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51. 发明授权

US06297027B1 Bovine leptin protein, nucleic acid sequences coding therefor and uses thereof 失效
标题翻译：牛瘦蛋白，其编码的核酸序列及其用途
公开(公告)号：US06297027B1
公开(公告)日：2001-10-02
申请号：US08688908
申请日：1996-07-31
申请人： Michael E. Spurlock
发明人： Michael E. Spurlock
IPC分类号： C07K14435
CPC分类号： C07K14/5759
摘要： A bovine adipocyte-specific polypeptide, termed leptin, is expressed in the fat tissue of cattle. Expression may be altered in over fat cattle, or expression may be in the form of a protein of lesser biological activity relative to that of leaner cattle. The bovine adipocyte polypeptide, DNA and RNA molecules coding therefor, methods for its preparation, and antibodies specific for the polypeptide are disclosed. Methods for determining the susceptibility of cattle to fat deposition are based on measuring the levels of the bovine adipocyte polypeptide in a biological fluid or tissue extract or by measuring mRNA encoding the bovine adipocyte polypeptide in cells of the subject. Methods of evaluating an agent related to the deposition of fat in cattle comprise contacting the agent with an adipocyte in vitro and measuring the amount of the bovine adipocyte polypeptide or mRNA that is produced by the adipocyte. Methods of limiting fat deposition include administering leptin or leptin DNA, and methods of altering intake include administering leptin, leptin DNA, or an antibody directed against leptin.
摘要翻译：称为瘦素的牛脂肪细胞特异性多肽在牛的脂肪组织中表达。表达可能在过度肥胖的牛中改变，或者表达可以是相对于瘦牛的生物活性较小的蛋白质的形式。公开了牛脂肪细胞多肽，其编码的DNA和RNA分子，其制备方法和针对该多肽的抗体。用于确定牛对脂肪沉积的易感性的方法是基于测量生物流体或组织提取物中牛脂肪细胞多肽的水平，或通过测量受试者细胞中编码牛脂肪细胞多肽的mRNA。评估与牛中脂肪沉积有关的试剂的方法包括在体外使试剂与脂肪细胞接触并测量由脂肪细胞产生的牛脂肪细胞多肽或mRNA的量。限制脂肪沉积的方法包括施用瘦蛋白或瘦蛋白DNA，以及改变摄入的方法包括施用瘦蛋白，瘦素DNA或针对瘦蛋白的抗体。

52. 发明授权

US6107069A Recombinant kynurenine-3-hydroxylase enzyme and process for its preparation 失效
标题翻译：重组犬尿氨酸-3-羟化酶及其制备方法
公开(公告)号：US6107069A
公开(公告)日：2000-08-22
申请号：US147522
申请日：1999-01-14
申请人： Simona Magagnin , Luca Benatti , Massimo Cini , Carmela Speciale , Nevie Covini
发明人： Simona Magagnin , Luca Benatti , Massimo Cini , Carmela Speciale , Nevie Covini
IPC分类号： C12N15/09 , A01K67/027 , A61K48/00 , C07K14/575 , C07K14/72 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N15/53 , C12N15/85 , C07H21/04
CPC分类号： C12N15/8509 , A01K67/0275 , A61K48/00 , C07K14/5759 , C07K14/72 , C12N9/0073 , A01K2217/05 , A01K2267/03 , C12N2799/022
摘要： The present invention provides an isolated polynucleotide encoding for the kynurenine-3-hydrolase (Kyn-3-OHase) and methods of transiently expressing thereof.
摘要翻译： PCT No.PCT / EP97 / 03589 371日期1999年1月14日第 102（e）1999年1月14日PCT PCT 1997年7月3日PCT公布。第WO98 / 02553号公报日期1998年1月22日本发明提供了编码犬尿氨酸-3-水解酶（Kyn-3-OHase）的分离的多核苷酸及其瞬时表达的方法。

