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51. 发明授权

US06468965B1 Pharmaceutical composition for oral administration of a mixture of chelating agents 失效
标题翻译：用于口服施用螯合剂混合物的药物组合物
公开(公告)号：US06468965B1
公开(公告)日：2002-10-22
申请号：US10127404
申请日：2002-04-22
申请人： Paul Cutler
发明人： Paul Cutler
IPC分类号： A61K3816
CPC分类号： A61K31/195 , A61K38/40 , A61K2300/00
摘要： A solid pharmaceutical composition for the oral administration of chelating agents to an individual consists essentially of: at least 100 milligrams of ethylenediamninctetraacetic acid (EDTA) or a molar equivalent amount of pharmaceutically acceptable salts or hydrated salts of EDTA, at least 75 milligrams of N-acetyl-L-cysteine, at least 10 milligrams of lactoferrin, and an appropriate amount of at least one pharmaceutical formulating agent.
摘要翻译：用于向个体口服施用螯合剂的固体药物组合物基本上由以下物质组成：至少100毫克乙二胺四乙酸（EDTA）或摩尔当量的EDTA药学上可接受的盐或水合盐，至少75毫克N- 乙酰基-L-半胱氨酸，至少10毫克乳铁蛋白和适量的至少一种药物配制剂。

52. 发明授权

US06448224B1 Antibiotics and methods of using the same 失效
标题翻译：抗生素及其使用方法
公开(公告)号：US06448224B1
公开(公告)日：2002-09-10
申请号：US09073541
申请日：1998-05-06
申请人： Rodger Novak , Elaine I. Tuomanen
发明人： Rodger Novak , Elaine I. Tuomanen
IPC分类号： A61K3816
CPC分类号： C07K7/08 , A61K38/00 , C07K14/3156 , C12N9/1223 , C12N9/14 , Y02A50/473 , Y02A50/475
摘要： The present invention discloses novel antibiotic peptides, including naturally occurring peptides. The present invention also includes the nucleic acid sequence encoding such peptides and the corresponding amino acid sequences. Methods of identifying, making, and using the antibiotic peptides are also disclosed.
摘要翻译：本发明公开了新型抗生素肽，包括天然存在的肽。本发明还包括编码这些肽的核酸序列和相应的氨基酸序列。还公开了鉴定，制备和使用抗生素肽的方法。

53. 发明授权

US06440932B1 Pharmaceutical combination preparations containing erythropoietin and modified haemoglobins 有权
标题翻译：含有红细胞生成素和改性血红蛋白的药物组合制剂
公开(公告)号：US06440932B1
公开(公告)日：2002-08-27
申请号：US09446378
申请日：2000-02-07
申请人： Paul Lehmann , Jürgen Feuerstein , Michael Harold Town
发明人： Paul Lehmann , Jürgen Feuerstein , Michael Harold Town
IPC分类号： A61K3816
CPC分类号： A61K38/42 , A61K2300/00
摘要： The present invention provides a pharmaceutical combination preparation comprising an erythropoietin preparation that provides active erythropoietin and at least one modified haemoglobin wherein the erythropoietin preparation and modified haemoglobin can be present in separate forms of administration or in a single form of administration. The pharmaceutical combination preparations of the present invention can be used to treat manifest anemias with or without iron utilization disorders.
摘要翻译：本发明提供了包含提供活性促红细胞生成素和至少一种修饰的血红蛋白的促红细胞生成素制剂的制剂组合制剂，其中红细胞生成素制剂和修饰的血红蛋白可以以分开的给药形式存在或以单一给药形式存在。本发明的药物组合制剂可用于治疗具有或不具有铁利用障碍的明显的贫血。

54. 发明授权

US06391851B1 Hydrochlorides of vancomycin antibiotics and process for producing the same 失效
标题翻译：万古霉素抗生素的盐酸盐及其制备方法
公开(公告)号：US06391851B1
公开(公告)日：2002-05-21
申请号：US09508528
申请日：2000-04-03
申请人： Seiji Sawai , Kenji Nishiwaki , Kazumi Ohtomo , Akira Kagayama
发明人： Seiji Sawai , Kenji Nishiwaki , Kazumi Ohtomo , Akira Kagayama
IPC分类号： A61K3816
CPC分类号： C07K9/008 , A61K38/14
摘要： Process for producing a hydrochloride of a vancomycin antibiotic, comprising subjecting an aqueous solution of a hydrochloride of a vancomycin antibiotic to a primary freezing at from −1° C. to −20° C. for a time sufficient to grow ice crystals, to form a primarily frozen substance, then subjecting said primarily frozen substance to a secondary freezing at from −25° C. to −80° C. to form a completely frozen solid, and then drying the resulting frozen solid in vacuo; and product obtained by the process.
摘要翻译：制备万古霉素抗生素的盐酸盐的方法，包括使万古霉素抗生素的盐酸盐水溶液在-1℃至-20℃下进行一次冰冻，持续足够的时间生长冰晶，形成然后将所述主要冷冻物质在-25℃至-80℃下进行二次冷冻，以形成完全冷冻的固体，然后真空干燥所得冷冻固体; 和通过该方法获得的产品。

