专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明授权

US06689620B1 Method, detector, and apparatus for colorimetric detection of chemical and biological agents 失效
标题翻译：用于化学和生物制剂比色检测的方法，检测器和装置
公开(公告)号：US06689620B1
公开(公告)日：2004-02-10
申请号：US10357338
申请日：2003-02-04
申请人： Alok Singh , Paul Schoen
发明人： Alok Singh , Paul Schoen
IPC分类号： G01N2175
CPC分类号： G01N21/78 , Y10T436/144444
摘要： A colorimetric detector for chemical and biological agents or toxins is made of a giant unilamellar vesicle (GUV) having a membrane bilayer which is polymerized to stabilize the giant unilamellar vesicle and to provide extended conjugated polymer backbone, and the GUV has at least one incorporated molecular recognition site for the chemical and biological agents or toxins. The GUVs are about 10-300 microns and preferably made of a polymerizable diacetylenic GUV where the acyl chains are crosslinked. When the agents or toxins bind to the recognition site the detector exhibits a color change. The detector can be used in a colorimetric detector apparatus where the samples can be present in air or in water.
摘要翻译：用于化学和生物制剂或毒素的比色检测器由具有聚合以稳定巨型单层囊泡并提供延伸的共轭聚合物主链的膜双层的巨型单层囊泡（GUV）制成，并且GUV具有至少一个并入的分子化学和生物制剂或毒素的识别部位。 GUV约为10-300微米，优选由酰基链交联的可聚合二乙酰GUV制成。当试剂或毒素与识别位点结合时，检测器显示颜色变化。检测器可用于比色检测器装置，其中样品可存在于空气或水中。

62. 发明授权

US06541270B2 Method, detector, and apparatus for colorimetric detection of chemical and biological agents 失效
标题翻译：用于化学和生物制剂比色检测的方法，检测器和装置
公开(公告)号：US06541270B2
公开(公告)日：2003-04-01
申请号：US09759149
申请日：2001-01-16
申请人： Alok Singh , Paul Schoen
发明人： Alok Singh , Paul Schoen
IPC分类号： G01N2175
CPC分类号： G01N21/78 , Y10T436/144444
摘要： A colorimetric detector for chemical and biological agents or toxins is made of a giant unilamellar vesicle (GUV) having a membrane bilayer which is polymerized to stabilize the giant unilamellar vesicle and to provide extended conjugated polymer backbone, and the GUV has at least one incorporated molecular recognition site for the chemical and biological agents or toxins. The GUVs are about 10-300 microns and preferably made of a polymerizable diacetylenic GUV where the acyl chains are crosslinked. When the agents or toxins bind to the recognition site the detector exhibits a color change. The detector can be used in a colorimetric detector apparatus where the samples can be present in air or in water.
摘要翻译：用于化学和生物制剂或毒素的比色检测器由具有聚合以稳定巨型单层囊泡并提供延伸的共轭聚合物主链的膜双层的巨型单层囊泡（GUV）制成，并且GUV具有至少一个并入的分子化学和生物制剂或毒素的识别部位。 GUV约为10-300微米，优选由酰基链交联的可聚合二乙酰GUV制成。当试剂或毒素与识别位点结合时，检测器显示颜色变化。检测器可用于比色检测器装置，其中样品可存在于空气或水中。

63. 发明授权

US06248842B1 Synthetic polymer matrices including pre-organized chelation sites for the selective and reversible binding of metals 失效
标题翻译：合成聚合物基质包括用于金属的选择性和可逆结合的预组织螯合位点
公开(公告)号：US06248842B1
公开(公告)日：2001-06-19
申请号：US09267920
申请日：1999-02-25
申请人： Alok Singh , Eddie L. Chang
发明人： Alok Singh , Eddie L. Chang
IPC分类号： C08F832
CPC分类号： C08F8/30
摘要： Selective, crosslinked chelating polymers are produced by substituting an acyclic chelating agent with a polymerizable functional group. The resulting substituted acyclic chelating agent is then complexed with the target metal ion. A crosslinkable monomer is then added and the complexed material is crosslinked. The complexed metal is then removed, providing a crosslinked polymeric chelating agent that has been templated for the target metal ion.
摘要翻译：通过用可聚合官能团取代无环螯合剂制备选择性交联的螯合聚合物。然后将所得的取代的无环螯合剂与目标金属离子络合。然后加入可交联的单体，并将络合的材料交联。然后去除络合的金属，提供已经被模板化为目标金属离子的交联聚合物螯合剂。

