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61. 发明授权

US07026132B2 Method of monitoring the effect of Cathepsin S inhibitors 失效
标题翻译：监测组织蛋白酶S抑制剂作用的方法
公开(公告)号：US07026132B2
公开(公告)日：2006-04-11
申请号：US09938941
申请日：2001-08-24
申请人： Robin Thurmond , Siquan Sun , Lars Karlsson
发明人： Robin Thurmond , Siquan Sun , Lars Karlsson
IPC分类号： G01N33/53
CPC分类号： G01N33/573 , C12Q1/37 , G01N2333/8139 , G01N2333/96466 , Y10S435/962 , Y10S436/811 , Y10S436/813 , Y10S436/825 , Y10T436/25125 , Y10T436/25375
摘要： The present invention relates to a method for monitoring the effect of in vivo administration of Cathepsin S inhibitors by measuring accumulation of an intermediate degradation product of invariant chain (Ii), in particular the p10 Ii fragment, in blood of dosed subjects.
摘要翻译：本发明涉及一种通过测定剂量血液中不变链（Ii）的中间降解产物（特别是p10Ii片段）的积累来监测组织蛋白酶S抑制剂的体内施用效果的方法。

62. 发明申请

US20060034324A1 Method and technique for the processing and display of wideband geolocation determination data 失效
公开(公告)号：US20060034324A1
公开(公告)日：2006-02-16
申请号：US11203016
申请日：2005-08-11
申请人： Lars Karlsson
发明人： Lars Karlsson
IPC分类号： H04J3/22
CPC分类号： G01S3/046 , G01S5/04
摘要： An interactive graphical user interface (GUI) for displaying frequency, amplitude and geolocation information provided by a local intelligence system is provided comprising: a plot of radio frequency (RF) versus amplitude, and a map indicating location of RF signals. The intelligence system has a front end to generate digital data based on received RF signals, a post processing stage to process the digital data, and a geolocation module to prevent the post-processing stage from processing a first portion of the digital data that corresponds to RF signals originating from a geographic location other than a predetermined geographic location. The GUI is updated continuously in near real time. Methods of operating the GUI are also provided.

63. 发明申请

US20050164319A1 Aggrecanase-1 and -2 peptide substrates and methods 有权
标题翻译：聚集蛋白酶-1和-2肽底物和方法
公开(公告)号：US20050164319A1
公开(公告)日：2005-07-28
申请号：US11012797
申请日：2004-12-15
申请人： Anne Fourie , Lars Karlsson , Fawn Coles
发明人： Anne Fourie , Lars Karlsson , Fawn Coles
IPC分类号： C12N9/64 , G01N33/53 , C07K7/08 , C07K14/47 , G01N33/537 , G01N33/543
CPC分类号： C12N9/6421
摘要： The present invention describes synthetic peptide substrates of the metalloproteases, agggrecanase-1 and/or -2 suitable for assays of enzyme activity. The invention also describes methods using these peptides to discover pharmaceutical agents that modulate these proteases.
摘要翻译：本发明描述了适合于酶活性测定的金属蛋白酶合成肽底物，聚集蛋白聚糖酶-1和/或-22。本发明还描述了使用这些肽发现调节这些蛋白酶的药剂的方法。

64. 发明申请

US20050085487A1 Heterocyclic compounds 审中-公开
标题翻译：杂环化合物
公开(公告)号：US20050085487A1
公开(公告)日：2005-04-21
申请号：US10961247
申请日：2004-10-08
申请人： Nicholas Carruthers , Wenying Chai , Curt Dvorak , James Edwards , Cheryl Grice , Jill Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer Kreisberg , Annette Kwok , Timothy Lovenberg , Kiev Ly , Barbara Pio , Chandravadan Shah , Siquan Sun , Robin Thurmond , Jianmei Wei , Wei Xiao
发明人： Nicholas Carruthers , Wenying Chai , Curt Dvorak , James Edwards , Cheryl Grice , Jill Jablonowski , Lars Karlsson , Haripada Khatuya , Jennifer Kreisberg , Annette Kwok , Timothy Lovenberg , Kiev Ly , Barbara Pio , Chandravadan Shah , Siquan Sun , Robin Thurmond , Jianmei Wei , Wei Xiao
IPC分类号： C07D307/84 , A61K31/496 , A61P1/04 , A61P7/00 , A61P9/06 , A61P17/06 , A61P19/02 , A61P25/28 , A61P29/00 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07D209/42 , C07D401/12 , C07D403/06 , A61K31/454 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号： C07D401/12 , A61K31/496 , C07D209/42
摘要： Heterocyclic compounds and methods of making them and using them.
摘要翻译：杂环化合物及其制备方法和使用方法。

