专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明授权

US07115596B2 Thiazole compounds as integrin receptor antagonists derivatives 失效
标题翻译：噻唑化合物作为整合素受体拮抗剂衍生物
公开(公告)号：US07115596B2
公开(公告)日：2006-10-03
申请号：US10741056
申请日：2003-12-19
申请人： John A. Wendt , Heather Stenmark , Hongwei Wu , Yaping Wang , Barbara B. Chen , Thomas D. Penning , Victoria L. Downs , Mark L. Boys , Mark Russell , Dale P. Spangler
发明人： John A. Wendt , Heather Stenmark , Hongwei Wu , Yaping Wang , Barbara B. Chen , Thomas D. Penning , Victoria L. Downs , Mark L. Boys , Mark Russell , Dale P. Spangler
IPC分类号： A61K31/55 , A61K31/5025 , A61K31/44 , A61K31/425 , A61K31/36 , C07D401/00 , C07D417/00 , C07D413/00 , C07D471/02 , C07D207/00 , C07D317/46
CPC分类号： C07D417/14 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 and/or the αvβ5 integrin without significantly inhibiting the αvβ6 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗α > 3和/或α5β5整联蛋白，而不显着抑制α3β6 整合素。

62. 发明授权

US06531494B1 Gem-substituted &agr;v&bgr;3 antagonists 失效
标题翻译：宝石取代的alphavbeta3拮抗剂
公开(公告)号：US06531494B1
公开(公告)日：2003-03-11
申请号：US09942214
申请日：2001-08-29
申请人： Ish Kumar Khanna , Yi Yu , Balekudru Devadas , Hwang-Fun Lu , Nizal S Chandrakumar , Renee M. Huff , Bipinchandra N. Desai , Srinivasan Raj Nagarajan , Alan F. Gasiecki , Thomas D. Penning , Mark A. Russell , Mark L. Boys , Lori A. Schretzman , Barbara B. Chen , Thomas Rogers , John Adam Wendt , Albert Khilevich , Yaping Wang
发明人： Ish Kumar Khanna , Yi Yu , Balekudru Devadas , Hwang-Fun Lu , Nizal S Chandrakumar , Renee M. Huff , Bipinchandra N. Desai , Srinivasan Raj Nagarajan , Alan F. Gasiecki , Thomas D. Penning , Mark A. Russell , Mark L. Boys , Lori A. Schretzman , Barbara B. Chen , Thomas Rogers , John Adam Wendt , Albert Khilevich , Yaping Wang
IPC分类号： A61K3144
CPC分类号： C07D213/74 , C07D213/73 , C07D401/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula I. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;V&bgr;3 and/or the &agr;V&bgr;5 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物，以及选择性抑制或拮抗αVβ3和/或αVβ5整联蛋白的方法。

63. 发明授权

US5773644A Cyclopropyl alkanoic acid derivatives 失效
标题翻译：环丙基链烷酸衍生物
公开(公告)号：US5773644A
公开(公告)日：1998-06-30
申请号：US825040
申请日：1997-03-27
申请人： Barbara B. Chen , Helen Y. Chen , Michael Clare , Shashidhar N. Rao , Mark A. Russell
发明人： Barbara B. Chen , Helen Y. Chen , Michael Clare , Shashidhar N. Rao , Mark A. Russell
IPC分类号： C07D239/14 , A61K31/00 , A61K31/195 , A61K31/196 , A61K31/215 , A61K31/216 , A61K31/505 , A61P3/00 , A61P3/14 , A61P9/00 , A61P9/10 , A61P35/00 , A61P35/04 , A61P43/00 , C07C279/18 , C07C279/24 , C07D239/42 , C07C241/00 , C07C229/00 , C07D239/00
CPC分类号： C07D239/42 , C07C279/18 , C07C279/24 , C07C2101/02
摘要： The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the .alpha..sub.v .beta..sub.3 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗αvβ3整联蛋白的方法。

