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61. 发明授权

US07919309B2 Method for expression of small antiviral RNA molecules within a cell 有权
标题翻译：在细胞内表达小抗病毒RNA分子的方法
公开(公告)号：US07919309B2
公开(公告)日：2011-04-05
申请号：US10243553
申请日：2002-09-13
申请人： Carlos Lois-Caballe , David Baltimore , Xiao-Feng Qin , Irvin S. Y. Chen , Dong Sung An
发明人： Carlos Lois-Caballe , David Baltimore , Xiao-Feng Qin , Irvin S. Y. Chen , Dong Sung An
IPC分类号： C12N15/00 , C12N15/88 , C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C12N7/00 , C12N15/113 , C12N15/1132 , C12N15/1138 , C12N15/867 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2310/531 , C12N2330/30 , C12N2740/15043 , C12N2740/16043 , C12N2830/003 , C12N2830/006 , C12N2830/008 , C12N2830/30 , C12N2830/48 , C12N2830/60 , C12N2830/85 , C12N2840/20 , C12N2840/203 , C12Q1/6897 , Y02A50/465
摘要： In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector. The methods can be used to express double stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, that interfere with a viral life cycle by down regulating either the viral genome, a viral genome transcript, or a host cell that. In another aspect the invention provides methods for treating patients having suffering from infection, particularly infection with HIV.
摘要翻译：一方面，本发明提供使用逆转录病毒载体在细胞内表达小RNA分子的方法和组合物。该方法可用于表达双链RNA复合物。小干扰RNA（siRNA）可以使用本发明的方法在细胞内表达以干扰病毒生命周期。另一方面，本发明提供了治疗患有感染，特别是HIV感染的患者的方法。

62. 发明授权

US07737124B2 Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell 有权
标题翻译：用于表达细胞内细胞毒性降低的小型抗病毒RNA分子的方法
公开(公告)号：US07737124B2
公开(公告)日：2010-06-15
申请号：US11683962
申请日：2007-03-08
申请人： Carlos Lois-Caballe , David Baltimore , Xiao-Feng Qin , Irvin S. Y. Chen , Dong Sung An
发明人： Carlos Lois-Caballe , David Baltimore , Xiao-Feng Qin , Irvin S. Y. Chen , Dong Sung An
IPC分类号： A01N43/04 , C12Q1/68 , C12P19/34 , C12N15/00 , C07H21/04
CPC分类号： C12N15/1132 , A61K48/00 , C12N15/111 , C12N15/113 , C12N15/1138 , C12N15/63 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2330/30 , C12N2740/16043 , C12N2740/16045 , C12N2760/20122 , C12N2799/027 , C12N2810/609 , C12N2830/003 , C12N2830/008 , C12N2830/48 , C12N2840/203
摘要： In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. 1A). Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell. In a further aspect, the invention provides methods for producing siRNA encoding lentivirus where the siRNA activity may interfere with the lentiviral life cycle. In yet a further aspect, the invention provides methods for expression of a small RNA molecule within a cell, such as an siRNA capable of downregulating CCR5, wherein expression of the small RNA molecule is relatively non-cytotoxic to the cell. The invention also includes small RNA molecules, such as an siRNA capable of downregulating CCR5, that are relatively non-cytotoxic to cells.
摘要翻译：一方面，本发明提供了使用逆转录病毒载体在细胞内表达小RNA分子的方法和组合物（图1A）。可以使用本发明的方法在细胞内表达小干扰RNA（siRNA）。另一方面，本发明提供了用于产生编码慢病毒的siRNA的方法，其中siRNA活性可能干扰慢病毒生命周期。在另一方面，本发明提供了在细胞内表达小RNA分子的方法，例如能够下调CCR5的siRNA，其中小RNA分子的表达对细胞是相对非细胞毒性的。本发明还包括对细胞相对非细胞毒性的小RNA分子，例如能够下调CCR5的siRNA。

