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61. 发明申请

US20040073236A1 Closure device and methods for making and using them 有权
公开(公告)号：US20040073236A1
公开(公告)日：2004-04-15
申请号：US10667144
申请日：2003-09-19
申请人： Integrated Vascular Systems, Inc.
发明人： Michael T. Carley , Richard S. Ginn , Javier Sagastegui , Ronald J. Jabba , William N. Aldrich , W. Martin Belef
IPC分类号： A61B017/08
CPC分类号： A61B17/08 , A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/083 , A61B90/39 , A61B2017/00004 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/00867 , A61B2017/0641 , A61B2017/081 , H03K3/356139 , H03K3/356156
摘要： A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.

62. 发明申请

US20030078598A1 Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use 有权
公开(公告)号：US20030078598A1
公开(公告)日：2003-04-24
申请号：US10264306
申请日：2002-10-03
申请人： Integrated Vascular Systems, Inc.
发明人： Richard S. Ginn , William N. Aldrich
IPC分类号： A61B017/10
CPC分类号： A61B17/0643 , A61B17/0057 , A61B17/064 , A61B17/083 , A61B17/1285 , A61B17/3415 , A61B2017/00004 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/00862 , A61B2017/0641 , A61M25/0662
摘要： Apparatus and methods are provided for use in sealing a vascular puncture site. The invention comprises an introducer sheath with an integrated closure component. The closure component includes a fastener and an advanceable, deformable clip having a delivery configuration in which opposing sides do not contact one another, and a deployed configuration, in which the fastener causes opposing sides of the deformable clip to close towards one another. The clip is advanced along the sheath until it pierces opposing sides of a vessel wall at a puncture site. The clip is then deformed with the fastener to draw opposing sides of the puncture together, and the sheath is withdrawn to seal the wound. The clip and fastener preferably are bioabsorbable.

63. 发明申请

US20020147496A1 Apparatus for treating spinal discs 审中-公开
标题翻译：用于治疗脊椎椎间盘的装置
公开(公告)号：US20020147496A1
公开(公告)日：2002-10-10
申请号：US09827427
申请日：2001-04-06
申请人： Integrated Vascular Systems, Inc.
发明人： W. Martin Belef , Stephen M. Salmon , William N. Aldrich , Richard S. Ginn , Ronald J. Jabba
IPC分类号： A61F002/44
CPC分类号： A61F2/441 , A61B18/14 , A61B18/1402 , A61B18/1477 , A61B18/1492 , A61B2017/00261 , A61B2018/00434 , A61B2018/0044 , A61B2018/00505 , A61B2018/1425 , A61F2/02 , A61F2/30744 , A61F2/442 , A61F2/4611 , A61F2002/30062 , A61F2002/3008 , A61F2002/30092 , A61F2002/30405 , A61F2002/30591 , A61F2002/30677 , A61F2002/4435 , A61F2002/444 , A61F2002/4627 , A61F2002/4651 , A61F2210/0004 , A61F2210/0014 , A61F2220/0025 , A61F2250/0098 , A61F2310/00017 , A61F2310/00023 , A61F2310/00365
摘要： Apparatus and methods for treating a spinal disc are disclosed. An opening is created in the annulus fibrosis, and nucleus pulposus is removed from the interior of the disc. The interior is lined with a nonporous, bioabsorbable liner, and filled with a fill material, such as nucleus pulposus, to cause the liner to expand to engage tissue surrounding the interior. The liner may be a sheet of extra-cellular matrix material that is introduced into-the interior, or a bladder of extra-cellular matrix material including a neck communicating with an interior region of the bladder. The sheet or bladder may be carried by a delivery device, e.g., a catheter or rod. After the interior region is filled, the opening is closed using a plug or other closure device. The plug may include threads on its external surface for securing the plug in the opening.
摘要翻译：公开了用于治疗脊椎盘的装置和方法。在环状纤维化中产生开口，并且从椎间盘的内部移除髓核。内部衬有无孔生物可吸收的衬垫，并填充有诸如髓核的填充材料，以使衬垫膨胀以接合内部周围的组织。衬垫可以是引入到内部的细胞外基质材料片，或者是细胞外基质材料的膀胱，包括与膀胱的内部区域连通的颈部。片或囊可以由输送装置（例如导管或杆）承载。在填充内部区域之后，使用塞子或其它封闭装置关闭开口。插头可以在其外表面上包括螺纹，用于将插头固定在开口中。

