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51. 发明申请

US20150086977A1 GRAPHENE COMPOSITION, METHOD OF FORMING A GRAPHENE COMPOSITION AND SENSOR SYSTEM COMPRISING A GRAPHENE COMPOSITION 有权
标题翻译：石墨组合物，形成石墨组合物的方法和包含石墨组合物的传感器系统
公开(公告)号：US20150086977A1
公开(公告)日：2015-03-26
申请号：US14554912
申请日：2014-11-26
申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education
发明人： ALEXANDER STAR , NARASIMHA HARINDRA VEDALA , GREGG PETER KOTCHEY
IPC分类号： G01N27/414 , G01N33/569 , G01N33/543 , C01B31/04 , G01N27/12
CPC分类号： G01N27/4146 , B82Y30/00 , B82Y40/00 , C01B32/192 , C01B32/194 , C12P3/00 , G01N27/127 , G01N27/4145 , G01N33/5438 , G01N33/56916 , G01N2333/245 , Y10S977/734 , Y10S977/898
摘要： A device including a composition formed by oxidation of graphene oxide to form holey graphene oxide having defects therein and reduction of the holey graphene oxide. A composition includes graphene oxide sheets including holes therein formed by oxidation to form a network of interconnected graphene oxide nanoribbons.
摘要翻译：包括由氧化石墨烯氧化物形成的组合物以形成其中具有缺陷的孔状石墨烯氧化物并减少有孔石墨烯氧化物的装置。组合物包括石墨烯氧化物片，其包括通过氧化形成的孔，以形成相互连接的氧化烯氧化物纳米带的网络。

52. 发明申请

US20150017664A1 GUT FLORA-DERIVED EXTRACELLULAR VESICLES, AND METHOD FOR SEARCHING FOR A DISEASE MODEL, VACCINE, AND CANDIDATE DRUG AND FOR DIAGNOSIS USING THE SAME 审中-公开
标题翻译：葛根衍生的细胞外细胞，以及用于搜索疾病模型，疫苗和候补药物的方法，并使用该方法进行诊断
公开(公告)号：US20150017664A1
公开(公告)日：2015-01-15
申请号：US14322831
申请日：2014-07-02
申请人： Aeon Medix Inc.
发明人： Yoon Keun KIM , Yong Song GHO , Kyoung Su PARK , Bok Sil HONG , Ji Hyun KIM , You Sun KIM , Won Hee LEE , Jung Wook KIM , Dae-Kyum KIM
IPC分类号： G01N33/569 , C12Q1/37
CPC分类号： G01N33/56916 , A01K67/027 , A01K2207/20 , A01K2217/075 , A01K2227/105 , A01K2267/0337 , A01K2267/035 , C12Q1/025 , C12Q1/37
摘要： The present application relates to a composition including gut flora-derived extracellular vesicles, and to an animal disease model using same. In addition, the present application relates to a method for using the gut flora-derived extracellular vesicles to efficiently search for a candidate drug which may prevent or treat diseases that occur due to gut flora-derived extracellular vesicles, and to a vaccine which can efficiently prevent or treat infections caused by gut flora or diseases that occur due to gut flora-derived extracellular vesicles. Further, the development of diagnostic technology to discover, using the gut flora-derived extracellular vesicles of the present application, the etiology of diseases that occur due to gut flora-derived extracellular vesicles, can be achieved.
摘要翻译：本申请涉及包含肠道菌群来源的细胞外囊泡的组合物以及使用其的动物疾病模型。此外，本申请涉及使用肠道菌群衍生的细胞外囊泡来有效地搜索可以预防或治疗由肠道菌群衍生的细胞外囊泡引起的疾病的候选药物的方法，以及可以有效地预防或治疗由肠道菌群衍生的细胞外囊泡引起的肠道菌群或疾病引起的感染。此外，可以实现使用本申请的肠道菌群衍生的细胞外囊泡发现由肠道菌群衍生的细胞外囊泡引起的疾病的病因的诊断技术的发展。

