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    • 54. 发明申请
    • Powder of a Vinylpyrrolidone Polymer and a Process for Production Thereof
    • 乙烯基吡咯烷酮聚合物的粉末及其制备方法
    • US20080153988A1
    • 2008-06-26
    • US11666883
    • 2005-11-02
    • Kazuhiro OkamuraNorihiro WakaoKeiji WatanabeKeiichi Fujise
    • Kazuhiro OkamuraNorihiro WakaoKeiji WatanabeKeiichi Fujise
    • C08L25/02
    • C08F226/10C08J3/12C08J2339/00C09D139/06C09J139/06
    • The present invention is a powder of a vinylpyrrolidone polymer having a K value of smaller than 50, characterized in that a content of particles having a particle diameter of 106 μm or smaller is 10% by mass or less and a content of particles having a particle diameter of greater than 1,000 μm is 5% by mass or lower. A process for production of a powder of a vinylpyrrolidone polymer according to the present invention is characterized in that a vinylpyrrolidone polymer having a K value of smaller than 50 is formed into a solution having a concentration from 30% to 70% by mass, and the solution is dried by using a hot surface adhesion-type dryer, followed by pulverization so that a content of particles having a particle diameter of 106 μm or smaller is 10% by mass or lower and a content of particles having a particle diameter of greater than 1,000 μm is 5% by mass or lower.Thus, there is provided a powder of a vinylpyrrolidone polymer, which has excellent solubility in spite of having a low K value determined by a Fikentscher method and can be made into solution with favorable handleability without dust rising, and a process for production of the same.
    • 本发明是K值小于50的乙烯基吡咯烷酮聚合物的粉末,其特征在于粒径为106μm以下的粒子的含量为10质量%以下,粒子的粒子含量为 大于1000μm的直径为5质量%以下。 本发明的乙烯基吡咯烷酮聚合物粉末的制造方法的特征在于,将K值小于50的乙烯基吡咯烷酮聚合物形成浓度为30〜70质量%的溶液, 溶液通过使用热表面粘附型干燥器进行干燥,然后粉碎,使得粒径为106μm以下的粒子的含量为10质量%以下,粒径为 1,000μm为5质量%以下。 因此,提供了一种乙烯基吡咯烷酮聚合物的粉末,尽管具有通过Fikentscher方法测定的低K值而具有优异的溶解性,并且可以制成具有良好可操作性而没有粉尘升高的溶液及其制备方法 。
    • 55. 发明申请
    • Band-Seals For Hard Capsules
    • 硬胶囊密封胶带
    • US20080008750A1
    • 2008-01-10
    • US11794175
    • 2005-12-08
    • Shinji TochioShunji NagataSatoshi Sakuma
    • Shinji TochioShunji NagataSatoshi Sakuma
    • A61K9/48
    • A61K9/4883A61J3/072A61K9/4816A61K9/4858C08L5/00C08L29/02C08L39/08C08L2666/04C09J139/06
    • The present invention has as its object to provide a band-seal to manufacture a leak-tight, stable hard capsule preparation not being susceptible to deformation after having filled pharmaceuticals, foods, healthy foods, etc. in a hard capsule comprising a polyvinyl alcohol copolymer or pullulan as a base, and in more particular, relates to a band-seal intended for use in the hard capsule comprising a polyvinyl alcohol copolymer or pullulan as a base, characterized in that the band-seal is incorporated with at least one or not less than two of the below-described (a) to (c): (a) A polyvinylpyrrolidone with a molecular weight of 100,000 to 4,000,000, (b) A polyvinylpyrrolidone with a molecular weight of 10,000 to 80,000 in the proportion of not more than 90% by weight against the total weight of the band-seal; and (c) A copolymer from 1-vinyl-2-pyrrolidone and vinyl acetate.
    • 本发明的目的是提供一种带密封,用于在包含聚乙烯醇共聚物的硬胶囊中填充药物,食品,健康食品等之后制造不易变形的密封性稳定的硬胶囊制剂 或支链淀粉作为基底,更具体地涉及旨在用于包含聚乙烯醇共聚物或支链淀粉作为基质的硬胶囊中的带状密封件,其特征在于,所述带状密封件与至少一个或多个 下述(a)〜(c)中的2种以下:(a)分子量为100,000〜4,000,000的聚乙烯吡咯烷酮,(b)分子量为10,000〜80,000的聚乙烯吡咯烷酮的比例不大于 相对于带封的总重量为90重量% 和(c)来自1-乙烯基-2-吡咯烷酮和乙酸乙烯酯的共聚物。