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51. 发明申请

US20060223119A1 Methods for monitoring and guiding therapeutic suppression of parathyroid hormone in renal patients having secondary hyperparathyroidism 审中-公开
标题翻译：监测和指导甲状旁腺激素治疗继发性甲状旁腺功能亢进患者的方法
公开(公告)号：US20060223119A1
公开(公告)日：2006-10-05
申请号：US11377980
申请日：2006-03-17
申请人： Thomas Cantor
发明人： Thomas Cantor
IPC分类号： G01N33/53 , A61K31/59 , G01N33/566
CPC分类号： G01N33/78 , A61K31/59 , A61K33/06 , G01N2800/046 , G01N2800/10 , G01N2800/347
摘要： The present invention relates to kits for monitoring and guiding therapeutic suppression of parathyroid hormone in renal patients having secondary hyperparathyroidism. The kit provides means to measure the level of a PTH agonist and a PTH antagonist in a patient, and it further provides means for administering a PTH suppressing therapeutic to the patient so as to reduce the level of a PTH agonist and minimize the level of parathyroid hormone antagonist.
摘要翻译：本发明涉及用于监测和指导具有继发性甲状旁腺功能亢进的肾脏患者甲状旁腺激素治疗抑制的试剂盒。该试剂盒提供了测量患者中PTH激动剂和PTH拮抗剂水平的方法，并且还提供了向患者施用PTH抑制治疗剂以降低PTH激动剂水平并使甲状旁腺水平最小化的方法激素拮抗剂。

52. 发明授权

US06689566B1 Methods, kits, and antibodies for detecting parathyroid hormone 有权
标题翻译：用于检测甲状旁腺激素的方法，试剂盒和抗体
公开(公告)号：US06689566B1
公开(公告)日：2004-02-10
申请号：US09231422
申请日：1999-01-14
申请人： Thomas L. Cantor , Ping Gao
发明人： Thomas L. Cantor , Ping Gao
IPC分类号： G01N3353
CPC分类号： C07K16/26 , C07K2317/34 , G01N33/6893 , G01N33/74 , G01N33/78 , G01N2800/046 , G01N2800/10 , Y10S436/811
摘要： The present invention relates to novel methods and devices for detecting whole or non-fragmented parathyroid hormone (wPTH) in a biological sample. In particular, a novel monoclonal or polyclonal antibody or antibody fragment is used that is specific for a portion of the initial peptide sequence for wPTH which comprises a domain for adenylate cyclase activation, (amino acids 2 to 8), wherein at least four amino acids in this sequence are part of the reactive portion with the antibody. The present wPTH assay can differentiate between the complete 1 to 84 amino acid sequence form of PTH and a large but incomplete 7 to 84 amino acid sequence form of PTH that is measured by commercially available “intact” or I-PTH assays. Measurement of both the complete biologically active form of PTH and the large but biologically inactive form of PTH can lead to the misdiagnosis of the parathyroid function in patients.
摘要翻译：本发明涉及用于检测生物样品中全部或非片段甲状旁腺激素（wPTH）的新方法和装置。特别地，使用对包含腺苷酸环化酶活化的结构域（氨基酸2至8）的wPTH的一部分初始肽序列特异性的新型单克隆或多克隆抗体或抗体片段，其中至少四个氨基酸在该序列中是抗体的反应性部分的一部分。本发明的wPTH测定可以区分完整的1至84个氨基酸序列形式的PTH和大量但不完全的7至84个氨基酸序列形式的PTH，其通过市售的“完整”或I-PTH测定法测量。测量PTH的完全生物活性形式和PTH的大但生物活性不大的形式可导致患者甲状旁腺功能的误诊。