65. 发明授权

US06583155B2 Method for treating allergies using substituted pyrazoles 有权
公开(公告)号：US06583155B2
公开(公告)日：2003-06-24
申请号：US10075692
申请日：2002-02-13
申请人： Christopher R. Butler , Hui Cai , James P. Edwards , Cheryl A. Grice , Yin Gu , Darin J. Gustin , Lars Karlsson , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Clark A. Sehon , Siquan Sun , Kevin L. Tays , Robin L. Thurmond , Jianmei Wei
发明人： Christopher R. Butler , Hui Cai , James P. Edwards , Cheryl A. Grice , Yin Gu , Darin J. Gustin , Lars Karlsson , Haripada Khatuya , Steven P. Meduna , Barbara A. Pio , Clark A. Sehon , Siquan Sun , Kevin L. Tays , Robin L. Thurmond , Jianmei Wei
IPC分类号： A61K3144
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/13 , A61K31/275 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/55
摘要： A method for treating an allergic condition, including an atopic allergic condition, using substituted pyrazoles.

66. 发明授权

US06355479B1 MHC class II antigen-presenting systems and methods for activating CD4+ T cells 有权
标题翻译： MHC II类抗原呈递系统和激活CD4 + T细胞的方法
公开(公告)号：US06355479B1
公开(公告)日：2002-03-12
申请号：US09194285
申请日：1999-04-12
申请人： Susan R. Webb , Ola Winqvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
发明人： Susan R. Webb , Ola Winqvist , Lars Karlsson , Michael R. Jackson , Per A. Peterson
IPC分类号： C12N510
CPC分类号： C07K14/70596 , A61K38/00 , A61K2039/5154 , A61K2039/5156 , C12N5/0601 , C12N2510/00 , Y10S424/81
摘要： The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+ T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.
摘要翻译：本发明涉及合成抗原呈递矩阵，其制备方法及其使用方法。一种这样的基质是已被转染以产生具有一种或多种辅助分子的MHC抗原呈递分子的细胞。这些基质用于激活幼稚的CD4 + T细胞，并将正在进行的激活状态转移到Th1或Th2细胞的优选分化群体中。

67. 发明授权

US06354145B1 Process control 失效
标题翻译：过程控制
公开(公告)号：US06354145B1
公开(公告)日：2002-03-12
申请号：US09355297
申请日：1999-07-28
申请人： Magnus Fransson , Lars Karlsson , Bengt Lagerholm , Anders Sparén
发明人： Magnus Fransson , Lars Karlsson , Bengt Lagerholm , Anders Sparén
IPC分类号： G01N3108
CPC分类号： G01N30/8651 , G01N30/8658 , G01N30/8682 , G01N2030/8804 , G01N2030/8886 , G01N2201/129
摘要： The present invention relates to a method for analyzing mixtures of components by a process selected from the group consisting of flow based separation processes and flow analysis processes. The method comprising the steps of: obtaining measurement signals by measuring process conditions at a plurality of positions throughout the system; applying signal processing to the measurement signals, said signal processing comprising multivariate data analysis for condensing the plurality of measurement signals to a smaller number of main signals being non-correlated; logging said main signals; and displaying said main signals versus time, where changes of said system conditions are indicated by one or more of the displayed main signals; detecting any error occurrence during an on going process, and determining what part of said system cause said error.
摘要翻译：本发明涉及通过选自流体分离方法和流动分析方法的方法分析组分混合物的方法。该方法包括以下步骤：通过测量整个系统中的多个位置处的处理条件来获得测量信号;对测量信号应用信号处理，所述信号处理包括多变量数据分析，用于将多个测量信号冷凝到较小数量的主信号不相关;记录主信号; 以及显示所述主信号与时间的关系，其中所述系统条件的变化由所显示的主信号中的一个或多个指示;检测正在进行的过程中的任何错误发生，以及确定所述系统的哪一部分引起所述错误。

