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61. 发明申请

US20130116753A1 IMPLANTABLE PULSE GENERATOR COMPRISING MRI CURRENT LIMITING WINDINGS IN HEADER STRUCTURE 有权
标题翻译：包含头部结构中的MRI电流限制绕组的可植入脉冲发生器
公开(公告)号：US20130116753A1
公开(公告)日：2013-05-09
申请号：US13663145
申请日：2012-10-29
申请人： Advanced Neuromodulation Systems, Inc.
发明人： John H. Erickson
IPC分类号： A61N1/375 , A61N1/40
CPC分类号： A61N1/37 , A61N1/086 , A61N1/3718
摘要： In one embodiment, a pulse generator for generating electrical stimulation for delivery to a patient, comprises: a hermetically sealed housing containing pulse generating circuitry; a header coupled to the housing for receiving one or more stimulation leads, wherein feedthrough wires are provided to conduct electrical pulses from the pulse generating circuitry to the header; the header comprising a plurality of connectors for electrically connecting to each terminal of the one or more stimulation leads, wherein an inductive winding is disposed around or adjacent to each of the connector structures and is electrically connected between the respective connector structure and a corresponding feedthrough wire to limit MRI induced heating of a respective electrode of the one or more stimulation leads.
摘要翻译：在一个实施例中，用于产生用于递送给患者的电刺激的脉冲发生器包括：包含脉冲发生电路的密封外壳; 连接到所述壳体以用于接收一个或多个刺激引线的头部，其中提供穿通线以将电脉冲从所述脉冲发生电路传导到所述头部; 所述头部包括用于电连接到所述一个或多个刺激引线的每个端子的多个连接器，其中感应绕组设置在每个所述连接器结构的周围或附近，并且电连接在相应的连接器结构和相应的馈通线以限制一个或多个刺激引线的相应电极的MRI诱导加热。

62. 发明申请

US20040243208A1 Winged electrode body for spinal cord stimulation 有权
标题翻译：翼状电极体用于脊髓刺激
公开(公告)号：US20040243208A1
公开(公告)日：2004-12-02
申请号：US10448243
申请日：2003-05-29
申请人： Advanced Neuromodulation Systems, Inc.
发明人： Richard Jordan
IPC分类号： A61N001/05
CPC分类号： A61N1/0553
摘要： An implantable stimulation system including epidural lead for spinal cord stimulation that includes a paddle having a curved proximal end and lateral winged tips and an array of electrodes coupled to conductors within a lead body. The conductors couple to a pulse generator or other stimulation device. The curved and winged paddle provides more complete electrical stimulation coverage to targeted human tissue by minimizing the potential gap between electrodes and targeted fibers.
摘要翻译：一种植入式刺激系统，包括用于脊髓刺激的硬膜外引线，其包括具有弯曲近端和侧翼翅尖的桨，以及耦合到引线体内导体的电极阵列。导体耦合到脉冲发生器或其他刺激装置。弯曲和翼状的桨通过最小化电极和目标纤维之间的潜在间隙来向目标人体组织提供更完整的电刺激覆盖。

63. 发明公开

US20240278021A1 NEUROSTIMULATOR OUTPUT SWITCHING CIRCUITRY WITH SELF-TEST MODE 审中-公开
公开(公告)号：US20240278021A1
公开(公告)日：2024-08-22
申请号：US18651413
申请日：2024-04-30
申请人： Advanced Neuromodulation Systems, Inc.
发明人： Daran DeShazo , Gavin L. Rade
IPC分类号： A61N1/372 , A61B5/367 , A61N1/36 , A61N1/362 , A61N1/378 , A61N1/38 , A61N1/39 , A61N2/00
CPC分类号： A61N1/37235 , A61N1/37223 , A61N1/378 , A61B5/367 , A61N1/36038 , A61N1/36053 , A61N1/36062 , A61N1/36082 , A61N1/362 , A61N1/38 , A61N1/39622 , A61N2/006
摘要： An implantable medical device (IMO) includes one or more stimulation engines (SEs) and selectively connectable output switching circuitry for driving a plurality of output nodes associated with a respective plurality of electrodes of the IMO's lead system when implanted in a patient. The output switching circuitry may be configured to facilitate self-test mode (STM) functionality in the IMO (e.g., when it is in a hermetically sealed package) by using a dual mode switch in series with a stimulation engine selection switch with respect to each output node in the output switching circuitry under mode selection control.