53. 发明授权

US5494806A DNA and vectors encoding the parathyroid hormone receptor, transformed cells, and recombinant production of PTHR proteins and peptides 失效
标题翻译：编码甲状旁腺激素受体，转化细胞的DNA和载体以及PTHR蛋白和肽的重组产生
公开(公告)号：US5494806A
公开(公告)日：1996-02-27
申请号：US864475
申请日：1992-04-06
申请人： Gino V. Segre , Henry M. Kronenberg , Abdul-Badi Abou-Samra , Harald Juppner , John T. Potts, Jr. , Ernestina Schipani
发明人： Gino V. Segre , Henry M. Kronenberg , Abdul-Badi Abou-Samra , Harald Juppner , John T. Potts, Jr. , Ernestina Schipani
IPC分类号： A01K67/027 , A61K38/00 , A61K39/00 , A61K39/395 , A61P3/00 , A61P3/02 , A61P3/14 , A61P5/12 , C07K5/00 , C07K7/06 , C07K7/08 , C07K14/435 , C07K14/635 , C07K14/705 , C07K14/72 , C07K16/00 , C07K16/28 , C12N1/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/113 , C12N15/12 , C12N15/85 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/68 , G01N33/78 , G01N33/84 , C12N15/63
CPC分类号： C12N15/1138 , C07K14/635 , C07K14/705 , C07K14/72 , C07K14/721 , C07K16/2869 , C12N15/8509 , G01N33/78 , G01N33/84 , A01K2217/05 , A01K2227/30 , A01K2267/02 , A61K38/00 , G01N2800/04 , G01N2800/046
摘要： DNA encoding a parathyroid hormone receptor; production and isolation of recombinant and synthetic parathyroid hormone receptor polypeptides and fragments; antibodies to parathyroid hormone receptors and receptor fragments; methods for screening candidate compounds for antagonistic or agonistic effects on parathyroid hormone receptor action; and diagnostic and therapeutic methods of these compounds are disclosed.
摘要翻译：编码甲状旁腺激素受体的DNA; 重组和合成甲状旁腺激素受体多肽和片段的生产和分离; 对甲状旁腺激素受体和受体片段的抗体; 用于筛选候选化合物对甲状旁腺激素受体作用的拮抗或激动作用的方法; 并公开了这些化合物的诊断和治疗方法。

54. 发明授权

US5261686A Semi-recumbent 失效
标题翻译：半卧
公开(公告)号：US5261686A
公开(公告)日：1993-11-16
申请号：US864465
申请日：1992-04-06
申请人： Clive E. Buckler
发明人： Clive E. Buckler
IPC分类号： B62K3/00 , B62K3/02 , G01N33/78
CPC分类号： G01N33/78 , B62K3/005 , B62K3/02 , G01N2800/046
摘要： A two wheel bicycle on which the rider sits elevated above and slightly forward of the rear wheel on a high-back seat. The seat is supported by the rearward end of a multiple angled main tube. The position of the pedal crank assembly is forward and upward of the pedal crank position of conventional bicycles and downward and rearward of that normally associated with fully recumbent bicycles relative to the seat. The rider steers by way of long upwardly curved handlebars affixed to an elongated multiple angled steering stem originating in a front steering head tube assembly and extending rearward in general parallel alignment with the multiple angled main tube. The steering stem extends upward and rearward terminating under the area of the rider's upper legs. The multiple angled main tube attaches at a forward portion thereof to the head tube and extends rearward therefrom in a generally horizontal plane for a distance prior to turning relatively sharply upward near the rear wheel, and continues extending upward and rearward at an approximately 45 degree angle. The main tube is fitted with an inner member telescopically slidable, and the slidable member being positioned above the rear wheel supports the seat in a adjustable manner. The elongated steering stem is positioned above the main tube and follows the approximate angled path as the main tube and thereby the bicycle is provided with a low step-over height for the rider to straddle and mount or dismount the bike.
摘要翻译：骑自行车的两轮自行车在高后座上升到后轮的上方并略微向前。座椅由多角度主管的后端支撑。踏板曲柄组件的位置是常规自行车的踏板曲柄位置向前和向上，并且通常与相对于座椅完全躺下的自行车相关联的向下和向后。骑车人通过长的向上弯曲的把手转向固定到源自前转向头管组件的细长多角度转向杆，并且与多个倾斜的主管大致平行对准地向后延伸。转向杆向上和向后延伸，终止于骑手大腿的区域下方。多角度的主管在其前部附接到头管并且在大体上水平的平面中向后延伸一段距离，然后在靠近后轮的相对急剧向上转动一段距离，并且以大约45度的角度继续向上和向后延伸。主管装配有可伸缩滑动的内部构件，并且位于后轮上方的可滑动构件以可调节的方式支撑座椅。细长的转向杆位于主管上方，并沿着主要管道的大致倾斜的路径，从而使自行车具有较低的步进高度，用于骑车者跨骑并安装或卸下自行车。

