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61. 发明授权

US07550474B2 Substituted phenyl acetamides and their use as protease inhibitors 有权
标题翻译：取代苯乙酰胺及其作为蛋白酶抑制剂的用途
公开(公告)号：US07550474B2
公开(公告)日：2009-06-23
申请号：US10816544
申请日：2004-04-01
申请人： Kevin D. Kreutter , Lily Lee , Tianbao Lu , Venkatraman Mohan , Sharmila Patel , Hui Huang , Guozhang Xu , Mark Fitzgerald
发明人： Kevin D. Kreutter , Lily Lee , Tianbao Lu , Venkatraman Mohan , Sharmila Patel , Hui Huang , Guozhang Xu , Mark Fitzgerald
IPC分类号： A61K31/435 , C07D221/02 , C07D335/00 , C07D309/00 , C07C321/00
CPC分类号： C07D213/73 , C07C279/00 , C07C291/04 , C07D213/26 , C07D213/89 , C07D215/12 , C07D413/12 , C07D487/04
摘要： Phenyl acetamide compounds are described, including compounds of Formula I: or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R3-R6, R11, B, Y and W are set forth in the specification. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as thrombin and factor Xa. Compositions for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation are described. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents. Additionally, the compounds can be detectably labeled and employed for in vivo imaging of thrombi.
摘要翻译：描述了苯基乙酰胺化合物，包括式I化合物或其溶剂合物，水合物或其药学上可接受的盐; 其中R3-R6，R11，B，Y和W在说明书中列出。本发明的化合物是蛋白酶的有效抑制剂，特别是胰蛋白酶样的丝氨酸蛋白酶，如凝血酶和因子Xa。描述了抑制血小板损失，抑制血小板聚集体形成，抑制纤维蛋白形成，抑制血栓形成和抑制栓塞形成的组合物。本发明化合物的其它用途是作为凝血剂或者物理上连接于用于血液收集，血液循环和血液储存（例如导管，血液透析机，采血注射器和管）中使用的装置的制造中使用的材料的抗凝剂，血线和支架。另外，化合物可以被可检测地标记并用于血栓的体内成像。

62. 发明授权

US07452565B2 Immobilization of bead-displayed ligands on substrate surfaces 有权
标题翻译：珠显示的配体在基底表面上的固定
公开(公告)号：US07452565B2
公开(公告)日：2008-11-18
申请号：US10868451
申请日：2004-06-13
申请人： Sukanta Banerjee , Hui Huang
发明人： Sukanta Banerjee , Hui Huang
IPC分类号： B05D3/00
CPC分类号： C40B40/06 , B01J19/0046 , B01J2219/00317 , B01J2219/00466 , B01J2219/00497 , B01J2219/005 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , B01L3/5085 , C40B50/18
摘要： Disclosed are two different approaches for immobilization of beads on a substrate, one of which involves forming a bead-nanoparticle composite by cross-linking of the bead mixture with nanoparticles. The other method involves surface modification of the substrate, using multi-layered polyelectrolytes. With either method, the beads are immobilized on the substrate in a manner suitable for viewing, as when the beads are used in assays and need to be analyzed following the assay. Different designs of depressions are also disclosed, some of which are suitable for holding beads in place without any deposition of nanoparticles or polyelectrolytes.
摘要翻译：公开了用于将珠固定在基材上的两种不同方法，其中之一涉及通过珠粒混合物与纳米颗粒的交联形成珠粒纳米颗粒复合物。另一种方法是使用多层聚电解质对基材进行表面改性。使用任一种方法，珠子以适于观察的方式固定在底物上，就像在珠粒用于测定中一样，并且需要在测定之后进行分析时。还公开了不同的凹陷设计，其中一些适用于将珠保持在位，而不会沉积纳米颗粒或聚电解质。