64. 发明授权

US12064617B2 Medical leads with segmented electrodes and methods of fabrication thereof 有权
公开(公告)号：US12064617B2
公开(公告)日：2024-08-20
申请号：US17317935
申请日：2021-05-12
申请人： ADVANCED NEUROMODULATION SYSTEMS, INC.
发明人： Ryan Sefkow , Christopher A. Crawford , Jeffrey Mitchell , Kevin Wilson , Raymond P. Bray , John R. Gonzalez
IPC分类号： A61N1/05 , B29C45/00 , B29C45/14 , B29K75/00 , B29L31/00
CPC分类号： A61N1/0534 , B29C45/0055 , B29C45/14311 , B29C45/14467 , B29C45/14565 , B29C45/14614 , B29C2045/14524 , B29C45/14639 , B29C2793/009 , B29K2075/00 , B29K2995/0056 , B29L2031/7546
摘要： In one embodiment, a method for fabricating a neurostimulation stimulation lead comprises: providing a plurality of ring components and hypotubes in a mold; placing an annular frame with multiple lumens over distal ends of the plurality of hypotubes to position a portion of each hypotube within a respective lumen of the annular frame; molding the plurality of ring components and the hypotubes to form a stimulation tip component for the stimulation lead, wherein the molding fills interstitial spaces between the plurality of ring components and hypotubes with insulative material; and forming segmented electrodes from the ring components after performing the molding.

65. 发明公开

US20240221928A1 IMPLANTABLE MEDICAL DEVICE (IMD) WITH CODE PATH METRICS 审中-公开
公开(公告)号：US20240221928A1
公开(公告)日：2024-07-04
申请号：US18540802
申请日：2023-12-14
申请人： Advanced Neuromodulation Systems, Inc.
发明人： Daran DeShazo , Edward Lundberg
IPC分类号： G16H40/40 , A61N1/02 , A61N1/08 , A61N1/372 , G16H40/67
CPC分类号： G16H40/40 , A61N1/025 , A61N1/08 , A61N1/37217 , G16H40/67
摘要： A system and method of quantifying, maintaining and managing the functional status and/or therapy settings of an IMD based on code path metrics is disclosed. The codebase of device firmware modules may be instrumented to obtain tracing data and timing metrics data corresponding to different code paths that may be taken when a device subsystem or associated functionality is accessed or activated. Code path metrics of actual code paths may be analyzed to detect a deviation from baseline code path metrics and generate a corresponding graduated response.

66. 发明公开

US20240123219A1 STIMULATION DESIGN FOR NEUROMODULATION 审中-公开
公开(公告)号：US20240123219A1
公开(公告)日：2024-04-18
申请号：US18530638
申请日：2023-12-06
申请人： ADVANCED NEUROMODULATION SYSTEMS, INC.
发明人： Dirk De Ridder
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/0553 , A61N1/36017 , A61N1/36021 , A61N1/3605 , A61N1/36062 , A61N1/36071 , A61N1/36085 , A61N1/36096 , A61N1/361 , A61N1/3611 , A61N1/36117 , A61M5/14276
摘要： The present application relates to a new stimulation design which can be utilized to treat neurological conditions. The stimulation system produces a burst mode stimulation which alters the neuronal activity of the predetermined site, thereby treating the neurological condition or disorder. The burst stimulus comprises a plurality of groups of spike pulses having a maximum inter-spike interval of 100 milliseconds. The burst stimulus is separated by a substantially quiescent period of time between the plurality of groups of spike pulses. This inter-group interval may comprise a minimum of 5 seconds.

67. 发明授权

US11931584B2 Implantable pulse generator with multiple stimulation engines 有权
公开(公告)号：US11931584B2
公开(公告)日：2024-03-19
申请号：US17460227
申请日：2021-08-29
申请人： Advanced Neuromodulation Systems, Inc.
发明人： Daran DeShazo , Steven Boor
IPC分类号： A61N1/36 , A61N1/372 , A61N1/378
CPC分类号： A61N1/36153 , A61N1/3606 , A61N1/37235 , A61N1/378
摘要： An implantable medical device (IMD) includes multiple stimulation engines for independently stimulating respective electrode sets of a lead system while avoiding collisions and/or channel contention during stimulation delivery. A first voltage multiplier is configured to generate an adjustable target voltage having sufficient headroom at an output node that is commonly coupled to anodic nodes of respective stimulation engines. Each stimulation engine includes a secondary voltage multiplier to drive the respective anode and a current regulator powered by a floating voltage supply, wherein the current regulator is coupled to a cathodic node and configured to control how much stimulation current is pulled from the patient tissue.