53. 发明申请

US20140377772A1 Detection of Conductive Polymer-Labeled Analytes 有权
标题翻译：导电聚合物标记分析物的检测
公开(公告)号：US20140377772A1
公开(公告)日：2014-12-25
申请号：US14480162
申请日：2014-09-08
申请人： BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
发明人： Evangelyn C. Alocilja , Emma Setterington
IPC分类号： G01N33/569
CPC分类号： G01N33/56916 , B82Y15/00 , G01N27/745 , G01N33/54326 , G01N33/54333 , G01N33/56911 , G01N33/56983 , G01N2333/245 , H01F1/0054
摘要： The disclosure relates to the detection of analytes (e.g., biological pathogens such as bacteria or viruses) using a conductive polymer label. The disclosed detection system utilizing the conductive polymer label generally involves the formation of an analyte conjugate between the target analyte and a conductive polymer moiety conjugated to the target analyte. The conductive polymer portion of the analyte conjugate is electrically activated to form an electrically activated analyte conjugate having an increased electrical conductivity relative to the analyte conjugate as originally formed. The electrically activated analyte conjugate can then be detected by any suitable means, such as by conductimetric or electrochemical detection.
摘要翻译：本公开涉及使用导电聚合物标签检测分析物（例如生物病原体，例如细菌或病毒）。所公开的利用导电聚合物标记的检测系统通常涉及在目标分析物和与目标分析物缀合的导电聚合物部分之间形成分析物结合物。分析物缀合物的导电聚合物部分被电活化以形成相对于最初形成的分析物缀合物具有增加的电导率的电激活分析物缀合物。然后可以通过任何合适的方法，例如通过电导或电化学检测来检测电活化的分析物缀合物。

54. 发明申请

US20140315219A1 Rapid Enzyme-Linked Immunosorbant Assay for Detection and Identification of Pathogens and Determination of Antimicrobial Susceptibility 审中-公开
标题翻译：用于病原体检测和鉴定的快速酶联免疫吸附测定法和抗微生物敏感性测定
公开(公告)号：US20140315219A1
公开(公告)日：2014-10-23
申请号：US14256694
申请日：2014-04-18
申请人： Bret T. Barnhizer , Jonathan P. Faro
发明人： Bret T. Barnhizer , Jonathan P. Faro
IPC分类号： G01N33/571 , C12Q1/18 , G01N33/569
CPC分类号： G01N33/571 , C12Q1/18 , G01N33/56916
摘要： The present invention provides a rapid, highly sensitive and specific enzyme-linked immunosorbent assay (ELISA), referred to as N-Assay, a device, and a kit, for detection and identification of microorganisms in a sample, in thirty minutes or less, with little or no interference from non-target microorganisms. The present invention also provides for simultaneous determination of antimicrobial susceptibility of microorganism in the N-Assay.
摘要翻译：本发明提供了用于在30分钟或更短时间内检测和鉴定样品中的微生物的快速，高灵敏度和特异性酶联免疫吸附测定（ELISA），称为N-测定，装置和试剂盒，很少或没有来自非目标微生物的干扰。本发明还提供了在N-测定中同时测定微生物的抗微生物敏感性。

55. 发明授权

US08859297B2 Detection of conductive polymer-labeled analytes 有权
标题翻译：导电聚合物标记分析物的检测
公开(公告)号：US08859297B2
公开(公告)日：2014-10-14
申请号：US13477205
申请日：2012-05-22
申请人： Evangelyn C. Alocilja , Emma Setterington
发明人： Evangelyn C. Alocilja , Emma Setterington
IPC分类号： G01N33/543 , G01N33/553 , H01F1/00 , G01N33/569 , G01N27/74 , B82Y15/00
CPC分类号： G01N33/56916 , B82Y15/00 , G01N27/745 , G01N33/54326 , G01N33/54333 , G01N33/56911 , G01N33/56983 , G01N2333/245 , H01F1/0054
摘要： The disclosure relates to the detection of analytes (e.g., biological pathogens such as bacteria or viruses) using a conductive polymer label. The disclosed detection system utilizing the conductive polymer label generally involves the formation of an analyte conjugate between the target analyte and a conductive polymer moiety conjugated to the target analyte. The conductive polymer portion of the analyte conjugate is electrically activated to form an electrically activated analyte conjugate having an increased electrical conductivity relative to the analyte conjugate as originally formed. The electrically activated analyte conjugate can then be detected by any suitable means, such as by conductimetric or electrochemical detection.
摘要翻译：本公开涉及使用导电聚合物标签检测分析物（例如生物病原体，例如细菌或病毒）。所公开的利用导电聚合物标记的检测系统通常涉及在目标分析物和与目标分析物缀合的导电聚合物部分之间形成分析物结合物。分析物缀合物的导电聚合物部分被电活化以形成相对于最初形成的分析物缀合物具有增加的电导率的电激活分析物缀合物。然后可以通过任何合适的方法，例如通过电导或电化学检测来检测电活化的分析物缀合物。

