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51. 发明申请

US20120214209A1 Methods For Producing End-Products From Carbon Substrates 审中-公开
标题翻译：从碳基材生产最终产品的方法
公开(公告)号：US20120214209A1
公开(公告)日：2012-08-23
申请号：US13458548
申请日：2012-04-27
申请人： Gopal K. Chotani , Manoj Kumar , Jeff P. Pucci , Karl J. Sanford , Jayarama K. Shetty
发明人： Gopal K. Chotani , Manoj Kumar , Jeff P. Pucci , Karl J. Sanford , Jayarama K. Shetty
IPC分类号： C12P19/20 , C12P7/20 , C12P7/56 , C12P7/04 , C12P7/58 , C12P17/04 , C12P7/46 , C12P7/14 , C12P7/18 , C12P7/60
CPC分类号： C12P7/56 , C12P7/06 , C12P7/10 , C12P7/18 , C12P7/20 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/58 , C12P7/60 , C12P19/02 , C12P2201/00 , Y02E50/16 , Y02E50/17
摘要： The present invention provides means for the production of desired end-products of in vitro and/or in vivo bioconversion of biomass-based feed stock substrates, including but not limited to such materials as starch and cellulose. In particularly preferred embodiments, the methods of the present invention do not require gelatinization and/or liquefaction of the substrate.
摘要翻译：本发明提供了生产基于生物质的原料基质的体外和/或体内生物转化所需的终产物的方法，包括但不限于淀粉和纤维素等材料。在特别优选的实施方案中，本发明的方法不需要基质的凝胶化和/或液化。

52. 发明申请

US20120115897A1 Aryl (Ethanoic) Propanoic Acid Ascorbyl Ester, Preparation Method Thereof And Medicament Containing The Same 有权
标题翻译：（乙酸）丙酸抗坏血酸酯，其制备方法和含有其的药物
公开(公告)号：US20120115897A1
公开(公告)日：2012-05-10
申请号：US13320101
申请日：2009-12-24
申请人： Luhong Tang , Ajuan Dai , Ze Wang , Yang Sun , Xinning Liu , Lingyan Xu , Xin Fang , Shuang Qiu , Yaqing Cao , Xiaomin Xu , Ruixia Jiang , Chao Wu
发明人： Luhong Tang , Ajuan Dai , Ze Wang , Yang Sun , Xinning Liu , Lingyan Xu , Xin Fang , Shuang Qiu , Yaqing Cao , Xiaomin Xu , Ruixia Jiang , Chao Wu
IPC分类号： A61K31/436 , C07D491/052 , C12P17/04 , C12P17/18 , A61K31/375 , A61K31/407 , A61P29/00 , A61P19/02 , A61P25/00 , A61P25/28 , A61P35/00 , A61P15/00 , A61P11/00 , A61P9/00 , C07D307/62
CPC分类号： C07D307/62 , C07D405/12 , C07D491/04 , C07D491/052 , C12P17/04 , C12P17/16 , C12P17/188 , C12Y301/01003
摘要： The present invention designs and synthesizes the ascorbyl ester derivatives of the aryl (ethanoic) propanoic acid non-steroidal anti-inflammatory medicaments, such as ibuprofen, ketoprofen and naproxen, and addition salt of the derivatives with pharmaceutical acid or pharmaceutical alkaline. The non-steroidal anti-inflammatory medicament which takes the ibuprofen as the representative is a common antipyretic analgesic medicament. The invention has remarkable antipyretic and analgesic effects and good safety except for anti-inflammatory effect, thus being not only suitable for adults, but also suitable for the elderly people, infants and children. The aryl (ethanoic) propanoic acid ascorbyl ester can be converted into ascorbyl ester derivatives and the addition salts of the derivatives with pharmaceutical acid or pharmaceutical alkaline, which can improve the water solubility thereof, facilitate intravenously administration, reduce the onset time, improve the bioavailability, reduce the stimulation effect to gastrointestinal tract, and enhance the penetrating capacity to hemato encephalic barrier, and can be used as a novel medicament to be applied for antiphlogistic, antipyresis, analgesia, treatment of arthritis, dysmenorrheal, multiple sclerosis, pneumonia cystic fibrosis and patent ductus arteriosus of premature infants, and prevention and treatment of cerebral apoplexy, hypoxic-ischemic brain damage, senile dementia and certain cancers.
摘要翻译：本发明设计和合成芳基（乙酸）丙酸非甾体抗炎药物如布洛芬，酮洛芬和萘普生的抗坏血酸酯衍生物，以及衍生物与药物酸或药物碱的加成盐。以布洛芬为代表的非甾体抗炎药是常见的解热止痛药。本发明除抗炎作用外，具有明显的解热镇痛作用，安全性好，不仅适用于成人，而且适用于老年人，婴儿和儿童。芳基（乙酸）丙酸抗坏血酸酯可以转化为抗坏血酸酯衍生物，并且衍生物的加成盐与药物酸或药物碱性可以改善其水溶性，有助于静脉内施用，减少发病时间，提高生物利用度降低对胃肠道的刺激作用，增强血液渗透屏障的穿透能力，可用作新型药物，用于消炎止痛，止痛，止痛，治疗关节炎，痛经，多发性硬化，肺炎囊性纤维化，以及早产儿动脉导管未闭，预防和治疗脑中风，缺氧缺血性脑损伤，老年性痴呆和某些癌症。