64. 发明申请

US20020147479A1 Apparatus and methods for sealing openings through tissue 审中-公开
标题翻译：用于通过组织密封开口的装置和方法
公开(公告)号：US20020147479A1
公开(公告)日：2002-10-10
申请号：US09827423
申请日：2001-04-06
申请人： Integrated Vascular Systems, Inc.
发明人： William N. Aldrich
IPC分类号： A61F007/00 , A61F002/00
CPC分类号： A61F2/441 , A61B18/14 , A61B18/1402 , A61B18/1477 , A61B18/1492 , A61B2017/00261 , A61B2018/00434 , A61B2018/0044 , A61B2018/00505 , A61B2018/1425 , A61F2/02 , A61F2/30744 , A61F2/442 , A61F2/4611 , A61F2002/30062 , A61F2002/3008 , A61F2002/30092 , A61F2002/30405 , A61F2002/30591 , A61F2002/30677 , A61F2002/4435 , A61F2002/444 , A61F2002/4627 , A61F2002/4651 , A61F2210/0004 , A61F2210/0014 , A61F2220/0025 , A61F2250/0098 , A61F2310/00017 , A61F2310/00023 , A61F2310/00365
摘要： An energy delivery device includes a handle member having a connector on its distal end, the connector including an electrically conductive region. An electrically insulated elongate element extends from the distal that terminates in an uninsulated distal tip. During use, a needle connected to a syringe is inserted through tissue, e.g., into the interior of a spinal disc. A therapeutic agent is delivered through the needle, and then the syringe is disconnected from the needle. The elongate element is inserted into the needle until the distal tip extends beyond the distal end of the needle, and the connector connects the needle to the conductive region. Electrical energy is delivered from a source of electrical energy via the distal tip and the needle to tissue surrounding the passage to close the passage as the needle is withdrawn.
摘要翻译：能量输送装置包括在其远端具有连接器的手柄构件，所述连接器包括导电区域。电绝缘的细长元件从远端延伸，终止于未绝缘的远端。在使用期间，连接到注射器的针通过组织例如插入脊椎盘的内部。通过针头递送治疗剂，然后注射器与针脱离。细长元件插入针中，直到远端尖端延伸超过针的远端，并且连接器将针连接到导电区。电能通过远端和针头从电源传送到围绕通道的组织，以在针被抽出时闭合通道。

65. 发明授权

US09320522B2 Closure device and methods for making and using them 有权
公开(公告)号：US09320522B2
公开(公告)日：2016-04-26
申请号：US13222899
申请日：2011-08-31
申请人： Michael T. Carley , Richard S. Ginn , Javier Sagastegui , Ronald J. Jabba , William N. Aldrich , W. Martin Belef
发明人： Michael T. Carley , Richard S. Ginn , Javier Sagastegui , Ronald J. Jabba , William N. Aldrich , W. Martin Belef
IPC分类号： A61B17/08 , A61B17/00 , A61B17/064 , A61B17/068 , H03K3/356 , A61B19/00
CPC分类号： A61B17/08 , A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/083 , A61B90/39 , A61B2017/00004 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/00867 , A61B2017/0641 , A61B2017/081 , H03K3/356139 , H03K3/356156
摘要： A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.