64. 发明授权

US5663387A Liposomes containing polymerized lipids for non-covalent immobilization of proteins and enzymes 失效
标题翻译：脂质体含有用于非共价固定蛋白质和酶的聚合脂质
公开(公告)号：US5663387A
公开(公告)日：1997-09-02
申请号：US512355
申请日：1995-08-08
申请人： Alok Singh
发明人： Alok Singh
IPC分类号： A61K9/127 , C07F9/10 , C07F9/02
CPC分类号： A61K9/1273 , C07F9/10 , Y10T428/2984
摘要： The lipids of this invention are derivatives of phosphatidyl choline having the general chemical formula: ##STR1## wherein at least one of R and R' is a polymerizable unsaturated alkyl group, acid or ester, wherein X includes an iminodiacetic acid in the polymerizable metal chelating lipid (2) and wherein z is an integer from 1-20 including 1 and 20. Lipid microstructures are formed by mixing the polymerizable metal chelating lipid monomers (2) with polymerizable non-chelating lipid monomers wherein X includes a non-chelating group, for example, --N.sup.+ (CH.sub.3).sub.3.
摘要翻译：本发明的脂质是具有以下通式的磷脂酰胆碱的衍生物：其中R和R'中的至少一个是可聚合的不饱和烷基，酸或酯，其中X包括亚氨基二乙酸可聚合的金属螯合脂质（2），其中z是1-20的包括1和20的整数。通过将可聚合金属螯合脂质单体（2）与可聚合的非螯合脂质单体混合形成脂质微结构，其中X包括非 - 螯合基团，例如-N +（CH 3）3。

65. 发明授权

US5466467A Liposomes containing polymerized lipids for non-covalent immobilization of proteins and enzymes 失效
标题翻译：脂质体含有用于非共价固定蛋白质和酶的聚合脂质
公开(公告)号：US5466467A
公开(公告)日：1995-11-14
申请号：US220124
申请日：1994-03-30
申请人： Alok Singh
发明人： Alok Singh
IPC分类号： A61K9/127 , C07F9/10
CPC分类号： A61K9/1273 , C07F9/10 , Y10T428/2984
摘要： The lipids of this invention are derivatives of phosphatidyl choline having the general chemical formula: ##STR1## wherein at least one of R and R' is a polymerizable unsaturated alkyl group, acid or ester, wherein X includes an iminodiacetic acid in the polymerizable metal chelating lipid (2) and wherein z is an integer from 1-20 including 1 and 20. Lipid microstructures are formed by mixing the polymerizable metal chelating lipid monomers (2) with polymerizable non-chelating lipid monomers wherein X includes a non-chelating group, for example, --N.sup.+ (CH.sub.3).sub.3.
摘要翻译：本发明的脂质是具有以下通式的磷脂酰胆碱的衍生物：其中R和R'中的至少一个是可聚合的不饱和烷基，酸或酯，其中X包括亚氨基二乙酸可聚合的金属螯合脂质（2），其中z是1-20的包括1和20的整数。通过将可聚合金属螯合脂质单体（2）与可聚合的非螯合脂质单体混合形成脂质微结构，其中X包括非 - 螯合基团，例如-N +（CH 3）3。

