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61. 发明授权

US09074229B2 Variants of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase 有权
标题翻译：编码甘油醛-3-磷酸脱氢酶的间隙基因的启动子的变体
公开(公告)号：US09074229B2
公开(公告)日：2015-07-07
申请号：US14607177
申请日：2015-01-28
申请人： Alexander Reth , Brigitte Bathe , Stephan Hans , Wilfried Claes
发明人： Alexander Reth , Brigitte Bathe , Stephan Hans , Wilfried Claes
IPC分类号： C12P13/06 , C12P13/08 , C12P13/04 , C12P13/10 , C12N15/77 , C12N9/02
CPC分类号： C12P13/08 , C12N9/0008 , C12N15/77 , C12P13/04 , C12P13/06 , C12P13/10
摘要： The invention relates to an isolated polynucleotide having promoter activity, a variant of the promoter of the gap gene coding for glyceraldehyde-3-phosphate dehydrogenase; and to a microorganism which produces and/or secretes a fine chemical, the microorganism including the isolated polynucleotide having promoter activity, which enables various genes to be overexpressed in comparison with the particular starting strain; and to a process for preparing fine chemicals using the microorganism.
摘要翻译：本发明涉及具有启动子活性的分离的多核苷酸，编码甘油醛-3-磷酸脱氢酶的间隙基因的启动子的变体; 以及产生和/或分泌精细化学物质的微生物，所述微生物包括具有启动子活性的分离的多核苷酸，其使各种基因与特定的起始菌株相比过表达; 以及使用微生物制备精细化学品的方法。

62. 发明授权

US08592177B2 Process for the fermentative preparation of organic chemical compounds using Coryneform bacteria in which the sugR gene is present in attenuated form 有权
标题翻译：使用棒状细菌发酵制备有机化合物的方法，其中sugR基因以减毒形式存在
公开(公告)号：US08592177B2
公开(公告)日：2013-11-26
申请号：US13355531
申请日：2012-01-21
申请人： Brigitte Bathe , Georg Thierbach , Volker Wendisch , Verena Engels , Bernhard Eikmanns , Bastian Blombach
发明人： Brigitte Bathe , Georg Thierbach , Volker Wendisch , Verena Engels , Bernhard Eikmanns , Bastian Blombach
IPC分类号： C12P13/04 , C12P13/08 , C12P13/06 , C12P1/00 , C12N1/21
CPC分类号： C12P13/08 , C12P13/06 , C12P13/10
摘要： The invention relates to a recombinant coryneform bacterium which secretes an organic chemical compound and in which the sugR gene which codes for a polypeptide having the activity of an SugR regulator has been attenuated. The invention further relates to a processes for using this bacterium for the fermentative preparation of organic chemical compounds.
摘要翻译：本发明涉及分泌有机化合物的重组棒状细菌，其中编码具有SugR调节剂活性的多肽的sugR基因已被减弱。本发明还涉及使用该细菌用于有机化合物的发酵制剂的方法。

63. 发明授权

US08293514B2 Alleles of the rel gene from coryneform bacteria 有权
标题翻译：来自棒状细菌的rel基因的等位基因
公开(公告)号：US08293514B2
公开(公告)日：2012-10-23
申请号：US12781230
申请日：2010-05-17
申请人： Brigitte Bathe , Caroline Kreutzer , Georg Thierbach
发明人： Brigitte Bathe , Caroline Kreutzer , Georg Thierbach
IPC分类号： C12N9/12
CPC分类号： C12P13/08 , A23L33/135 , A23L33/175 , C12N9/1235 , C12P13/04
摘要： An isolated mutant of a coryneform bacterium comprising a gene coding for a polypeptide having GTP-pyrophosphate kinase activity, wherein said polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids other than L-proline is present in position 38 or a corresponding or comparable position. In addition, an isolated polynucleotide encoding a polypeptide having GTP-pyrophosphate kinase enzyme activity, a vector comprising the isolated polynucleotide, a recombinant microorganism comprising the vector, and a process for preparing the recombinant coryneform bacterium is described. A method for over-expressing a GTP-pyrophosphate kinase, a method of preparing an L-amino acid, an L-lysine comprising and L-tryptophan comprising feed is also described.
摘要翻译：棒状细菌的分离突变体，其包含编码具有GTP-焦磷酸激酶活性的多肽的基因，其中所述多肽包含氨基酸序列，其中除了L-脯氨酸以外的蛋白原氨基酸之一存在于位置38或相应的或相当的地位。此外，描述了编码具有GTP焦磷酸激酶酶活性的多肽的分离的多核苷酸，包含分离的多核苷酸的载体，包含载体的重组微生物和制备重组棒状杆菌型细菌的方法。还描述了过表达GTP焦磷酸激酶的方法，制备L-氨基酸的方法，包含L-赖氨酸的L-赖氨酸和包含L-色氨酸的饲料。

