专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明授权

US07319092B2 Methods of suppressing microglial activation 失效
标题翻译：抑制小胶质细胞活化的方法
公开(公告)号：US07319092B2
公开(公告)日：2008-01-15
申请号：US11091336
申请日：2005-03-29
申请人： Daniel T. Laskowitz , William D. Matthew , Michael McMillian
发明人： Daniel T. Laskowitz , William D. Matthew , Michael McMillian
IPC分类号： A61K38/00
CPC分类号： A61K38/1709 , A61K38/16 , A61K38/1841 , A61K38/191 , A61K38/193 , A61K38/204 , A61K38/2066 , A61K38/215 , C07K14/775 , C12N2517/02 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N33/5044 , G01N33/5047 , G01N33/5055 , G01N33/5058 , G01N33/92 , G01N2333/775 , G01N2500/00 , A61K2300/00
摘要： Methods of suppressing the activation of microglial cells in the Central Nervous System (CNS), methods of ameliorating or treating the neurological effects of cerebral ischemia or cerebral inflammation, and methods of combating specific diseases that affect the CNS by administering a compound that binds to microglial receptors and prevents or reduces microglial activation are described. Also described are methods of screening compounds for the ability to suppress or reduce microglial activation.
摘要翻译：抑制中枢神经系统（CNS）中小胶质细胞活化的方法，改善或治疗脑缺血或脑炎症的神经作用的方法，以及通过施用与小胶质细胞结合的化合物来对抗CNS的特定疾病的方法描述了受体并预防或减少小胶质细胞的活化。还描述了筛选化合物抑制或减少小胶质细胞活化能力的方法。

52. 发明申请

US20070166758A1 Diagnostic method for stroke 有权
标题翻译：中风诊断方法
公开(公告)号：US20070166758A1
公开(公告)日：2007-07-19
申请号：US10568093
申请日：2004-08-16
申请人： Pierre Lescuyer , Denis Hochstrasser , Jean-Charles Sanchez , Laure Allard , Elisabeth Guillaume
发明人： Pierre Lescuyer , Denis Hochstrasser , Jean-Charles Sanchez , Laure Allard , Elisabeth Guillaume
IPC分类号： G01N33/53 , C12M3/00
CPC分类号： G01N33/6893 , G01N2333/4709 , G01N2333/775 , G01N2333/8128 , G01N2800/2871
摘要： Stroke is diagnosed in a subject by determining the concentration of at least one polypeptide selected from Apo C-III, Serum Amyloid A, Apo C-I, Antithrombin III fragment and Apo A-I in a sample of body fluid taken from the subject.
摘要翻译：通过从取自受试者的体液样品中测定至少一种选自Apo C-III，血清淀粉样蛋白A，Apo C-I，抗凝血酶III片段和Apo A-I的多肽的浓度，在受试者中诊断中风。

53. 发明授权

US06808889B2 Method and device for detection of Apo A, Apo B and the ratio thereof in saliva 失效
标题翻译：用于检测Apo A，Apo B及其在唾液中的比例的方法和装置
公开(公告)号：US06808889B2
公开(公告)日：2004-10-26
申请号：US09526582
申请日：2000-03-16
申请人： Judith Fitzpatrick , Regina B. Lenda , Christopher L. Jones
发明人： Judith Fitzpatrick , Regina B. Lenda , Christopher L. Jones
IPC分类号： G01N3353
CPC分类号： G01N33/92 , G01N2333/775 , G01N2800/044 , Y10S435/81 , Y10S436/808 , Y10T436/25
摘要： A method has been developed to detect the levels of apolipoproteins A-1 and B in saliva, which is correlated with the levels of HDL and LDL in serum, respectively. In unstimulated saliva, the ration of Apo A to Apo B is correlated with the ration of HDL to LDL in serum. Albumin can be used to normalize the sample for dilution. The high degree of correlation in combination with a simple, quick test that can be performed at the site of collection provides a cost effective, patient friendly means to monitor an individual's risk of heart disease. In the preferred embodiment, saliva production is stimulated by means such as breath mint or tart solution (such as lemon) and the effect of dilution controlled by reference to albumin.
摘要翻译：已经开发了一种检测唾液中载脂蛋白A-1和B水平的方法，分别与血清中的HDL和LDL水平相关。在未刺激的唾液中，Apo A对Apo B的配对与血清中HDL与LDL的比例相关。白蛋白可用于标准化样品进行稀释。结合高度相关性，可以在收集现场进行的简单，快速的检测提供了一种成本效益高，耐心的手段来监测个体的心脏病风险。在优选的实施方案中，通过诸如呼吸薄荷或挞溶液（例如柠檬）的手段刺激唾液产生，并通过参照白蛋白控制稀释效果。

