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61. 发明申请

US20060000665A1 Low frequency acoustic attenuator for use in downhole applications 有权
标题翻译：低频声衰减器用于井下应用
公开(公告)号：US20060000665A1
公开(公告)日：2006-01-05
申请号：US10882915
申请日：2004-06-30
申请人： Vimal Shah , Eugene Linyaev , Donald Kyle , Wallace Gardner
发明人： Vimal Shah , Eugene Linyaev , Donald Kyle , Wallace Gardner
IPC分类号： G01V1/00
CPC分类号： E21B47/16 , G01V1/523
摘要： An acoustic attenuator includes a housing having an inner side surface which defines an interior chamber and at least one dampening member both physically and acoustically coupled to the housing and projecting into the interior chamber. Acoustic energy propagating within the housing is deflected into the dampening members for acoustically dispersal within the interior chamber. In various aspects thereof, the dampening members may include one or a group of two or more generally cylindrical sleeves having one end both physically and acoustically coupled to the housing and a second end projecting into the interior chamber. Preferably, when a group of two or more cylindrical sleeves are employed, the sleeves are nested within one another. The dampening members may further include a second, oppositely disposed, group of two or more acoustic attenuators nested within one another and interdigitated with the first group of cylindrical sleeves.
摘要翻译：声衰减器包括壳体，该壳体具有限定内腔的内侧表面和至少一个阻尼构件，物理和声学耦合到壳体并突出到内腔中。在壳体内传播的声能被偏转到阻尼构件中，用于在内腔内声扩散。在其各个方面，阻尼构件可以包括一个或一组两个或更多个大致圆柱形的套筒，其中一个端部物理上和声学上耦合到壳体，第二端突出到内部腔室中。优选地，当使用一组两个或更多个圆柱形套筒时，套筒彼此嵌套。阻尼构件还可以包括彼此嵌套的两个或更多个声衰减器的第二相对设置的组，并与第一组圆柱形套筒相互指向。

62. 发明申请

US20050227974A9 Aminoalkyl-substituted aryl compounds and their use as sodium channel blockers 审中-公开
标题翻译：氨基烷基取代的芳基化合物及其作为钠通道阻断剂的用途
公开(公告)号：US20050227974A9
公开(公告)日：2005-10-13
申请号：US10630763
申请日：2003-07-31
申请人： Qun Sun , Donald Kyle
发明人： Qun Sun , Donald Kyle
IPC分类号： C07D295/12 , A61K31/4453 , A61K31/5377 , A61P3/10 , A61P9/10 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/24 , C07D295/13 , A61K31/54 , A61K31/40 , A61K31/421 , A61K31/426 , A61K31/445 , A61K31/495 , A61K31/537
CPC分类号： C07D295/13
摘要： This invention relates to a method of treating disorders responsive to the blockade of sodium ion channels using novel aminoalkyl-substituted aryl compounds of Formula I: or a pharmaceutically-acceptable salt or solvate thereof, wherein n, X, R1, R2 and R3 are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global or focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of acute or chronic pain, neuropathic pain or surgical pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
摘要翻译：本发明涉及使用式I的新的氨基烷基取代的芳基化合物或其药学上可接受的盐或溶剂合物来治疗对钠离子通道阻断有反应的病症的方法，其中n，X，R 1，在本说明书中定义了R 2，R 2和R 3。本发明还涉及式I化合物用于治疗全身或局部缺血后神经元损伤，用于治疗或预防神经变性疾病如肌萎缩性侧索硬化（ALS）以及治疗，预防或改善的用途急性或慢性疼痛，神经性疼痛或外科手术疼痛，作为抗惊厥药，抗惊厥药，抗抑郁药，作为局部麻醉剂，作为抗心律失常药物和用于治疗或预防糖尿病性神经病变。

63. 发明申请

US20050222188A1 Process for preparing oxycodone hydrochloride having less than 25 PPM 14-hydroxycodeinone 有权
标题翻译：制备具有小于25PPM的14-羟可待因酮的羟考酮盐酸盐的方法
公开(公告)号：US20050222188A1
公开(公告)日：2005-10-06
申请号：US11093626
申请日：2005-03-30
申请人： Robert Chapman , Lonn Rider , Qi Hong , Donald Kyle , Robert Kupper
发明人： Robert Chapman , Lonn Rider , Qi Hong , Donald Kyle , Robert Kupper
IPC分类号： A61K31/485 , C07D489/00 , C07D489/08
CPC分类号： C07D489/08 , A61K9/14 , A61K9/20 , A61K9/2095 , A61K9/48 , A61K9/4833 , A61K31/485 , C07D489/02 , C07D489/04
摘要： In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
摘要翻译：在某些实施方案中，本发明涉及制备具有小于25ppm的14-羟可待因酮的盐酸羟考酮组合物的方法。