64. 发明申请

US20090311758A1 PROCESS FOR PREPARING L-AMINO ACIDS 有权
标题翻译：制备L-氨基酸的方法
公开(公告)号：US20090311758A1
公开(公告)日：2009-12-17
申请号：US12468512
申请日：2009-05-19
申请人： Nadja Jessberger , Andreas Burkovski , Brigitte Bathe , Alexander Reth
发明人： Nadja Jessberger , Andreas Burkovski , Brigitte Bathe , Alexander Reth
IPC分类号： C12P13/08 , C12N1/21 , C12P13/04 , C12N15/74 , C07H21/04
CPC分类号： C12N15/77 , C07K14/34 , C12P13/04 , C12P13/08
摘要： A process for preparing L-amino acids employing coryneform bacteria in which the AmtR regulator has been attenuated is provided. Recombinant bacteria, polynucleotides and vectors corresponding to or having the attenuated AmtR regulator are disclosed.
摘要翻译：提供了使用其中AmtR调节剂已被减毒的棒状细菌制备L-氨基酸的方法。公开了对应于或具有衰减的AmtR调节剂的重组细菌，多核苷酸和载体。

65. 发明授权

US07306932B2 Coryneform bacteria with altered glucokinase activity in the production of L-lysine 有权
标题翻译：在L-赖氨酸生产中具有改变的葡萄糖激酶活性的棒状细菌
公开(公告)号：US07306932B2
公开(公告)日：2007-12-11
申请号：US10498889
申请日：2002-11-07
申请人： Brigitte Bathe , Stephan Hans , Caroline Reynen
发明人： Brigitte Bathe , Stephan Hans , Caroline Reynen
IPC分类号： C07H21/02 , C12P23/00 , C12N15/00 , C12N1/12
CPC分类号： C12N9/1205 , C12P13/08
摘要： The invention relates to alleles of the glk gene from coryneform bacteria coding for glucokinases, and to processes for the production of L-lysine by fermentation using bacteria containing such alleles.
摘要翻译：本发明涉及编码葡萄糖激酶的棒状细菌的glk基因的等位基因，以及使用含有这种等位基因的细菌通过发酵生产L-赖氨酸的方法。

66. 发明申请

US20070259408A1 Method for producing L-amino acids using the GAP promoter 审中-公开
标题翻译：使用GAP启动子产生L-氨基酸的方法
公开(公告)号：US20070259408A1
公开(公告)日：2007-11-08
申请号：US11783061
申请日：2007-04-05
申请人： Brigitte Bathe , Wilfried Claes , Stephan Hans
发明人： Brigitte Bathe , Wilfried Claes , Stephan Hans
IPC分类号： C12P13/08 , C12P13/06 , C12P13/12
CPC分类号： C12P13/08 , C12P13/06 , C12P13/12
摘要： The present invention is directed to bacteria which contain a lysCFBR that encodes a feedback resistant aspartokinase enzyme and whose expression is under the control of a gleceraldehyde-3-phosphate dehydrogenase (gap) promoter. The bacteria may be used in the fermentative production of L-amino acids, especially, L-lysine.
摘要翻译：本发明涉及含有编码反馈性天冬氨酸激酶并且其表达在格隆醛-3-磷酸脱氢酶（间隙）启动子控制下的lysCFBR的细菌。细菌可用于发酵生产L-氨基酸，特别是L-赖氨酸。