64. 发明授权

US5416119A Alkylaminoalkyl-terminated sulfide/sulfonyl-containing cycloalkyl-alanine amino-diol compounds for treatment of hypertension 失效
标题翻译：用于治疗高血压的烷基氨基烷基封端的硫化物/含磺酰基的环烷基 - 丙氨酸氨基二醇化合物
公开(公告)号：US5416119A
公开(公告)日：1995-05-16
申请号：US141771
申请日：1993-10-25
申请人： Barbara B. Chen , Gunnar J. Hanson , John S. Baran
发明人： Barbara B. Chen , Gunnar J. Hanson , John S. Baran
IPC分类号： A61K31/16 , A61K31/165 , C07C317/44 , C07C323/60 , C07C323/25
CPC分类号： C07C323/60 , A61K31/16 , A61K31/165 , C07C317/44 , C07C2101/04 , C07C2101/14 , Y10S514/912 , Y10S514/913
摘要： Compounds characterized generally as alkylaminoalkyl-terminated sulfide/sulfonyl-containing cycloalkylalkyl alanine amino-diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of Formula II: ##STR1## wherein m is two or three; wherein x is zero or two; wherein R.sup.2 is selected from hydrido, methyl, ethyl and phenyl; wherein R.sup.3 is selected from hydrido, cyclohexylmethyl, benzyl, fluorobenzyl, chlorobenzyl, fluoronaphthylmethyl and chloronaphthylmethyl; wherein R.sup.5 is selected from cycloalkylalkyl groups containing from three to about twelve carbon atoms; wherein R.sup.7 is cyclohexylmethyl; wherein R.sup.8 is selected from n-propyl, isobutyl, cyclopropyl, cyclopropylmethyl, allyl and vinyl; and wherein each of R.sup.9 and R.sup.10 is a group independently selected from methyl, ethyl and isopropyl; or a pharmaceutically-acceptable salt thereof.
摘要翻译：通常作为烷基氨基烷基封端的硫化物/含磺酰基的环烷基烷基丙氨酸氨基二醇衍生物的化合物可用作治疗高血压的肾素抑制剂。特别感兴趣的化合物是式II的化合物：其中m为2或3; 其中x为0或2; 其中R2选自氢，甲基，乙基和苯基; 其中R 3选自氢，环己基甲基，苄基，氟苄基，氯苄基，氟萘基甲基和氯萘基甲基; 其中R 5选自含有3至约12个碳原子的环烷基烷基; 其中R 7为环己基甲基; 其中R8选自正丙基，异丁基，环丙基，环丙基甲基，烯丙基和乙烯基; 并且其中R 9和R 10各自独立地选自甲基，乙基和异丙基; 或其药学上可接受的盐。

65. 发明授权

US5314920A Ethynyl-alanine aryl/alkylsulfonyl-terminated amino-diol compounds for treatment of hypertension 失效
标题翻译：用于治疗高血压的乙炔基 - 丙氨酸芳基/烷基磺酰基封端的氨基二醇化合物
公开(公告)号：US5314920A
公开(公告)日：1994-05-24
申请号：US916447
申请日：1992-07-20
申请人： Barbara B. Chen , Gunnar J. Hanson , John S. Baran
发明人： Barbara B. Chen , Gunnar J. Hanson , John S. Baran
IPC分类号： C07C317/44 , A61K31/16
CPC分类号： C07C317/44 , C07C2101/02 , C07C2101/14
摘要： Compounds characterized generally as ethynyl alanine aryl/alkylsulfonyl-terminated amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of the formula ##STR1## wherein R.sup.1 is selected from isopropyl, isobutyl, sec-butyl, tert-butyl, phenyl, fluorophenyl, chlorophenyl, benzyl, fluorobenzyl, chlorobenzyl, naphthyl, fluoronaphthyl, chloronaphthyl, fluoronaphthylmethyl and chloronaphthylmethyl; wherein R.sup.2 is selected from hydrido, methyl, ethyl and phenyl; wherein R.sup.3 is selected from hydrido, cyclohexylmethyl, benzyl, fluorobenzyl, chlorobenzyl, fluoronaphthylmethyl and chloronaphthylmethyl; wherein R.sup.5 is propargyl or a propargyl-containing moeity; wherein R.sup.7 is cyclohexylmethyl; and wherein R.sup.8 is selected from n-propyl, isobutyl, cyclopropyl, cyclopropylmethyl, allyl and vinyl.
摘要翻译：通常表示乙炔基丙氨酸芳基/烷基磺酰基封端的氨基二醇衍生物的化合物可用作治疗高血压的肾素抑制剂。特别感兴趣的化合物是下式的化合物，其中R 1选自异丙基，异丁基，仲丁基，叔丁基，苯基，氟苯基，氯苯基，苄基，氟苄基，氯苄基，萘基，氟萘基，氯萘基，氟萘基甲基和氯萘基甲基 ; 其中R2选自氢，甲基，乙基和苯基; 其中R 3选自氢，环己基甲基，苄基，氟苄基，氯苄基，氟萘基甲基和氯萘基甲基; 其中R5是炔丙基或含炔丙基的摩尔; 其中R 7为环己基甲基; 并且其中R8选自正丙基，异丁基，环丙基，环丙基甲基，烯丙基和乙烯基。

