使用点击化学和寡核苷酸修饰的纳米颗粒来检测样品中铜的存在的方法。

68. 发明申请

US20100291707A1 Multiplexed Scanometric Assay for Target Molecules 审中-公开
标题翻译：目标分子的多重扫描测定
公开(公告)号：US20100291707A1
公开(公告)日：2010-11-18
申请号：US12770488
申请日：2010-04-29
申请人： Chad A. Mirkin , Dongwoo Kim , Weston L. Daniel
发明人： Chad A. Mirkin , Dongwoo Kim , Weston L. Daniel
IPC分类号： G01N33/50
CPC分类号： G01N33/54346 , G01N33/54393 , G01N33/553
摘要： The present invention is directed to compositions and methods of use of a functionalized nanoparticle having a catalytic metal deposit.
摘要翻译：本发明涉及使用具有催化金属沉积物的官能化纳米颗粒的组合物和方法。

69. 发明申请

US20100167290A1 MOLECULE ATTACHMENT TO NANOPARTICLES 审中-公开
标题翻译：分子与纳米颗粒的连接
公开(公告)号：US20100167290A1
公开(公告)日：2010-07-01
申请号：US12527623
申请日：2008-02-27
申请人： Robert Elghanian , Chad A. Mirkin
发明人： Robert Elghanian , Chad A. Mirkin
IPC分类号： C12Q1/68 , C07H21/00 , C07K14/00 , C07K9/00 , C07K16/00 , G01N33/553
CPC分类号： C12Q1/6876 , G01N33/5432
摘要： Disclosed herein are molecule-modified nanoparticles and methods of making and using the same. More specifically, disclosed herein are molecule-modified nanoparticles wherein the molecule is attached to the surface of the nanoparticle via an oligonucleotide. Also disclosed are methods of preparing nanoparticles having oligonucleotides and molecules (e.g., biomolecules, such as proteins, peptides, antibodies, lipids, and/or carbohydrates) attached to the nanoparticle surface, wherein the oligonucleotide and molecule are covalently attached. Further disclosed are methods of detecting an analyte of interest using these disclosed molecule-modified nanoparticles.
摘要翻译：本文公开了分子修饰的纳米颗粒及其制备和使用方法。更具体地，本文公开了分子修饰的纳米颗粒，其中分子经由寡核苷酸连接到纳米颗粒的表面。还公开了制备与寡核苷酸和分子（例如生物分子，如蛋白质，肽，抗体，脂质和/或碳水化合物）连接在纳米颗粒表面上的纳米颗粒的方法，其中寡核苷酸和分子是共价连接的。进一步公开的是使用这些公开的分子修饰的纳米颗粒检测感兴趣分析物的方法。

70. 发明授权

US07722928B2 Nanolithography methods and products therefor and produced thereby 有权
标题翻译：纳米光刻方法和产品，由此生产
公开(公告)号：US07722928B2
公开(公告)日：2010-05-25
申请号：US11100483
申请日：2005-04-07
申请人： Chad A. Mirkin , Seunghun Hong , Vinayak P. Dravid
发明人： Chad A. Mirkin , Seunghun Hong , Vinayak P. Dravid
IPC分类号： B05D5/00 , B05D1/36 , B05D7/24 , B01J19/08 , C12Q1/68 , C12P19/34
CPC分类号： G03F7/0002 , B05D1/007 , B05D1/185 , B05D1/26 , B82B3/00 , G01Q80/00 , G03F7/165 , Y10S977/85 , Y10S977/857 , Y10S977/86 , Y10S977/862 , Y10S977/863 , Y10S977/878 , Y10S977/882 , Y10S977/884 , Y10S977/885 , Y10S977/886
摘要： In one aspect, a method of nanolithography is provided using a driving force to control the movement of a deposition compound from a scanning probe microscope tip to a substrate. Another aspect of the invention provides a tip for use in nanolithography having an internal cavity and an aperture restricting movement of a deposition compound from the tip to the substrate. The rate and extent of movement of the deposition compound through the aperture is controlled by a driving force.
摘要翻译：一方面，使用驱动力来提供纳米光刻的方法，以控制沉积化合物从扫描探针显微镜尖端到基底的移动。本发明的另一方面提供了一种用于纳米光刻的尖端，其具有内腔和限制沉积化合物从尖端到基底的运动的孔。沉积化合物通过孔的运动速度和程度由驱动力控制。

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