63. 发明申请

US20070060578A1 5-Oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of c-fms kinase 失效
标题翻译：作为c-fms激酶的抑制剂的5-氧代-5,8-二氢 - 吡啶并 - 嘧啶
公开(公告)号：US20070060578A1
公开(公告)日：2007-03-15
申请号：US11519662
申请日：2006-09-12
申请人： Mark Player , Hui Huang , Hu Huaping
发明人： Mark Player , Hui Huang , Hu Huaping
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/519 , A61K31/4745 , A61K31/496 , C07D487/02 , C07D471/02
CPC分类号： C07D471/04
摘要： The invention addresses the current need for selective and potent protein tyrosine kinase inhibitors by providing potent inhibitors of c-fms kinase. The invention is directed to the novel compounds of Formula I: or a solvate, hydrate, tautomer or pharmaceutically acceptable salt thereof, wherein:W, A, Y, n, Z, and R102 are described in the specification.
摘要翻译：本发明通过提供c-fms激酶的有效抑制剂来解决当前对选择性和有效的蛋白酪氨酸激酶抑制剂的需要。本发明涉及新的式I化合物或其溶剂化物，水合物，互变异构体或其药学上可接受的盐，其中：W，A，Y，n，Z和R 102描述于规格。

64. 发明申请

US20050112277A1 Immobilization of bead-displayed ligands on substrate surfaces 有权
标题翻译：珠显示的配体在基底表面上的固定
公开(公告)号：US20050112277A1
公开(公告)日：2005-05-26
申请号：US10868451
申请日：2004-06-13
申请人： Sukanta Banerjee , Hui Huang
发明人： Sukanta Banerjee , Hui Huang
IPC分类号： B01L3/00 , B05D1/00 , B05D1/12 , B05D1/36 , B05D3/00 , B05D3/02 , B05D3/14 , B05D5/04 , B05D5/12 , C12Q20060101
CPC分类号： C40B40/06 , B01J19/0046 , B01J2219/00317 , B01J2219/00466 , B01J2219/00497 , B01J2219/005 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , B01L3/5085 , C40B50/18
摘要： Disclosed are two different approaches for immobilization of beads on a substrate, one of which involves forming a bead-nanoparticle composite by cross-linking of the bead mixture with nanoparticles. The other method involves surface modification of the substrate, using multi-layered polyelectrolytes. With either method, the beads are immobilized on the substrate in a manner suitable for viewing, as when the beads are used in assays and need to be analyzed following the assay. Different designs of depressions are also disclosed, some of which are suitable for holding beads in place without any deposition of nanoparticles or polyelectrolytes.
摘要翻译：公开了用于将珠固定在基材上的两种不同方法，其中之一涉及通过珠粒混合物与纳米颗粒的交联形成珠粒纳米颗粒复合物。另一种方法是使用多层聚电解质对基材进行表面改性。使用任一种方法，珠子以适于观察的方式固定在底物上，就像在珠粒用于测定中一样，并且需要在测定之后进行分析时。还公开了不同的凹陷设计，其中一些适用于将珠保持在位，而不会沉积纳米颗粒或聚电解质。

65. 发明授权

US09123906B2 Organic electroluminescence device and manufacturing method thereof 有权
标题翻译：有机电致发光元件及其制造方法
公开(公告)号：US09123906B2
公开(公告)日：2015-09-01
申请号：US13823044
申请日：2010-09-30
申请人： Mingjie Zhou , Ping Wang , Hui Huang , Xiaoming Feng
发明人： Mingjie Zhou , Ping Wang , Hui Huang , Xiaoming Feng
IPC分类号： H01L51/50 , H01L51/56 , H01L51/00
CPC分类号： H01L51/50 , H01L51/0036 , H01L51/5012 , H01L51/5088 , H01L51/5092 , H01L51/56
摘要： An organic electroluminescence device is provided. The device comprises an anode base layer (110), a hole injection layer (120) on the anode base layer (110), a light emitting layer (130) on the hole injection layer (120), and a cathode electrode layer (140) on the light emitting layer (130). The material of the hole injection layer (120) is metal oxide or thiophene type compound. The hole injection layer (120) has advantages of improving the recombination probability of electron-hole and not being easily oxidized, so that the efficiency of the organic electroluminescence device is increased and the service life is prolonged. A method for manufacturing the organic electroluminescence device is also provided.
摘要翻译：提供了一种有机电致发光器件。该器件包括阳极基底层（110），阳极基底层（110）上的空穴注入层（120），空穴注入层（120）上的发光层（130）和阴极电极层（140））在发光层（130）上。空穴注入层（120）的材料是金属氧化物或噻吩型化合物。空穴注入层（120）具有提高电子空穴的复合概率而不容易氧化的优点，有机电致发光元件的效率提高，使用寿命延长。还提供了一种制造有机电致发光器件的方法。

