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    • 51. 发明授权
    • 9-amino-1,4ethano-1,2,3,4-tetrahydroacridine and related compounds
    • 9-氨基-1,4-乙烷-1,2,3,4-四氢吖啶及相关化合物
    • US5401749A
    • 1995-03-28
    • US218755
    • 1988-07-08
    • Gregory M. ShutskeKevin J. Kapples
    • Gregory M. ShutskeKevin J. Kapples
    • A61K31/47A61P25/02A61P25/28C07C251/24C07D219/10C07D221/22C07D221/18A61K31/435
    • C07D219/10C07C251/24C07D221/22C07C2102/18
    • There are disclosed compounds having the formula ##STR1## wherein R is hydrogen, loweralkyl or loweralkylcarbonyl; R.sub.1 is hydrogen, loweralkyl, loweralkylcarbonyl, aryl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, oxygen-bridged arylloweralkyl or oxygen-bridged diarylloweralkyl; R.sub.2 and R.sub.3 are independently H or CH.sub.3 ; X is hydrogen, loweralkyl, cycloalkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, formyl, loweralkylcarbonyl, arylcarbonyl, --SH, loweralkylthio, --NHCOR.sub.4 or --NR.sub.5 R.sub.6 where R.sub.4 is hydrogen or loweralkyl, and R.sub.5 and R.sub.6 are independently hydrogen, loweralkyl or cycloalkyl; Y and Z are independently a direct bond, CR.sub.7 R.sub.8 or CR.sub.7 R.sub.8 --CR.sub.9 R.sub.10 ; and L and Q are independently CR'.sub.7 R'.sub.8, CR'.sub.7 R'.sub.8 --CR'.sub.9 R'.sub.10, CR'.sub.7 .dbd.CR'.sub.9 or CR'.sub.7 R'.sub.8 --CR'.sub.9 R'.sub.10 --CR.sub.11 R.sub.12, where each of R.sub.7 through R.sub.12 and R'.sub.7 through R'.sub.10 is independently H or CH.sub.3 ; a stereo, optical and geometrical isomers thereof, and pharmaceutically acceptable acid addition salts thereof, which are useful for enhancing memory.
    • 公开了具有式“IMAGE”的化合物,其中R是氢,低级烷基或低级烷基羰基; R 1是氢,低级烷基,低级烷基羰基,芳基,二低级烷基氨基低级烷基,芳基低级烷基,二芳基低级烷基,氧桥连的芳基低级烷基或氧桥连的二芳基低级烷基。 R2和R3独立地是H或CH3; X是氢,低级烷基,环烷基,低级烷氧基,卤素,羟基,硝基,三氟甲基,甲酰基,低级烷基羰基,芳基羰基,-SH,低级烷硫基,-NHCOR4或-NR5R6,其中R4是氢或低级烷基,R5和R6独立地是氢, 或环烷基; Y和Z独立地是直接键,CR7R8或CR7R8-CR9R10; L和Q独立地为CR'7R'8,CR'7R'8-CR'9R'10,CR'7 = CR'9或CR'7R'8-CR'9R'10-CR11R12,其中R7 通过R12和R'7至R'10独立地是H或CH3; 其立体,光学和几何异构体及其药学上可接受的酸加成盐,其可用于增强记忆。