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61. 发明申请

US20150072315A1 Formulations and kit for biometric deposition of apatite on teeth 审中-公开
标题翻译：磷灰石生物沉积在牙齿上的配方和试剂盒
公开(公告)号：US20150072315A1
公开(公告)日：2015-03-12
申请号：US14481429
申请日：2014-09-09
申请人： Heraeus Kulzer GmbH
发明人： Susanne BUSCH , Andreas UTTERODT , Michael GERLACH
IPC分类号： A61C19/06 , A61K6/00 , A61L24/02
CPC分类号： A61C19/063 , A61K6/0017 , A61K6/0082 , A61L24/02
摘要： The invention proposes formulations for biomimetic deposition of apatite from a partially elastic shaped body on teeth, whereby the shaped body a) contains at least one mineralization matrix containing a gel that comprises water-soluble phosphates or phosphates that can be hydrolyzed to form water-soluble phosphate ions and has a pH value of 2 to 8, optionally fluorides, and b) the at least one or a second mineralization matrix comprises a second gel having a pH value of 3.5 to 14 comprising calcium ions or compounds releasing calcium ions. Moreover, the method for producing the formulation for the deposition of apatite, in particular of needle-shaped fluorapatite crystals, is claimed. Using the formulations according to the invention, it is feasible to deposit more than or equal to 1 μm apatite, in particular fluorapatite, on tooth surfaces in order to seal or brighten porous tooth surfaces.
摘要翻译：本发明提出了用于从牙齿上部分弹性成形体的磷灰石仿生沉积的制剂，其中成形体a）包含至少一个含有凝胶的矿化基质，该凝胶包含水溶性磷酸盐或磷酸盐，其可水解形成水溶性磷酸根离子，pH值为2-8，任选氟化物，和b）至少一种或第二种矿化基质包含pH值为3.5至14的第二种凝胶，其包含钙离子或释放钙离子的化合物。此外，要求保护磷灰石，特别是针状氟磷灰石晶体的沉积配方的方法。使用根据本发明的制剂，在牙齿表面上沉积多于或等于1μm的磷灰石，特别是氟磷灰石是可行的，以便密封或增亮多孔牙齿表面。

62. 发明申请

US20020183265A1 Manufacture and use of an antibiotic/antibiotics preparation 审中-公开
标题翻译：生产和使用抗生素/抗生素制剂
公开(公告)号：US20020183265A1
公开(公告)日：2002-12-05
申请号：US10101254
申请日：2002-03-19
申请人： Heraues Kulzer GmbH & Co.KG
发明人： Sebastian Vogt , Matthias Schnabelrauch , Klaus-Dieter Kuhn
IPC分类号： A61K031/7048 , A61K031/7008 , B27N003/00 , A61K031/65 , A61K031/47 , A61K031/496
CPC分类号： A61K9/0024 , A61K9/2013 , A61K9/204 , A61K31/00 , A61K31/7036 , A61L27/54 , A61L31/16 , A61L2300/406 , A61L2300/606
摘要： The present invention concerns the manufacture and use of an antibiotic/antibiotics preparation for human and veterinary medicine, for the treatment of local microbial infections in hard and soft tissue. The manufacture in accordance with the invention of an antibiotic/antibiotics preparation takes place according to the invention in that water, an amphiphilic component of a representative of the alkyl sulfates, aryl sulfates, alkylaryl sulfates, cycloalkyl sulfates, alkylcycloalkyl sulfates, alkyl sulfamates, cycloalkyl sulfamates, alkylcycloalkyl sulfamates, aryl sulfamates, alkylaryl sulfamates, alkyl sulfonates, fatty acid-2-sulfonates, aryl sulfonates, alkylaryl sulfonates, cycloalkyl sulfonates, cycloalkyl sulfonates, alkylcycloalkyl sulfonates, alkyl disulfates, cycloalkyl disulfates, alkyl disulfonates, cycloalkyl disulfonates, aryl disulfonates, alkylaryl disulfonates, aryl trisulfonates and alkylaryl trisulfonates, one or more antibiotic components from the group of aminoglycoside antibiotics, lincosamide antibiotics and tetracycline antibiotics, an organic auxiliary component and/or an inorganic auxiliary component and if need be at least one biologically active component are mixed together and shaped into molded elements, granulates, powders, foils, shaped masses and threads.
摘要翻译：本发明涉及用于人和兽药的抗生素/抗生素制剂的制造和使用，用于治疗硬组织和软组织中的局部微生物感染。根据本发明的根据本发明的抗生素/抗生素制剂的制造是根据本发明进行的，因为水，代表烷基硫酸盐，芳基硫酸盐，烷基芳基硫酸盐，环烷基硫酸盐，烷基环烷基硫酸盐，烷基亚磺酸盐，环烷基氨基磺酸盐，烷基环烷基氨基磺酸盐，芳基磺酸盐，烷基芳基磺酸盐，烷基磺酸盐，脂肪酸-2-磺酸盐，芳基磺酸盐，烷基芳基磺酸盐，环烷基磺酸盐，环烷基磺酸盐，烷基环烷基磺酸盐，烷基二硫酸盐，环烷基二硫酸盐，烷基二磺酸盐，环烷基二磺酸盐，芳基二磺酸盐，烷基芳基二磺酸盐，芳基三磺酸盐和烷基芳基三磺酸盐，一种或多种抗生素组分，氨基糖苷类抗生素组，林可素类抗生素和四环素抗生素，有机辅助组分和/或无机辅助组分，如果需要至少一种生物活性组分 e混合在一起并成型为模制元件，颗粒，粉末，箔，成形块和线。

