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51. 发明授权

US4687854A Bispiperidone precursor of 2-substituted-5-methyl-pyridines 失效
标题翻译： 2-取代-5-甲基 - 吡啶的双哌啶酮前体
公开(公告)号：US4687854A
公开(公告)日：1987-08-18
申请号：US937383
申请日：1986-12-03
申请人： Ludwig A. Hartmann , John F. Stephen
发明人： Ludwig A. Hartmann , John F. Stephen
IPC分类号： C07D211/76 , C07D211/86 , C07D213/61 , C07D213/64 , C07D295/02 , C07D295/03 , C07D295/155
CPC分类号： C07D213/64 , C07C255/00 , C07D211/86 , C07D213/61 , C07D295/03 , C07D295/155
摘要： A process for the synthesis of compounds which are known intermediates for the pyridyloxyphenoxy herbicides as well as intermediates used in the process. Propionaldehyde and an acrylic compound, two radily available starting materials, are reacted to form a 2-formylpentanoic compound which is cyclized to a dihydro pyridone which is then oxidized to the 2-hydroxy pyridine. The hydroxypyridine may be halogenated to a 2-halopyridine.
摘要翻译：用于合成作为吡啶氧基苯氧基除草剂的已知中间体的化合物的方法以及该方法中使用的中间体。使丙醛和丙烯酸化合物（两种可用的原料）反应形成2-甲酰基戊酸化合物，将其环化成二氢吡啶酮，然后氧化成2-羟基吡啶。羟基吡啶可以被卤化成2-卤代吡啶。

52. 发明授权

US4658031A Synthesis of 2-substituted-5-methyl-pyridines and intermediates therefor 失效
标题翻译： 2-取代-5-甲基吡啶的合成及其中间体
公开(公告)号：US4658031A
公开(公告)日：1987-04-14
申请号：US807850
申请日：1985-12-11
申请人： Ludwig A. Hartmann , John F. Stephen
发明人： Ludwig A. Hartmann , John F. Stephen
IPC分类号： C07D211/86 , C07D213/12 , C07D213/61 , C07D213/64 , C07D295/02 , C07D295/03 , C07D295/155 , C07D401/12
CPC分类号： C07D213/64 , C07C255/00 , C07D211/86 , C07D213/61 , C07D295/03 , C07D295/155
摘要： A process for the synthesis of compounds which are known intermediates for the pyridyloxyphenoxy herbicies as well as intermediates used in the process. Propionaldehyde and an acrylic compound, two readily available starting materials, are reacted to form a 2-formylpentanoic compound which is cyclized to a dihydro pyridone which is then oxidized to the 2-hydroxy pyridine. The hydroxypyridine may be halogenated to a 2-halopyridine.
摘要翻译：用于合成化合物的方法，其为已知的吡啶氧基苯氧基草本中间体以及该方法中使用的中间体。将丙醛和丙烯酸化合物（两种容易获得的原料）反应以形成2-甲酰基戊酸化合物，将其环化成二氢吡啶酮，然后将其氧化成2-羟基吡啶。羟基吡啶可以被卤化成2-卤代吡啶。

53. 发明授权

US4645839A Sulphur dehydrogenation process to yield 5-methyl-2-pyridone 失效
标题翻译：硫脱氢工艺得到5-甲基-2-吡啶酮
公开(公告)号：US4645839A
公开(公告)日：1987-02-24
申请号：US725680
申请日：1985-04-22
申请人： Walter M. Kruse , John F. Stephen
发明人： Walter M. Kruse , John F. Stephen
IPC分类号： C07D213/64 , C07D211/86
CPC分类号： C07D213/64
摘要： A method for synthesizing the aromatic compound 5-methyl-2-pyridone from the corresponding 3,4-dihydro compound by dehydrogenation using sulphur. Particular advantages are achieved by reaction at about 180.degree. C. or less. The product is useful as an intermediate for the preparation of various pyridyloxyphenoxy herbicides.
摘要翻译：通过使用硫脱氢从相应的3,4-二氢化合物合成芳族化合物5-甲基-2-吡啶酮的方法。通过在约180℃或更低温度下反应可以实现特别的优点。该产品可用作制备各种吡啶氧基苯氧基除草剂的中间体。

