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51. 发明申请

US20210024453A1 AMINATED LIGNIN-DERIVED COMPOUNDS AND USES THEREOF 有权
公开(公告)号：US20210024453A1
公开(公告)日：2021-01-28
申请号：US16967898
申请日：2019-02-13
申请人： CMBLU PROJEKT AG
发明人： Jan HARTWIG , Nastaran KRAWCZYK , Alexander MÖLLER , Peter GEIGLE , Evgeny LARIONOV
IPC分类号： C07C215/50 , C07G1/00 , C07C45/55 , C07C45/71 , C07C51/235 , C07C51/60 , C07C45/41 , C07C45/67 , C07C41/26 , C07C45/29 , C07C303/04 , C07C309/44 , C07C213/02 , H01M8/18 , H01M8/08
摘要： The present invention relates to novel lignin-derived compounds and compositions comprising the same and their use as redox flow battery electrolytes. The invention further provides a method for preparing said compounds and compositions as well as a redox flow battery comprising said compounds and compositions. Additionally, an assembly for carrying out the inventive method is provided.

52. 发明授权

US10727516B2 Compound and polymer electrolyte membrane using same 有权
公开(公告)号：US10727516B2
公开(公告)日：2020-07-28
申请号：US15519978
申请日：2015-12-02
申请人： LG CHEM, LTD.
发明人： Yong Jin Jang , Joong Jin Han , Sehee Jung , Youngjea Kim , Esder Kang , Hyun Woog Ryu
IPC分类号： H01M8/1039 , H01M8/18 , H01M8/1025 , H01M8/1027 , C07C309/44 , H01M8/1032 , C07C317/14
摘要： The present specification relates to a novel compound, a polymer electrolyte membrane including the same, a membrane-electrode assembly including the polymer electrolyte membrane, a fuel cell including the membrane-electrode assembly, and a redox flow battery including the polymer electrolyte membrane.

53. 发明申请

US20190115594A1 STABLE POSITIVE SIDE MATERIAL FOR ALL-ORGANIC FLOW BATTERY 审中-公开
公开(公告)号：US20190115594A1
公开(公告)日：2019-04-18
申请号：US16161647
申请日：2018-10-16
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： BO YANG , G.K. SURYA PRAKASH , ROBERT ANISZFELD , SRI R. NARAYAN , LENA HOOBER-BURKHARDT , SANKARGANESH KRISHNAMOORTHY , ADVAITH MURALI , ARCHITH NIRMALCHANDAR
IPC分类号： H01M4/36 , H01M8/18 , H01M4/60 , H01M8/08 , C07C309/44 , C07C309/42 , C07C309/43
摘要： A quinone derivative with a high redox potential that does not undergo Michael addition or proto-desulfonation. This molecule addresses the key issues faced with the positive side material of an aqueous all-organic flow battery. This new molecule is 2,5-dihydroxy-4,6-dimethylbenzene-1,3-disulfonic acid (or the disulfonate salt thereof). This quinone derivative offers good solubility, electrochemical reversibility, and robustness to charge/discharge cycling. Quinones with reduced crossover are also provided.

54. 发明授权

US10227282B2 Anti-virulence compositions and methods 有权
公开(公告)号：US10227282B2
公开(公告)日：2019-03-12
申请号：US14445713
申请日：2014-07-29
申请人： Case Western Reserve University
发明人： Menachem Shoham
IPC分类号： A61K31/12 , A61K45/06 , C07C49/84 , C07C65/24 , A61K31/185 , A61K31/192 , A61K31/404 , C07C309/44 , C07C49/83 , A61K31/166 , A61K31/36 , C12N1/36
摘要： A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.

55. 发明授权

US09790605B2 Iridium complexes for electrocatalysis 有权
公开(公告)号：US09790605B2
公开(公告)日：2017-10-17
申请号：US14317906
申请日：2014-06-27
申请人： Yale University
发明人： Stafford Wheeler Sheehan , Ulrich Hintermair , Julianne M. Thomsen , Gary W. Brudvig , Robert H. Crabtree
IPC分类号： C25B11/04 , C02F1/467 , H01M4/92 , C25B1/00 , C25B3/02 , C07C309/44 , C07C303/32 , C07F15/00 , C07F17/00 , C02F1/461
CPC分类号： C25B11/0489 , C02F1/4672 , C02F2001/46142 , C02F2303/10 , C07C303/32 , C07C309/44 , C07F15/0033 , C07F17/00 , C25B1/003 , C25B3/02 , C25B11/0405 , C25B11/0447 , H01M4/923 , H01M4/925 , H01M4/926 , Y02W10/30
摘要： Solution-phase (e.g., homogeneous) or surface-immobilized (e.g., heterogeneous) electrode-driven oxidation catalysts based on iridium coordination compounds which self-assemble upon chemical or electrochemical oxidation of suitable precursors and methods of making and using thereof are. Iridium species such as {[Ir(LX)x(H2O)y(μ-O)]zm+}n wherein x, y, m are integers from 0-4, z and n from 1-4 and LX is an oxidation-resistant chelate ligand or ligands, such as such as 2(2-pyridyl)-2-propanolate, form upon oxidation of various molecular iridium complexes, for instance [Cp*Ir(LX)OH] or [(cod)Ir(LX)] (Cp*=pentamethylcyclopentadienyl, cod=cis-cis,1,5-cyclooctadiene) when exposed to oxidative conditions, such as sodium periodate (NaIO4) in aqueous solution at ambient conditions.