54. 发明申请

US20040198656A1 Methods of screening molecules that are used to prevent cardiovascular diseases 审中-公开
标题翻译：筛选用于预防心血管疾病的分子的方法
公开(公告)号：US20040198656A1
公开(公告)日：2004-10-07
申请号：US10487334
申请日：2004-02-20
发明人： Jamila Najib , Zouher Majd
IPC分类号： C12Q001/68 , G01N033/53
CPC分类号： C07K14/47 , G01N33/92 , G01N2333/775 , G01N2500/00
摘要： The invention relates to compositions and methods for screening molecules that are used for the prevention or treatment of metabolic syndrome, cardiovascular diseases and/or atherosclerosis. In particular, the invention relates to methods and kits for screening compounds based on determining the effect of test compounds on the activity of a novel protein which is similar to apolipoprotein AIV. The invention also relates to compositions and methods for reducing the concentration of triglycerides and/or reducing the concentration or the expression of apolipoprotein CIII (apo CIII) and/or reducing the concentration of VLDL and/or increasing the activity of LpL and/or of HL and/or for increasing reverse cholesterol transport.
摘要翻译：本发明涉及用于筛选用于预防或治疗代谢综合征，心血管疾病和/或动脉粥样硬化的分子的组合物和方法。特别地，本发明涉及用于基于确定测试化合物对类似于载脂蛋白AIV的新型蛋白质的活性的影响来筛选化合物的方法和试剂盒。本发明还涉及用于降低甘油三酯浓度和/或降低载脂蛋白CIII（载脂蛋白CIII）的浓度或表达和/或降低VLDL浓度和/或增加LpL和/或 HL和/或用于增加反向胆固醇转运。

55. 发明申请

US20030181407A1 Steatosis-modulating factors and uses thereof 审中-公开
标题翻译：脂肪变性调节因子及其用途
公开(公告)号：US20030181407A1
公开(公告)日：2003-09-25
申请号：US10257826
申请日：2003-04-14
发明人： Marie-France Palin , Candido Pomar , Claude Gariepy
IPC分类号： A61K048/00 , C12Q001/68
CPC分类号： G01N33/6887 , A61K38/00 , C12Q1/6883 , C12Q2600/158 , G01N33/82 , G01N2333/475 , G01N2333/71 , G01N2333/715 , G01N2333/72 , G01N2333/775 , G01N2333/90283 , G01N2333/91215
摘要： The present invention relates to a method of modulating the muscular steatosis-modulating factors (MSMF). The determination of concentrations of the MSMF is described for the establishment of the steatotic state in individuals. Also, is disclosed a method of selecting individuals to serve as founders of animal lineages. The present method involved too the treatment of human and animals with agonists or antagonists of MSMF depending of the effects desired.
摘要翻译：本发明涉及调节肌肉脂肪变性调节因子（MSMF）的方法。描述了确定个体中脂肪状态的MSMF的浓度。此外，还公开了选择作为动物谱系的创始者的个体的方法。本方法还涉及根据所需效果的人和动物用MSMF的激动剂或拮抗剂的治疗。

