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51. 发明授权

US09574222B2 Self-immolative probes for enzyme activity detection 有权
标题翻译：用于酶活性检测的自发性探针
公开(公告)号：US09574222B2
公开(公告)日：2017-02-21
申请号：US14447817
申请日：2014-07-31
申请人： Enzo Life Sciences, Inc.
发明人： Maciej Szczepanik , Irina V. Lebedeva , Yuejun Xiang , Praveen Pande , Wayne Forrest Patton
IPC分类号： C12Q1/26 , C12Q1/48 , C09K11/06 , C12Q1/37 , C12Q1/44
CPC分类号： C12Q1/26 , C07D311/08 , C07D491/052 , C07D491/20 , C07D493/10 , C09K11/06 , C09K2211/1022 , C09K2211/1088 , C12Q1/37 , C12Q1/44 , C12Q1/485 , G01N2333/902 , G01N2500/00 , Y10T436/18
摘要： Provided is a compound comprising the structure: (SIG)-(SI-MOD)m. In this compound, SIG is a signaling molecule, SI is a self-immolative structure bound to SIG such that SIG has a reduced signal relative to the signal of SIG without SI, MOD is a moiety bound to SI that is subject to modification by an activator, and m is an integer from 1 to about 10. With this compound, when MOD is modified by an activator, SI is destabilized and self-cleaved from SIG such that SIG generates an increased signal. Also provided is a method of determining whether a sample comprises an activator, using the above-described compound. Additionally provided is a method of determining whether a cell comprises a nitroreductase using the above-described compound where nitroreductase is the activator. Further provided is a method of determining whether a mammalian cell is hypoxic using the above-described compound where nitroreductase is the activator. A method of detecting a microorganism that comprises a nitroreductase, using the above-described compound where nitroreductase is the activator, is also provided. Also provided is a method of identifying nitroreductase in a sample, using the above-described compound where nitroreductase is the activator.
摘要翻译：在该化合物中，SIG是信号分子，SI是与SIG结合的自消除结构，使得SIG相对于没有SI的SIG的信号具有降低的信号，MOD是与SI结合的部分，其经受活化剂，m为1至约10的整数。用该化合物，当MOD被活化剂修饰时，SI是不稳定的并且从SIG自我切割，使得SIG产生增加的信号。还提供了使用上述化合物来确定样品是否包含活化剂的方法。另外提供了使用上述硝基还原酶是活化剂的化合物来确定细胞是否包含硝基还原酶的方法。还提供了使用上述硝基还原酶是活化剂的化合物来确定哺乳动物细胞是否缺氧的方法。还提供了使用上述硝基还原酶为活化剂的化合物检测包含硝基还原酶的微生物的方法。还提供了使用上述硝酸还原酶是活化剂的化合物来鉴定样品中的硝基还原酶的方法。

52. 发明申请

US20170044590A1 METHODS FOR DETECTION AND TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：检测和治疗神经损伤性疾病的方法
公开(公告)号：US20170044590A1
公开(公告)日：2017-02-16
申请号：US15022928
申请日：2014-09-18
申请人： Kasturi HALDAR , Suhail ALAM
发明人： Kasturi HALDAR , Suhail ALAM
IPC分类号： C12Q1/37 , C12Q1/68 , C12Q1/34
CPC分类号： C12Q1/37 , C12Q1/34 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/6896 , G01N2333/936 , G01N2333/96466 , G01N2500/00 , G01N2800/28 , G01N2800/52
摘要： Provided herein are methods for detecting an increased probability or risk of neurodegeneration in a subject. In some embodiments the method comprises assaying a sample from the subject for lysozyme and/or cathepsin S and detecting the lysozyme and/or cathepsin S from the sample, wherein an increased lysozyme and/or cathepsin S compared to levels in a control subject sample indicate an increased probability or risk of neurodegeneration. Methods of treatment and screening assays for determining drug effectiveness are also provided herein.
摘要翻译：本文提供了用于检测受试者中增加的神经变性概率或风险的方法。在一些实施方案中，该方法包括测定来自受试者的样品用于溶菌酶和/或组织蛋白酶S，并从样品中检测溶菌酶和/或组织蛋白酶S，其中与对照受试者样品中的水平相比增加的溶菌酶和/或组织蛋白酶S 增加神经变性的概率或风险。本文还提供了用于确定药物有效性的治疗和筛选测定方法。