66. 发明申请

US20150028311A1 DOPED ORGANIC ELECTROLUMINESCENT DEVICE AND METHOD FOR PREPARING SAME 审中-公开
标题翻译：有机电致发光器件及其制备方法
公开(公告)号：US20150028311A1
公开(公告)日：2015-01-29
申请号：US14360922
申请日：2011-11-28
申请人： Mingjie Zhou , Ping Wabg , Hui Huang , Xiaoming Feng
发明人： Mingjie Zhou , Ping Wabg , Hui Huang , Xiaoming Feng
IPC分类号： H01L51/50 , H01L51/00 , H01L51/56
CPC分类号： H01L51/5096 , H01L51/002 , H01L51/0059 , H01L51/006 , H01L51/0061 , H01L51/007 , H01L51/0072 , H01L51/0081 , H01L51/0085 , H01L51/5012 , H01L51/5056 , H01L51/506 , H01L51/5072 , H01L51/5088 , H01L51/5092 , H01L51/56 , H01L2051/0063
摘要： Disclosed is a doped organic electroluminescent device, comprising the following structures laminated in succession: a conductive anode substrate, a hole injecting layer, a hole transportation layer, an electron barrier layer, a light-emitting layer, an electron transportation layer, an electron injecting layer and a cathode; and the material for the electron barrier layer is a hole transportation material doped with a cerium salt. The material for an electron barrier layer in such a doped organic electroluminescent device is a hole transportation material doped with a cerium salt which has a low work function of approximately −2.0 eV and can effectively block electrons. By doping the cerium salt having a low work function into the hole transportation material as the electron barrier layer, the LUMO energy level of the hole transportation material is greatly increased, thereby elevating the potential barrier between the electron barrier layer and the light-emitting layer, so that it is difficult for the electrons to transit to the side of the hole transportation layer and a good electron barrier effect is achieved. The present invention also provides a method for preparing the doped organic electroluminescent device.
摘要翻译：公开了一种掺杂有机电致发光器件，其包括以下结构：依次层压：导电阳极衬底，空穴注入层，空穴传输层，电子势垒层，发光层，电子传输层，电子注入层和阴极; 并且用于电子阻挡层的材料是掺杂有铈盐的空穴传输材料。这种掺杂的有机电致发光器件中的电子势垒层的材料是掺杂有铈盐的空穴传输材料，其具有大约-2.0eV的低功函数并且可以有效地阻挡电子。通过将具有低功函数的铈盐作为电子阻挡层掺杂到空穴传输材料中，空穴传输材料的LUMO能级大大增加，从而提高电子势垒层和发光层之间的势垒使得电子难以转移到空穴传输层的侧面并且实现良好的电子势垒效应。本发明还提供了一种制备掺杂有机电致发光器件的方法。

