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61. 发明申请

US20130056633A1 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：US20130056633A1
公开(公告)日：2013-03-07
申请号：US13667386
申请日：2012-11-02
申请人： Yuichiro HASHIMOTO , Hideki HASEGAWA , Masuyuki SUGIYAMA , Hidetoshi MOROKUMA
发明人： Yuichiro HASHIMOTO , Hideki HASEGAWA , Masuyuki SUGIYAMA , Hidetoshi MOROKUMA
IPC分类号： H01J49/04 , H01J49/36
CPC分类号： H01J49/0422 , H01J49/0013 , H01J49/0495 , H01J49/24
摘要： A mass spectrometer having a resolution improved by introducing ions into a mass spectrometry part with a high efficiency is provided with a small-sized, simple configuration. The mass spectrometer includes an opening/closing mechanism provided between a sample introducing piping part for introducing a sample into the mass spectrometry part and the mass spectrometry part to conduct gas introduction intermittently and control sample passage. The mass spectrometer further includes a pump mechanism to evacuate a high pressure side of the sample introducing piping part, that is, an opposite side of the opening/closing mechanism to the mass spectrometry part to have a pressure in a range of 100 to 10,000 Pa.
摘要翻译：具有小型，简单的结构，提供通过以高效率将离子引入质谱部分而提高分辨率的质谱仪。该质谱仪包括设置在用于将样品引入质谱部分的样品导入管道部分和质谱部分间歇地导入气体引入并控制样品通道的开/关机构。质谱仪还包括泵机构，用于将样品导入管道部分的高压侧排出，即，将质量分析部件的开闭机构的相反侧压力为100〜10000Pa 。

62. 发明申请

US20120223223A1 MASS SPECTROMETER METHOD AND MASS SPECTROMETER 有权
标题翻译：质谱仪和质谱仪
公开(公告)号：US20120223223A1
公开(公告)日：2012-09-06
申请号：US13365355
申请日：2012-02-03
申请人： Masuyuki SUGIYAMA , Yuichiro HASHIMOTO , Hideki HASEGAWA , Shuhei HASHIBA , Shun KUMANO
发明人： Masuyuki SUGIYAMA , Yuichiro HASHIMOTO , Hideki HASEGAWA , Shuhei HASHIBA , Shun KUMANO
IPC分类号： H01J49/26 , H01J49/00
CPC分类号： H01J49/0031 , H01J49/0045
摘要： A variation in an ionization efficiency and the amount of sample which is introduced into an ion trap is corrected and quantified. Ions of an internal standard and ions of a sample are trapped in the ion trap at the same time, and a concentration of the sample is quantified according to an intensity of the ions of the internal standard which are mass-selectively ejected, and an intensity of fragment ions of the sample.
摘要翻译：电离效率的变化和引入离子阱的样品量被校正和量化。将内标的离子和样品的离子同时捕获在离子阱中，并且根据质量选择性地喷射的内标的离子的强度来量化样品的浓度，强度的样品的碎片离子。