55. 发明申请

US20180196062A1 THYROGLOBULIN QUANTITATION BY MASS SPECTROSCOPY 审中-公开
公开(公告)号：US20180196062A1
公开(公告)日：2018-07-12
申请号：US15906078
申请日：2018-02-27
申请人： Quest Diagnostics Investments Incorporated
发明人： Yanni Zhang , Nigel J. Clarke , Richard E. Reitz
IPC分类号： G01N33/68 , C12Q1/37
CPC分类号： G01N33/6848 , C12Q1/37 , G01N33/6893 , G01N33/78 , G01N2333/47 , G01N2496/00 , G01N2560/00 , G01N2800/046 , G01N2800/7028
摘要： Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.

56. 发明授权

US09915663B2 Thyroglobulin quantitation by mass spectroscopy 有权
公开(公告)号：US09915663B2
公开(公告)日：2018-03-13
申请号：US15443805
申请日：2017-02-27
申请人： Quest Diagnostics Investments Incorporated
发明人： Yanni Zhang , Nigel J. Clarke , Richard E. Reitz
IPC分类号： A61K38/00 , G01N33/68 , C12Q1/37
CPC分类号： G01N33/6848 , C12Q1/37 , G01N33/6893 , G01N33/78 , G01N2333/47 , G01N2496/00 , G01N2560/00 , G01N2800/046 , G01N2800/7028
摘要： Provided are methods for determining the amount of thyroglobulin in a sample using various purification steps followed by mass spectrometry. The methods generally involve purifying thyroglobulin in a test sample, digesting thyroglobulin to form peptide T129, purifying peptide T129, ionizing peptide T129, detecting the amount of peptide T129 ion generated, and relating the amount of peptide T129 ion to the amount of thyroglobulin originally present in the sample.

57. 发明申请

US20170089929A1 Antibodies to TTR and Methods of Use 审中-公开
公开(公告)号：US20170089929A1
公开(公告)日：2017-03-30
申请号：US15373657
申请日：2016-12-09
申请人： University Health Network
发明人： Avijit Chakrabartty , Rishi Rakhit , Anita Antoinette Bugyei-Twum
IPC分类号： G01N33/78 , C07K14/47 , C07K16/18
CPC分类号： G01N33/78 , C07K14/47 , C07K14/575 , C07K16/18 , C07K16/26 , C07K2317/34 , C07K2317/76 , G01N33/74 , G01N2800/046 , G01N2800/28 , G01N2800/325 , G01N2800/7047
摘要： The disclosure pertains to antibodies and binding fragments thereof that specifically binds all or part of EHAEVVFTA. Also provided are isolated peptides, isolated nucleic acids, immunogens, compositions, immunoassays and kits and method of using said reagents to detect misfolded TTR.