53. 发明申请

US20120029070A1 BURDOCK FRUIT EXTRACT CONTAINING ARCTIGENIN AT HIGH CONTENT AND PROCESS FOR PRODUCING SAME 有权
标题翻译：含有高含量的含有ARCTIGENIN的包装水果提取物及其生产方法
公开(公告)号：US20120029070A1
公开(公告)日：2012-02-02
申请号：US13260506
申请日：2010-02-05
申请人： Keiichi Yamamoto , Toshiki Okubo , Satoshi Yomoda , Hiroyasu Esumi , Chika Miyoshi , Shigetoshi Kadota
发明人： Keiichi Yamamoto , Toshiki Okubo , Satoshi Yomoda , Hiroyasu Esumi , Chika Miyoshi , Shigetoshi Kadota
IPC分类号： A61K31/365 , A61P35/00 , C12P17/04
CPC分类号： C07D307/33 , A61K9/1623 , A61K9/1688 , A61K9/19 , A61K9/2054 , A61K31/365 , A61K36/28
摘要： PROBLEM TO BE SOLVEDA burdock fruit extract containing arctigenin at high content and its production method are provided, and both of which are used for treatment of pancreatic cancer.SOLUTIONThe burdock fruit extract containing arctigenin at high content by enzymatically converted arctiin into arctigenin with beta-glucosidase, which is an enzyme occurring endogenously in a burdock fruit, and adding ethanol, extracting, concentrating and then freeze-drying or spray drying.
摘要翻译：待解决的问题提供含有高含量的牛蒡子黄素的牛蒡果实提取物及其制备方法，其均用于治疗胰腺癌。解决方案：牛蒡果实提取物含有高含量的玉米赤霉素，通过酶法转化成arctigenin与β-葡萄糖苷酶，其是在牛蒡果实内生发酵的酶，并加入乙醇，提取，浓缩，然后冷冻干燥或喷雾干燥。

54. 发明授权

US08084237B2 Microorganism and method for producing dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan intermediate using the novel microorganism 有权
标题翻译：微生物和使用新型微生物制备十二氢-3a,6,6,9a-四甲基萘并[2,1-b]呋喃中间体的方法
公开(公告)号：US08084237B2
公开(公告)日：2011-12-27
申请号：US12280067
申请日：2006-12-21
申请人： Kazuaki Igarashi , Shuichi Takizawa , Norihiko Higaki , Hiroshi Hagihara
发明人： Kazuaki Igarashi , Shuichi Takizawa , Norihiko Higaki , Hiroshi Hagihara
IPC分类号： C12P17/04 , C12N1/16 , C12N1/14
CPC分类号： C12N1/14 , C12P17/04
摘要： This invention relates to a novel microorganism that efficiently produces a dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan intermediate using sclareol as a substrate. As a result of concentrated studies, a plurality of novel microorganisms having properties of interest that are not classified as conventional microorganisms were isolated and identified. The novel microorganism of the present invention belongs to Ascomycetes and has the ability of producing a dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan intermediate using sclareol as a substrate. Such microorganism of Ascomycetes represents a new finding and it can be effective for producing dodecahydro-3a,6,6,9a-tetramethylnaphtho[2,1-b]furan and an intermediate thereof.
摘要翻译：本发明涉及一种利用香紫苏醇作为底物有效生产十二氢-3a,6,6,9a-四甲基萘并[2,1-b]呋喃中间体的新型微生物。作为浓缩研究的结果，分离并鉴定出许多具有未分类为常规微生物的感兴趣的新型微生物。本发明的新型微生物属于子囊菌纲，具有使用香紫苏醇作为底物生产十二氢-3a,6,6,9a-四甲基萘并[2,1-b]呋喃中间体的能力。子囊菌的这种微生物代表新的发现，对于生产十二氢-3a,6,6,9a-四甲基萘并[2,1-b]呋喃及其中间体是有效的。

