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61. 发明授权

US08071323B2 Human monoclonal antibodies that bind human insulin like growth factors and their use 有权
标题翻译：结合人胰岛素如生长因子的人单克隆抗体及其用途
公开(公告)号：US08071323B2
公开(公告)日：2011-12-06
申请号：US12296328
申请日：2007-04-06
申请人： Dimiter S. Dimitrov , Zhongyu Zhu
发明人： Dimiter S. Dimitrov , Zhongyu Zhu
IPC分类号： C07K16/22 , G01N33/53 , G01N33/567 , G01N33/574 , A61K39/395 , A61K51/10 , C12N5/10 , C12N15/13 , C12N15/63
CPC分类号： C07K16/22 , A61K47/6803 , A61K47/6817 , A61K47/6843 , A61K51/1018 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/5011 , G01N33/574 , G01N33/74
摘要： Antibody compositions and methods for treatment of neoplastic disease in a mammalian subject are provided. Methods of diagnosing cancer in a mammalian subject are also provided.
摘要翻译：提供了用于治疗哺乳动物受试者的肿瘤疾病的抗体组合物和方法。还提供了在哺乳动物受试者中诊断癌症的方法。

62. 发明授权

US08048630B2 Methods and agents for detecting Parechovirus 有权
标题翻译：检测鱼腥草病的方法和试剂
公开(公告)号：US08048630B2
公开(公告)日：2011-11-01
申请号：US12299097
申请日：2006-05-01
申请人： William Allan Nix , M. Steven Oberste
发明人： William Allan Nix , M. Steven Oberste
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/701 , C12N2770/32511
摘要： The present disclosure provides methods that permit detection of all known species of Parechovirus, including Human parechovirus and Ljungan virus (LV). In particular examples the method includes amplifying at least a portion of the 5′NTR of parechovirus nucleic acid molecules obtained from a sample, and detecting the resulting amplicons, but does not require culturing of the virus. The present disclosure also provides methods for determining which particular species or serotype of parechovirus is present in a biological sample. Also provided are oligonucleotide primers and probes that can be used in the disclosed methods.
摘要翻译：本公开提供了允许检测所有已知种类的Parechovirus，包括人类parechovirus和Ljungan病毒（LV）的方法。在具体实例中，该方法包括扩增从样品获得的鹦鹉病毒核酸分子的5NTR的至少一部分，并检测所得扩增子，但不需要培养病毒。本公开还提供了用于确定生物样品中存在有哪些特定种类或血清型的parechovirus的方法。还提供了可用于所公开的方法中的寡核苷酸引物和探针。

63. 发明授权

US08044185B2 Conformationally stabilized HIV envelope immunogens and triggering HIV-I envelope to reveal cryptic V3-loop epitopes 有权
标题翻译：构象稳定的艾滋病毒包膜免疫原，并引发HIV-1信封揭示神秘的V3环表位
公开(公告)号：US08044185B2
公开(公告)日：2011-10-25
申请号：US12065894
申请日：2006-09-06
申请人： Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Chih-Chin Huang , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
发明人： Peter Kwong , John Mascola , Gary Nabel , Richard Wyatt , Barna Dey , Ling Xu , Tongqing Zhou , Chih-Chin Huang , Joseph Sodroski , Wen Yuan , Shi-Hua Xiang
IPC分类号： C07H21/02 , C12N15/00 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/21 , A61K2039/53 , A61K2039/54 , A61K2039/545 , C07K14/70514 , C12N2740/15022 , C12N2740/16122 , C12N2740/16134
摘要： Stabilized forms of gp120 polypeptide, nucleic acids encoding these stabilized forms, vectors comprising these nucleic acids, and methods of using these polypeptides, nucleic acids, vectors and host cells are disclosed. Crystal structures and computer systems including atomic coordinates for stabilized forms of gp120, and gp120 with an extended V3 loop, and methods of using these structures and computer systems are also disclosed.
摘要翻译：公开了稳定形式的gp120多肽，编码这些稳定形式的核酸，包含这些核酸的载体，以及使用这些多肽，核酸，载体和宿主细胞的方法。还公开了包括gp120的稳定形式的原子坐标和具有扩展的V3循环的gp120的晶体结构和计算机系统，以及使用这些结构和计算机系统的方法。