56. 发明申请

US20140206016A1 Rapid Method for Detection of Pathogen 审中-公开
标题翻译：快速检测病原体的方法
公开(公告)号：US20140206016A1
公开(公告)日：2014-07-24
申请号：US14161117
申请日：2014-01-22
申请人： IMICROQ, S.L.
发明人： Pablo Lozano Sánchez , Gemma Freixes Prous , Sergio Martinez Montequín , Anna Pallares Lleo , Cristina Perez Girona , Katia Uliaque Cugat
IPC分类号： G01N33/569
CPC分类号： C12Q1/10 , C12Q1/04 , C12Q1/045 , C12Q1/6888 , G01N33/52 , G01N33/569 , G01N33/56916 , G01N33/66 , G01N2333/255 , Y02A50/451 , Y02A50/52 , Y02A50/56 , Y02A50/57 , Y02A50/58 , Y02A50/59 , Y02A50/60
摘要： The present specification discloses methods of detecting a pathogen of interest and components useful in carrying out these methods, including a pre-enrichment media, and enrichment media and a detection solution.
摘要翻译：本说明书公开了检测感兴趣的病原体的方法和用于实施这些方法的组分，包括预富集培养基，富集培养基和检测溶液。

57. 发明申请

US20140187446A1 AFFINITY-BASED DETECTION OF BIOLOGICAL TARGETS 有权
标题翻译：基于生物目标的基于亲属的检测
公开(公告)号：US20140187446A1
公开(公告)日：2014-07-03
申请号：US14188784
申请日：2014-02-25
申请人： Nadezhda V. Kulagina , Chris Rowe Taitt , George P. Anderson , Frances S. Ligler
发明人： Nadezhda V. Kulagina , Chris Rowe Taitt , George P. Anderson , Frances S. Ligler
IPC分类号： G01N33/569 , G01N33/543
CPC分类号： G01N33/56916 , G01N33/5308 , G01N33/54366 , G01N33/554 , G01N33/56911 , G01N33/56983
摘要： A method of biochemical identification by: providing a plurality of capture species bound to one or more substrates and suspected of having one or more biological targets affinity bound to at least one capture species; detecting which capture species contain bound biological targets to generate a binding pattern; and identifying the biological target based on the binding pattern. The capture species are independently selected from the group consisting of antimicrobial peptides, cytotoxic peptides, antibiotics, and combinations thereof. A device having the capture species bound to the substrates. At least two of the capture species are capable of multi-specific binding to one or more biological targets and may have overlapping but not identical affinity properties.
摘要翻译：生物化学鉴定的方法是：提供与一种或多种底物结合的多种捕获物质，并怀疑具有与至少一种捕获物质结合的一种或多种生物靶标; 检测哪些捕获物种含有结合的生物靶标以产生结合模式; 以及基于所述结合模式识别所述生物学目标。捕获物种独立地选自抗微生物肽，细胞毒性肽，抗生素及其组合。具有捕获物质与基底结合的装置。至少两种捕获物质能够与一种或多种生物靶标进行多特异性结合，并且可以具有重叠但不相同的亲和性质。

58. 发明申请

US20140179806A1 BIOMARKERS FOR EARLY DETERMINATION OF A CRITICAL OR LIFE THREATENING RESPONSE TO ILLNESS AND/OR TREATMENT RESPONSE 审中-公开
标题翻译：生物标志物早期确定关键或生命对无效和/或治疗反应的反应
公开(公告)号：US20140179806A1
公开(公告)日：2014-06-26
申请号：US14019447
申请日：2013-09-05
申请人： Fio Corporation
发明人： Kevin Kain , W. Conrad Liles , Laura Erdman , Andrea Conroy
IPC分类号： G01N33/569
CPC分类号： G01N33/56983 , G01N33/53 , G01N33/569 , G01N33/56905 , G01N33/56916 , G01N33/56944 , G01N33/68 , G01N33/6893 , Y02A50/53 , Y02A50/56 , Y02A50/58
摘要： The invention relates to the use of novel biomarkers and biomarker combinations having utility in the early determination of an individual's critical and/or life threatening response to illness and/or in predicting outcome of said illness. The measurement of expression levels of the products of the biomarkers and combinations of biomarkers of the invention have utility in making the determination of an individual's critical and/or life threatening response to illness. In some embodiments, the biomarker and biomarker combinations are agnostic and are independent of the pre-identification and/or determination of the cause or nature of the illness. In some embodiments, the biomarkers and biomarker combinations can be utilized to select treatment and/or monitor the effectiveness of treatment interventions for an individual who has a critical illness.
摘要翻译：本发明涉及使用新的生物标志物和生物标志物组合，其可用于早期确定个体对疾病的危及生命和/或威胁生命的反应和/或预测所述疾病的结果。本发明的生物标志物的产物和生物标志物的组合的表达水平的测量可用于确定个体对疾病的关键和/或威胁生命的反应。在一些实施方案中，生物标志物和生物标志物组合是不可知的，并且独立于疾病的原因或性质的预先识别和/或确定。在一些实施方案中，生物标志物和生物标志物组合可用于选择治疗和/或监测具有严重疾病的个体的治疗干预的有效性。