53. 发明授权

US09568484B2 MECP2E1 gene 有权
标题翻译： MECP2E1基因
公开(公告)号：US09568484B2
公开(公告)日：2017-02-14
申请号：US12313251
申请日：2008-11-18
申请人： Berge A. Minassian , John B. Vincent
发明人： Berge A. Minassian , John B. Vincent
IPC分类号： C12Q1/68 , G01N33/68 , C07K14/47 , A61K38/00 , A61K48/00
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , C07K14/47 , C12Q2600/156 , C12Q2600/158 , G01N33/6896 , G01N2500/00 , G01N2800/28
摘要： The invention is a novel MECP2E1 splice variant and its corresponding polypeptide. The invention also includes methods of using these nucleic acid sequences and proteins in medical diagnosis and treatment of neuropsychiatric disorders or development disorders.
摘要翻译：本发明是一种新型的MECP2E1剪接变体及其相应的多肽。本发明还包括在神经精神障碍或发育障碍的医学诊断和治疗中使用这些核酸序列和蛋白质的方法。

54. 发明授权

US09562072B2 Compositions and methods for regulating glucose metabolism 有权
标题翻译：用于调节葡萄糖代谢的组合物和方法
公开(公告)号：US09562072B2
公开(公告)日：2017-02-07
申请号：US14364466
申请日：2012-12-20
申请人： The J. David Gladstone Institutes
发明人： Katerina Akassoglou
IPC分类号： C07K7/08 , C07K14/715 , A61K38/10 , A61K38/46 , C12Q1/54 , G01N33/60 , G01N33/66
CPC分类号： G01N33/6872 , A61K38/10 , A61K38/46 , C07K7/08 , C07K14/7151 , C12Q1/54 , C12Y306/05002 , G01N33/5041 , G01N33/60 , G01N33/66 , G01N2333/71 , G01N2333/91171 , G01N2500/00 , G01N2500/02 , G01N2800/042 , A61K2300/00
摘要： The present disclosure provides compositions for regulating glucose metabolism. The compositions provide for reduced levels of p75NTR and/or reduced binding of p75NTR to a GTPase such as Rab31 or Rab5. The compositions are useful in methods of regulating glucose metabolism, which methods are also provided.
摘要翻译：本公开提供了用于调节葡萄糖代谢的组合物。组合物提供p75NTR的降低水平和/或减少p75NTR与GTP酶如Rab31或Rab5的结合。该组合物可用于调节葡萄糖代谢的方法，也提供了这些方法。

55. 发明授权

US09556470B2 Enzyme quantification 有权
标题翻译：酶定量
公开(公告)号：US09556470B2
公开(公告)日：2017-01-31
申请号：US14122766
申请日：2012-06-01
申请人： Darren Link , Michael L. Samuels
发明人： Darren Link , Michael L. Samuels
IPC分类号： C12Q1/25 , B01F5/06 , B01J19/00 , B01F13/00 , B01L3/00 , B01F3/08 , C40B40/04 , C40B50/08 , C40B60/10 , G01N33/50 , B01L7/00 , G01N21/64
CPC分类号： G01N33/573 , B01F3/0807 , B01F5/0646 , B01F5/0653 , B01F13/0062 , B01J19/0046 , B01J2219/00286 , B01J2219/00351 , B01J2219/00418 , B01J2219/00479 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00599 , B01J2219/0065 , B01J2219/00657 , B01J2219/00664 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/0074 , B01J2219/00743 , B01L3/502761 , B01L7/52 , B01L2200/027 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0681 , B01L2300/0864 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , C12Q1/25 , C12Q1/6804 , C12Q1/6818 , C12Q1/6827 , C40B40/04 , C40B50/08 , C40B60/10 , G01N21/6428 , G01N21/6445 , G01N33/5008 , G01N33/542 , G01N33/582 , G01N2500/00
摘要： The invention generally relates to methods for quantifying an amount of enzyme molecules. Systems and methods of the invention are provided for measuring an amount of target by forming a plurality of fluid partitions, a subset of which include the target, performing an enzyme-catalyzed reaction in the subset, and detecting the number of partitions in the subset. The amount of target can be determined based on the detected number.
摘要翻译：本发明一般涉及量化酶分子量的方法。提供了本发明的系统和方法，用于通过形成多个流体分隔物来测量目标物质的量，所述流体分隔物的一部分包括靶，在该子集中进行酶催化的反应，以及检测该子集中的分区数。可以基于检测到的数量来确定目标量。