64. 发明授权

US08030341B2 Dmt-derivative compounds and related compositions and methods of use 失效
标题翻译： Dmt衍生化合物及相关组合物和使用方法
公开(公告)号：US08030341B2
公开(公告)日：2011-10-04
申请号：US12065121
申请日：2006-08-30
申请人： Lawrence H. Lazarus , Yoshio Okada , Tingyou Li
发明人： Lawrence H. Lazarus , Yoshio Okada , Tingyou Li
IPC分类号： C07D401/12 , A61K31/4725
CPC分类号： C07K14/005 , A61K38/00 , C12N2730/10122
摘要： The present invention relates to symmetric and asymmetric dimeric Dmt (2′,6′-ditnethyl) compounds and Dmt derivative compounds with dual δ and μ opioid receptor antagonist activity. Also, the present invention provides compositions comprising these compounds and it provides methods of using these compounds.
摘要翻译：本发明涉及具有双重δ和μ阿片受体拮抗剂活性的对称和不对称二聚Dmt（2'，6'-二甲基）化合物和Dmt衍生化合物。此外，本发明提供包含这些化合物的组合物，并提供使用这些化合物的方法。

65. 发明授权

US08029788B2 Variants of humanized anti-carcinoma MAb CC49 有权
标题翻译：人源化抗癌MAb CC49的变体
公开(公告)号：US08029788B2
公开(公告)日：2011-10-04
申请号：US12819920
申请日：2010-06-21
申请人： Syed V S Kashmiri , Eduardo A. Padlan , Jeffrey Schlom
发明人： Syed V S Kashmiri , Eduardo A. Padlan , Jeffrey Schlom
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： A61K49/0002 , A61K38/00 , A61K51/1045 , A61K2039/505 , C07K16/30 , C07K16/3046 , C07K16/4208 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2799/026 , G01N33/5743
摘要： The invention is directed towards mouse-human chimeric variants of CC49 monoclonal antibodies with minimal murine content. A first aspect of the invention provides CDR variants of humanized monoclonal antibody (HuCC49) in which less than all six (three heavy chain and three light chain) Complementarity Determining Regions (CDRs) of CC49 are present. A second aspect of the invention provides SDR variants of humanized monoclonal antibody (HuCC49) in which only Specificity Determining Regions (SDRs) of at least one CDR from CC49 are present. The invention is also directed towards biotechnological methods of making the variants and therapeutic methods of using the variants.
摘要翻译：本发明针对具有最小鼠含量的CC49单克隆抗体的小鼠 - 人嵌合变体。本发明的第一方面提供了存在CC49的全部六（三个重链和三个轻链）互补决定区（CDR）的人源化单克隆抗体（HuCC49）的CDR变体。本发明的第二方面提供了仅存在来自CC49的至少一个CDR的特异性确定区（SDR）的人源化单克隆抗体（HuCC49）的SDR变体。本发明还涉及制备使用变体的变体和治疗方法的生物技术方法。

66. 发明授权

US08017578B2 Orally active peptides that prevent cell damage and death 有权
标题翻译：口服活性肽，可防止细胞损伤和死亡
公开(公告)号：US08017578B2
公开(公告)日：2011-09-13
申请号：US12102760
申请日：2008-04-14
申请人： Douglas Brenneman , Illana Gozes , Catherine Y. Spong , Albert Pinhasov , Eliezer Giladi
发明人： Douglas Brenneman , Illana Gozes , Catherine Y. Spong , Albert Pinhasov , Eliezer Giladi
IPC分类号： A61K38/08 , C07K7/06
CPC分类号： A61K38/04 , A61K38/185
摘要： This invention provides an ADNF polypeptide comprising an active core site, the active core site comprising at least one D-amino acid. The invention also provides a pharmaceutical composition comprising an ADNF polypeptide comprising an active core site, the active core site comprising at least one D-amino acid. In particular, the pharmaceutical composition of the invention is orally active. The invention further provides methods for reducing neuronal cell death, methods for reducing oxidative stress, and methods for reducing a condition associated with fetal alcohol syndrome using the ADNF polypeptides and the pharmaceutical compositions of the invention.
摘要翻译：本发明提供了包含活性核心位点的ADNF多肽，所述活性核心位点包含至少一个D-氨基酸。本发明还提供了包含包含活性核心位点的ADNF多肽的药物组合物，所述活性核心位点包含至少一个D-氨基酸。特别地，本发明的药物组合物是口服活性的。本发明还提供了使用ADNF多肽和本发明的药物组合物减少神经元细胞死亡的方法，用于降低氧化应激的方法以及用于降低与胎儿酒精综合征相关的病症的方法。