67. 发明申请

US20140326318A1 POLYMER SOLAR CELL DEVICE AND METHOD FOR PREPARING SAME 审中-公开
标题翻译：聚合物太阳能电池装置及其制备方法
公开(公告)号：US20140326318A1
公开(公告)日：2014-11-06
申请号：US14361007
申请日：2011-11-28
申请人： Mingjie Zhou , Ping Wang , Hui Huang , Jixing Chen
发明人： Mingjie Zhou , Ping Wang , Hui Huang , Jixing Chen
IPC分类号： H01L51/00 , H01L51/44
CPC分类号： H01L51/0037 , H01L51/0003 , H01L51/0036 , H01L51/0038 , H01L51/0047 , H01L51/0067 , H01L51/007 , H01L51/0072 , H01L51/4253 , H01L51/426 , H01L51/4273 , H01L51/44 , H01L2051/0063 , H01L2251/301 , Y02E10/549
摘要： Provided are a polymer solar cell (100) and a method for preparing the same. The solar cell (100) comprises the following structures: a conductive anode substrate (10), a hole buffer layer (20), an active layer (30), an electron transportation layer (40) and a cathode (50); and the material for the electron transportation layer (40) is an electron transportation material doped with a cerium salt and metal particles. The solar cell (100) effectively increases the rate of electron transportation, and decreases the potential barrier between the electron transportation layer (40) and the cathode (50).
摘要翻译：提供聚合物太阳能电池（100）及其制备方法。太阳能电池（100）包括以下结构：导电阳极基板（10），空穴缓冲层（20），有源层（30），电子传输层（40）和阴极（50）并且电子传输层（40）的材料是掺杂有铈盐和金属颗粒的电子传输材料。太阳能电池（100）有效地增加电子传输速率，并降低电子传输层（40）和阴极（50）之间的势垒。

68. 发明授权

US08871897B2 Amine-containing difluoro benzotriazolyl polymer, preparation method and use thereof 有权
标题翻译：含胺二氟苯并三唑基聚合物，其制备方法和用途
公开(公告)号：US08871897B2
公开(公告)日：2014-10-28
申请号：US14128707
申请日：2011-09-23
申请人： Mingjie Zhou , Ping Wang , Zhenhua Zhang , Hui Huang
发明人： Mingjie Zhou , Ping Wang , Zhenhua Zhang , Hui Huang
IPC分类号： C08G75/00 , H01L51/00 , C08G61/12 , H01L51/42
CPC分类号： H01L51/0043 , B82Y10/00 , C08G61/12 , C08G61/123 , C08G61/126 , C08G2261/1424 , C08G2261/146 , C08G2261/3162 , C08G2261/3223 , C08G2261/3227 , C08G2261/3241 , C08G2261/3327 , C08G2261/344 , C08G2261/364 , C08G2261/413 , C08G2261/91 , C08G2261/94 , C09B57/008 , C09B69/105 , C09B69/109 , H01L51/0035 , H01L51/0036 , H01L51/0047 , H01L51/4253 , Y02E10/549 , Y02P70/521
摘要： An amine-containing difluoro benzotriazolyl polymer, preparation method, and use thereof are provided; the polymer has a structure as represented by formula (I), both R1 and R2 are alkyls from C1 to C20, n is an integer from 10 to 50. In the polymer of the present disclosure, because the 1,2,3-benzotriazole solar cell material contains two fluorine atoms, the HOMO energy level is reduced by 0.11 eV, the fluorine-substituted 1,2,3-benzotriazole has two imido groups with strong electron-withdrawing property; the 1,2,3-benzotriazole is a heterocyclic compound with strong electron-withdrawing property, and an alkyl chain can be easily introduced to the N-position of the N—H bond of the benzotriazole; the functional group of the alkyl chain can improve solar energy conversion efficiency, thus solving the low efficiency problem of the solar cell made from the solar cell material.
摘要翻译：提供含胺的二氟苯并三唑基聚合物，其制备方法和用途; 聚合物具有由式（I）表示的结构，R1和R2均为C1至C20的烷基，n为10至50的整数。在本公开的聚合物中，由于1,2,3-苯并三唑太阳能电池材料含有两个氟原子，HOMO能级降低0.11eV，氟取代的1,2,3-苯并三唑具有两个吸电子性强的亚氨基; 1,2,3-苯并三唑是具有强吸电性的杂环化合物，可以容易地将烷基链引入苯并三唑的N-H键的N位; 烷基链的官能团可以提高太阳能转换效率，从而解决由太阳能电池材料制成的太阳能电池的低效率问题。