66. 发明授权

US5366881A Polymerizable lipids for preparing vesicles that controllably release an encapsulant 失效
标题翻译：用于制备可控制地释放密封剂的囊泡的可聚合脂质
公开(公告)号：US5366881A
公开(公告)日：1994-11-22
申请号：US23834
申请日：1993-02-23
申请人： Alok Singh , Joel M. Schnur
发明人： Alok Singh , Joel M. Schnur
IPC分类号： A61K8/14 , A61K9/127 , A61Q13/00 , C12N11/02 , C12N11/04 , A61K7/46 , A61K37/22 , B29C39/10
CPC分类号： C12N11/04 , A61K8/14 , A61K9/1273 , A61Q13/00 , Y10S435/968
摘要： The present invention provides novel polymerizable lipids and mixtures thof with non-polymerizable lipids and methods for the controlled release of encapsulated materials using stabilized or polymerized vesicles. Release is induced by pH, ions, temperature, light or other changes in the environment. Time release mechanisms are also employed. Applications of the present invention especially include encapsulation of enzymes and their subsequent sustained release for degradation of environmental pollutants, encapsulation of fluorescent markers for use in sensor systems, and encapsulation and release of fragrant molecules in detergents.
摘要翻译：本发明提供新的可聚合脂质及其与不可聚合脂质的混合物，以及使用稳定或聚合的囊泡控制释放包封材料的方法。释放是由pH，离子，温度，光或其他环境变化引起的。也采用时间释放机制。本发明的应用特别包括酶的包封及其随后的环境污染物降解的持续释放，用于传感器系统的荧光标记的封装以及清洁剂中香料分子的包封和释放。

67. 发明授权

US5290960A Diacetylenic phospholipids containing heteroatom near diacetylenic functionality for modulation of microstructure morphology 失效
标题翻译：含有二乙炔官能团的杂原子的二乙炔磷脂用于调节微结构形态
公开(公告)号：US5290960A
公开(公告)日：1994-03-01
申请号：US22228
申请日：1993-02-25
申请人： Alok Singh
发明人： Alok Singh
IPC分类号： A61K9/127 , C07F9/10 , C07F7/00 , C07F9/00
CPC分类号： C07F9/10 , A61K9/1274
摘要： Novel diacetylenic phospholipids having the diacetylenic moieties chemically decoupled from the rest of the acyl chains by the inclusion of one or more heteroatom, preferably oxygen, spacers on the acyl chains have the chemical formula: ##STR1## where m is 7, 8, 9, 10, 11, 12, or 13, where n is 8, 9, 10, 11, 12, or 13, where W is --O(CO)-- or --OCH.sub.2 --, where X is --CH.sub.2 --, --OCH.sub.2 --, --SCH.sub.2 --, --NHCH.sub.2 --, or --SiMe.sub.2 CH.sub.2 --, where Y is --CH.sub.2 --, --CH.sub.2 O--, --CH.sub.2 S--, --CH.sub.2 NH--, or --CH.sub.2 SiMe.sub.2 --, where Z is --N(CH.sub.3).sub.3, saccharide, or --ROH where R is --(CH.sub.2).sub.p -- and p is 0, 1, 2 or 3, and where X and Y are not both --CH.sub.2 --. Novel tubules made from these diacetylenic phospholipids have high flexibility and variable morphology.
摘要翻译：通过在酰基链上包含一个或多个杂原子，优选氧的间隔基，具有二酰基部分与其余酰基链化学脱钩的新型二炔基磷脂具有化学式：（*化学结构*），其中m为7,8 ，9,10,11,12或13，其中n为8,9,10,11,12或13，其中W为-O（CO） - 或-OCH 2 - ，其中X为-CH 2 - ， - OCH 2 - ， - CH 2 - ， - NHCH 2 - 或-SiMe 2 CH 2 - ，其中Y是-CH 2 - ， - CH 2 O - ， - CH 2 S - ， - CH 2 NH-或-CH 2 SiMe 2 - ，其中Z是-N（CH 3）糖或-ROH，其中R为 - （CH 2）p - ，p为0,1,2或3，并且其中X和Y不同时为-CH 2 - 。由这些二乙炔磷脂制成的新型小管具有高柔韧性和可变形态。