66. 发明授权

US08758400B2 Closure system and methods of use 有权
标题翻译：封闭系统和使用方法
公开(公告)号：US08758400B2
公开(公告)日：2014-06-24
申请号：US12941809
申请日：2010-11-08
申请人： Richard S. Ginn , William N. Aldrich , William Martin Belef , Steven N. Roe , Michael T. Carley , Ronald J. Jabba , Stephen M. Salmon , Anthony J. Pantages , Francisco Javier Sagastegui
发明人： Richard S. Ginn , William N. Aldrich , William Martin Belef , Steven N. Roe , Michael T. Carley , Ronald J. Jabba , Stephen M. Salmon , Anthony J. Pantages , Francisco Javier Sagastegui
IPC分类号： A61B17/08 , A61D1/00
CPC分类号： A61B17/083 , A61B17/0057 , A61B17/064 , A61B17/0643 , A61B17/1285 , A61B18/148 , A61B2017/00623 , A61B2017/00654 , A61B2017/00668 , A61B2017/00672 , A61B2017/00862 , A61B2017/00986 , A61B2017/081 , A61B2018/00595 , A61B2018/0063
摘要： An apparatus for sealing a passage through tissue communicating with a body lumen is provided. The apparatus includes an elongate member having a proximal end a distal end and a lumen extending from the distal end toward the proximal end defining a longitudinal axis. A plug member is disposed on the distal end and extends distally from the elongate member in a pre-deployed and deployed configuration. The plug member includes a distal port therein in communication with the lumen and has a cross-sectional diameter at a plug proximal end and a plug distal end greater than a cross-sectional diameter of the distal end of the elongate member in the pre-deployed configuration. The apparatus also includes a member extendable distally from the distal port, the member including a proximal end and a distal end.
摘要翻译：提供了一种用于密封通过与体腔连通的组织的通道的装置。所述装置包括细长构件，所述细长构件具有近端，远端和从远端朝向限定纵向轴线的近端延伸的内腔。插塞构件设置在远端上并且以预先展开和展开的构型从细长构件向远侧延伸。插塞构件包括其中与内腔连通的远端端口，并且在插塞近端处具有截面直径，并且塞子远端大于预先部署的细长构件的远端的横截面直径组态。该装置还包括从远端端口向远端延伸的构件，该构件包括近端和远端。

67. 发明授权

US08585836B2 Methods for manufacturing a clip and clip 有权
标题翻译：制造夹子和夹子的方法
公开(公告)号：US08585836B2
公开(公告)日：2013-11-19
申请号：US13525839
申请日：2012-06-18
申请人： Michael T. Carley , Richard S. Ginn
发明人： Michael T. Carley , Richard S. Ginn
IPC分类号： C22F1/00 , A61B17/08
CPC分类号： A61B17/068 , A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/083 , A61B90/39 , A61B2017/00004 , A61B2017/00867 , C22C19/007 , C22F1/00 , C22F1/10 , C22F1/16
摘要： The present disclosure relates to a clip manufactured according to a method which can be used to engage body tissue for the purpose of closing wounds. Such clips are generally annular in shape and have radially inwardly extending tines. The present disclosure first forms a precursor which, in one embodiment, has the tines extending radially outwardly from the annular body and then forms the clip by inverting the precursor such that the tines extend radially inwardly. In an alternate embodiment, the precursor is formed with an over-sized lateral dimension and then compressed inwardly to bring the tines closer together and to reduce the lateral dimension of the precursor. Such clips may be manufactured from a superelastic alloy such as nickel-titanium, in which case the inverted or compressed precursor must be heated and quenched to heat set the clip in its final shape.
摘要翻译：本公开涉及一种根据可以用于接合身体组织以便关闭伤口的方法制造的夹子。这种夹子通常是环形的并且具有径向向内延伸的尖齿。本公开内容首先形成前体，在一个实施例中，前体具有从环形体径向向外延伸的齿，然后通过倒转前体形成夹子，使得尖齿径向向内延伸。在替代实施例中，前体形成为具有超大尺寸的侧向尺寸，然后被向内压缩以使尖齿更靠近在一起并减小前体的横向尺寸。这样的夹子可以由超弹性合金例如镍钛制造，在这种情况下，必须加热和淬火反转或压缩的前体以将夹子热定型成其最终形状。