59. 发明授权

US08518658B1 ATP-bioluminescence immunoassay 有权
标题翻译： ATP生物发光免疫测定
公开(公告)号：US08518658B1
公开(公告)日：2013-08-27
申请号：US12767946
申请日：2010-04-27
申请人： Daniel V. Lim , Dawn M. Hunter
发明人： Daniel V. Lim , Dawn M. Hunter
IPC分类号： C12Q1/66
CPC分类号： G01N33/56916 , C12Q1/04 , C12Q1/10 , C12Q1/14 , G01N33/56938 , G01N33/56944 , Y02A50/451
摘要： Disclosed is a method and associated device for the rapid identification of viable bacterial contaminants in food products. The method detects viable microbes by using a combined ATP-bioluminescence immunoassay. Escherichia coli O157:H7 and Salmonella enterica serovar Typhimurium were selected as target organisms in various matrices including ground beef homogenate, apple juice, milk, and phosphate-buffered saline. Specific antibodies were immobilized on the surface of well plates in which the sample matrices were incubated. The plates were washed, and the wells were incubated with BacTiter-Glo reagent in Mueller-Hinton II broth. Bioluminescent output was measured with a luminometer and signal-to-noise ratios were calculated. The LOD was not affected by the presence of non-target cells. A strong linear correlation was observed between the number of cells and luminescent output over 4 orders of magnitude. This method provides a means of simultaneously detecting and identifying viable pathogens in complex matrices.
摘要翻译：公开了用于快速鉴定食品中的活细菌污染物的方法和相关装置。该方法通过使用组合的ATP-生物发光免疫测定来检测活微生物。选择大肠杆菌O157：H7和沙门氏菌血清型鼠伤寒沙门氏菌作为各种基质的靶生物，包括研磨牛肉匀浆，苹果汁，牛奶和磷酸盐缓冲盐水。将特异性抗体固定在其中样品基质孵育的孔板的表面上。洗涤板，并将孔与Mueller-Hinton II肉汤中的BacTiter-Glo试剂一起温育。用发光计测量生物发光输出，并计算信噪比。 LOD不受非靶细胞的存在的影响。在4个数量级的细胞数和发光量之间观察到强烈的线性相关性。该方法提供了一种在复杂基质中同时检测和鉴定活的病原体的方法。

60. 发明授权

US08507249B2 Bacterial virulence factors and uses thereof 失效
标题翻译：细菌毒力因子及其用途
公开(公告)号：US08507249B2
公开(公告)日：2013-08-13
申请号：US13182334
申请日：2011-07-13
申请人： Brett Finlay , Samantha Gruenheid , Wanyin Deng , Bruce A. Vallance , Jose L. Puente
发明人： Brett Finlay , Samantha Gruenheid , Wanyin Deng , Bruce A. Vallance , Jose L. Puente
IPC分类号： C12N1/20 , C12N1/00 , A61K39/00 , A61K39/02 , C07K1/00 , C07H21/02
CPC分类号： C07K16/1228 , A61K35/00 , A61K38/00 , A61K39/025 , A61K39/0258 , A61K2039/522 , C07K14/24 , C07K14/245 , C07K16/1232 , C12Q1/689 , C12Q2600/158 , G01N33/56916 , G01N2500/10 , Y02A50/474
摘要： The invention relates to, in part, secreted proteins of bacterial pathogens and methods for their use. More specifically, the invention provides in part several new common secreted proteins for A/E pathogens. In some embodiments of the invention, these polypeptides and nucleic acid molecules encoding these polypeptides, or portions thereof, are useful as vaccines, diagnostics, or drug screening tools for A/E pathogenic infections, or as reagents.
摘要翻译：本发明部分地涉及细菌病原体的分泌蛋白质及其使用方法。更具体地，本发明部分地提供了用于A / E病原体的几种新的常见分泌蛋白质。在本发明的一些实施方案中，编码这些多肽或其部分的这些多肽和核酸分子可用作A / E致病性感染或作为试剂的疫苗，诊断或药物筛选工具。

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