55. 发明申请

US20110244525A1 MICROORGANISM EXPRESSING XYLOSE ISOMERASE 审中-公开
标题翻译： MICROORGANISM表达XYLOSE异构体
公开(公告)号：US20110244525A1
公开(公告)日：2011-10-06
申请号：US13133242
申请日：2009-12-10
申请人： Birgitte Rönnow , Thomas Hvid Andersen , Ole Sibbesen
发明人： Birgitte Rönnow , Thomas Hvid Andersen , Ole Sibbesen
IPC分类号： C12P19/24 , C12N1/19 , C12N15/81 , C12N1/22 , C12P1/02 , C12P7/06 , C12P7/56 , C12P7/46 , C12P7/54 , C12P5/02 , C12P7/24 , C12P5/00 , C12P7/26 , C12P13/00 , C12P17/04 , C12P7/44 , C12P13/14 , C12P7/48 , C12P7/22 , C12P13/08 , C12P7/00 , C07C31/08 , C10L1/02
CPC分类号： C12N15/81 , C12N9/90 , C12N9/92 , C12P7/06 , C12P19/24 , Y02E50/17 , Y02P20/52
摘要： The present invention relates to a transformed microorganism capable of (a) a higher xylose isomerase activity than the equivalent microorganism prior to transformation; and/or (b) a higher growth rate in or on a growth medium comprising xylose than the equivalent microorganism prior to transformation; and/or (c) a faster metabolism of xylose than the equivalent microorganism prior to transformation; and/or (d) a higher production of ethanol when grown anaerobically on xylose as the carbon source than the equivalent microorganism prior to transformation.
摘要翻译：本发明涉及在转化前能够（a）比等效微生物更高的木糖异构酶活性的转化微生物; 和/或（b）在转化之前在包含木糖的生长培养基中或其上的等效微生物生长速率更高; 和/或（c）在转化之前木糖的代谢速度高于等效微生物; 和/或（d）当在转化之前与在等效微生物上的作为碳源的木糖上厌氧生长时，乙醇的产量较高。

56. 发明申请

US20110229943A1 METHODS FOR CONVERTING GLUCOSE TO ASCORBIC ACID 失效
标题翻译：将葡萄糖转化为抗坏血酸的方法
公开(公告)号：US20110229943A1
公开(公告)日：2011-09-22
申请号：US13041176
申请日：2011-03-04
申请人： MARK DONNELLY , WILLIAM H. ESCHENFELDT , JONATHAN TRENT
发明人： MARK DONNELLY , WILLIAM H. ESCHENFELDT , JONATHAN TRENT
IPC分类号： C12P17/04
CPC分类号： C12N9/0006 , C12P7/60 , C12P17/04 , C12Q1/26 , C12Y101/01274
摘要： Described herein are novel nucleic acids, proteins and methods that can be used to provide new catalysts with desirable traits for industrial processes. In particular, novel reductases isolated from the environment using PCR methods are described.
摘要翻译：本文描述的是新的核酸，蛋白质和方法，其可用于为工业过程提供具有期望特性的新型催化剂。特别地，描述了使用PCR方法从环境分离的新的还原酶。

57. 发明申请

US20100317070A1 COMPLETE LIQUEFICATION OF LIGNOCELLULOSIC AGROWASTE TO FORM LIQUID BIOFUELS 有权
标题翻译：木瓜脂肪酸完全液化生成液体
公开(公告)号：US20100317070A1
公开(公告)日：2010-12-16
申请号：US12866350
申请日：2009-02-04
申请人： Pradyot A. Agaskar
发明人： Pradyot A. Agaskar
IPC分类号： C12P17/04 , C10L1/00
CPC分类号： C12P7/10 , C10G1/002 , C10G2300/1014 , C10L1/023 , C10L2290/10 , C10L2290/30 , C10L2290/543 , C10L2290/544 , C12P7/22 , Y02E50/16 , Y02E50/17 , Y02P30/20
摘要： A process for converting lignocellulosic materials which are field residues such as cotton stalks and corn stover, process residues such as sugarcane bagasse and sweet sorghum bagasse, woody parts of energy crops such as switchgrass and miscanthus, forest residues or byproducts of the wood processing industries such as sawdust from sawmills to a liquid biofuel by a series of processing steps wherein the feed materials are hydrolysed in three stages and withdrawn as three product streams each consisting of solubilized fragments of one of the three major components of the feed materials and a set of concurrently operating processing steps wherein each of the three product streams is transformed through chemical or biochemical processes into products, such as pure lignin and ethanol, that have a high calorific value and process wherein these products with high calorific value are combined to form a liquid biofuel.
摘要翻译：用于转化木质纤维素材料的方法，这些木质纤维素材料是诸如棉花秸秆和玉米秸秆的残留物，甘蔗渣和甜高粱甘蔗渣等过程残渣，诸如柳枝稷和芒草的能量作物的木质部分，木材加工业的森林残留物或副产品，通过一系列加工步骤将锯木厂从锯木厂转移到液体生物燃料，其中进料以三个阶段水解并作为三个产物流排出，每个产物流由进料的三个主要成分之一的溶解碎片组成，操作处理步骤，其中三个产物流中的每一个通过化学或生物化学过程转化成具有高发热量和过程的产物，例如纯木质素和乙醇，其中将这些具有高热值的产物组合以形成液体生物燃料。