63. 发明申请

US20090203136A1 MODULATING IMMUNE SYSTEM DEVELOPMENT AND FUNCTION THROUGH MICRORNA MIR-146 有权
标题翻译：通过MICRORNA MIR-146调节免疫系统发育和功能
公开(公告)号：US20090203136A1
公开(公告)日：2009-08-13
申请号：US12337525
申请日：2008-12-17
申请人： David Baltimore , Mark Boldin , Konstantin Taganov
发明人： David Baltimore , Mark Boldin , Konstantin Taganov
IPC分类号： C12N5/08
CPC分类号： C12N15/113 , C12N2310/111 , C12N2310/113 , C12N2310/141 , C12N2330/10
摘要： The present disclosure relates to the finding that microRNA-146 plays a role in modulating the development and function of the immune system. Immune cell development and function can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells or precursor cells. For example, in some embodiments, activity and/or proliferation of certain immune cells is regulated by administering miR-146 oligonucleotides or anti-miR-146 oligonucleotides. In other embodiments, pro-inflammatory cytokine expression in immune cells is regulated by administering a miR-146 oligonucleotide or anti-miR-146. In further embodiments, methods of regulating macrophage activity using antisense miR-146 are provided. Additional methods and compositions for regulating immune system function and development using miR-146 are disclosed.
摘要翻译：本公开涉及微RNA-146在调节免疫系统的发育和功能中起作用的发现。免疫细胞发育和功能可以通过将microRNA-146（miR-146）或反义miR-146递送到靶向免疫细胞或前体细胞来调节。例如，在一些实施方案中，通过施用miR-146寡核苷酸或抗miR-146寡核苷酸调节某些免疫细胞的活性和/或增殖。在其它实施方案中，通过施用miR-146寡核苷酸或抗miR-146调节免疫细胞中的促炎细胞因子表达。在另外的实施方案中，提供了使用反义miR-146调节巨噬细胞活性的方法。公开了使用miR-146调节免疫系统功能和发育的其它方法和组合物。

64. 发明申请

US20080003682A1 METHOD FOR EXPRESSION OF SMALL ANTIVIRAL RNA MOLECULES WITH REDUCED CYTOTOXICITY WITHIN A CELL 有权
标题翻译：用于表达细胞中具有降低细胞毒性的小抗病毒RNA分子的方法
公开(公告)号：US20080003682A1
公开(公告)日：2008-01-03
申请号：US11683962
申请日：2007-03-08
申请人： Carlos Lois-Caballe , David Baltimore , Xiao-Feng Qin , Irvin Chen , Dong An
发明人： Carlos Lois-Caballe , David Baltimore , Xiao-Feng Qin , Irvin Chen , Dong An
IPC分类号： C07H21/04 , C12N15/86
CPC分类号： C12N15/1132 , A61K48/00 , C12N15/111 , C12N15/113 , C12N15/1138 , C12N15/63 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2330/30 , C12N2740/16043 , C12N2740/16045 , C12N2760/20122 , C12N2799/027 , C12N2810/609 , C12N2830/003 , C12N2830/008 , C12N2830/48 , C12N2840/203
摘要： In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. 1A). Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell. In a further aspect, the invention provides methods for producing siRNA encoding lentivirus where the siRNA activity may interfere with the lentiviral life cycle. In yet a further aspect, the invention provides methods for expression of a small RNA molecule within a cell, such as an siRNA capable of downregulating CCR5, wherein expression of the small RNA molecule is relatively non-cytotoxic to the cell. The invention also includes small RNA molecules, such as an siRNA capable of downregulating CCR5, that are relatively non-cytotoxic to cells.
摘要翻译：一方面，本发明提供使用逆转录病毒载体在细胞内表达小RNA分子的方法和组合物（图1A）。可以使用本发明的方法在细胞内表达小干扰RNA（siRNA）。另一方面，本发明提供了用于产生编码慢病毒的siRNA的方法，其中siRNA活性可能干扰慢病毒生命周期。在另一方面，本发明提供了在细胞内表达小RNA分子的方法，例如能够下调CCR5的siRNA，其中小RNA分子的表达对细胞是相对非细胞毒性的。本发明还包括对细胞相对非细胞毒性的小RNA分子，例如能够下调CCR5的siRNA。