68. 发明授权

US11904159B2 Implantable stimulation lead including a coiled lead body and methods for forming the same 有权
公开(公告)号：US11904159B2
公开(公告)日：2024-02-20
申请号：US17008058
申请日：2020-08-31
申请人： Advanced Neuromodulation Systems, Inc.
发明人： Aaron Raines
IPC分类号： A61N1/05 , H01B13/008 , H01B13/00 , A61B18/14
CPC分类号： A61N1/05 , H01B13/008 , H01B13/0016 , A61B18/1492 , A61N1/056 , A61N1/0551
摘要： A method of forming a stimulation lead includes forming an implantable lead body, including helically winding at least one cable about a mandrel to form a coiled cable assembly in a first, restrained state. Helically winding the at least one cable includes applying a tensile force to the at least one cable as the at least one cable is wound about the mandrel. Forming the lead body also includes releasing the tensile force from the at least one cable to allow the coiled cable assembly to release stored mechanical energy and transition from the restrained state to a second, relaxed state in which the coiled cable assembly is substantially free of stored mechanical energy. The method further includes subjecting the lead body to a reflow process by applying heat to the lead body, where the tensile force is released prior to the lead body being subjected to the reflow process.

69. 发明授权

US11865332B2 Stimulation lead and method including a multi-dimensional electrode array 有权
公开(公告)号：US11865332B2
公开(公告)日：2024-01-09
申请号：US17541531
申请日：2021-12-03
申请人： ADVANCED NEUROMODULATION SYSTEMS, INC.
发明人： Jodi T. Dubuclet , Cory Brinkman
IPC分类号： A61N1/05
CPC分类号： A61N1/0553 , A61N1/05 , A61N1/0551 , A61N1/0556
摘要： Stimulation lead includes an elongated lead body having distal and proximal ends and wire conductors extending therebetween. The stimulation lead also includes a lead paddle having a multi-dimensional array of electrodes positioned along a contact side of the lead paddle. The electrodes are electrically coupled to the wire conductors. The lead paddle includes a paddle body and a conductor organizer disposed within the paddle body. The conductor organizer has multiple channels extending along the lead paddle. The channels receive the wire conductors and retain the wire conductors in a designated arrangement with respect to the lead paddle. The conductor organizer has openings to the channels. The wire conductors extend through the openings and are terminated to the respective electrodes.

70. 发明授权

US11786309B2 System and method for facilitating DBS electrode trajectory planning 有权
公开(公告)号：US11786309B2
公开(公告)日：2023-10-17
申请号：US17135022
申请日：2020-12-28
申请人： ADVANCED NEUROMODULATION SYSTEMS, INC.
发明人： Yagna Pathak , Simeng Zhang , Dehan Zhu , Anahita Kyani , Hyun-Joo Park , Erika Ross
IPC分类号： A61B34/10 , G06T7/70 , G16H30/40 , G06V10/25 , A61B5/055 , A61B6/03 , A61B6/00 , G06N3/08 , G06T7/00 , G06F18/214 , A61N1/05
CPC分类号： A61B34/10 , A61B5/055 , A61B6/032 , A61B6/469 , A61B6/501 , A61B6/5223 , A61B6/5247 , G06F18/214 , G06N3/08 , G06T7/0014 , G06T7/70 , G06V10/25 , G16H30/40 , A61B2034/107 , A61B2505/05 , A61N1/0534 , G06T2207/10081 , G06T2207/10088 , G06T2207/20081 , G06T2207/20084 , G06T2207/30016 , G06T2207/30241 , G06V2201/031
摘要： A system and method for facilitating DBS electrode trajectory planning using a machine learning (ML)-based feature identification scheme configured to identify and distinguish between various regions of interest (ROIs) and regions of avoidance (ROAs) in a patient's brain scan image. In one arrangement, standard orientation image slices as well as re-sliced images in non-standard orientations are provided in a labeled input dataset for training a CNN/ANN for distinguishing between ROIs and ROAs. Upon identification of the ROIs and ROAs in the patient's brain scan image, an optimal trajectory for implanting a DBS lead may be determined relative to a particular ROI while avoiding any ROAs.

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