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61. 发明授权

US07642255B2 Compounds and compositions as protein kinase inhibitors 失效
标题翻译：化合物和组合物作为蛋白激酶抑制剂
公开(公告)号：US07642255B2
公开(公告)日：2010-01-05
申请号：US12099708
申请日：2008-04-08
申请人： Taebo Sim , Hyun Soo Lee , Pingda Ren , Qiang Ding , Yi Liu , Bing Li , Lintong Li , Xia Wang , Tetsuo Uno , Guobao Zhang , Nathanael Schiander Gray , Shuli You
发明人： Taebo Sim , Hyun Soo Lee , Pingda Ren , Qiang Ding , Yi Liu , Bing Li , Lintong Li , Xia Wang , Tetsuo Uno , Guobao Zhang , Nathanael Schiander Gray , Shuli You
IPC分类号： C07D413/14 , C07D471/04 , C07D487/04 , A61K31/535 , A61K31/497 , A61K31/519 , C07D251/12 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, Bmx, c-Raf, Csk, Fes, FGFR, Flt3, Ikk, IR, JNK, Lck, Mkk, PKC, PKD, Rsk, SAPK, Syk, Trk, BTK, Src, EGFR, IGF, Mek, Ros and Tie2 kinases.
摘要翻译：本发明提供了一类新颖的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是涉及Abl，BCR-Abl异常活化的疾病或病症，Bmx，c-Raf，Csk，Fes，FGFR，Flt3，Ikk，IR，JNK，Lck，Mkk，PKC，PKD，Rsk，SAPK，Syk，Trk，BTK，Src，EGFR，IGF，Mek，Ros和Tie2 激酶。

62. 发明授权

US07595148B2 Methods and compositions for modulating T lymphocytes 失效
标题翻译：用于调节T淋巴细胞的方法和组合物
公开(公告)号：US07595148B2
公开(公告)日：2009-09-29
申请号：US10764330
申请日：2004-01-23
申请人： Michael P. Cooke , Karsten Sauer , Tim Wiltshire , Lisa Tarantino , Colin Fletcher , Ben Wen
发明人： Michael P. Cooke , Karsten Sauer , Tim Wiltshire , Lisa Tarantino , Colin Fletcher , Ben Wen
IPC分类号： C12Q1/00 , C12Q1/68 , C12N5/00 , C12N5/02
CPC分类号： C12Q1/485 , G01N33/505 , G01N2333/70514 , G01N2333/70517
摘要： This invention provides novel methods and compositions for modulating T cell differentiation and T cell responses. The modulators are identified by screening test compounds for ability to modulate an inositol 1,4,5-trisphosphate 3-kinase (IP3K). The IP3K modulators can be further examined for their activity in modulating development of progenitor T cells (e.g., CD4+/CD8+ double positive T cells) into mature CD4+ or CD8+ single positive T cells. Pharmaceutical compositions comprising these T cell modulators can be administered to a subject to modulate T cell immune responses, to suppress inflammations, and to treat disease conditions such as autoimmune diseases, graft rejection or allergies.
摘要翻译：本发明提供用于调节T细胞分化和T细胞应答的新方法和组合物。通过筛选测试化合物以调节肌醇1,4,5-三磷酸3-激酶（IP3K）的能力来鉴定调节剂。可以进一步检查IP3K调节剂在调节祖细胞T细胞（例如CD4 + / CD8 +双重阳性T细胞）发育成为成熟CD4 +或CD8 +单一阳性T细胞的活性。包含这些T细胞调节剂的药物组合物可以施用于受试者以调节T细胞免疫应答，抑制炎症，以及治疗疾病状况，例如自身免疫疾病，移植排斥反应或过敏。

63. 发明授权

US07514447B2 Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors 有权
公开(公告)号：US07514447B2
公开(公告)日：2009-04-07
申请号：US11535455
申请日：2006-09-26
申请人： Valentina Molteni , Xiaolin Li , Donatella Chianelli , Jon Loren , Juliet Nabakka , Xiadong Liu , Shifeng Pan , Yi Liu , Donald S. Karanewsky , Pascal Furet , Vito Guagnano , Shuli You
发明人： Valentina Molteni , Xiaolin Li , Donatella Chianelli , Jon Loren , Juliet Nabakka , Xiadong Liu , Shifeng Pan , Yi Liu , Donald S. Karanewsky , Pascal Furet , Vito Guagnano , Shuli You
IPC分类号： C07D239/42 , C07D403/10 , C07D403/14 , A61K31/505 , A61K31/506 , A61P35/00
CPC分类号： C07D403/04 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D491/10
摘要： Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.