56. 发明授权

US09610257B2 Small molecule xanthine oxidase inhibitors and methods of use 有权
公开(公告)号：US09610257B2
公开(公告)日：2017-04-04
申请号：US14483055
申请日：2014-09-10
申请人： Baylor College of Medicine
发明人： Changyi Chen , Jian-Ming Lu , Qizhi Yao
IPC分类号： A61K31/11 , C07C205/44 , A61K31/185 , A61K31/277 , A61K45/06 , C07C255/56 , C07C309/44 , C07C317/22 , A61K31/519 , C07C47/544 , C07C47/565 , C07C255/57 , C07C47/54 , C07C313/04 , A61K9/00
CPC分类号： A61K31/11 , A61K9/0053 , A61K31/185 , A61K31/277 , A61K31/519 , A61K45/06 , C07C47/54 , C07C47/544 , C07C47/565 , C07C205/44 , C07C255/56 , C07C255/57 , C07C309/44 , C07C313/04 , C07C317/22
摘要： Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.

57. 发明申请

US20140155625A1 Modified Naturally-Derived Colorants For Phase Change Ink Applications 审中-公开
标题翻译：用于相变油墨应用的改性天然着色剂
公开(公告)号：US20140155625A1
公开(公告)日：2014-06-05
申请号：US13690857
申请日：2012-11-30
申请人： XEROX CORPORATION
发明人： Mihaela Maria Birau , Salma Falah Toosi , C. Geoffrey Allen , Biby Esther Abraham , Peter G. Odell , Sandra J. Gardner
IPC分类号： C07D403/04 , C07C309/44
CPC分类号： C09B7/02 , C09B7/00 , C09D11/322 , C09D11/34
摘要： A modified naturally-derived colorant comprising a naturally-derived colorant that is modified with an aliphatic quaternary ammonium salt, an aromatic quaternary ammonium salt, or a mixture or combination thereof. The modified naturally-derived colorant is compatible with phase change ink vehicles.
摘要翻译：一种改性天然衍生的着色剂，其包含用脂族季铵盐，芳族季铵盐或其混合物或其组合改性的天然衍生的着色剂。改性天然衍生的着色剂与相变油墨载体相容。

58. 发明申请

US20050054876A1 Sulphonation of phenols 失效
标题翻译：酚的磺化
公开(公告)号：US20050054876A1
公开(公告)日：2005-03-10
申请号：US10490361
申请日：2002-09-18
申请人： Jonathan Hill , Bernard Capai , Carlo Neri
发明人： Jonathan Hill , Bernard Capai , Carlo Neri
IPC分类号： C07C303/08 , C07C309/42 , C07C309/44 , C07C309/00
CPC分类号： C07C303/08 , C07C309/42 , C07C309/44
摘要： A process for the preparation of sulphonated phenols of general formula (I) where R1 is hydrogen, a C1-C20 alkyl group which is unsubstituted or substituted by halogen, cyano, hydroxyl, C1-C20 alkoxy, C2-C20 alkoxycarbonyl, acyloxy and/or phenyl which is unsubstituted or substituted by C1-C4 alkyl, C1-C4 alkoxy and/or halogen, R2 is hydrogen, C1-C20 alkyl or benzoyl of general formula (II) where R3 and R4 independently of one another are each hydrogen, halogen, C1-C12 alkyl, C1-C12 alkoxy, C1-C4 haloalkyl, C3-C8 cycloalkyl, C4-C12 cycloalkylalkyl, cyano, hydroxyl, or hydroxyethyl or are each phenoxy, C7-C10 phenylalkyl or phenyl which is unsubstituted or substituted by C1-C4 alkyl, C1-C4 alkoxy and/or halogen, and R5 is hydrogen or the group SO3X where X can be hydrogen, a monovalent metal or a group —N(R6)3, where each of the three radicals R6 can be independently of one another hydrogen, C1-C6 alkyl or C1-C6 hydroxy alkyl, which process comprises reacting a phenol of general formula (III) where R1 and R2 are as defined above, with a halosulphonic acid in a solvent which is a mixture of a C5-C10 aliphatic or cycloaliphatic hydrocarbon and a dialkyl carbonate of general formula (IV) R7—O—CO—O—R8 where R7 and R8 each represent independently a C1-C4 alkyl group.
摘要翻译：制备通式（I）的磺化酚的方法，其中R 1为氢，未被取代或被卤素，氰基，羟基，C 1 -C 20烷氧基，C 2 -C 20烷氧基羰基，酰氧基和/或C 1 -C 20烷氧基取代的C 1 -C 20烷基，或未被取代或被C 1 -C 4烷氧基和/或卤素取代的苯基，R 2是氢，通式（II）的C 1 -C 20烷基或苯甲酰基，其中R 3和R 4彼此独立地为氢，卤素，C 1 -C 12烷基，C 1 -C 12烷氧基，C 1 -C 4卤代烷基，C 3 -C 8环烷基，C 4 -C 12环烷基烷基，氰基，羟基或羟乙基，或者各自为苯氧基，未被取代或被 C1-C4烷基，C1-C4烷氧基和/或卤素，R5是氢或X3可以是氢的基团SO3X，一价金属或基团-N（R6）3，其中三个基团R6可以是独立于氢，C 1 -C 6烷基或C 1 -C 6羟基烷基，该方法包括使通式为酚（III）其中R 1和R 2如上所定义，与卤代磺酸在溶剂中是C5-C10脂族或脂环族烃和通式（Ⅳ）的二烷基碳酸酯的混合物，R7-O-CO-O- R8，其中R7和R8各自独立地表示C1-C4烷基。