69. 发明申请

US20140251430A1 POLYMER SOLAR CELL AND METHOD FOR PREPARING SAME 审中-公开
标题翻译：聚合物太阳能电池及其制备方法
公开(公告)号：US20140251430A1
公开(公告)日：2014-09-11
申请号：US14355004
申请日：2011-11-28
申请人： Mingjie Zhou , Ping Wang , Hui Huang , Zhenhua Zhang
发明人： Mingjie Zhou , Ping Wang , Hui Huang , Zhenhua Zhang
IPC分类号： H01L51/44 , H01L51/00
CPC分类号： H01L51/441 , H01L51/0035 , H01L51/0036 , H01L51/0038 , H01L51/4246 , H01L51/4253 , H01L2251/301 , Y02E10/549 , Y02P70/521
摘要： The present invention relates to a polymer solar cell and a method for preparing the same. The cell comprises a conductive anode substrate, a hole buffer layer, an active polymer layer, an electron buffer layer and a cathode laminated in succession, wherein the hole buffer layer comprises a metal compound host and a guest doped in the metal compound host, the metal compound host being one selected from ZnO, ZnS and CdS and the doped gust being one selected from Li2CO3, Li2O, LiF, LiCl and LiBr. By doping a lithium compound with few electrons as a dopant into the metal compound host, a p-type doped layer facilitating the hole transportation is formed in the polymer solar cell. The dopant and the metal compound host have stable properties and would not corrode the conductive anode substrate, facilitating industrial production in the future and effectively improving the energy conversion efficiency of the polymer solar cell.
摘要翻译：聚合物太阳能电池及其制备方法技术领域本发明涉及聚合物太阳能电池及其制备方法。电池包括导电阳极基板，空穴缓冲层，活性聚合物层，电子缓冲层和阴极层叠，其中空穴缓冲层包含金属化合物主体和掺杂在金属化合物主体中的客体，金属化合物主体为选自ZnO，ZnS和CdS，掺杂阵风为选自Li2CO3，Li2O，LiF，LiCl和LiBr中的一种。通过将少量电子的锂化合物掺杂到金属化合物主体中，在聚合物太阳能电池中形成有助于空穴传输的p型掺杂层。掺杂剂和金属化合物主体具有稳定的性能，不会腐蚀导电阳极基板，有利于将来的工业生产，并有效提高聚合物太阳能电池的能量转换效率。

70. 发明授权

US08816340B2 Organic electroluminescence device and manufacturing method thereof 有权
标题翻译：有机电致发光元件及其制造方法
公开(公告)号：US08816340B2
公开(公告)日：2014-08-26
申请号：US13823450
申请日：2010-09-30
申请人： Mingjie Zhou , Ping Wang , Hui Huang , Xiaoming Feng
发明人： Mingjie Zhou , Ping Wang , Hui Huang , Xiaoming Feng
IPC分类号： H01L51/50 , H01L51/56
CPC分类号： H01L51/5088 , H01L51/0014 , H01L51/0035 , H01L51/0036 , H01L51/56 , H01L2251/5369
摘要： An organic electroluminescence device comprises the following structure: a conductive base (110), a hole injection layer (120), a light emission layer (140), and a cathode layer (170) are laminated in sequence. The material of the hole injection layer (120) comprises a conductive polymer and an azo initiator. A nano-network structure is provided on the connecting surface of the hole injection layer (120) and the light emission layer (140). After being heated to a higher temperature, the azo initiator can be decompounded to release N2, thus the nano-network structure is formed on the surface of the hole injection layer (120). The nano-network structure can efficiently increase the contacting area of the hole injection layer (120) and the adjacent layer. The injection efficiency of the hole is improved. A manufacturing method of the organic electroluminescence device is also provided.
摘要翻译：一种有机电致发光器件包括以下结构：依次层压导电基底（110），空穴注入层（120），发光层（140）和阴极层（170）。空穴注入层（120）的材料包括导电聚合物和偶氮引发剂。在空穴注入层（120）和发光层（140）的连接表面上设置纳米网络结构。在加热到较高温度后，可以分解偶氮引发剂以释放N 2，从而在空穴注入层（120）的表面上形成纳米网络结构。纳米网络结构可以有效地增加空穴注入层（120）和相邻层的接触面积。孔的注射效率提高。还提供了有机电致发光器件的制造方法。

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