56. 发明授权

US09555032B2 Methods for treatment and prevention of tauopathies and amyloid beta amyloidosis by modulating CRF receptor signaling 有权
标题翻译：通过调节CRF受体信号传导治疗和预防tau蛋白病和淀粉样蛋白β淀粉样变性的方法
公开(公告)号：US09555032B2
公开(公告)日：2017-01-31
申请号：US12663805
申请日：2008-06-13
申请人： Robert A. Rissman , Kuo-Fen Lee , Wylie W. Vale , Paul E. Sawchenko
发明人： Robert A. Rissman , Kuo-Fen Lee , Wylie W. Vale , Paul E. Sawchenko
IPC分类号： A61K31/519 , A61K45/06 , A61K38/22 , G01N33/68
CPC分类号： A61K31/519 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0318 , A61K9/0019 , A61K38/2228 , A61K45/06 , G01N33/6896 , G01N2440/14 , G01N2500/00 , G01N2800/2814 , G01N2800/2821 , A61K2300/00
摘要： Methods for treating or preventing tauopathies and/or Aβ amyloidosis by modulating CRF receptor signaling. Accumulation of hyperphosphorlyated tau protein in the CNS may be reduced by administration of CRF-R1 selective antagonists and/or CRF-R2 selective agonists. For example, in some aspects, methods for preventing the onset of Alzheimer's disease by administration of CRF-R1 selective antagonist are provided.
摘要翻译：通过调节CRF受体信号传导治疗或预防tau蛋白病和/或Aβ淀粉样变性的方法。通过施用CRF-R1选择性拮抗剂和/或CRF-R2选择性激动剂可以减少CNS中超磷酸化tau蛋白的积累。例如，在一些方面，提供了通过施用CRF-R1选择性拮抗剂来预防阿尔茨海默病发作的方法。

57. 发明授权

US09541546B2 Method of promoting excitatory synapse formation with an anti-Ephexin5 phospho-Y361 antibody 有权
标题翻译：用抗Ephexin5磷酸-Y361抗体促进兴奋性突触形成的方法
公开(公告)号：US09541546B2
公开(公告)日：2017-01-10
申请号：US14615083
申请日：2015-02-05
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： John Salogiannis , Michael E. Greenberg , Seth S. Margolis
IPC分类号： G01N33/53 , A61K39/395 , A61K49/00 , G01N33/50
CPC分类号： G01N33/5058 , G01N2500/00
摘要： The invention provides methods of screening a compound that can increase spine/excitatory synapse formation and/or numbers. The compound is identified by contacting Ephexin5 with a test compound and selecting the compounds that inhibit Rho GEF activity of Ephexin5. Additionally, the invention also provides methods for increasing spine/excitatory synapse formation and/or numbers by contacting a neuron with an Ephexin5 inhibitor.
摘要翻译：本发明提供筛选能增加脊柱/兴奋性突触形成和/或数量的化合物的方法。通过将Ephexin5与测试化合物接触并选择抑制Ephexin5的Rho GEF活性的化合物来鉴定化合物。此外，本发明还提供了通过使神经元与Ephexin5抑制剂接触来增加脊柱/兴奋性突触形成和/或数量的方法。