59. 发明授权

US5196452A Macrocyclic anti-viral compound and method 失效
标题翻译：大环抗病毒化合物及方法
公开(公告)号：US5196452A
公开(公告)日：1993-03-23
申请号：US647720
申请日：1991-01-29
申请人： Kou M. Hwang , You M. Qi , Su-Ying Liu
发明人： Kou M. Hwang , You M. Qi , Su-Ying Liu
IPC分类号： A61K31/18 , A61K31/185 , A61K31/19 , A61K31/215 , A61K31/255 , A61K31/795 , C07C309/42 , C07C309/43 , C07C309/44 , C07C309/50 , C07C309/58 , C07C309/60 , C07C309/77 , C07C311/29 , C07C311/37 , C07C311/48 , C07C317/22 , C07C323/21
CPC分类号： A61K31/795 , A61K31/18 , A61K31/185 , A61K31/19 , A61K31/215 , A61K31/255 , C07C309/42 , C07C309/43 , C07C309/44 , C07C309/50 , C07C309/58 , C07C309/60 , C07C309/77 , C07C311/29 , C07C311/37 , C07C311/48 , C07C317/22 , C07C323/21
摘要： A compound and method for inhibiting cell infection by an enveloped virus. The compound is a macrocyclic chromotropic acid derivative which can be substituted at a variety of naphthalene ring and bridge positions. The compound may be administered parenterally, orally, or topically for treating infection by enveloped viruses.
摘要翻译：用于抑制包膜病毒细胞感染的化合物和方法。该化合物是可在各种萘环和桥位置被取代的大环变色酸衍生物。该化合物可以肠胃外，口服或局部施用以治疗包膜病毒的感染。

60. 发明授权

US5101007A Process for the preparation of naphthalenesulfonic acid/formaldehyde condensates having a low free formaldehyde content 失效
标题翻译：制备具有低免费甲醛含量的萘磺酸/甲醛缩合物的方法
公开(公告)号：US5101007A
公开(公告)日：1992-03-31
申请号：US653229
申请日：1991-02-08
申请人： Emmerich Jager , Walter Lechner
发明人： Emmerich Jager , Walter Lechner
IPC分类号： C04B24/22 , C04B16/04 , C04B24/20 , C04B28/02 , C04B103/30 , C07C309/44 , C08G16/00 , C08G16/02 , C08L61/00
CPC分类号： C08G16/0237
摘要： Process for the preparation of naphthalenesulfonic acid/formaldehyde condensates having a low content of free formaldehyde, in which the condensation products of naphthalenesulfonic acid and formaldehyde obtained after the condensation are brought to a pH of greater than 11.5 at a temperature of not less than 80.degree. C. immediately after the condensation, and are kept under these conditions until the desired formaldehyde content is reached. The resins are preferably used as plasticizers for building materials, for example as concrete plasticizers.
摘要翻译：制备游离甲醛含量低的萘磺酸/甲醛缩合物的方法，其中在冷凝后获得的萘磺酸和甲醛的缩合产物在不低于80℃的温度下达到大于11.5的pH 在冷凝后立即，并保持在这些条件下，直到达到所需的甲醛含量。树脂优选用作建筑材料的增塑剂，例如作为混凝土增塑剂。

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