68. 发明授权

US4867917A Method for synthesis of diacetylenic compounds 失效
标题翻译：二乙炔化合物的合成方法
公开(公告)号：US4867917A
公开(公告)日：1989-09-19
申请号：US946440
申请日：1986-12-24
申请人： Joel M. Schnur , Alok Singh
发明人： Joel M. Schnur , Alok Singh
IPC分类号： C07C51/347 , C07C51/353
CPC分类号： C07C51/347 , C07C51/353 , C07C67/343
摘要： A method for synthesizing a diynoic acid having the formula CH.sub.3 (CH.sub.2).sub.n --C.tbd.C--C.tbd.C--(CH.sub.2).sub.m CO.sub.2 H comprising the steps of: selecting a one-halo alkyne from the group consisting of CH.sub.3 (CH.sub.2).sub.n C.tbd.CX, where X is a selected halogen; selecting an omega-alkynoic acid having the formula, HC.tbd.C(CH.sub.2).sub.m CO.sub.2 H; dissolving the alkynoic acid in an aqueous solution of base; adding a catalytic amount of cuprous halide dissolved in an aqueous solution of alkylamine to the aqueous solution of alkynoic acid; adding a reducing agent to the solution of alkynoic acid and cuprous halide; adding the one-halo alkyne to the solution; adding as much more of the reducing agent to the solution as is necessary to maintain the cuprous ion in the cuprous state; wherein m is selected from the group of 5, 6, 7, 8, 9, 10, and 11, and n is selected from the group of 7, 8, 9, 10, 11, 12, 13, 14, 15, and 16.
摘要翻译：该方法用于合成具有式CH 3（CH 2）n C 3 CF 3 CH 3 - （CH 2）m CO 2 H的二炔酸，该方法包括以下步骤：从由CH 3（CH 2）n C 3 CFON组成的组中选择一个卤代炔，其中X 是选择的卤素; 选择具有下式的ω-炔酸：HC 3BOND C（CH2）mCO2H; 将炔烃溶于碱的水溶液中; 将溶解在烷基胺水溶液中的催化量的卤化亚铜加入到炔酸的水溶液中; 向炔丙酸和卤化亚铜的溶液中加入还原剂; 向溶液中加入单卤代炔; 向维溶液中添加更多的还原剂，以保持亚铜离子在亚铜状态; 其中m选自5,6,7,8,9,10和11组，n选自7,8,9,10,11,12,13,14,15和 16。

69. 发明授权

US10789562B2 Compensation patterns for adjusting long running order management fulfillment processes in an distributed order orchestration system 有权
公开(公告)号：US10789562B2
公开(公告)日：2020-09-29
申请号：US12718647
申请日：2010-03-05
申请人： Raju Addala , Alok Singh , Sagar Boyapati , Leah Reed , Nikhilkumar Parikh , Khanderao Kand , Clemens Utschig
发明人： Raju Addala , Alok Singh , Sagar Boyapati , Leah Reed , Nikhilkumar Parikh , Khanderao Kand , Clemens Utschig
IPC分类号： G06Q10/06 , G06Q10/10
摘要： A computer-readable medium, computer-implemented method, and system are provided. In one embodiment, a compensation pattern is defined for a step of an executable process, and the step of the executable process is executed. A change request is received, and, based on the change request, the compensation pattern is applied to the step of the executable process.

70. 发明授权

US09904898B2 Distributed order orchestration system with rules engine 有权
公开(公告)号：US09904898B2
公开(公告)日：2018-02-27
申请号：US12718536
申请日：2010-03-05
申请人： Raju Addala , Alok Singh , Kolanupaka Suman , Lavanya Siliveri , Shrikant Nene
发明人： Raju Addala , Alok Singh , Kolanupaka Suman , Lavanya Siliveri , Shrikant Nene
IPC分类号： G06Q10/06
CPC分类号： G06Q10/06393
摘要： A computer-readable medium, computer-implemented method, and system are provided. In one embodiment, a business rule is created, and, when a rule set does not already exist, a rule set is already created. The business rule is added to the rule set, and the rule set is added to a rule dictionary of a business process. The rule dictionary is stored in a process definition table.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式