63. 发明申请

US20020150549A1 Antibiotic(s)-polymer combination 审中-公开
标题翻译：抗生素 - 聚合物组合
公开(公告)号：US20020150549A1
公开(公告)日：2002-10-17
申请号：US10100865
申请日：2002-03-19
申请人： Heraues Kulzer GmbH & Co.KG
发明人： Sebastian Vogt , Matthias Schnabelrauch , Klaus-Dieter Kuhn
IPC分类号： A61K031/78 , A61K031/7008 , A61K031/496 , A61K031/47
CPC分类号： A61L31/16 , A61K9/0019 , A61K9/0024 , A61K31/00 , A61K31/7036 , A61K47/10 , A61K47/32 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/406 , A61L2300/45 , A61L2300/602 , A61L2300/606 , C08L33/04
摘要： The present invention relates to an antibiotic(s)-polymer combination, which under physiological conditions guarantees the continuous release of antibiotics over a period of several days and can be used in human and veterinary medicine. The invented antibiotic(s)-polymer combination is whereinin a homogeneous polymer mixture, consisting of one or more hydrophobic polymers from the groups of poly(methacrylic acid esters), the poly(acrylic acid esters) and the poly(methacrylic acid ester-co-acrylic acid esters) and one or more hydrophilic polymers from the group of polyethers, one or more slightly water-soluble antibiotics from the groups of aminoglycoside antibiotics, the lincosamide antibiotics, the tetracycline antibiotics and quinolone antibiotics, possibly an easily water-soluble antibiotic from the groups of aminoglycoside antibiotics, the lincosamide antibiotics and the tetracycline antibiotics, and possibly one or more organic adjuvants are suspended, and that this suspension forms a composite.
摘要翻译：本发明涉及抗生素 - 聚合物组合，其在生理条件下保证抗生素在数天内持续释放并可用于人和兽医学。本发明的抗生素聚合物组合是由均匀的聚合物混合物组成，其由聚（甲基丙烯酸酯），聚（丙烯酸酯）和聚（甲基丙烯酸酯 - 共聚物）组中的一种或多种疏水性聚合物组成丙烯酸酯）和一种或多种来自聚醚组的亲水聚合物，一种或多种来自氨基糖苷类抗生素组的轻微水溶性抗生素，林可素抗生素，四环素抗生素和喹诺酮抗生素，可能是易溶于水的抗生素从氨基糖苷类抗生素组，氯胺素抗生素和四环素类抗生素以及可能的一种或多种有机助剂悬浮，并且该悬浮液形成复合物。