53. 发明授权

US6057109A Compositions for the treatment of body weight disorders including obesity 失效
标题翻译：用于治疗体重障碍（包括肥胖症）的组合物
公开(公告)号：US6057109A
公开(公告)日：2000-05-02
申请号：US210681
申请日：1998-12-14
申请人： Louis Anthony Tartaglia
发明人： Louis Anthony Tartaglia
IPC分类号： A61K38/00 , C07K14/47 , C07K14/575 , C12N15/12 , C12Q1/68
CPC分类号： C07K14/5759 , C07K14/4702 , A01K2217/05 , A61K38/00
摘要： The present invention relates to methods and compositions for the treatment of body weight disorders, including, but not limited to, obesity. Specifically, the present invention identifies and describes genes which are differentially expressed in body weight disorder states, relative to their expression in normal, or non-body weight disorder states, and/or in response to manipulations relevant to appetite and/or weight regulation. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in body weight disorders and/or appetite and/or body weight regulation. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of body weight disorders. Additionally, the present invention describes methods for the diagnostic evaluation and prognosis of various body weight disorders, and for the identification of subjects exhibiting a predisposition to such conditions.
摘要翻译：本发明涉及用于治疗体重障碍的方法和组合物，包括但不限于肥胖症。具体地，本发明鉴定并描述了相对于在正常或非体重紊乱状态下表达和/或响应于与食欲和/或体重调节相关的操作而在体重紊乱状态下差异表达的基因。此外，本发明通过其基因产物与涉及体重紊乱和/或食欲和/或体重调节的基因产物相互作用的能力来鉴定和描述基因。此外，本发明提供了用于鉴定和治疗使用化合物作为体重紊乱治疗的方法。此外，本发明描述了各种体重障碍的诊断评价和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。

54. 发明授权

US6017876A Chemical modification of granulocyte-colony stimulating factor (G-CSF) bioactivity 失效
标题翻译：化学修饰粒细胞集落刺激因子（G-CSF），提高生物相容性和生物活性
公开(公告)号：US6017876A
公开(公告)日：2000-01-25
申请号：US119800
申请日：1998-07-21
申请人： Colin Gegg , Olaf Kinstler
发明人： Colin Gegg , Olaf Kinstler
IPC分类号： A61K38/00 , A61K47/48 , A61P3/04 , A61P7/00 , A61P43/00 , C07K1/107 , C07K14/53 , C07K14/535 , C07K14/575 , A61K38/16
CPC分类号： C07K1/1077 , A61K47/48023 , A61K47/48076 , C07K14/53 , C07K14/535 , C07K14/5759 , A61K38/00
摘要： The present invention broadly relates to chemical modification of biologically active proteins or analogs thereof. More specifically, the present invention describes novel methods for site-specific chemical modification of various proteins, and resultant compositions having improved biocompatibility and bioactivity.
摘要翻译：本发明广泛涉及生物活性蛋白质或其类似物的化学修饰。更具体地，本发明描述了用于各种蛋白质的位点特异性化学修饰的新方法，以及具有改善的生物相容性和生物活性的所得组合物。

55. 发明授权

US5871931A Methods for detecting mammalian tub protein and RNA 失效
标题翻译：检测哺乳动物卵泡蛋白和RNA的方法
公开(公告)号：US5871931A
公开(公告)日：1999-02-16
申请号：US936707
申请日：1997-09-24
申请人： Patrick W. Kleyn , Karen J. Moore
发明人： Patrick W. Kleyn , Karen J. Moore
IPC分类号： A61K38/00 , A61K39/395 , A61K48/00 , C07K14/575 , C07K16/18 , C12N1/00 , C12N15/11 , C12N15/12 , C12N15/63 , C12P21/02 , C12Q1/00 , C12Q1/68
CPC分类号： C07K14/5759 , A61K38/00 , A61K48/00
摘要： The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the control of mammalian body weight. The nucleic acid molecules of the present invention represent the genes corresponding to the mammalian tub gene, a gene that is involved in the regulation of body weight.
摘要翻译：本发明涉及鉴定参与哺乳动物体重控制的新型核酸分子和由此类核酸分子或其简并变体编码的蛋白质。本发明的核酸分子代表与哺乳动物浴基因相对应的基因，该基因涉及调节体重的基因。