66. 发明授权

US5169788A Methods of measuring membrane potential using J-aggregate forming dyes 失效
标题翻译：使用聚集体形成染料测量膜电位的方法
公开(公告)号：US5169788A
公开(公告)日：1992-12-08
申请号：US363674
申请日：1989-06-09
申请人： Lan B. Chen , Glenn D. Steele, Jr. , Stephen T. Smiley
发明人： Lan B. Chen , Glenn D. Steele, Jr. , Stephen T. Smiley
IPC分类号： G01N15/14 , G01N33/50
CPC分类号： G01N33/5005 , G01N15/14 , G01N21/6428 , Y10S435/968 , Y10S436/80
摘要： Disclosed is a method of detecting a localized biochemical event in a cell, wherein said event results in a change in the membrane potential of that cell. The method includes treating the cell with a composition containing a lipophilic, cationic dye having a delocalized positive charge and the ability to undergo multiple changes in fluorescence spectra upon aggregation. The cell is treated with the dye for a time sufficient to enable the dye to associate with the cell. Dye which has not associated with the cell is then removed. Fluorescence is observed when the cell is exposed to light having a wavelength suitable for exciting the dye. The spectrum obtained is indicative of the relative membrane potential of said cell, and a change in that membrane potential being indicative of the occurrence of a biochemical event.
摘要翻译：公开了一种检测细胞中局部生化事件的方法，其中所述事件导致该细胞的膜电位发生变化。该方法包括用包含具有离域正电荷的亲脂阳离子染料和在聚集时经受多次荧光光谱变化的能力的组合物处理细胞。用染料处理细胞足以使染料与细胞缔合的时间。然后除去与细胞没有关联的染料。当细胞暴露于适合于激发染料的波长的光时，观察到荧光。获得的光谱指示所述细胞的相对膜电位，并且该膜电位的变化指示生化事件的发生。

67. 发明授权

US4341754A Diagnostic reagent for herpes simplex virus encephalitis 失效
标题翻译：单纯疱疹病毒性脑炎诊断试剂
公开(公告)号：US4341754A
公开(公告)日：1982-07-27
申请号：US114739
申请日：1980-01-24
申请人： Albert S. Kaplan , Tamar B. Kaplan , Anthony B. Chen
发明人： Albert S. Kaplan , Tamar B. Kaplan , Anthony B. Chen
IPC分类号： C07K14/035 , G01N33/569 , A61K43/00 , G01N33/56 , G01N33/60
CPC分类号： G01N33/56994 , C07K14/005 , C12N2710/16622 , Y10S530/806
摘要： A cerebral spinal fluid diagnostic reagent for herpes simplex virus encephalitis consists essentially of the glycoprotein derived from Type 1 herpes simplex virus (HSV-1) having an approximate molecular weight of 132,000 which is antigenically reactive with HSV-1 antiserum. The reactive protein is in radiolabeled form and comprises at least 50% of the total radiolabeled protein present in the reagent.
摘要翻译：用于单纯疱疹病毒脑炎的脑脊髓液诊断试剂基本上由衍生自具有与HSV-1抗血清抗原反应性的约132,000分子量的1型单纯疱疹病毒（HSV-1）的糖蛋白组成。反应蛋白是放射性标记的形式，并且包含试剂中存在的总放射性标记的蛋白质的至少50％。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式