56. 发明申请

US20030017523A1 Method of measuring lipid components and method of examining of renal failure 审中-公开
标题翻译：脂质成分测定方法及肾功能衰竭检查方法
公开(公告)号：US20030017523A1
公开(公告)日：2003-01-23
申请号：US10203255
申请日：2002-08-07
发明人： Osamu Hotta , Yasushi Shirahase , Hisahide Hiura
IPC分类号： C12Q001/26
CPC分类号： C12Q1/44 , C12Q1/25 , C12Q1/26 , C12Q1/32 , C12Q1/485 , C12Q1/60 , C12Q1/61 , G01N33/6896 , G01N33/92 , G01N2333/775
摘要： The problems of the present invention are to provide a simple and convenient means for the examination of renal failure and to provide a method for the measurement of a lipid component in urine utilizing the said examining means. Means for solving the problems according to the present invention is a method for the measurement of a lipid component contained in urine and it provides a method for measurement of a lipid component in urine which is characterized in using a surface-active agent in a sufficient amount for solubilizing the insoluble fat in urine and in using an enzyme acting the lipid component. It also provides a simple and convenient means for the examination of renal failure by the measurement of a lipid component contained in urine, by the measurement of lipoproteins in urine and/or apoproteins in urine in addition to the above measurement and by a combination of measurement of surface antigen of leukocyte contained in urine therewith.
摘要翻译：本发明的问题是提供一种用于检查肾功能衰竭的简单方便的手段，并且提供一种利用所述检查装置测量尿中的脂质成分的方法。解决本发明问题的方法是尿中含有的脂质成分的测定方法，提供尿中脂质成分的测定方法，其特征在于使用足量的表面活性剂用于将不溶性脂肪溶解在尿液中和使用作用于脂质组分的酶。还提供了通过测量尿中包含的脂质成分的方法，通过除了上述测量之外的尿中和/或尿蛋白中的脂蛋白的测量以及测量的组合来提供用于检查肾功能衰竭的简单和方便的手段的尿液中含有的白细胞的表面抗原。

57. 发明申请

US20020164789A1 Methods of suppressing microglial activation 有权
标题翻译：抑制小胶质细胞活化的方法
公开(公告)号：US20020164789A1
公开(公告)日：2002-11-07
申请号：US09957909
申请日：2001-09-21
发明人： Daniel T. Laskowitz , William D. Matthew , Michael McMillian
IPC分类号： A61K038/17 , C12Q001/70 , A61K038/00 , A61K031/70 , A01N043/04 , C12N005/06 , C12N005/16
CPC分类号： A61K38/1709 , A61K38/16 , A61K38/1841 , A61K38/191 , A61K38/193 , A61K38/204 , A61K38/2066 , A61K38/215 , C07K14/775 , C12N2517/02 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N33/5044 , G01N33/5047 , G01N33/5055 , G01N33/5058 , G01N33/92 , G01N2333/775 , G01N2500/00 , A61K2300/00
摘要： Methods of suppressing the activation of microglial cells in the Central Nervous System (CNS), methods of ameliorating or treating the neurological effects of cerebral ischemia or cerebral inflammation, and methods of combating specific diseases that affect the CNS by administering a compound that binds to microglial receptors and prevents or reduces microglial activation are described. Also described are methods of screening compounds for the ability to suppress or reduce microglial activation.
摘要翻译：抑制中枢神经系统（CNS）中小胶质细胞活化的方法，改善或治疗脑缺血或脑炎症的神经作用的方法，以及通过施用与小胶质细胞结合的化合物来对抗CNS的特定疾病的方法描述了受体并预防或减少小胶质细胞的活化。还描述了筛选化合物抑制或减少小胶质细胞活化能力的方法。