58. 发明申请

US20160339078A1 Nutritive Polypeptides and Formulations Thereof, and Methods of Production and Use Thereof 审中-公开
标题翻译：营养多肽及其制剂及其生产和使用方法
公开(公告)号：US20160339078A1
公开(公告)日：2016-11-24
申请号：US15081004
申请日：2016-03-25
申请人： Pronutria Biosciences, Inc.
发明人： Michael Hamill , Brett Boghigian , Caitlyn Harvey , David Berry , David Young , Geoffrey Von Maltzahn , John Kramarczyk , Jameson Rogers , Kathryn Heard , Michael Doherty , Nathaniel Silver , Phillip Samayoa , Subhayu Basu , Shaila Rahman , Vimal Vaidya , Ying-Ja Chen
IPC分类号： A61K38/16 , A61K38/10 , A23L33/195 , A61K38/45 , G01N33/68 , A61K9/00 , A61K38/17
CPC分类号： A61K38/1709 , A23L2/66 , A23L33/17 , A23L33/175 , A23L33/18 , A23L33/195 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K9/0053 , A61K9/0075 , A61K9/0095 , A61K9/146 , A61K9/2054 , A61K9/2866 , A61K38/00 , A61K38/10 , A61K38/16 , A61K38/164 , A61K38/168 , A61K38/17 , A61K38/1703 , A61K38/1767 , A61K38/38 , A61K38/45 , A61K45/06 , C12Y207/04003 , G01N33/6803 , G01N33/6806 , G01N33/6848 , G01N2500/00 , G16B20/00
摘要： Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
摘要翻译：本文提供营养多肽。还提供了各种其它实施方案，包括编码多肽的核酸，制备多肽的重组微生物，用于表达多肽的载体，使用重组微生物制备多肽的方法，包含多肽的组合物和制剂，以及使用多肽的方法，组合物和制剂。

59. 发明申请

US20160331784A1 COMPOSITIONS, METHODS, AND DEVICES FOR TREATING DISEASE 审中-公开
标题翻译：用于治疗疾病的组合物，方法和装置
公开(公告)号：US20160331784A1
公开(公告)日：2016-11-17
申请号：US14967028
申请日：2015-12-11
申请人： The General Hospital Corporation d/b/a Massachusetts General Hospital , Massachusetts Institute of Technology
发明人： Martin Leon Yarmush , Biju Parekkadan
IPC分类号： A61K35/28 , A61M1/34 , G01N33/50 , C12M1/00 , C12N5/0775
CPC分类号： A61K35/28 , A61M1/3472 , A61M1/3489 , A61M1/3687 , A61M1/3689 , C12M29/16 , C12N5/0663 , C12N5/067 , C12N2502/1358 , G01N33/5067 , G01N33/5073 , G01N2500/00 , G01N2800/085
摘要： Described are compositions and methods for treating liver disease, e.g., acute liver disease, using bone marrow-derived stem cells and bone marrow-derived stem cell conditioned media.
摘要翻译：描述了使用骨髓来源的干细胞和来自骨髓的干细胞条件培养基治疗肝脏疾病，例如急性肝病的组合物和方法。

60. 发明申请

US20160317614A1 Compositions and Formulations for Treatment of Gastrointestinal Tract Malabsorption Diseases and Inflammatory Conditions and Methods of Production and Use Thereof 有权
标题翻译：用于治疗胃肠道吸收障碍和炎症病症的组合物和制剂及其生产和使用方法
公开(公告)号：US20160317614A1
公开(公告)日：2016-11-03
申请号：US15024636
申请日：2014-09-25
申请人： PRONUTRIA, INC.
发明人： Alison Williams , Michael J. Hamill , Nathaniel W. Silver , Ying-Ja Chen , David Arthur Berry , David V. Erbe , Chung-Wei Lee , Luke Hamm
IPC分类号： A61K38/17 , A23L33/18 , A23L33/00 , A61K45/06
CPC分类号： A61K38/1709 , A23L2/66 , A23L33/17 , A23L33/175 , A23L33/18 , A23L33/195 , A23L33/30 , A23L33/40 , A23V2002/00 , A61K9/0053 , A61K9/0075 , A61K9/0095 , A61K9/146 , A61K9/2054 , A61K9/2866 , A61K38/00 , A61K38/10 , A61K38/16 , A61K38/164 , A61K38/168 , A61K38/17 , A61K38/1703 , A61K38/1767 , A61K38/38 , A61K38/45 , A61K45/06 , C12Y207/04003 , G01N33/6803 , G01N33/6806 , G01N33/6848 , G01N2500/00 , G06F19/18
摘要： Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.
摘要翻译：本文提供营养多肽。还提供了各种其它实施方案，包括编码多肽的核酸，制备多肽的重组微生物，用于表达多肽的载体，使用重组微生物制备多肽的方法，包含多肽的组合物和制剂，以及使用多肽的方法，组合物和制剂。

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