54. 发明授权

US4622332A Asymmetric diesters of Hantzsch dihydropyridines with hypotensive activity 失效
标题翻译：具有降血压活性的汉坦二氢吡啶类不对称二酯
公开(公告)号：US4622332A
公开(公告)日：1986-11-11
申请号：US468621
申请日：1983-02-22
申请人： Egbert Wehinger , Horst Meyer , Andreas Knorr
发明人： Egbert Wehinger , Horst Meyer , Andreas Knorr
IPC分类号： A61K31/455 , A61P1/00 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/28 , C07D211/90 , C07D309/32 , C07D211/86
CPC分类号： C07D211/90 , C07D309/32
摘要： Compounds of the formula ##STR1## in which R is an optionally substituted aryl or heterocyclic radical,R.sup.1 is a hydrocarbon radical which is optionally interrupted by 1 oxygen atom in the chain, and/or which is optionally substituted,R.sup.4 is an aliphatic hydrocarbon radical having 7 to 14 carbon atoms, which is optionally interrupted by one oxygen atom and/or which is optionally substituted,R.sup.2 and R.sup.3 each independently is hydrogen, an alkyl radical, an aryl radical or an aralkyl radical, or, for the case where one of the substituents R.sup.2 or R.sup.3 has the above-mentioned meaning, the other is hydroxymethyl, acetoxymethyl or amino, andX is N-R.sup.5, wherein R.sup.5 is hydrogen, an alkyl radical which is optionally interrupted by an oxygen atom, a morpholinoalkyl radical, an aryl radical or an aralkyl radical orX is an oxygen atom, when one of the radicals R.sup.2 or R.sup.3 denotes an amino group,or pharmaceutically acceptable acid addition salts thereof, exhibit hypotensive activity.
摘要翻译：其中R是任选取代的芳基或杂环基团的式“IMAGE”的化合物，R 1是任选被链中1个氧原子中断的烃基，和/或任选地被取代，R 4是脂族烃基具有7至14个碳原子，其任选地被一个氧原子和/或任选地被取代，R2和R3各自独立地是氢，烷基，芳基或芳烷基，或者对于一个的取代基R2或R3具有上述含义，另一个是羟甲基，乙酰氧基甲基或氨基，X是N-R 5，其中R 5是氢，任选被氧原子间隔的烷基，吗啉代烷基，芳基或芳烷基或X是氧原子，当基团R 2或R 3中的一个表示氨基或其药学上可接受的酸加成盐时，表现出降血压活性。

55. 发明授权

US4508722A 1-Benzoyl-3-(arylpyridyl)urea compounds 失效
标题翻译： 1-苯甲酰基-3-（芳基吡啶基）脲化合物
公开(公告)号：US4508722A
公开(公告)日：1985-04-02
申请号：US503971
申请日：1983-06-13
申请人： John L. Miesel
发明人： John L. Miesel
IPC分类号： A01N47/36 , A61K31/44 , C07C45/45 , C07D211/86 , C07D213/64 , C07D213/73 , C07D213/75 , C07D213/80 , C07D213/82 , C07D213/85 , C07D213/89
CPC分类号： C07D213/64 , A01N47/36 , C07C255/00 , C07C45/455 , C07D211/86 , C07D213/73 , C07D213/75 , C07D213/80 , C07D213/82 , C07D213/85 , C07D213/89
摘要： The present invention is directed to 1-benzoyl-3-(arylpyridyl)urea compounds useful as insecticides.
摘要翻译：本发明涉及可用作杀虫剂的1-苯甲酰基-3-（芳基吡啶基）脲化合物。