55. 发明授权

US06358917B1 Cosmetic use of botulinum toxin for treatment of downturned mouth 有权
标题翻译：化妆品使用肉毒杆菌毒素治疗下颚口
公开(公告)号：US06358917B1
公开(公告)日：2002-03-19
申请号：US09382002
申请日：1999-08-24
申请人： Jean D. A. Carruthers , Alastair Carruthers
发明人： Jean D. A. Carruthers , Alastair Carruthers
IPC分类号： A61K3816
CPC分类号： A61Q19/08 , A61K8/02 , A61K8/64 , Y10S514/844 , Y10S514/906
摘要： This invention provides the use of Botulinum toxin (BTX) to cause paralysis of a depressor anguli oris (DAO) musculature in a patient to alleviate downturn at corners of the patient's mouth.
摘要翻译：本发明提供了使用肉毒杆菌毒素（BTX）来引起患者抑郁者血管瘤（DAO）肌肉组织麻痹，以缓解患者口腔角落的衰退。

56. 发明授权

US06329340B1 Human Defensin DEF-X 失效
标题翻译：人防御素DEF-X
公开(公告)号：US06329340B1
公开(公告)日：2001-12-11
申请号：US09486580
申请日：2000-02-25
申请人： Lydie Bougueleret , Ilya Chumakov
发明人： Lydie Bougueleret , Ilya Chumakov
IPC分类号： A61K3816
CPC分类号： A61Q17/005 , A61K8/64 , A61K38/00 , A61Q19/00 , C07K14/4723 , G01N33/53 , G01N33/68 , G01N2333/4721 , Y10S514/885 , Y10S514/886 , Y10S514/887
摘要： The present invention relates to a human polypeptide defensin Def-X, homologous to HNP-4, its genomic DNA and cDNA, vectors, cells transformed with said vectors, the use of said polypeptides as antibiotic, cytotoxic, repair and endocrine regulatory agent and as pesticide as well as cosmetic or pharmaceutical compositions for the treatment of microbial infections, in particular bacterial, fungal and viral infections, or parasitic infections, cancers, of inflammation and of immune deficiency. Finally, the invention comprises diagnostic methods and kits for the determination of a microbial or parasitic infection and of an inflammation, or for screening for predisposition to immune deficiencies or cancer diseases.
摘要翻译：本发明涉及与HNP-4同源的人多肽防御素Def-X，其基因组DNA和cDNA，载体，用所述载体转化的细胞，所述多肽作为抗生素，细胞毒性，修复和内分泌调节剂以及作为农药以及用于治疗微生物感染，特别是细菌，真菌和病毒感染或寄生虫感染，癌症，炎症和免疫缺陷的化妆品或药物组合物。最后，本发明包括用于测定微生物或寄生虫感染和炎症或用于筛选免疫缺陷或癌症疾病倾向的诊断方法和试剂盒。

57. 发明授权

US06319896B1 Method of solubilizing, purifying, and refolding protein 失效
公开(公告)号：US06319896B1
公开(公告)日：2001-11-20
申请号：US09443098
申请日：1999-11-18
申请人： Glenn J. Dorin , Bo H. Arve , Gregory L. Pattison , Robert F. Halenbeck , Kirk Johnson , Bao-Lu Chen , Rajsharan K. Rana , Maninder S. Hora , Hassan Madani , Michael Tsang , Mark E. Gustafson , Gary S. Bild , Gary V. Johnson
发明人： Glenn J. Dorin , Bo H. Arve , Gregory L. Pattison , Robert F. Halenbeck , Kirk Johnson , Bao-Lu Chen , Rajsharan K. Rana , Maninder S. Hora , Hassan Madani , Michael Tsang , Mark E. Gustafson , Gary S. Bild , Gary V. Johnson
IPC分类号： A61K3816
CPC分类号： C07K14/475 , A23L7/111 , A23L7/165 , A23L9/10 , A23L9/22 , A23L19/09 , A23L19/18 , A23L21/15 , A23L29/212 , A23L29/219 , A23P20/12 , A61K9/0019 , A61K9/08 , A61K38/57 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/36 , C07K1/1136 , C07K14/8114 , Y10S514/97 , Y10S514/973
摘要： A method of modifying protein solubility employs polyionic polymers. These facilitate the solubilization, formulation, purification and refolding of proteins especially incorrectly folded proteins and aggregated proteins. Compositions are described that are suitable for formulating TFPI. The compositions allow preparation of pharmaceutically acceptable compositions of TFPI at concentrations above 0.2 mg/mL and above 10 mg/mL.