58. 发明授权

US09534048B2 Antibodies to TTR and methods of use 有权
标题翻译： TTR抗体和使用方法
公开(公告)号：US09534048B2
公开(公告)日：2017-01-03
申请号：US13974761
申请日：2013-08-23
申请人： University Health Network
发明人： Avijit Chakrabartty , Rishi Rakhit , Anita Antoinette Bugyei-Twum
IPC分类号： G01N33/68 , C07K16/26 , G01N33/74 , C07K14/575 , C07K16/18 , G01N33/78 , C07K14/47
CPC分类号： G01N33/78 , C07K14/47 , C07K14/575 , C07K16/18 , C07K16/26 , C07K2317/34 , C07K2317/76 , G01N33/74 , G01N2800/046 , G01N2800/28 , G01N2800/325 , G01N2800/7047
摘要： The disclosure pertains to antibodies and binding fragments thereof that specifically binds all or part of EHAEVVFTA. Also provided are isolated peptides, isolated nucleic acids, immunogens, compositions, immunoassays and kits and method of using said reagents to detect misfolded TTR.
摘要翻译：本公开涉及特异性结合全部或部分EHAEVVFTA的抗体及其结合片段。还提供了分离的肽，分离的核酸，免疫原，组合物，免疫测定和试剂盒以及使用所述试剂检测错误折叠的TTR的方法。

59. 发明授权

US09285362B2 Measuring multiple analytes over a broad range of concentrations using optical diffraction 有权
$Measuring multiple analytes over a broad range of concentrations using optical diffraction$
标题翻译：使用光学衍射在宽范围的浓度范围内测量多种分析物
公开(公告)号：US09285362B2
公开(公告)日：2016-03-15
申请号：US12445760
申请日：2007-10-18
申请人： Jean-Francois Houle , Sriram Kumaraswamy
发明人： Jean-Francois Houle , Sriram Kumaraswamy
IPC分类号： G01N33/543 , G01N21/03 , G01N21/47 , G01N33/68 , G01N33/72 , G01N33/74 , G01N33/78 , G01N33/92
CPC分类号： G01N33/54373 , G01N21/0303 , G01N21/4788 , G01N33/6896 , G01N33/723 , G01N33/74 , G01N33/78 , G01N33/92 , G01N2800/04 , G01N2800/042 , G01N2800/046 , G01N2800/32
摘要： Methods, devices, and kits for measuring multiple analytes in a sample having a broad range of concentrations using optical diffraction are disclosed. Devices, methods, and kits useful for monitoring and diagnosing diabetes, cardiovascular disease, thyroid disease, hormone-related conditions, and sepsis are also described.
摘要翻译：公开了使用光学衍射测量具有宽范围浓度的样品中的多种分析物的方法，装置和试剂盒。还描述了可用于监测和诊断糖尿病，心血管疾病，甲状腺疾病，激素相关病症和败血症的装置，方法和试剂盒。

60. 发明申请

US20150346223A1 FT4 ELECTROCHEMICAL ASSAY DETECTION SYSTEM 审中-公开
标题翻译： FT4电化学测定系统
公开(公告)号：US20150346223A1
公开(公告)日：2015-12-03
申请号：US14759759
申请日：2014-01-09
申请人： VANTIX HOLDINGS LIMITED
发明人： Andy Gover
IPC分类号： G01N33/78
CPC分类号： G01N27/3276 , G01N33/78 , G01N2333/575 , G01N2800/046
摘要： Some embodiments provide a method for performing a free thyroxin assay. The method may include providing a flow cell that may include a plurality of sensors at least partially coated with a plurality of antibodies that bind to free thyroxin. The method may further provide introducing a sample into the flow cell so that the sample contacts the sensors, and incubating the sample therein for a time. As a result, at least a portion of any free thyroxin within the sample can bind at least some of the antibodies. In addition the method may include introducing a wash agent into the flow cell to clear the flow cell of any substantial amount of the sample.
摘要翻译：一些实施方案提供了进行游离甲状腺素测定的方法。该方法可以包括提供可以包括至少部分地涂覆有结合游离甲状腺素的多种抗体的多个传感器的流动池。该方法还可以提供将样品引入流动池中，使得样品接触传感器，并将样品在其中孵育一段时间。结果，样品中任何游离甲状腺素的至少一部分可以结合至少一些抗体。此外，该方法可以包括将洗涤剂引入流动池以清除任何相当数量的样品的流动池。

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