56. 发明授权

US4405552A 1-Benzoyl-3-(arylphyridyl)urea compounds 失效
标题翻译： 1-苯甲酰基-3-（芳基吡啶基）脲化合物
公开(公告)号：US4405552A
公开(公告)日：1983-09-20
申请号：US264494
申请日：1981-05-18
申请人： John L. Miesel
发明人： John L. Miesel
IPC分类号： A01N47/36 , C07C45/45 , C07D211/86 , C07D213/64 , C07D213/73 , C07D213/75 , C07D213/80 , C07D213/82 , C07D213/85 , C07D213/89 , A01N43/40 , C07D213/74
CPC分类号： C07D213/64 , A01N47/36 , C07C255/00 , C07C45/455 , C07D211/86 , C07D213/73 , C07D213/75 , C07D213/80 , C07D213/82 , C07D213/85 , C07D213/89
摘要： The present invention is directed to 1-benzoyl-3-(arylpyridyl)urea compounds useful as insecticides.
摘要翻译：本发明涉及可用作杀虫剂的1-苯甲酰基-3-（芳基吡啶基）脲化合物。

57. 发明授权

US4321371A Substituted N-benzoylanthranilic acid derivatives and their anhydro compounds 失效
标题翻译：取代的N-苯甲酰邻氨基苯甲酸衍生物及其脱水化合物
公开(公告)号：US4321371A
公开(公告)日：1982-03-23
申请号：US178677
申请日：1980-08-15
申请人： Adolf Parg , Bruno Wuerzer , Gerhard Hamprecht
发明人： Adolf Parg , Bruno Wuerzer , Gerhard Hamprecht
IPC分类号： C07D237/06 , A01N37/22 , A01N37/34 , A01N37/46 , A01N37/48 , A01N43/40 , A01N43/58 , A01N43/82 , A01N43/836 , A01N43/86 , A01P13/02 , C07C67/00 , C07C231/00 , C07C231/02 , C07C235/56 , C07C253/00 , C07C255/54 , C07C255/60 , C07C313/00 , C07C315/04 , C07C317/22 , C07C319/20 , C07C323/20 , C07D213/64 , C07D213/643 , C07D237/12 , C07D237/14 , C07D265/10 , C07D265/16 , C07D265/22 , C07D285/08 , C07D413/12 , C07D417/12 , C07D265/12 , C07C79/46 , C07D211/86 , C07D213/62
CPC分类号： C07D213/643 , A01N37/46 , A01N37/48 , A01N43/40 , A01N43/58 , A01N43/82 , A01N43/86 , C07D237/14 , C07D265/22 , C07D285/08
摘要： Substituted N-benzoylanthranilic acid derivatives of the formula I ##STR1## and their anhydro compounds, of the formula II ##STR2## where R.sup.1 is substituted phenyl,R.sup.2 is hydrogen, nitro, cyano or halogen,X is hydrogen, halogen, nitro or cyano, or is alkyl, haloalkyl, alkoxy, haloalkoxy, haloalkylmercapto or alkylmercapto, each of 1 to 4 carbon atoms, andY is --OR.sup.6 or ##STR3## where R.sup.6 is hydrogen, or is alkyl, alkenyl or alkynyl each of up to 4 carbon atoms, or is one equivalent of an alkaline earth metal cation, of an alkali metal cation or of an ammonium ion which is unsubstituted or is substituted by alkyls of 1 to 4 carbon atoms, andR.sup.7 and R.sup.8 independently of one another are hydrogen or alkyl of 1 to 4 carbon atoms, herbicides containing these compounds, and processes for controlling undesired plant growth by means of these compounds.
摘要翻译：取代的式I的N-苯甲酰邻氨基苯甲酸衍生物及其脱水化合物，其中R 1是取代的苯基，R 2是氢，硝基，氰基或卤素，X是氢，卤素，硝基或氰基，或为烷基，卤代烷基，烷氧基，卤代烷氧基，卤代烷基巯基或烷基巯基，各自为1至4个碳原子，Y为-OR 6或者其中R 6为氢或为烷基，烯基或炔基， 4个碳原子，或是1当量碱土金属阳离子，碱金属阳离子或铵离子，其是未取代的或被1至4个碳原子的烷基取代，并且R 7和R 8彼此独立地为氢或1-4个碳原子的烷基，含有这些化合物的除草剂，以及通过这些化合物控制不期望的植物生长的方法。