58. 发明授权

US06294649B1 Method of cell inhibition using polypeptides derived from the venom of the Austrialian jumper ant Myrmecia pilosula 失效
标题翻译：使用衍生自奥地利跳跨蚂蚁Myrmecia pilosula的毒液的多肽进行细胞抑制的方法
公开(公告)号：US06294649B1
公开(公告)日：2001-09-25
申请号：US09269229
申请日：1999-10-08
申请人： Gregory Donovan , Brian Baldo
发明人： Gregory Donovan , Brian Baldo
IPC分类号： A61K3816
CPC分类号： C07K14/43563 , A61K38/00
摘要： An isolated polypeptide having cytotoxic activity comprising the amino acid sequence of Pilosulin 1 shown in the figure, and active portion thereof, or a functionally equivalent amino acid sequence thereof, and a method of inhibiting the growth of a cell comprising exposing the cell to an effective amount of Pilosulin 1 shown in the figure, and active portion thereof, or a functionally equivalent amino acid sequence thereof, such that the growth of the cell is inhibited.
摘要翻译：一种具有细胞毒活性的分离多肽，其包含图中所示的派洛林素1的氨基酸序列及其活性部分或其功能等同的氨基酸序列，以及抑制细胞生长的方法，包括将细胞暴露于有效的图中所示的吡咯啉素1的量及其活性部分或其功能等同的氨基酸序列，使得细胞的生长被抑制。

59. 发明授权

US06291638B1 Hepatotropic conjugates of antiviral drugs carriers thereof and pharmaceutical compositions containing them 失效
标题翻译：其抗病毒药物载体的肝素共轭物和含有它们的药物组合物
公开(公告)号：US06291638B1
公开(公告)日：2001-09-18
申请号：US09325182
申请日：1999-06-03
申请人： Luigi Fiume , Corrado Busi , Guiseppina Di Stefano , Alessandro Mattioli , Massimo Baldacci
发明人： Luigi Fiume , Corrado Busi , Guiseppina Di Stefano , Alessandro Mattioli , Massimo Baldacci
IPC分类号： A61K3816
CPC分类号： A61K47/645 , A61K47/61
摘要： The present invention refers to conjugated compounds of antiviral drugs having hepatotropic activity, methods of making these compounds, and compositions thereof.
摘要翻译：本发明涉及具有肝致激素活性的抗病毒药物的共轭化合物，制备这些化合物的方法及其组合物。

60. 发明授权

US06281192B1 Mucin containing ophthalmic preparations 失效
标题翻译：粘蛋白含眼用制剂
公开(公告)号：US06281192B1
公开(公告)日：2001-08-28
申请号：US09516671
申请日：2000-03-01
申请人： Charles D. Leahy , Edward J. Ellis , Jeanne Y. Ellis
发明人： Charles D. Leahy , Edward J. Ellis , Jeanne Y. Ellis
IPC分类号： A61K3816
CPC分类号： A61K9/0048 , A61K38/1709 , Y10S514/912
摘要： The present invention discloses the ophthalmic applications of mucin derived from mammalian milk or milk byproducts. This mucin has been found to be a MUC1 type mucin similar to the transmembrane mucin expressed on the surface of the human eye. The mucin-containing preparations described in this invention can be in the form of an aqueous formulation to be instilled into the eye, or in which to pre-soak or store an object to be inserted into the eye, such as a contact lens, an ointment, or a solid device to be inserted into the conjunctival sac. The preparations disclosed are utilized for the treatment of tear film and ocular surface disorders associated with the signs and symptoms of dry eye. Furthermore, mucin-based formulations are also effective for the relief of symptoms of eye irritation, such as those caused by environmental conditions or by contact lens wear.
摘要翻译：本发明公开了衍生自哺乳动物乳或乳副产物的粘蛋白的眼科应用。已发现这种粘蛋白是类似于在人眼表面上表达的跨膜粘蛋白的MUC1型粘蛋白。本发明中描述的含粘蛋白的制剂可以是要滴入眼中的水性制剂的形式，或其中预先浸泡或储存待插入眼睛的物体，例如隐形眼镜，软膏，或插入结膜囊的固体装置。所公开的制剂用于治疗与干眼症状和症状相关的泪液和眼表疾病。此外，基于粘蛋白的制剂也有助于缓解眼睛刺激症状，例如由环境条件引起的或隐形眼镜磨损引起的症状。

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