65. 发明授权

US07195916B2 Method for expression of small antiviral RNA molecules within a cell 有权
标题翻译：在细胞内表达小抗病毒RNA分子的方法
公开(公告)号：US07195916B2
公开(公告)日：2007-03-27
申请号：US10319341
申请日：2002-12-12
申请人： Xiao-Feng Qin , David Baltimore
发明人： Xiao-Feng Qin , David Baltimore
IPC分类号： C12Q1/68 , C12P19/34 , C12N15/87 , C07H21/02 , C07H21/04
CPC分类号： C12N15/111 , A61K38/00 , A61K48/00 , C12N15/1132 , C12N15/1138 , C12N15/86 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/31 , C12N2330/30 , C12N2740/16043 , C12N2830/003 , C12N2830/006 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12N2840/20 , C12N2840/203
摘要： In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector. The methods can be used to express double stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, that interfere with a viral life cycle by down regulating either the viral genome, a viral genome transcript, or a host cell that. In another aspect the invention provides methods for treating patients having suffering from infection, particularly infection with HIV. In a further aspect, the invention provides methods for producing siRNA encoding lentivirus where the siRNA activity may interfere with the lentiviral life cycle.
摘要翻译：一方面，本发明提供使用逆转录病毒载体在细胞内表达小RNA分子的方法和组合物。该方法可用于表达双链RNA复合物。可以使用本发明的方法在细胞内表达小干扰RNA（siRNA），其通过下调病毒基因组，病毒基因组转录物或宿主细胞来干扰病毒生命周期。另一方面，本发明提供了治疗患有感染，特别是HIV感染的患者的方法。另一方面，本发明提供了用于产生编码慢病毒的siRNA的方法，其中siRNA活性可能干扰慢病毒生命周期。

66. 发明申请

US20060063709A1 Nuclear factors associated with transcriptional regulation 审中-公开
标题翻译：与转录调控相关的核因子
公开(公告)号：US20060063709A1
公开(公告)日：2006-03-23
申请号：US10037415
申请日：2002-01-04
申请人： David Baltimore , Ranjan Sen , Phillip Sharp , Harinder Singh , Louis Staudt , Jonathan LeBowitz , Albert Baldwin , Roger Clerc , Lynn Corcoran , Patrick Baeuerle , Michael Lenardo , Chen-Ming Fan , Thomas Maniatis
发明人： David Baltimore , Ranjan Sen , Phillip Sharp , Harinder Singh , Louis Staudt , Jonathan LeBowitz , Albert Baldwin , Roger Clerc , Lynn Corcoran , Patrick Baeuerle , Michael Lenardo , Chen-Ming Fan , Thomas Maniatis
IPC分类号： A61K38/17 , C07K14/47 , C07H21/04
CPC分类号： C07K14/005 , C07K14/4702 , C07K2319/00 , C12N15/85 , C12N2740/16022 , C12N2800/108 , C12N2830/00 , C12N2830/008 , C12N2830/15 , C12N2830/30 , C12N2830/85 , C12Q1/68 , C12Q1/6813 , C12Q1/6897 , G01N33/6872 , G01N2500/02
摘要： Constitutive and tissue-specific protein factors which bind to transcriptional regulatory elements of Ig genes (promoter and enhancer) are described. The factors were identified and isolated by an improved assay for protein-DNA binding. Genes encoding factors which positively regulate transcription can be isolated and employed to enhance transcription of Ig genes. In particular, NF-kB, the gene encoding NF-kB, IkB and the gene encoding IkB and uses therefor.
摘要翻译：描述了结合Ig基因转录调控元件（启动子和增强子）的组成型和组织特异性蛋白因子。通过改进的蛋白质-DNA结合测定鉴定和分离因子。可以分离用于正调节转录的编码因子的基因，以增强Ig基因的转录。特别地，NF-kB，编码NF-kB，IkB的基因和编码IkB的基因并用于其。