58. 发明授权

US4299970A Oxy-alkylamino carboxylic esters 失效
标题翻译：氧基 - 烷基氨基羧酸酯
公开(公告)号：US4299970A
公开(公告)日：1981-11-10
申请号：US181432
申请日：1980-08-25
申请人： Frederick Cassidy , Gordon Wootton
发明人： Frederick Cassidy , Gordon Wootton
IPC分类号： C07D223/10 , C07C405/00 , C07D207/26 , C07D207/27 , C07D207/36 , C07D211/42 , C07D211/74 , C07D211/86 , C07D211/90 , C07D491/10 , C07C101/20
CPC分类号： C07D207/26 , C07C405/00 , C07D207/36 , C07D211/42 , C07D211/74 , C07D211/86 , C07D491/10
摘要： Compounds of formula (I): ##STR1## wherein: X is CO, protected CO, CROH in which R is hydrogen or C.sub.1-4 alkyl and in which the OH moiety may be protected;Y is CH.sub.2 CH.sub.2 or CH.dbd.CH;Z is CO or CH.sub.2 ;n is 1 to 8;m is 1, 2 or 3;R.sub.1 is hydrogen, CH.sub.2 OH, CH.sub.2 OH in which the OH moiety is protected, CO.sub.2 W wherein W is hydrogen or CO.sub.2 W represents an ester group in which the ester moiety contains from 1 to 12 carbon atoms, or CONH.sub.2 ;R.sub.2 is hydrogen, C.sub.1-4 alkyl, or taken together with R.sub.3 and the carbon atom to which it is attached represents a carbonyl group;R.sub.3 is hydrogen, hydroxy or protected hydroxy;R.sub.4 is hydrogen or C.sub.1-9 alkyl;and salts thereof--have useful pharmacological properties.
摘要翻译：式（I）化合物：其中：X为CO，保护的CO，CROH，其中R为氢或C1-4烷基，其中OH部分可被保护; Y是CH 2 CH 2或CH = CH; Z是CO或CH 2; n为1至8; m为1,2或3; R1是其中OH部分被保护的氢，CH 2 OH，CH 2 OH，其中W是氢的CO 2 W或CO 2 W表示酯部分含有1至12个碳原子的酯基或CONH 2; R 2是氢，C 1-4烷基，或与R 3一起并且与它相连的碳原子代表羰基; R3是氢，羟基或被保护的羟基; R 4是氢或C 1-8烷基; 及其盐具有有用的药理学性质。

59. 发明授权

US4284779A Amino acid derivatives 失效
公开(公告)号：US4284779A
公开(公告)日：1981-08-18
申请号：US846734
申请日：1977-10-31
申请人： Miguel A. Ondetti , Michael E. Condon
发明人： Miguel A. Ondetti , Michael E. Condon
IPC分类号： A61K38/00 , C07D207/16 , C07D207/46 , C07D209/20 , C07D211/60 , C07D211/86
CPC分类号： C07D211/86 , C07C327/00 , C07D207/16 , C07D207/46 , C07D209/20 , C07D211/60 , A61K38/00
摘要： New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.

60. 发明授权

US4154960A Amino acid derivatives 失效
公开(公告)号：US4154960A
公开(公告)日：1979-05-15
申请号：US920590
申请日：1978-06-29
申请人： Miguel A. Ondetti , Michael E. Condon
发明人： Miguel A. Ondetti , Michael E. Condon
IPC分类号： A61K31/19 , A61K31/195 , A61K31/215 , A61K31/22 , A61K31/395 , A61K31/40 , A61K31/403 , A61K31/404 , A61K38/00 , A61P9/12 , A61P43/00 , C07C67/00 , C07C313/00 , C07C323/60 , C07C327/20 , C07C327/22 , C07C327/34 , C07D207/08 , C07D207/10 , C07D207/16 , C07D207/46 , C07D209/20 , C07D211/60 , C07D211/86 , C07D233/64 , C07K5/02 , C07K5/06 , C07K5/062 , C07C101/26
CPC分类号： C07K5/0606 , C07C327/00 , C07D207/16 , C07D207/46 , C07D209/20 , C07D211/60 , C07D211/86 , A61K38/00 , Y10S514/929 , Y10S530/80
摘要： New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.

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