67. 发明授权

US07135313B2 Method for producing L-lysine or L-lysine containing feed additives with a cornebacteria containing a mutated lysC 有权
标题翻译：含有含有突变型lysC的角膜细菌的含L-赖氨酸或含L-赖氨酸的饲料添加剂的方法
公开(公告)号：US07135313B2
公开(公告)日：2006-11-14
申请号：US10865813
申请日：2004-06-14
申请人： Brigitte Bathe , Stephen Hans
发明人： Brigitte Bathe , Stephen Hans
IPC分类号： C12P13/08 , C12N9/10 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/12 , C07H21/04
摘要： Alleles of the lysC gene from corynebacteria that code for desensitized aspartokinases, and to processes for the preparation of L-lysine using bacteria containing these alleles.
摘要翻译：来自编码脱敏天冬氨酸激酶的棒状杆菌的lysC基因的等位基因，以及使用含有这些等位基因的细菌制备L-赖氨酸的方法。

68. 发明申请

US20060134761A1 Nucleotide sequences coding for the LuxR gene 失效
标题翻译：编码LuxR基因的核苷酸序列
公开(公告)号：US20060134761A1
公开(公告)日：2006-06-22
申请号：US11020188
申请日：2004-12-27
申请人： Bettina Moeckel , Caroline Kreutzer , Brigitte Bathe
发明人： Bettina Moeckel , Caroline Kreutzer , Brigitte Bathe
IPC分类号： C12P13/08 , C12N1/21
CPC分类号： C07K14/34 , C12P13/08
摘要： The present invention relates to polynucleotides corresponding to the luxR gene and which encode a LuxR transcriptional activator, methods of producing L-amino acids, and methods of screening for polynucleotides which encode proteins having LuxR transcriptional activation activity.
摘要翻译：本发明涉及对应于luxR基因并编码LuxR转录激活剂的多核苷酸，产生L-氨基酸的方法，以及筛选编码具有LuxR转录激活活性的蛋白质的多核苷酸的方法。

69. 发明授权

US06692946B2 Polynucleotides encoding the nadA gene and methods of producing nicotinic acid or nicotinic acid derivatives 失效
标题翻译：编码nadA基因的多核苷酸和产生烟酸或烟酸衍生物的方法
公开(公告)号：US06692946B2
公开(公告)日：2004-02-17
申请号：US09789599
申请日：2001-02-22
申请人： Christine Bastuck , Brigitte Bathe , Nicole Dusch , Bettina Moeckel , Georg Thierbach
发明人： Christine Bastuck , Brigitte Bathe , Nicole Dusch , Bettina Moeckel , Georg Thierbach
IPC分类号： C12N904
CPC分类号： C12N9/00 , C12P17/12
摘要： The present invention relates to polynucleotides corresponding to the nadA gene and which encode the quinolinate synthetase A protein, methods of producing nicotinic acid or nicotinic acid derivatives, and methods of screening for polynucleotides which encode proteins having quinolinate synthetase A activity.
摘要翻译：本发明涉及对应于nadA基因并编码喹啉酸合成酶A蛋白质的多核苷酸，产生烟酸或烟酸衍生物的方法，以及筛选编码具有喹啉酸合成酶A活性的蛋白质的多核苷酸的方法。

70. 发明授权

US09422568B2 Process for preparing L-amino acids 有权
标题翻译：制备L-氨基酸的方法
公开(公告)号：US09422568B2
公开(公告)日：2016-08-23
申请号：US14059900
申请日：2013-10-22
申请人： Nadja Jessberger , Andreas Burkovski , Brigitte Bathe , Alexander Reth
发明人： Nadja Jessberger , Andreas Burkovski , Brigitte Bathe , Alexander Reth
IPC分类号： C12N1/20 , C12N15/00 , C07H21/04 , C12N15/77 , C07K14/34 , C12P13/04 , C12P13/08
CPC分类号： C12N15/77 , C07K14/34 , C12P13/04 , C12P13/08
摘要： A process for preparing L-amino acids employing coryneform bacteria in which the AmtR regulator has been attenuated is provided. Recombinant bacteria, polynucleotides and vectors corresponding to or having the attenuated AmtR regulator are disclosed.
摘要翻译：提供了使用其中AmtR调节剂已被减毒的棒状细菌制备L-氨基酸的方法。公开了对应于或具有衰减的AmtR调节剂的重组细菌，多核苷酸和载体。

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