64. 发明公开

US20240326329A2 DEVICE AND METHOD FOR SIMULTANEOUS ADDITIVE MANUFACTURING OF COMPONENTS COMPOSED OF DIFFERENT MATERIALS 审中-公开
公开(公告)号：US20240326329A2
公开(公告)日：2024-10-03
申请号：US18277169
申请日：2022-02-14
申请人： KULZER GMBH
发明人： Jochen SAGOLLA , Lars DIEZ
IPC分类号： B29C64/182 , B22F10/12 , B22F12/30 , B22F12/49 , B22F12/55 , B22F12/90 , B29C64/135 , B29C64/232 , B29C64/236 , B29C64/245 , B29C64/255 , B29C64/277 , B29C64/336 , B33Y10/00 , B33Y30/00 , B33Y50/02
CPC分类号： B29C64/182 , B22F10/12 , B22F12/30 , B22F12/49 , B22F12/55 , B22F12/90 , B29C64/135 , B29C64/232 , B29C64/236 , B29C64/245 , B29C64/255 , B29C64/277 , B29C64/336 , B33Y10/00 , B33Y30/00 , B33Y50/02 , B22F2998/10
摘要： Devices for the layer-by-layer generative production of at least one three-dimensional shaped part from at least two radiation-curable compositions are provided and comprise at least one radiation source and/or beam deflection device and at least one pressure trough with at least two process chambers openable at the top, wherein the at least two process chambers are arrangeable above the radiation source or a radiation deflection device, so that the curable compositions in the process chambers are exposable to radiation from below via the radiation source and/or the radiation deflection device. The devices further comprise a building platform having an underside which is exposable to rays from the radiation source, wherein the bottom of the pressure trough comprises at least partially a transparent material. Additionally, processes for producing at least one three-dimensional shaped part from at least two different curable compositions are provided

65. 发明公开

US20240317918A1 RADIATION-CURABLE COMPOSITION FOR USE IN RAPID PROTOTYPING OR RAPID MANUFACTURING METHODS 审中-公开
公开(公告)号：US20240317918A1
公开(公告)日：2024-09-26
申请号：US18585324
申请日：2024-02-23
申请人： KULZER GMBH
发明人： Alfred HOHMANN
IPC分类号： C08F283/06 , A61C13/00 , A61K6/62 , A61K6/893 , B29C64/124 , B29K33/00 , B33Y70/00
CPC分类号： C08F283/06 , A61C13/0019 , A61C13/0022 , A61K6/62 , A61K6/893 , B33Y70/00 , B29C64/124 , B29K2033/12 , B29K2995/0077 , B29K2995/0082
摘要： A polymerisable radiation-curable composition comprising:

(i) monomers, comprising at least (a) a first monomer having a TG (glass-transition point) of the homopolymer of said first monomer≥ 120° C. and at least (b) a second monomer having a TG (glass-transition point) of the homopolymer of the second monomer≤ 100° C., wherein at least one of the at least one first monomer or of the at least one second monomer has an alicyclic group, and
comprising (ii) at least one further component, comprising at least one photo-initiator for the UV and/or Vis spectral region or a photo-initiator system for the UV and/or Vis spectral region. Also disclosed is a blank in the form of a three-dimensional moulded body of a polymerised composition, in particular a radiation-cured composition, for producing 3D moulded bodies, dental prosthetic parts, orthopaedic appliances or dental pre-forms in a rapid prototyping, rapid manufacturing, or rapid tooling method.