64. 发明授权

US07495016B2 Pyrrolidones with anti-HIV activity 失效
标题翻译：具有抗HIV活性的吡咯烷酮
公开(公告)号：US07495016B2
公开(公告)日：2009-02-24
申请号：US10690873
申请日：2003-10-21
申请人： Baogen Wu , Yun He , Truc Ngoc Nguyen , Kelli L. Kuhen , David Archer Ellis , Tao Jiang , Xiaohui He , Kunyong Yang , Badry Bursulaya
发明人： Baogen Wu , Yun He , Truc Ngoc Nguyen , Kelli L. Kuhen , David Archer Ellis , Tao Jiang , Xiaohui He , Kunyong Yang , Badry Bursulaya
IPC分类号： A61K31/443 , A61K31/402 , C07D401/04 , C07D207/08
CPC分类号： C07D207/26 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/14 , C07D413/12 , C07D417/12
摘要： The present invention relates to inhibition of viruses, e.g., HIV using pyrrolidones and compounds related to pyrrolidones. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to methods of prophylaxis, and therapy related to HIV infection and related disease states such as AIDS.
摘要翻译：本发明涉及使用吡咯烷酮和与吡咯烷酮有关的化合物来抑制病毒，例如HIV。本发明还涉及用于鉴定和使用试剂的方法，包括抑制细胞中HIV的小分子化学组合物; 以及与艾滋病毒感染和相关疾病状态如艾滋病相关的预防和治疗方法。

65. 发明授权

US07422411B2 Gripping mechanisms, apparatus and methods 有权
标题翻译：抓握机构，装置和方法
公开(公告)号：US07422411B2
公开(公告)日：2008-09-09
申请号：US11516826
申请日：2006-09-06
申请人： Robert Charles Downs , Mark Richard Weselak , James Kevin Mainquist
发明人： Robert Charles Downs , Mark Richard Weselak , James Kevin Mainquist
IPC分类号： B25J15/00
CPC分类号： B25J15/0253 , B25J17/0208 , B65G47/90 , B65H29/02 , B65H2555/31 , Y10S294/902 , Y10S414/136 , Y10S414/141
摘要： The present invention provides grasping mechanisms, gripper apparatus/systems, and related methods. Grasping mechanisms that include stops, support surfaces, and height adjusting surfaces to determine three translational axis positions of a grasped object are provided. In addition, grasping mechanisms that are resiliently coupled to other gripper apparatus components are also provided.
摘要翻译：本发明提供了抓握机构，夹持装置/系统及相关方法。提供了包括停止，支撑表面和高度调节表面以确定被抓取物体的三个平移轴位置的抓握机构。此外，还提供了弹性耦合到其他夹持器装置部件的抓握机构。

66. 发明授权

US07256206B2 Bicyclic compounds and compositions 有权
标题翻译：双环化合物和组合物
公开(公告)号：US07256206B2
公开(公告)日：2007-08-14
申请号：US10776946
申请日：2004-02-11
申请人： Shifeng Pan , Nathanael S. Gray , Yuan Mi , Wenqi Gao , Yi Fan , Sophie Lefebvre
发明人： Shifeng Pan , Nathanael S. Gray , Yuan Mi , Wenqi Gao , Yi Fan , Sophie Lefebvre
IPC分类号： A61K31/421 , C07D263/30 , C07D261/06
CPC分类号： C07D213/30 , C07C251/48 , C07C251/52 , C07C251/54 , C07D307/42 , C07D333/16 , C07F9/094 , C07F9/655345
摘要： The present invention relates to bicyclic derivatives, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG/S1P receptor mediated signal transduction.
摘要翻译：本发明涉及双环衍生物，其制备方法及其用途和含有它们的药物组合物。本发明提供了一类新颖的化合物，其可用于治疗或预防由淋巴细胞相互作用介导的疾病或病症，特别是与EDG / S1P受体介导的信号转导相关的疾病。