68. 发明申请

US20130190778A1 CLIP APPLIER AND METHODS OF USE 有权
标题翻译：夹具应用和使用方法
公开(公告)号：US20130190778A1
公开(公告)日：2013-07-25
申请号：US13791846
申请日：2013-03-08
申请人： INTEGRATED VASCULAR SYSTEMS, INC.
发明人： Thomas J. Palermo , William M. Belef , Michael T. Carley , Richard S. Ginn , Anthony J. Pantages , Ronald J. Jabba , Brian A. Ellingwood , Laveille Kao Voss , Kelly J. McCrystle , T. Daniel Gross , Arkady Kokish
IPC分类号： A61B17/00 , A61B17/10
CPC分类号： A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/10 , A61B17/1227 , A61B2017/0003 , A61B2017/00106 , A61B2017/00349 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/0649 , A61B2017/12018 , A61B2090/065
摘要： An apparatus for delivering a closure element can include a splittable carrier tube and a splitter to split the tube. The carrier tube can have an outer surface retaining a closure element in a tubular configuration and can be split into radially-expandable flaps. A closure element can have a shape-memory body having a relaxed configuration with a planar-annular body defining a lumen with tines directed inwardly from the body. The clip can be held in a retaining configuration having a substantially asymmetrically-elongated tubular shape with a trapezoidal longitudinal cross-sectional profile and a proximal end having the tines being longitudinally directed with a first tine being more distally oriented compared to a substantially opposite second tine being more proximal, and retracting to a deploying configuration having a tubular shape with a rectangular longitudinal cross-sectional profile with the first tine being even with the second tine when being delivered.
摘要翻译：用于传送闭合元件的装置可以包括可拆卸的载体管和用于分裂管的分离器。载体管可以具有将封闭元件保持为管状构造的外表面，并且可以被分割成径向可膨胀的瓣。封闭元件可以具有形状记忆体，该形状记忆体具有松弛构型，其中平面环形主体限定具有从身体向内指向的尖齿的内腔。夹具可以保持在具有梯形纵截面轮廓的基本上不对称的细长管状形状的保持构造中，并且具有尖端的尖端与第一齿纵向对准，该第一齿与基本上相对的第二齿相比更向远侧取向更靠近并且缩回到具有矩形纵向截面轮廓的管状形状的展开构造，其中第一齿在被递送时与第二齿均匀。

69. 发明申请

US20120245626A1 METHODS OF USE OF A CLIP APPLIER 有权
标题翻译：使用夹具的方法
公开(公告)号：US20120245626A1
公开(公告)日：2012-09-27
申请号：US13490143
申请日：2012-06-06
申请人： Brian A. Ellingwood , Laveille K. Voss , T. Daniel Gross , Kelly McCrystle
发明人： Brian A. Ellingwood , Laveille K. Voss , T. Daniel Gross , Kelly McCrystle
IPC分类号： A61B17/03
CPC分类号： A61B17/10 , A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/083 , A61B17/1227 , A61B2017/00637
摘要： A method for closing an opening formed in a wall of a body lumen or body tissue can include positioning a splittable carrier tube adjacent to the opening, the carrier tube having a splittable distal end with an outer surface retaining a closure element in a substantially tubular configuration or having an asymmetrically-elongated tubular shape with a trapezoidal longitudinal cross-sectional profile. The method including splitting a distal end of the carrier tube with a splitter and deploying the closure element from the carrier flaps of the carrier tube and over the splitter to allow the closure element to engage at least a portion of the wall of the body lumen or the body tissue and substantially close the opening.
摘要翻译：用于闭合形成在体腔或身体组织的壁中的开口的方法可以包括将可分开的载体管定位成邻近开口，载体管具有可分开的远端，外表面将闭合元件保持为基本管状构造或具有具有梯形纵截面轮廓的不对称拉长的管状形状。该方法包括用分离器分离载体管的远端并且从承载管的载体翼片并在分离器上方展开闭合元件，以允许闭合元件接合体腔壁的至少一部分或身体组织并基本上封闭开口。

70. 发明授权

US08257390B2 Closure device and methods for making and using them 有权
公开(公告)号：US08257390B2
公开(公告)日：2012-09-04
申请号：US11675462
申请日：2007-02-15
申请人： Michael T. Carley , Richard S. Ginn , Javier Sagastegui , Ronald J. Jabba , William N. Aldrich , W. Martin Belef
发明人： Michael T. Carley , Richard S. Ginn , Javier Sagastegui , Ronald J. Jabba , William N. Aldrich , W. Martin Belef
IPC分类号： A61B17/08
CPC分类号： A61B17/08 , A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/083 , A61B90/39 , A61B2017/00004 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/00867 , A61B2017/0641 , A61B2017/081 , H03K3/356139 , H03K3/356156
摘要： A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.

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