67. 发明授权

US08012490B2 Recombinant influenza viruses expressing tumor-associated antigens as antitumor agents 失效
标题翻译：表达肿瘤相关抗原的重组流感病毒作为抗肿瘤剂
公开(公告)号：US08012490B2
公开(公告)日：2011-09-06
申请号：US12564702
申请日：2009-09-22
申请人： Peter Palese , Adolfo Garcia-Sastre , Nicholas P. Restifo
发明人： Peter Palese , Adolfo Garcia-Sastre , Nicholas P. Restifo
IPC分类号： A61K39/00 , A61K39/145
CPC分类号： C07K14/005 , A61K2039/5256 , A61K2039/53 , C07K2319/00 , C12N15/86 , C12N2760/16122 , C12N2760/16143 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to the engineering of recombinant influenza viruses that express tumor-associated antigens. Expression of tumor-associated antigens by these viruses can be achieved by engineering specific epitopes into influenza virus proteins, or by engineering viral genes that encode a viral protein and the specific antigen as independent polypeptides. Tumor-bearing patients can be immunized with the recombinant influenza viruses alone, or in combination with another treatment, to induce an immune response that leads to tumor reduction. The recombinant viruses can also be used to vaccinate high risk tumor-free patients to prevent tumor formation in vivo.
摘要翻译：本发明涉及表达肿瘤相关抗原的重组流感病毒的工程。通过这些病毒表达肿瘤相关抗原可以通过将特异性表位设计成流感病毒蛋白质，或通过编码病毒蛋白质和特异性抗原作为独立多肽的病毒基因来实现。肿瘤患者可以单独用重组流感病毒或与另一种治疗组合免疫，以诱导导致肿瘤减少的免疫应答。重组病毒也可用于接种高危无肿瘤患者以预防体内肿瘤形成。

68. 发明授权

US07959929B2 Materials and methods for respiratory disease control in canines 有权
公开(公告)号：US07959929B2
公开(公告)日：2011-06-14
申请号：US11584818
申请日：2006-10-19
申请人： Patti C. Crawford , Paul J. Gibbs , Edward J. Dubovi , Ruben Omar Donis , Jacqueline Katz , Alexander I. Klimov , Nallakannu P. Lakshmanan , Melissa Anne Lum , Daniel Ghislena Emiel Goovaerts , Mark William Mellencamp , Nancy J. Cox , William L. Castleman
发明人： Patti C. Crawford , Paul J. Gibbs , Edward J. Dubovi , Ruben Omar Donis , Jacqueline Katz , Alexander I. Klimov , Nallakannu P. Lakshmanan , Melissa Anne Lum , Daniel Ghislena Emiel Goovaerts , Mark William Mellencamp , Nancy J. Cox , William L. Castleman
IPC分类号： A61K49/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K45/00 , C12Q1/70 , C12N7/00 , C12N7/04 , C07K14/00 , C07K16/00 , A61K39/285
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/53 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , C07K14/005 , C07K16/1018 , C12N7/00 , C12N15/86 , C12N2710/24043 , C12N2760/16121 , C12N2760/16122 , C12N2760/16134 , C12N2760/16151 , C12N2760/16171 , C12Q1/701 , G01N33/56983 , G01N2333/11
摘要： The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and methods for inducing an immune response against an influenza virus of the present invention. The subject invention also pertains to compositions and methods for identifying a virus of the invention and diagnosing infection of an animal with a virus of the invention.