67. 发明申请

US20050271647A1 Chimeric pro-caspases and methods of using same 审中-公开
公开(公告)号：US20050271647A1
公开(公告)日：2005-12-08
申请号：US11176129
申请日：2005-07-06
申请人： David Baltimore , Xiaolu Yang , Howard Chang
发明人： David Baltimore , Xiaolu Yang , Howard Chang
IPC分类号： A61K38/48 , A61K39/395 , C07H21/04 , C12N9/64 , C12P21/06 , C12Q1/68
CPC分类号： C12N9/6475 , C07H21/04 , C07K2319/00 , C07K2319/50
摘要： The present invention relates to a chimeric pro-caspase, which contains a pro-caspase domain and an oligomerizing domain. The invention also relates to an antibody that reacts specifically with a chimeric pro-caspase. In addition, the invention further relates to a polynucleotide encoding a chimeric pro-caspase, and to nucleotide sequences, which can hybridize specifically with a polynucleotide encoding a chimeric pro-caspase. The present invention also relates to a method of inducing apoptosis in a cell by providing a chimeric pro-caspase in the cell, wherein the chimeric pro-caspase includes a pro-caspase domain and an oligomerizing domain, whereby the chimeric pro-caspase forms an oligomer in the cell, thereby activating caspase activity of the chimeric pro-caspase and inducing apoptosis in the cell. The present invention further relates to a method of reducing the severity of a pathologic condition in a subject, by providing cells of the subject that are involved in the pathologic condition with a chimeric pro-caspase comprising a pro-caspase domain and an oligomerizing domain, whereby the chimeric pro-caspase forms an oligomer in the cells, thereby activating caspase activity of the chimeric pro-caspase, inducing apoptosis in the cells, and reducing the severity of the pathologic condition in the subject.

68. 发明申请

US20050009180A1 Method for the generation of antigen-specific lymphocytes 审中-公开
标题翻译：产生抗原特异性淋巴细胞的方法
公开(公告)号：US20050009180A1
公开(公告)日：2005-01-13
申请号：US10789938
申请日：2004-02-27
申请人： Lili Yang , Luk Parijs , David Baltimore
发明人： Lili Yang , Luk Parijs , David Baltimore
IPC分类号： C12N5/0783 , C12N5/0789 , C12N5/08 , A61K48/00 , C12N15/85
CPC分类号： C12N5/0647 , A61K2039/5156 , C12N5/0636 , C12N2510/00 , C12N2799/027
摘要： The invention provides systems and methods for the generation of lymphocytes having a unique antigen specificity. In a preferred embodiment, the invention provides methods of virally infecting cells from bone marrow with one or more viral vectors that encode antigen-specific T cell receptors. The resulting lymphocytes, and in particular, T cells express the T cell receptor (TCR) that was introduced. The lymphocytes generated can be used for a variety of therapeutic purposes including the treatment of various cancers and the generation of a desired immune response to viruses and other pathogens. The resulting cells develop normally and respond to antigen both in vitro and in vivo. It is also possible to modify the function of lymphocytes by using stem cells from different genetic backgrounds. Thus the system constitutes a powerful tool to generate desired lymphocyte populations both for research and therapy. The invention may be used in treatments for infectious diseases, such as HIV/AIDS, allergy, autoimmune disease and cancer therapy.
摘要翻译：本发明提供用于产生具有独特抗原特异性的淋巴细胞的系统和方法。在优选的实施方案中，本发明提供了用编码抗原特异性T细胞受体的一种或多种病毒载体来病毒感染骨髓细胞的方法。所得淋巴细胞，特别是T细胞表达导入的T细胞受体（TCR）。所产生的淋巴细胞可用于各种治疗目的，包括治疗各种癌症和产生对病毒和其它病原体的所需免疫应答。所得细胞正常发育并在体外和体内对抗原起反应。还可以通过使用不同遗传背景的干细胞来修饰淋巴细胞的功能。因此，该系统构成用于产生所需淋巴细胞群体用于研究和治疗的有力工具。本发明可用于感染性疾病如艾滋病毒/艾滋病，过敏，自身免疫疾病和癌症治疗的治疗。