66. 发明公开

US20240216229A1 SELF-ADHESIVE FISSURE SEALANT 审中-公开
公开(公告)号：US20240216229A1
公开(公告)日：2024-07-04
申请号：US18284933
申请日：2022-03-31
申请人： KULZER GMBH
发明人： Maria LECHMANN-DORN , Michael GERLACH
IPC分类号： A61K6/887 , A61K6/62 , A61K6/77 , A61K6/78
CPC分类号： A61K6/887 , A61K6/62 , A61K6/77 , A61K6/78
摘要： Self-adhesive, radiation-curable fissure sealants and methods comprise a white pigment, A) a monomer component comprising a) at least one difunctional urethane (meth)acrylate, b) at least one hydrophilic alkylene oxide-based difunctional (meth)acrylate-based crosslinker, c) a mixture of acidic monomers of an olefinic carboxylic acid and/or of an olefinic carboxylic anhydride in combination with an olefinic acidic monoester of a phosphoric acid and/or an olefinic acidic monoester of a thiophosphoric acid, and d) an initiator and/or an initiator system, each having an absorption maximum of 420 to 550 nm, optionally with a co-initiator, and B) a filler component comprising at least one dental glass, wherein A) the monomer component and B) the filler component are present in a mass ratio of 60:40 to 100:0 in the fissure sealant, and wherein the total composition of the fissure sealant comprises 100 wt.-%.

67. 发明公开

US20240207026A1 METHOD FOR PRODUCING A DENTAL PROSTHESIS BY FILLING AN INTERSPACE 审中-公开
公开(公告)号：US20240207026A1
公开(公告)日：2024-06-27
申请号：US18545267
申请日：2023-12-19
申请人： Kulzer GmbH
发明人： Frank-Uwe Stange , Matthias Moeller , Karl-Heinz Renz
IPC分类号： A61C13/36 , A61C13/00 , A61C13/103
CPC分类号： A61C13/1016 , A61C13/0004 , A61C13/1009
摘要： The invention relates to a method for producing a dental prosthesis with:

A) provision of a milling body and a prosthesis base preform with a holding structure (34);
B) production of a connecting surface in the milling body by a subtractive CAM method;
C) production of mating holding structure which fits with the holding structure in the surface of the milling body or said mating holding structure is present;
D) attachment, spaced via the holding structure, of the prosthesis base preform to the mating holding structure, wherein an interspace is obtained;
E) introduction or application of a fluid polymerizable plastic into the interspace;
F) curing or partial curing of the plastic to yield a plastics material in the interspace which connects the prosthesis base preform to the milling body; and
G) subtractive machining of the plastics material, the prosthesis base preform and the milling body by a CAM method in accordance with a model of the dental prosthesis.

The invention also relates to a dental prosthesis produced with such a method and a device for implementing such a method.

68. 发明公开

US20240197577A1 SELF-ADHESIVE DENTAL MATERIAL 审中-公开
公开(公告)号：US20240197577A1
公开(公告)日：2024-06-20
申请号：US18285275
申请日：2022-03-31
申请人： Kulzer GmbH
发明人： Maria LECHMANN-DORN , Michael GERLACH
IPC分类号： A61K6/887 , A61K6/54 , A61K6/62 , A61K6/77
CPC分类号： A61K6/887 , A61K6/54 , A61K6/62 , A61K6/77
摘要： A self-adhesive, radiation-curable, dental material comprising A) a monomer component comprising a difunctional urethane (meth)acrylate, hydrophilic alkylene oxide-based di-functional (meth)acrylate-based crosslinkers, at least one acidic monomer of an olefinic acidic monoester of a phosphoric acid and/or an olefinic acidic monoester of a thiophosphoric acid optionally in combination with an olefinic carboxylic acid and/or olefinic carboxylic acid anhydrides and an initiator and/or an initiator system having an absorption maximum of from 420 to 550 nm and optionally having a co-initiator and optionally B) a filler component comprising at least one dental glass, wherein in particular A) the monomer component and B) the filler component are present in a mass ratio of a) 100:0 to 60:40 in fissure sealants or b) from 59:41 to 20:80 in composite materials, and wherein the total composition of the fissure sealant or composite material comprises 100 wt.- %.