63. 发明授权

US07800058B2 Mass spectrometer and mass spectrometry method 有权
标题翻译：质谱仪和质谱法
公开(公告)号：US07800058B2
公开(公告)日：2010-09-21
申请号：US11979811
申请日：2007-11-08
申请人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Izumi Waki
发明人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Izumi Waki
IPC分类号： H01J49/00
CPC分类号： H01J49/4225 , H01J49/4215
摘要： A mass spectrometer that is switchable to operate as a linear trap or as a mass filter, and attaining both high ejection efficiency when operated as a linear trap and high mass resolving power when operated as a mass filter. A mass spectrometer includes an ion source for ionizing a sample, a linear trap quadrupole rod lens supplied with ionized ions, a trap electrode for forming a potential to trap the supplied ions between one end of the quadrupole lens and the other end, a control unit to regulate the trap lens voltage, and a mass analyzer or detector to detect ions ejected from the linear trap, and characterized in switching between an operation where the supplied ions are trapped in a section quadrupole rod lens and ejected by the controller unit regulating the trap electrode voltage; and an operation where ions are selective passed through according to their mass. The ejection efficiency when operated as an ion trap, and the mass resolving power when operated as a quadrupole mass filter are vastly improved compared to conventional methods.
摘要翻译：可以切换为线性捕集器或质量过滤器的质谱仪，当作为质量过滤器操作时，作为线性捕集器操作时获得高喷射效率和高质量分辨能力的质谱仪。质谱仪包括用于电离样品的离子源，提供有离子化离子的线性捕获四极杆透镜，用于形成用于捕获四极透镜的一端与另一端之间的供应离子的电位的捕获电极，控制单元调节陷波透镜电压，以及质量分析器或检测器，用于检测从线性阱捕获的离子，并且其特征在于，在所提供的离子被捕获在四极杆棒状透镜中并由调节阱的控制器单元喷射的操作之间进行切换电极电压; 以及根据其质量选择性地通过离子的操作。当作为离子阱操作时的喷射效率以及当作为四极质量过滤器操作时的质量分辨能力与常规方法相比大大提高。

64. 发明授权

US07608819B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07608819B2
公开(公告)日：2009-10-27
申请号：US12078523
申请日：2008-04-01
申请人： Takashi Baba , Yuichiro Hashimoto
发明人： Takashi Baba , Yuichiro Hashimoto
IPC分类号： H01J49/00
CPC分类号： H01J49/4225 , H01J49/0054 , H01J49/422
摘要： The present invention provides a mass spectrometry capable of high-efficiency and high-throughput ECD. An electron source and a two-dimensional combined ion trap in which a magnetic field along and generally parallel to a central axis is applied are used, thereby to achieve the foregoing object. First, precursor ions are trapped. By adopting the two-dimensional combined ion trap, it is possible to obtain a high ion trapping efficiency upon being injected and trapping. Subsequently, electrons are made incident thereon in such a manner as to be wound along the central axis to which no radio frequency is applied by using a magnetic field. For this reason, it is possible to allow energy-controlled electrons to reach the precursor ions. It is possible to implement a mass spectrometer capable of avoiding heating due to a radio frequency electric field, and effecting high-throughput/high-efficiency ECD.
摘要翻译：本发明提供能够实现高效率和高通量ECD的质谱。使用其中施加沿着并且大致平行于中心轴的磁场的电子源和二维组合离子阱，从而实现上述目的。首先，前体离子被捕获。通过采用二维组合离子阱，可以在注入和捕获时获得高离子捕获效率。随后，使电子以这样的方式入射，即沿着不通过使用磁场施加射频的中心轴缠绕。因此，可以使能量控制的电子达到前体离子。可以实现能够避免由于射频电场引起的加热并且实现高通量/高效率ECD的质谱仪。

65. 外观设计

USD595327S1 Microscope 有权
公开(公告)号：USD595327S1
公开(公告)日：2009-06-30
申请号：US29293822
申请日：2007-12-13
申请人： Keiji Okada , Yuichiro Hashimoto , Takashi Yoneyama
设计人： Keiji Okada , Yuichiro Hashimoto , Takashi Yoneyama