64. 发明申请

US20050192307A1 Benzimidazolone compounds 审中-公开
标题翻译：苯并咪唑酮化合物
公开(公告)号：US20050192307A1
公开(公告)日：2005-09-01
申请号：US11091229
申请日：2005-03-28
申请人： R. Goehring , Zhengming Chen , Sam Victory , Donald Kyle
发明人： R. Goehring , Zhengming Chen , Sam Victory , Donald Kyle
IPC分类号： A61K31/435 , A61K31/454 , A61P3/04 , A61P7/08 , A61P7/10 , A61P9/12 , A61P11/06 , A61P11/14 , A61P13/12 , A61P21/02 , A61P23/00 , A61P25/04 , A61P25/08 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/32 , A61P25/36 , A61P27/16 , A61P29/00 , C07D401/04 , A61K31/4747 , C07D43/02
CPC分类号： C07D401/04
摘要： Disclosed are compounds of the formula (I): wherein A, B, C, M1-M4, R, R1, R2 and n are as described herein.
摘要翻译：公开了式（I）的化合物：其中A，B，C，M 1-M 4，R 1，R 1，R 2，R ＆lt; 2＆gt;和n如本文所述。

65. 发明申请

US20050126717A1 Overhead door locking operator with remote light assembly 有权
标题翻译：具有远程灯组件的顶盖门锁定操作器
公开(公告)号：US20050126717A1
公开(公告)日：2005-06-16
申请号：US11041840
申请日：2005-01-24
申请人： Willis Mullet , Donald Kyle
发明人： Willis Mullet , Donald Kyle
IPC分类号： E06B9/06 , E05F15/10 , E05F15/16 , E06B9/08
CPC分类号： E05F15/603 , E05D13/1261 , E05F15/668 , E05F15/686 , E05Y2201/214 , E05Y2201/22 , E05Y2201/238 , E05Y2201/244 , E05Y2201/434 , E05Y2600/11 , E05Y2900/106 , Y10T74/18576 , Y10T74/18688 , Y10T74/18792 , Y10T74/19828 , Y10T74/20636
摘要： A system for raising and lowering a sectional overhead door between an open position and a closed position including, a counterbalance system adapted to be connected to the door, an operator motor assembly mounted proximate to the sectional overhead door in the closed position of the sectional overhead door, at least a portion of the operator motor assembly movable between a door operating position and a door locking position, and a locking assembly (370) having an engaged position to hold the motor assembly in the operating position and a disengaged position to release the motor assembly allowing it to move to the door locking position. The system may be provided with a remote light assembly having a switchable light source in sensing communication with the operator motor such that operation of the motor activates the light source. The system is further provided with a handle assembly (515) operatively engaging the motor assembly (40) and counterbalance system (30) to selectively disconnect the motor assembly (40) from the counterbalance system (30), whereby urging of a rotatable handle (516) to a disconnect position (516′) allows the door (D) to be manually freely moveable with the aid of the counterbalance system (30).
摘要翻译：一种用于升高和降低打开位置和关闭位置之间的剖面顶门的系统，包括适于连接到门的平衡系统，操作者电动机组件，其安装在截面顶部门附近，在截面顶部的关闭位置门，操作者电动机组件的至少一部分可在门操作位置和门锁定位置之间移动，以及锁定组件（370），其具有用于将电动机组件保持在操作位置的接合位置和脱离位置以释放电机组件允许其移动到门锁定位置。系统可以设置有远程灯组件，其具有可感测与操作者电动机的通信的可切换光源，使得电动机的操作激活光源。该系统还设置有可操作地接合马达组件（40）和平衡系统（30）的手柄组件（515），以选择性地将马达组件（40）与平衡系统（30）断开，由此推动可旋转手柄 516）到断开位置（516'）允许门（D）借助于平衡系统（30）可手动地自由移动。

66. 发明授权

US06867222B2 Nociceptin analogs 有权
标题翻译：伤害感受类似物
公开(公告)号：US06867222B2
公开(公告)日：2005-03-15
申请号：US10126471
申请日：2002-04-18
申请人： Qun Sun , R. Richard Goehring , Donald Kyle , Zhengming Chen , Sam Victory , John Whitehead
发明人： Qun Sun , R. Richard Goehring , Donald Kyle , Zhengming Chen , Sam Victory , John Whitehead
IPC分类号： A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/445 , A61K31/454 , A61K31/48 , A61P3/04 , A61P7/10 , A61P9/00 , A61P9/12 , A61P11/06 , A61P11/10 , A61P11/14 , A61P13/02 , A61P21/02 , A61P23/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/22 , A61P25/28 , A61P25/32 , A61P25/36 , A61P27/16 , A61P29/00 , A61P43/00 , C07D209/34 , C07D211/04 , C07D211/06 , C07D235/24 , C07D235/26 , C07D263/58 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04 , A61K31/495
CPC分类号： C07D401/04 , C07D235/26 , C07D263/58 , C07D405/14 , C07D413/04 , C07D413/14 , C07D471/04
摘要： A compound of the formula (I), (II), (III) or (IV) wherein Z, A, B, C, R, R1, R2, Q, and n are as described herein.
摘要翻译：式（I），（II），（III）或（IV）的化合物其中Z，A，B，C，R，R 1，R 2，Q和n如本文所述。

