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51. 发明授权

US07109312B2 Dark quenchers for donor-acceptor energy transfer 有权
公开(公告)号：US07109312B2
公开(公告)日：2006-09-19
申请号：US11192705
申请日：2005-07-29
申请人： Ronald M. Cook , Matt Lyttle , Daren Dick
发明人： Ronald M. Cook , Matt Lyttle , Daren Dick
IPC分类号： C07C245/00 , C07H21/04 , C07H19/04
CPC分类号： C07H21/00 , C07B2200/11 , C07C245/08 , C07D241/46 , C07F9/091 , C07F9/2408 , C09B31/043 , C09B56/00 , C09B56/12 , C12Q1/6818 , C40B40/00 , G01N33/542 , G01N33/582
摘要： The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.

52. 发明授权

US07019129B1 Dark quenchers for donor-acceptor energy transfer 有权
公开(公告)号：US07019129B1
公开(公告)日：2006-03-28
申请号：US09567863
申请日：2000-05-09
申请人： Ronald M. Cook , Matt Lyttle , Daren Dick
发明人： Ronald M. Cook , Matt Lyttle , Daren Dick
IPC分类号： C07H19/04 , C12Q1/68 , C12M3/00 , C07K1/00
CPC分类号： C07H21/00 , C07B2200/11 , C07C245/08 , C07D241/46 , C07F9/091 , C07F9/2408 , C09B31/043 , C09B56/00 , C09B56/12 , C12Q1/6818 , C40B40/00 , G01N33/542 , G01N33/582
摘要： The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.

53. 发明申请

US20050272088A1 Dark quenchers for donor-acceptor energy transfer 有权
标题翻译：供体 - 受体能量转移的暗猝灭剂
公开(公告)号：US20050272088A1
公开(公告)日：2005-12-08
申请号：US11192705
申请日：2005-07-29
申请人： Ronald Cook , Matt Lyttle , Daren Dick
发明人： Ronald Cook , Matt Lyttle , Daren Dick
IPC分类号： C07B61/00 , C07D241/46 , C07F9/09 , C07F9/24 , C07H21/00 , C09B31/043 , C09B56/00 , C12Q1/68 , C07H21/04 , C09B31/072
CPC分类号： C07H21/00 , C07B2200/11 , C07C245/08 , C07D241/46 , C07F9/091 , C07F9/2408 , C09B31/043 , C09B56/00 , C09B56/12 , C12Q1/6818 , C40B40/00 , G01N33/542 , G01N33/582
摘要： The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.
摘要翻译：本发明提供了一种称为黑洞猝灭剂（“BHQ”）的暗猝灭剂，它们是激发态能的有效猝灭剂，但它们本身基本上是非荧光的。还提供了使用BHQ，并入BHQ的探针和使用探针的方法的方法。

54. 发明授权

US06242602B1 One pot synthesis of 5,10-dihydrophenazine compounds and 5,10-substituted dihydrophenazines 有权
标题翻译：一锅合成5,10-二氢吩嗪化合物和5,10-取代二氢吩嗪
公开(公告)号：US06242602B1
公开(公告)日：2001-06-05
申请号：US09280396
申请日：1999-03-29
申请人： Punam Giri , Harlan J. Byker , Kelvin L. Baumann
发明人： Punam Giri , Harlan J. Byker , Kelvin L. Baumann
IPC分类号： C07D24146
CPC分类号： C07D241/48 , C07D241/46
摘要： Dihydrophenazines and bis(dihydrophenazines) are prepared in high yield under commercially viable reaction conditions by reacting a catechol with a 1,2-diaminoaryl compound, wherein either the catechol or the 1,2-diaminoaryl compound is provided in at least 50% molar stoichiometric excess. The product may be oxidized to the corresponding phenazine, but is preferably derivatized at one or both of the 5,10-positions to form a monosubstituted or disubstituted dihydrophenazine or bis(dihydrophenazine). Most preferably, 5,10-dialkyl-5,10-dihydrophenazines are prepared starting from catechol and 1,2-diaminoaryl compound in a one pot synthesis. The products are useful as dyes, and in particular as chromophores in electrochromic systems.
摘要翻译：在商业上可行的反应条件下，通过使邻苯二酚与1,2-二氨基芳基化合物反应，以高产率制备二氢苯并嗪和双（二氢苯并嗪），其中儿茶酚或1,2-二氨基芳基化合物以至少50％的摩尔化学计量过量。产物可以被氧化成相应的吩嗪，但优选在5,10-位的一个或两个上衍生化，以形成单取代或二取代的二氢吩嗪或双（二氢吩嗪）。最优选地，在一锅合成中从儿茶酚和1,2-二氨基芳基化合物开始制备5,10-二烷基-5,10-二氢吩嗪。该产品可用作染料，特别是作为电致变色系统中的发色团。