66. 发明申请

US20080121795A1 Mass spectrometer and mass spectrometry method 有权
标题翻译：质谱仪和质谱法
公开(公告)号：US20080121795A1
公开(公告)日：2008-05-29
申请号：US11979811
申请日：2007-11-08
申请人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Izumi Waki
发明人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Izumi Waki
IPC分类号： H01J49/42
CPC分类号： H01J49/4225 , H01J49/4215
摘要： A mass spectrometer that is switchable to operate as a linear trap or as a mass filter, and attaining both high ejection efficiency when operated as a linear trap and high mass resolving power when operated as a mass filter. A mass spectrometer includes an ion source for ionizing a sample, a linear trap quadrupole rod lens supplied with ionized ions, a trap electrode for forming a potential to trap the supplied ions between one end of the quadrupole lens and the other end, a control unit to regulate the trap lens voltage, and a mass analyzer or detector to detect ions ejected from the linear trap, and characterized in switching between an operation where the supplied ions are trapped in a section quadrupole rod lens and ejected by the controller unit regulating the trap electrode voltage; and an operation where ions are selective passed through according to their mass. The ejection efficiency when operated as an ion trap, and the mass resolving power when operated as a quadrupole mass filter are vastly improved compared to conventional methods.
摘要翻译：可以切换为线性捕集器或质量过滤器的质谱仪，当作为质量过滤器操作时，作为线性捕集器操作时获得高喷射效率和高质量分辨能力的质谱仪。质谱仪包括用于电离样品的离子源，提供有离子化离子的线性捕获四极杆透镜，用于形成用于捕获四极透镜的一端与另一端之间的供应离子的电位的捕获电极，控制单元调节陷波透镜电压，以及质量分析器或检测器，用于检测从线性阱捕获的离子，并且其特征在于，在所提供的离子被捕获在四极杆棒状透镜中并由调节阱的控制器单元喷射的操作之间进行切换电极电压; 以及根据其质量选择性地通过离子的操作。当作为离子阱操作时的喷射效率以及当作为四极质量过滤器操作时的质量分辨能力与常规方法相比大大提高。

67. 发明授权

US07329862B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07329862B2
公开(公告)日：2008-02-12
申请号：US11495534
申请日：2006-07-31
申请人： Yuichiro Hashimoto , Takashi Baba , Hideki Hasegawa , Izumi Waki
发明人： Yuichiro Hashimoto , Takashi Baba , Hideki Hasegawa , Izumi Waki
IPC分类号： H01J49/00
CPC分类号： H01J49/4225 , H01J49/004 , H01J49/401
摘要： A mass spectrometer capable of analyzing a wide mass range with high sensitivity and high mass accuracy. A mass spectrometer has an ionization source generating ions; an ion transfer optics transferring the ions; a first linear trap accumulating the ions and ejecting the ions in the specific mass range; a second linear trap having an end electrode disposed at the exit end ejecting the ions to change a DC potential gradient relative to a DC potential of the end electrode and trapping the ions ejected from the first linear trap to repeatedly eject them in pulse form; a time-of-flight mass spectrometer accelerating the ions ejected from the second linear trap in the orthogonal direction to detect them; and a controller changing the time duration of the ions in which the ions are ejected from the second linear trap or delay time from the completion of ejection to application of an accelerating voltage of the time-of-flight mass spectrometer according to the mass range of the ions ejected from the first linear trap to the second linear trap.
摘要翻译：能够以高灵敏度和高质量精度分析宽质量范围的质谱仪。质谱仪具有产生离子的电离源; 离子转移光学器件转移离子; 积聚离子并在特定质量范围内喷射离子的第一线性阱; 第二线性阱，其具有设置在出射端处的终端电极，其排出离子，以相对于端电极的DC电位改变DC电位梯度，并且捕获从第一线性阱捕获的离子重复地以脉冲形式喷射; 飞行时间质谱仪在正交方向加速从第二线性阱捕获的离子以检测它们; 以及控制器，其将离子从第二线性阱捕获的离子或从完成喷射的延迟时间的持续时间改变为根据飞行时间质谱仪的加速电压的质量范围离子从第一线性捕集器喷射到第二线性阱。