69. 发明公开

US20240182744A1 POLYMERIZABLE COMPOSITION 审中-公开
公开(公告)号：US20240182744A1
公开(公告)日：2024-06-06
申请号：US17773361
申请日：2020-10-29
申请人： KULZER GMBH
发明人： Andreas UTTERODT , Christoph MEIER , Nelli SCHOENHOF , Jutta SCHNEIDER , Kurt REISCHL , Raif KOCOGLU , Michael ECK
IPC分类号： C09D135/02 , B29C64/135 , B29K33/04 , B29K105/00 , B29K509/00 , B33Y10/00 , B33Y70/10 , C08F222/22 , C08K3/16 , C08K3/22 , C08K3/36 , C08K3/40 , C08K5/132 , C08K9/04 , C08K13/06 , C09D4/00 , C09D7/48 , C09D7/62 , C09D7/63
CPC分类号： C09D135/02 , B33Y70/10 , C08F222/22 , C08K13/06 , C09D4/00 , C09D7/48 , C09D7/62 , C09D7/63 , B29C64/135 , B29K2033/04 , B29K2105/0002 , B29K2509/00 , B33Y10/00 , C08F2800/20 , C08K3/16 , C08K2003/2241 , C08K3/36 , C08K3/40 , C08K5/132 , C08K9/04 , C08K2201/005 , C08K2201/011 , C08K2201/014
摘要： The invention relates to a polymerisable composition comprising

(i) 0 to 90% by weight of at least one inorganic filler component,
(ii) 5 to 99.98% by weight of at least one urethane (alkyl) acrylate of the idealised formula I,
(iii) 0.01 to 25% by weight of at least one di-, tri-, tetra- or multi-functional monomer, not being a urethane (alkyl) acrylate,
(iv) 0.01 to 10% by weight of at least one initiator, of an initiator system as well as optionally of at least one stabiliser and optionally of at least one pigment, the total composition of the composition amounting to 100% by weight, as well as a polymerised composition having improved fracture toughness.

70. 发明授权

US11911234B2 Two-component mixing capsule, in particular for the field of dentistry 有权
公开(公告)号：US11911234B2
公开(公告)日：2024-02-27
申请号：US17268829
申请日：2019-09-11
申请人： KULZER GMBH
发明人： Andrea Kemeny
IPC分类号： A61C5/64 , A61C5/66 , A61C5/68
CPC分类号： A61C5/68 , A61C5/64 , A61C5/66
摘要： The invention relates to a mixing capsule (1) comprising a housing in the form of a cylinder, characterised in that the mixing capsule has an applicator (2) at the top surface (15) of the cylinder and an auxiliary capsule (3) at the base surface of the cylinder being mounted displaceably in the direction of the longitudinal axis, the auxiliary capsule (3) being mounted displaceably in the direction of the longitudinal axis in a cylindrical inside pipe (4) and/or a mounting of the mixing capsule (1), the housing of the mixing capsule comprising an outer housing sleeve (5) and an inner housing sleeve (6) being mounted rotatably against each other and displaceably into each other, the auxiliary capsule (3) and the cylindrical inside pipe (4) and/or the mounting taking a first partial volume of the internal volume (9) of the mixing capsule (1) in a first position of the inner housing sleeve (6), the mixing capsule (1) having a second partial volume of the internal volume (9) being independent from the auxiliary capsule (3) and the cylindrical inside pipe (4) and/or the mounting, the second partial volume having a composition A, the auxiliary capsule (3) containing a composition B, the internal volume (9) of the cylinder being increased compared to the first position in a second position of the inner housing sleeve (6) after the outer housing sleeve (5) and the inner housing sleeve (6) being pushed apart along the longitudinal axis, the increased internal volume (9) being adapted to receive composition B besides composition A, composition A and composition B being mixable to composition C by moving the mixing capsule, composition C being ejectable via the applicator (2) when the outer housing sleeve (5) and the inner housing sleeve (6) being telescoped. Furthermore, the invention relates to a method for mixing at least two compositions A and B to a composition C in a mixing capsule. The invention likewise refers to a use of a mixing capsule.

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