67. 发明授权

US06828440B2 Spiroindene and spiroindane compounds 有权
标题翻译：螺茚和螺茚二烯化合物
公开(公告)号：US06828440B2
公开(公告)日：2004-12-07
申请号：US10126472
申请日：2002-04-18
申请人： R. Richard Goehring , Sam Vicotry , Donald Kyle
发明人： R. Richard Goehring , Sam Vicotry , Donald Kyle
IPC分类号： C07D47110
CPC分类号： C07D405/04 , C07D221/20
摘要： A compound of the formula (I): wherein Z, A, B, C, R1, R2, X1, X2, Q and n are as disclosed herein.
摘要翻译：式（I）的化合物：其中Z，A，B，C，R 1，R 2，X 1，X 2，Q和n如本文所公开。

68. 发明授权

US06686370B2 Triazospiro compounds having nociceptin receptor affinity 有权
标题翻译：具有伤害感受肽受体亲和力的三唑螺酮化合物
公开(公告)号：US06686370B2
公开(公告)日：2004-02-03
申请号：US09730938
申请日：2000-12-06
申请人： Donald Kyle , R. Richard Goehring
发明人： Donald Kyle , R. Richard Goehring
IPC分类号： A61K314747
CPC分类号： A61K31/00 , A61K31/445 , C07D471/10 , Y10S514/812
摘要： Disclosed are compounds of the formula (I) wherein A, R1, R2, R3, R4 and X1 are as disclosed herein. The compounds have affinity for the ORL1 receptor and are useful in the treatment of chronic and acute pain.
摘要翻译：公开了式（I）的化合物，其中A，R 1，R 2，R 3，R 4和X 1如本文所公开。该化合物对ORL1受体具有亲和力，可用于治疗慢性和急性疼痛。

69. 发明授权

US6137747A Single point contact acoustic transmitter 失效
标题翻译：单点接触式声发射器
公开(公告)号：US6137747A
公开(公告)日：2000-10-24
申请号：US87220
申请日：1998-05-29
申请人： Vimal V. Shah , James R. Birchak , John W. Minear , Wallace R. Gardner , Donald Kyle , John R. Dennis , Kenny McConnell , George S. Reagan , Rebecca McConnell
发明人： Vimal V. Shah , James R. Birchak , John W. Minear , Wallace R. Gardner , Donald Kyle , John R. Dennis , Kenny McConnell , George S. Reagan , Rebecca McConnell
IPC分类号： B06B1/06 , G01V11/00 , G10K11/00 , H04H9/00
CPC分类号： G01V11/002 , B06B1/0611
摘要： The invention is an acoustic transmitter that imparts vibratory stresses onto a signal propagation medium such as oil well tubing when actuated by an electric driver. In one embodiment, the acoustic transmitter utilizes a mechanical driver that includes piezoelectric elements to generate the vibratory stresses. The acoustic transmitter is mechanically attached at only one point to the signal propagation medium. This single point attachment eliminates loading on the acoustic transmitter from compressive and tensile forces carried by the signal propagation medium. A mass backing the mechanical driver may be used to extend the frequency range over which the acoustic transmitter is operable. In addition, the resonance response of the acoustic transmitter may be minimized by the use of a viscous dampener. The viscous dampener is configured to "couple" with the mechanical driver when the acoustic transmitter is operating and to "uncouple" with the mechanical driver at other times.
摘要翻译：本发明是一种在由电动驱动器致动时将振动应力施加到诸如油井管道之类的信号传播介质上的声发射器。在一个实施例中，声发射器利用包括压电元件的机械驱动器来产生振动应力。声发射机仅在一个点处机械连接到信号传播介质。这种单点附件消除了声发射器上由信号传播介质承载的压缩和拉伸力的负担。可以使用机械驱动器的质量来扩展声发射器可操作的频率范围。此外，通过使用粘性阻尼器可以使声发射器的共振响应最小化。粘性阻尼器被配置为当声发射器操作时与机械驱动器“耦合”，并且在其它时间与机械驱动器“脱离”。

70. 发明授权

US09073933B2 Oxycodone hydrochloride having less than 25 PPM 14-hydroxycodeinone 有权
标题翻译：具有小于25PPM的14-羟可待因酮的羟考酮盐酸盐
公开(公告)号：US09073933B2
公开(公告)日：2015-07-07
申请号：US13366755
申请日：2012-02-06
申请人： Robert Chapman , Lonn S. Rider , Qi Hong , Donald Kyle , Robert Kupper
发明人： Robert Chapman , Lonn S. Rider , Qi Hong , Donald Kyle , Robert Kupper
IPC分类号： A61K31/485 , C07D489/08 , C07D489/02
CPC分类号： C07D489/08 , A61K9/14 , A61K9/20 , A61K9/2095 , A61K9/48 , A61K9/4833 , A61K31/485 , C07D489/02 , C07D489/04
摘要： In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
摘要翻译：在某些实施方案中，本发明涉及制备具有小于25ppm的14-羟可待因酮的盐酸羟考酮组合物的方法。

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