58. 发明授权

US07846699B2 Process for gibberellic acid production with “Fusarium moniliforme” strains 失效
标题翻译：用“镰刀菌”菌株生产赤霉酸的方法
公开(公告)号：US07846699B2
公开(公告)日：2010-12-07
申请号：US11854072
申请日：2007-09-12
申请人： Vidhya Rangaswamy , Guduri Balu
发明人： Vidhya Rangaswamy , Guduri Balu
IPC分类号： C12P17/04 , C12N1/00
CPC分类号： C12P27/00
摘要： The present invention provides an improved process for the production of gibberellic acid (GA3), achieving a yield over 225 g/kg of GA3 with solid substrate fermentation, and over 15 g/L by submerged fermentation. The method also provides novel substrates, including the use of Jatropha seed cake. The present invention has in particular provided an improved, cost-effective process for the manufacture of GA3, as the process has a surprisingly high yield of product, achieves the maximal yield in shorter time than other techniques, consumes less energy, and works with very inexpensive substrates. In all, the manufacturing costs are significantly reduced.
摘要翻译：本发明提供一种生产赤霉酸（GA3）的改进方法，通过固体底物发酵获得超过225g / kg的GA3，通过浸没发酵获得超过15g / L的产量。该方法还提供了新颖的底物，包括使用麻疯树种子蛋糕。本发明特别提供了一种用于制造GA3的改进的，具有成本效益的方法，因为该方法具有令人惊讶的高产率，在较短时间内达到最大产量，消耗更少的能量，并且非常适用廉价的基板。总而言之，制造成本大大降低。

59. 发明申请

US20100255549A1 MICROBIAL PRODUCTION OF 3-HYDROXYACIDS FROM GLUCOSE AND GLYCOLATE 有权
标题翻译：从葡萄糖和甘油酸中微生物生产3-羟基己酸
公开(公告)号：US20100255549A1
公开(公告)日：2010-10-07
申请号：US12718469
申请日：2010-03-05
申请人： Collin Hunter Martin , Kristala Lanett Jones Prather
发明人： Collin Hunter Martin , Kristala Lanett Jones Prather
IPC分类号： C12P7/62 , C12N1/21 , C12N1/15 , C12N1/19 , C12N5/10 , C12P17/04
CPC分类号： C12N9/1229 , C12N9/0006 , C12N9/13 , C12P7/42 , C12P7/52 , C12P17/04
摘要： The invention relates to recombinant cells and their use in the production of 3-hydroxyacids such as 3,4-dihydroxybutyrate and 3-hydroxybutyrolactone.
摘要翻译：本发明涉及重组细胞及其在生产3-羟基酸如3,4-二羟基丁酸酯和3-羟基丁内酯中的用途。

60. 发明申请

US20100152467A1 METHOD FOR PRODUCING CERCOSPORAMIDE 失效
标题翻译：生产羧甲基纤维素的方法
公开(公告)号：US20100152467A1
公开(公告)日：2010-06-17
申请号：US11997112
申请日：2006-08-08
申请人： Tsuyoshi Hosoya , Jun Ohsumi , Kiyoshi Hamano , Yasunori Ono , Masami Miura
发明人： Tsuyoshi Hosoya , Jun Ohsumi , Kiyoshi Hamano , Yasunori Ono , Masami Miura
IPC分类号： C07D307/77 , C12P17/04 , C12N1/14
CPC分类号： C07D307/91 , C12P17/04 , C12R1/645
摘要： The present invention provides a process for producing cercosporamide comprising culturing a fungus belonging to the genus Lachnum and/or fungus belonging to the genus Pseudaegerita and recovering cercosporamide from the culture thereof. In addition, the present invention provides cercosporamide acquired according to this production process. Further, the present invention provides novel microorganisms consisting of Lachnum fuscescens SANK 19096, Lachnum calycioides SANK 12497, Lachnum caesaliatum SANK 10906, and Pseudaegerita websteri SANK 11006.
摘要翻译：本发明提供了一种生产铈孢子酰胺的方法，其包括培养属于属于假单胞菌属的Lachnum属和/或真菌的真菌并从其培养物中回收孢子虫酰胺。此外，本发明提供根据该制造方法获得的孢霉素。此外，本发明提供了由Lachnum fuscescens SANK 19096，Lachnum calycioides SANK 12497，Lachnum caesaliatum SANK 10906和Pseudaegerita websterica SANK 11006组成的新型微生物。

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