68. 发明授权

US07319222B2 Mass spectrometer and mass analysis method 有权
标题翻译：质谱仪和质量分析方法
公开(公告)号：US07319222B2
公开(公告)日：2008-01-15
申请号：US11325444
申请日：2006-01-05
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Izumi Waki
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Izumi Waki
IPC分类号： H01J49/00
CPC分类号： H01J49/0027 , H01J49/4225
摘要： A linear trap which allows for charge separation and ion mobility separation in a speedy manner, and enables measurement with high duty cycle. A mass spectrometer comprises an ion source, an ion trap for trapping ions ionized by the ion source, an ion trap controller for controlling a voltage on an electrode included in the ion trap, and a detector for detecting the ions ejected from the ion trap. The ion trap controller includes a table for each mass-to-charge ratio, the table containing a frequency of the voltage used for charge separation, and a gain of the voltage for ejecting a first ion with a first charge outside the ion trap, and retaining in the ion trap a second group of ions with a second charge that is lower than that of the first charge. The ion trap controller controls the voltage based on the mass-to-charge ratio set. The mass spectrometer has significantly improved sensitivity, as compared to the prior art.
摘要翻译：线性阱可以快速分离电荷和离子迁移分离，并能够以高占空比进行测量。质谱仪包括离子源，用于捕获由离子源离子化的离子的离子阱，用于控制离子阱中包含的电极上的电压的离子阱控制器和用于检测从离子阱排出的离子的检测器。离子阱控制器包括用于每个质荷比的表，该表包含用于电荷分离的电压的频率，以及用于在离子阱外部用第一电荷喷射第一离子的电压的增益，以及在离子阱中保留具有低于第一电荷的第二组电荷的第二组离子。离子阱控制器根据设定的质荷比来控制电压。与现有技术相比，质谱仪具有显着提高的灵敏度。

69. 发明申请

US20070181803A1 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20070181803A1
公开(公告)日：2007-08-09
申请号：US11653859
申请日：2007-01-17
申请人： Hideki Hasegawa , Yuichiro Hashimoto , Izumi Waki
发明人： Hideki Hasegawa , Yuichiro Hashimoto , Izumi Waki
IPC分类号： B01D59/44
CPC分类号： H01J49/4225 , H01J49/0063
摘要： In a mass spectrometer in which a high ion dissociation efficiency is possible, inserted electrodes are arranged with a form divided into two or more in the axial direction of the ion trap, an electric static harmonic potential is formed from a DC voltage applied to the inserted electrodes, and with an Supplemental AC voltage applied, ions in the ion trap are oscillated between the divided inserted electrodes in the axial direction of the ion trap by resonance excitation, and the ion with a mass/charge ratio within a specific range is mass-selectively dissociated. Thus, a high ion dissociation efficiency is realized by the use of ion trap of the present invention.
摘要翻译：在能够实现高离子解离效率的质谱仪中，插入电极以离子阱的轴向分割成两个以上的形式配置，从施加到插入的DC电压形成电静电谐波电位电极，并且通过施加补充AC电压，离子阱中的离子通过共振激发在离子阱的轴向方向上在分离的插入电极之间振荡，并且质量/电荷比在特定范围内的离子是质量 - 选择性离解。因此，通过使用本发明的离子阱来实现高离子解离效率。

70. 发明申请

US20070115542A1 Microscope system 有权
标题翻译：显微镜系统
公开(公告)号：US20070115542A1
公开(公告)日：2007-05-24
申请号：US11593216
申请日：2006-11-06
申请人： Yuichiro Hashimoto , Hideyuki Kawanabe , Ryuichi Hirano , Tetsuya Shirota
发明人： Yuichiro Hashimoto , Hideyuki Kawanabe , Ryuichi Hirano , Tetsuya Shirota
IPC分类号： G02B21/00
CPC分类号： G02B21/365
摘要： A microscope system having a selectively mountable optical element, comprises: a first noncontact type storage medium, being equipped in the optical element, for enabling a noncontact readout of information externally; and a first readout unit for reading information non-contactingly from the first noncontact type storage medium, wherein the first noncontact type storage medium stores information related to the optical element.
摘要翻译：一种具有可选择安装的光学元件的显微镜系统，包括：第一非接触型存储介质，其被配备在所述光学元件中，用于使外部信息不接触地读出; 以及第一读取单元，用于从第一非接触式存储介质非接触地读取信息，其中第一非接触式存储介质存储与光学元件有关的信息。

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