67. 发明授权

US07179619B2 Methods and compositions for inhibiting herpesviral replication 失效
标题翻译：用于抑制疱疹病毒复制的方法和组合物
公开(公告)号：US07179619B2
公开(公告)日：2007-02-20
申请号：US10885862
申请日：2004-07-07
申请人： Sheng-Hao Chao , Jeremy S. Caldwell
发明人： Sheng-Hao Chao , Jeremy S. Caldwell
IPC分类号： C12P21/06
CPC分类号： C12Q1/705
摘要： This invention provides methods of screening for compounds that inhibit herpesviral transcription and replication. The methods comprise screening test compounds for ability to enhance the activity of homeodomain transcription factor PDX1 in repressing transcription of herpesviral genes (e.g., the IE gene of cytomegalovirus). Transcriptional repression by PDX1 can be monitored using an expression vector comprising a reporter gene operably linked to a PDX1-binding, upstream transcription regulatory sequence of the herpesvirus. The invention further provides methods and pharmaceutical compositions for stimulating PDX1-mediated transcriptional repression in a subject and for treating diseases and conditions associated with herpesviral infection.
摘要翻译：本发明提供了筛选抑制疱疹病毒转录和复制的化合物的方法。所述方法包括筛选测试化合物以增强同源异型域转录因子PDX1在抑制疱疹病毒基因（例如，巨细胞病毒的IE基因）的转录中的活性的能力。可以使用包含与疱疹病毒的PDX1结合的上游转录调节序列可操作地连接的报告基因的表达载体来监测PDX1的转录抑制。本发明还提供用于刺激受试者中PDX1介导的转录抑制并用于治疗与疱疹病毒感染相关的疾病和病症的方法和药物组合物。

68. 发明授权

US07151096B2 Cyclic compounds and compositions as protein kinase inhibitors 失效
标题翻译：环化合物和组合物作为蛋白激酶抑制剂
公开(公告)号：US07151096B2
公开(公告)日：2006-12-19
申请号：US10794454
申请日：2004-03-05
申请人： Pingda Ren , Francisco Adrian , Nathanael S. Gray , Xia Wang
发明人： Pingda Ren , Francisco Adrian , Nathanael S. Gray , Xia Wang
IPC分类号： C07D471/21 , C07D259/00 , A61K31/395
CPC分类号： C07D471/18 , C07D498/18 , C07D513/18
摘要： The invention provides a novel class of cyclic compounds, pharmaceutical compositions comprising such cyclic compounds and methods of using such compounds to treat or prevent diseases and disorders associated with cyclin-dependent kinases (CDKs) activity, particularly diseases associated with the activity of CDK2 and CDK5.
摘要翻译：本发明提供了一类新颖的环状化合物，包含这种环状化合物的药物组合物和使用这些化合物治疗或预防与细胞周期蛋白依赖性激酶（CDK）活性相关的疾病和病症的方法，特别是与CDK2和CDK5的活性有关的疾病。

69. 发明授权

US07060697B2 Immunosuppressant compounds and compositions 失效
公开(公告)号：US07060697B2
公开(公告)日：2006-06-13
申请号：US10849079
申请日：2004-05-19
申请人： Thomas H. Marsilje , Nathanael S. Gray , Tao Jiang , Wenshuo Lu , Shifeng Pan
发明人： Thomas H. Marsilje , Nathanael S. Gray , Tao Jiang , Wenshuo Lu , Shifeng Pan
IPC分类号： A61K31/397 , A61K31/40 , A61K31/197 , C07D207/06 , C07D205/04
CPC分类号： C07C323/32 , C07C317/32 , C07C2601/14 , C07D205/04
摘要： The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.

70. 发明授权

US10662247B2 Compositions and methods of use for augmented immune response and cancer therapy 有权
公开(公告)号：US10662247B2
公开(公告)日：2020-05-26
申请号：US15517867
申请日：2015-10-08
申请人： NOVARTIS AG
发明人： Jennifer Brogdon , Daniela Cipolletta , Glenn Dranoff , Deborah A. Knee , Fei Wang
IPC分类号： C07K16/28 , A61K39/00 , A61K45/06
摘要： The present invention provides antibody compositions, including, e.g., antibodies, engineered antibodies and antibody fragments that bind to a tumor necrosis factor receptor superfamily member (i.e., 18). Provided compositions are useful in enhancing CD4+ and CD8+ T cell responses, and in the treatment, amelioration and prevention of diseases that can be counteracted with an augmented immune response, e.g., cancers. Also provided in the invention are polynucleotides and vectors that encode such molecules and host cells that harbor the polynucleotides or vectors; as well as pharmaceutical compositions that comprise such molecules and methods of use thereof.

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