68. 发明授权

US5572312A Arrangement for calibration of at least one radiation-sensitive detector means 失效
标题翻译：用于校准至少一种辐射敏感检测器装置的装置
公开(公告)号：US5572312A
公开(公告)日：1996-11-05
申请号：US343470
申请日：1995-01-17
申请人： Lars Karlsson , Ulf Handberg
发明人： Lars Karlsson , Ulf Handberg
IPC分类号： G01J5/08 , G01J5/48 , G01J5/52 , H04N3/09 , H04N5/33
CPC分类号： H04N3/09 , G01J5/52 , G01J5/522 , H04N5/33
摘要： An arrangement for calibration of at least one radiation-sensitive detector, comprising an aperture (90), at least one reference body (50, 60, 600) which emits radiation with a measurable intensity, at least one deflection member (160, 170, 620) which deflects radiation from the reference body, and at least one radiation-sensitive detector (30) which detects the radiation value and generates an output signal dependent on the detected radiation value. During reference measurement the deflection member is arranged to reproduce the aperture (90) on the reference body (50, 60, 600), and the deflection member (160, 170, 620) deflects the radiation such that the midpoint of the reproduction of the aperture (90) remains on substantially the same area of the surface of the reference body (50, 60, 600) during that time period in which the detector receives radiation which is transmitted from the reference body and which passes through the aperture (90).
摘要翻译： PCT No.PCT / SE93 / 00465 Sec。 371日期1995年1月17日 102（e）日期1995年1月17日PCT提交1993年5月26日PCT公布。出版物WO93 / 24815 日期1993年12月9日用于校准至少一个辐射敏感检测器的装置，包括孔（90），至少一个用可测量强度发射辐射的参考体（50,60,600），至少一个偏转构件（160,170,620），其偏转来自参考体的辐射;以及至少一个辐射敏感检测器（30），其检测辐射值并根据检测到的辐射值产生输出信号。在参考测量期间，偏转构件被布置成在基准体（50,60,600）上再现孔（90），并且偏转构件（160,170,620）使辐射偏转，使得再现的中点在检测器接收从参考体传送并穿过孔径（90）的辐射的时间段期间，孔（90）保留在参考体（50,60,600）的表面的基本相同的区域上，。

69. 发明授权

US4766308A Optical scanner with refractive material positioned on inner reflective facets 失效
$Optical scanner with refractive material positioned on inner reflective facets$
标题翻译：具有折射材料的光学扫描仪位于内部反射面上
公开(公告)号：US4766308A
公开(公告)日：1988-08-23
申请号：US943214
申请日：1986-11-24
申请人： Lars Karlsson
发明人： Lars Karlsson
IPC分类号： G02B26/10 , H04N1/113 , G02B26/08 , H01J3/14
CPC分类号： G02B26/10
摘要： Scanner arrangement which incorporates at least one rotatable unit (15) provided with one or more reflecting facets (16) positioned in the beam path of the scanner arrangement so as to deflect the beam path during a scan. Reflection against the facets takes place within a material (17) having a refractive index greater than 1. The scanning facet against which reflection takes place appears to change from the aspect of the beam path within the material, whereas a transition surface between the material and air appears to be stationary from the aspect of the beam path, or at least moves in space irregularly with movement of the scanning facet.
摘要翻译： PCT No.PCT / SE86 / 00104 Sec。 371日期：1986年11月24日 102（e）1986年11月24日PCT PCT公布1986年3月11日PCT。公开号WO86 / 05597 日期：1986年9月25日。扫描器装置包括设置有位于扫描器装置的光束路径中的一个或多个反射刻面（16）的至少一个可旋转单元（15），以便在扫描期间偏转光束路径。相对于小面的反射发生在折射率大于1的材料（17）内。发生反射的扫描面似乎从材料内的光束路径的方面改变，而材料和空气似乎从光束路径的方面是静止的，或者至少在扫描面的移动中不规则地在空间中移动。

70. 发明授权

US09161287B2 Technique for efficient message delivery in Ad Hoc, mesh, wireless computer networks 有权
标题翻译：技术在Ad Hoc，mesh，无线计算机网络中高效的消息传递
公开(公告)号：US09161287B2
公开(公告)日：2015-10-13
申请号：US13653112
申请日：2012-10-16
申请人： Lars Karlsson
发明人： Lars Karlsson
IPC分类号： G06F15/16 , H04W40/00 , H04L12/701
CPC分类号： H04W40/00 , H04L45/00
摘要： A Technique for Efficient Message Delivery in Ad Hoc, Mesh, Wireless Computer Networks. The method and system of the present invention permits reliable wireless messaging between nodes on an ad hoc basis. The method is executed at each node in an iterative fashion, If a node is not the destination node for a particular message, that node will retransmit a received message. As the message is received and retransmitted from node to node, the message will propagate through the networked nodes until it reaches its destination node. In order to prevent the retransmission of messages into perpetuity, the method will limit the number of times that a particular node can retransmit a particular message. Once that retransmission limit is reached by a particular node for a particular message, the message retransmission will cease at that node, and the message will expire. The message will also expire after a pre-set time to live parameter has elapsed.
摘要翻译：一种在特殊，网状，无线计算机网络中高效消息传递的技术。本发明的方法和系统允许节点之间的可靠的无线消息传送。该方法以迭代方式在每个节点处执行。如果节点不是特定消息的目标节点，则该节点将重传接收到的消息。当消息从节点接收和重传时，消息将通过网络节点传播，直到它到达其目标节点。为了防止消息重传成永久性，该方法将限制特定节点可以重传特定消息的次数。一旦特定消息的特定节点达到了该重发限制，那么消息重传将在该节点停止，并且该消息将到期。消息也将在预设时间到期后过期。

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