56. 发明授权

US5840517A Process for preparing obesity protein analogs 失效
标题翻译：制备肥胖蛋白类似物的方法
公开(公告)号：US5840517A
公开(公告)日：1998-11-24
申请号：US823104
申请日：1997-03-24
申请人： Paul Robert Atkinson , Lisa Kay Foster , Thomas Charles Furman , Warren Cameron MacKellar
发明人： Paul Robert Atkinson , Lisa Kay Foster , Thomas Charles Furman , Warren Cameron MacKellar
IPC分类号： C12P21/02 , A61K38/00 , C07K14/47 , C07K14/575 , C12N9/48 , C12N9/64 , C12N15/09 , C12P21/06
CPC分类号： C12N9/6402 , C07K14/5759 , C12N9/48 , C12P21/06 , A61K38/00
摘要： The present invention is directed to an improved process for preparing in high yield an obesity protein analog using a dipeptidylaminopeptidase isolated from the slime mold, Dictyostelium discoideum.
摘要翻译：本发明涉及一种使用从粘液霉（Dictyostelium discoideum）分离的二肽基氨基肽酶以高产量制备肥胖蛋白类似物的改进方法。

57. 发明授权

US5574133A Anti-obesity proteins 失效
公开(公告)号：US5574133A
公开(公告)日：1996-11-12
申请号：US381049
申请日：1995-01-31
申请人： Richard D. DiMarchi , David B. Flora , William F. Heath, Jr. , James A. Hoffmann , James E. Shields , David L. Smiley
发明人： Richard D. DiMarchi , David B. Flora , William F. Heath, Jr. , James A. Hoffmann , James E. Shields , David L. Smiley
IPC分类号： A61K38/00 , C07K14/575 , C07K7/00 , C07K7/10
CPC分类号： C07K14/5759 , A61K38/00
摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.

58. 发明授权

US5563245A Anti-obesity proteins 失效
公开(公告)号：US5563245A
公开(公告)日：1996-10-08
申请号：US381163
申请日：1995-01-31
申请人： Richard D. DiMarchi , David B. Flora , William F. Heath, Jr. , James A. Hoffmann , James E. Shields , David L. Smiley
发明人： Richard D. DiMarchi , David B. Flora , William F. Heath, Jr. , James A. Hoffmann , James E. Shields , David L. Smiley
IPC分类号： A61K38/00 , C07K14/575 , C07K7/10
CPC分类号： C07K14/5759 , A61K38/00
摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.

59. 发明授权

US5559208A Anti-obesity proteins 失效
公开(公告)号：US5559208A
公开(公告)日：1996-09-24
申请号：US383639
申请日：1995-02-06
申请人： Margret B. Basinski , Richard D. DiMarchi , William F. Heath, Jr. , Brigitte E. Schoner
发明人： Margret B. Basinski , Richard D. DiMarchi , William F. Heath, Jr. , Brigitte E. Schoner
IPC分类号： A61K38/00 , C07K14/575 , A61K35/00 , C07K7/10
CPC分类号： C07K14/5759 , A61K38/00
摘要： The present invention provides anti-obesity proteins, which when administered to a patient regulate fat tissue. Accordingly, such agents allow patients to overcome their obesity handicap and live normal lives with much reduced risk for type II diabetes, cardiovascular disease and cancer.

60. 发明申请

US20180230189A1 Polypeptides Capable of Inhibiting the Binding Between Leptin and Neuropilin-1 审中-公开
公开(公告)号：US20180230189A1
公开(公告)日：2018-08-16
申请号：US15761828
申请日：2016-09-21
申请人： INSERM (Institut National de la Sante et de la Recherche Medicale) , Fondation Imagine , Assistance Publique-Hopitaux de Paris (APHP) , Universite Paris Descartes , Centre National de la Recherche Scientifique (CNRS) , Université de Bourgogne , CNAM - Conservatoire National des Arts et Metiers
发明人： Zakia Belaid-Choucair , Olivier Hermine , Matthieu Montes , Carmen Garrido-Fleury , Renaud Seigneuric , Guillaume Marcion
IPC分类号： C07K14/475 , A61K38/18 , C07K16/22 , A61K39/395 , A61P35/00
CPC分类号： C07K14/475 , A61K38/1866 , A61K39/3955 , A61K2039/505 , A61P35/00 , C07K14/5759 , C07K14/705 , C07K14/72 , C07K16/22 , C07K2317/76
摘要： The present invention relates to agents capable of inhibiting the binding between Leptin and Neuropilin-1 (NRP1) and uses thereof in the therapeutic field.

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