58. 发明公开

US20240331862A1 SCREENING METHOD AND INDENDITIES OF BIOMARKERS FOR DIFFERENTIAL DIAGNOSIS OF PARKINSONISM AND/OR COGNITIVE IMPAIRMENT 审中-公开
公开(公告)号：US20240331862A1
公开(公告)日：2024-10-03
申请号：US18622407
申请日：2024-03-29
申请人： National Taiwan University , National Taiwan University Hospital , Academia Sinica , National Tsing Hua University
发明人： Shau-Ping LIN , Ruey-Meei WU , Frederick Kin Hing Phoa , Ming-Che KUO , Yi-Tzang TSAI , Jing-Wen HUANG , Yan-Han LIN , Hsiang-Hsuan LIN WANG , Chia-Lang HSU , Ya-Fang HSU , Pin-Jui KUNG
IPC分类号： G16H50/20 , C12Q1/6806 , C12Q1/6883 , G01N33/68 , G16H10/60
CPC分类号： G16H50/20 , C12Q1/6806 , C12Q1/6883 , G01N33/6896 , G16H10/60 , C12Q2600/112 , C12Q2600/158 , G01N2333/4706 , G01N2333/521 , G01N2333/575 , G01N2333/7051 , G01N2333/70596 , G01N2333/726 , G01N2333/775 , G01N2333/82 , G01N2333/90203 , G01N2333/91057 , G01N2333/91091 , G01N2333/91215 , G01N2333/96419 , G01N2333/99 , G01N2800/2821 , G01N2800/2835
摘要： The present invention provides a data analytic scheme for screening biomarkers for differential diagnosis of the status of Parkinson's disease, Parkinson's disease with mild cognitive impairment, Parkinson's disease dementia, Alzheimer's disease, and/or multiple system atrophy, the methodology implementing the same and the results of the screening thereof. Biomedical Oriented Logistic Dantzig Selector (BOLD Selector) was developed to identify candidate microRNAs and extracellular vesicle proteins effective at discerning between any two of the above mentioned disease categories from profiling results. The prediction models are finalized by establishing logistic regression formula for each pair of patient group differentiation.

59. 发明授权

US11987645B2 Peptide for treating rheumatoid arthritis and use thereof 有权
公开(公告)号：US11987645B2
公开(公告)日：2024-05-21
申请号：US17257492
申请日：2019-07-02
申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
发明人： Yeong Wook Song , Joo Youn Lee , Eugene C. Yi , Min Jueng Kang
IPC分类号： C07K7/08 , A23L33/00 , A23L33/18 , A61K38/00 , A61P19/02 , G01N33/92
CPC分类号： C07K7/08 , A23L33/18 , A23L33/40 , A61P19/02 , G01N33/92 , A23V2002/00 , A61K38/00 , G01N2333/775 , G01N2333/988
摘要： A peptide for treating rheumatoid arthritis and use thereof are provided, and a peptide consisting of an amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 3, or SEQ ID NO: 5 or a polynucleotide encoding the same, and a pharmaceutical composition for treating rheumatoid arthritis or a health functional food composition for improving rheumatoid arthritis, each including the peptide, are provided.

60. 发明公开

US20240125801A1 MARKER FOR DIAGNOSIS OF NONALCOHOLIC FATTY LIVER DISEASE 审中-公开
公开(公告)号：US20240125801A1
公开(公告)日：2024-04-18
申请号：US18276218
申请日：2022-05-13
申请人： BREXOGEN INC.
发明人： Sue KIM , Ji Min KIM
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2333/775 , G01N2800/085 , G01N2800/50 , G01N2800/52
摘要： The present invention relates to a marker for diagnosing non-alcoholic fatty liver disease and, more specifically, to: a composition and a kit which can diagnose non-alcoholic steatohepatitis (NASH) with high accuracy by comprising an agent for measuring the level of exosome-derived ApoA-1 (exosomal ApoA-1) protein; and a composition and a kit which can accurately predict prognosis after the administration of a therapeutic agent for non-alcoholic steatohepatitis. The composition and the kit of the present invention can be variously used for the diagnosis of non-alcoholic fatty liver disease, for the prognosis prediction of non-alcoholic fatty liver disease and as an agent for screening for therapeutic agents for non-alcoholic fatty liver disease.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式