69. 发明授权

US07954486B2 Aerosol delivery systems and methods 有权
标题翻译：气溶胶输送系统和方法
公开(公告)号：US07954486B2
公开(公告)日：2011-06-07
申请号：US10587814
申请日：2005-04-01
申请人： Mark J. Papania , James J. Barry , Mark C. Bagley , Nabil A. Elkouh , Darin Knaus , Robert Trabka
发明人： Mark J. Papania , James J. Barry , Mark C. Bagley , Nabil A. Elkouh , Darin Knaus , Robert Trabka
IPC分类号： A61M11/00 , A61M15/00 , B05B17/06
CPC分类号： B05B17/0638 , A61M15/0033 , A61M15/0065 , A61M15/0085 , A61M2205/07 , A61M2205/3306 , A61M2205/825 , B05B12/008 , B05B12/082 , B05B17/0623 , B05B17/0676
摘要： Methods and systems for aerosol delivery of agents to a patient are described herein. The present system can be used to administer various types of agents, such as a vaccine or other types of pharmaceutical substances. Certain embodiments of the present system utilize an actuator coupled to a disposable aerosolizing element that aerosolizes an agent for delivery to a patient when acted upon by the actuator. The aerosolizing element prevents the agent from contacting the actuator and other non-disposable components of the system so that little or no cleaning or maintenance is required. The present system also can include an aerosolization rate monitor that monitors the rate at which an agent is being aerosolized and provides feedback to the user to ensure that the proper dose is being administered.
摘要翻译：本文描述了将药剂气雾剂递送至患者的方法和系统。本系统可用于施用各种类型的试剂，例如疫苗或其他类型的药物。本系统的某些实施例利用联接到一次性雾化元件的致动器，其在由致动器作用时使药剂雾化以递送给患者。雾化元件防止试剂与系统的致动器和其他非一次性部件接触，从而不需要或不需要清洁或维护。本系统还可以包括气雾化速率监测器，其监测试剂被雾化的速率，并向使用者提供反馈以确保施用适当的剂量。

70. 发明授权

US07871779B2 Molecular identification of Aspergillus species 有权
标题翻译：曲霉菌的分子鉴定
公开(公告)号：US07871779B2
公开(公告)日：2011-01-18
申请号：US12115493
申请日：2008-05-05
申请人： Christine J. Morrison , Hans Peter Hinrikson
发明人： Christine J. Morrison , Hans Peter Hinrikson
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/04
CPC分类号： C12Q1/6895
摘要： Novel techniques for the detection of Aspergillus in samples are disclosed. These techniques relate to PCR amplification and/or detection of Aspergillus ITS1 rDNA sequences, and the identification of particular species of Aspergillus by detecting differences in the ITS1-V1, ITS-V2, ITS-V3, ITS-V4, and ITS-V5 nucleic acid sequences of Aspergillus. The highly variable regions of the ITS1 rDNA sequences are particularly useful in distinguishing, for example, Aspergillus clavatus, Aspergillus granulosus, Aspergillus sydowii, Aspergillus flavipes, Aspergillus restrictus, Aspergillus versicolor, Aspergillus wentii, and Aspergillus chevalieri. In particular embodiments, the sequence differences are also able to distinguish among variants of particular species, such as Aspergillus granulosus CBS 119.5A, Aspergillus granulosus strain NRRL 1932, Aspergillus sydowii strain NRRL 250, Aspergillus sydowii strain NRRL 4768, Aspergillus sydowii strain CUHI, Aspergillus sydowii strain CUH2, Aspergillus sydowii strain CUH7, and Aspergillus sydowii strain CUH8.
摘要翻译：公开了用于检测样品中曲霉菌的新技术。这些技术涉及通过检测ITS1-V1，ITS-V2，ITS-V3，ITS-V4和ITS-V5核酸中的差异来鉴定曲霉ITS1 rDNA序列的PCR扩增和/或检测，并鉴定特定的曲霉种曲霉酸序列。 ITS1 rDNA序列的高度可变区特别可用于区分例如曲霉菌（Aspergillus clavatus），粒细菌（Aspergillus granulosus），曲霉（Aspergillus sydowii），曲霉（Aspergillus flavipes），限制曲霉（Aspergillus restrictionus），曲霉（Aspergillus versicolor），曲霉（Aspergillus goii）和曲霉（Aspergillus chevalieri）。在特定的实施方案中，序列差异也能够区分特定种类的变体，例如粒细菌芽孢杆菌CBS 119.5A，粒细菌菌株NRRL 1932，曲霉菌株NRRL 250，曲霉菌菌株NRRL 4768，曲霉菌菌株CUHI，曲霉属（Aspergillus sydowii） sydowii菌株CUH2，曲霉菌菌株CUH7和曲霉菌菌株CUH8。

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