69. 发明授权

US06410516B1 Nuclear factors associated with transcriptional regulation 失效
标题翻译：与转录调控相关的核因子
公开(公告)号：US06410516B1
公开(公告)日：2002-06-25
申请号：US08464364
申请日：1995-06-05
申请人： David Baltimore , Ranjan Sen , Phillip A. Sharp , Harinder Singh , Louis Staudt , Jonathan H. Lebowitz , Albert S. Baldwin, Jr. , Roger G. Clerc , Lynn M. Corcoran , Patrick A. Baeuerle , Michael J. Lenardo , Chen-Ming Fan , Thomas P. Maniatis
发明人： David Baltimore , Ranjan Sen , Phillip A. Sharp , Harinder Singh , Louis Staudt , Jonathan H. Lebowitz , Albert S. Baldwin, Jr. , Roger G. Clerc , Lynn M. Corcoran , Patrick A. Baeuerle , Michael J. Lenardo , Chen-Ming Fan , Thomas P. Maniatis
IPC分类号： A61K31711
CPC分类号： C07K14/005 , C07K14/4702 , C07K2319/00 , C12N15/85 , C12N2740/16022 , C12N2800/108 , C12N2830/00 , C12N2830/008 , C12N2830/15 , C12N2830/30 , C12N2830/85 , C12Q1/68 , C12Q1/6813 , C12Q1/6897 , G01N33/6872 , G01N2500/02
摘要： Constitutive and tissue-specific protein factors which bind to transcriptional regulatory elements of Ig genes (promoter and enhancer) are described. The factors were identified and isolated by an improved assay for protein-DNA binding. Genes encoding factors which positively regulate transcription can be isolated and employed to enhance transription of Ig genes. In particular, NF-kB, the gene encoding NF-kB, IkB and the gene encoding IkB and uses therefor.
摘要翻译：描述了结合Ig基因转录调控元件（启动子和增强子）的组成型和组织特异性蛋白因子。通过改进的蛋白质-DNA结合测定鉴定和分离因子。可以分离用于正调节转录的编码因子的基因以增强Ig基因的转录。特别地，NF-kB，编码NF-kB，IkB的基因和编码IkB的基因并用于其。

70. 发明授权

US5919458A Non-infectious HIV particles and uses therefor 失效
公开(公告)号：US5919458A
公开(公告)日：1999-07-06
申请号：US477081
申请日：1995-06-07
申请人： Anna Aldovini , Richard A. Young , Mark B. Feinberg , Didier Trono , David Baltimore
发明人： Anna Aldovini , Richard A. Young , Mark B. Feinberg , Didier Trono , David Baltimore
IPC分类号： A61K39/00 , A61K39/21 , A61P31/18 , C07K14/16 , C12N7/00 , C12N7/04 , C12N15/867 , C12N15/86
CPC分类号： C12N15/86 , A61K39/12 , A61K39/21 , C07K14/005 , C12N7/00 , A61K39/00 , C12N2740/16021 , C12N2740/16023 , C12N2740/16052 , C12N2740/16062 , C12N2740/16122 , C12N2740/16222 , Y10S530/826
摘要： This invention related to constructs comprising mutant HIV genomes having an alteration in a nucleotide sequence which is critical for genomic RNA packaging and non-infectious, immunogenic HIV particles produced by expression of these constructs in mammalian cells. Cell lines which stably produce non-infectious, immunogenic HIV particles are also included. Prophylactic and therapeutic vaccines, diagnostic reagents, and related methods are further described.

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