55. 发明授权

US6133283A Mono- or polyenic carboxylic acid derivatives 失效
标题翻译：单或多元羧酸衍生物
公开(公告)号：US6133283A
公开(公告)日：2000-10-17
申请号：US236644
申请日：1999-01-26
申请人： Shigeki Hibi , Kouichi Kikuchi , Hiroyuki Yoshimura , Mitsuo Nagai , Katsuya Tagami , Shinya Abe , Ieharu Hishinuma , Junichi Nagakawa , Norimasa Miyamoto , Takayuki Hida , Aichi Ogasawara , Seiko Higashi , Kenji Tai , Takashi Yamanaka , Makoto Asada
发明人： Shigeki Hibi , Kouichi Kikuchi , Hiroyuki Yoshimura , Mitsuo Nagai , Katsuya Tagami , Shinya Abe , Ieharu Hishinuma , Junichi Nagakawa , Norimasa Miyamoto , Takayuki Hida , Aichi Ogasawara , Seiko Higashi , Kenji Tai , Takashi Yamanaka , Makoto Asada
IPC分类号： A61P19/02 , C07C57/03 , C07C229/44 , C07D209/08 , C07D213/69 , C07D215/12 , C07D215/14 , C07D215/18 , C07D223/16 , C07D225/06 , C07D231/12 , C07D241/38 , C07D241/42 , C07D241/46 , C07D261/18 , C07D263/32 , C07D265/36 , C07D333/76 , C07D405/14 , C07D455/04 , C07D487/04 , C07D495/04 , G06F17/30 , C07D455/06 , A61K31/44
CPC分类号： C07D213/69 , C07C229/44 , C07C57/03 , C07D209/08 , C07D215/12 , C07D215/14 , C07D215/18 , C07D223/16 , C07D225/06 , C07D231/12 , C07D233/16 , C07D241/38 , C07D241/42 , C07D241/46 , C07D261/18 , C07D263/32 , C07D265/36 , C07D333/76 , C07D405/14 , C07D455/04 , C07D487/04 , C07D495/04 , G06F17/30607 , Y02P20/55
摘要： To provide novel compounds relating to retinoid which can substitute for retinoic acid used for preventing and treating several diseases and having antagonism against retinoid. Heterocyclic compounds represented by the general formula (1-I) or physiologically acceptable salts thereof:Z--(CR.sup.3 .dbd.CR.sup.2).sub.n --COOR.sup.1-- (1-I)Compounds represented by the general formula (2-I) or physiologically acceptable salts thereof: ##STR1## The compounds according to the present invention exhibit extremely high ability to bind RARs and are effective for treating various kind of diseases such as abnormality in cornification and rheumatoid arthritis.
摘要翻译：提供与维甲酸相关的新化合物，其可以代替用于预防和治疗几种疾病并对类视黄醇具有拮抗作用的视黄酸。由通式（1-I）表示的杂环化合物或其生理学上可接受的盐：Z-（CR 3 = CR 2）n -COOR1-（1-I）由通式（2-I）表示的化合物或其生理学上可接受的盐：根据本发明的化合物显示出极高的结合RAR的能力，并且对于治疗各种类型的疾病如角质化和类风湿性关节炎的异常是有效的。

56. 发明授权

US6030964A Mono- or polyenic carboxylic acid derivatives 失效
标题翻译：单或多元羧酸衍生物
公开(公告)号：US6030964A
公开(公告)日：2000-02-29
申请号：US106112
申请日：1998-06-29
申请人： Shigeki Hibi , Kouichi Kikuchi , Hiroyuki Yoshimura , Mitsuo Nagai , Katsuya Tagami , Shinya Abe , Ieharu Hishinuma , Junichi Nagakawa , Norimasa Miyamoto , Takayuki Hida , Aichi Ogasawara , Seiko Higashi , Kenji Tai , Takashi Yamanaka , Makoto Asada
发明人： Shigeki Hibi , Kouichi Kikuchi , Hiroyuki Yoshimura , Mitsuo Nagai , Katsuya Tagami , Shinya Abe , Ieharu Hishinuma , Junichi Nagakawa , Norimasa Miyamoto , Takayuki Hida , Aichi Ogasawara , Seiko Higashi , Kenji Tai , Takashi Yamanaka , Makoto Asada
IPC分类号： A61P19/02 , C07C57/03 , C07C229/44 , C07D209/08 , C07D213/69 , C07D215/12 , C07D215/14 , C07D215/18 , C07D223/16 , C07D225/06 , C07D231/12 , C07D241/38 , C07D241/42 , C07D241/46 , C07D261/18 , C07D263/32 , C07D265/36 , C07D333/76 , C07D405/14 , C07D455/04 , C07D487/04 , C07D495/04 , G06F17/30 , A61K31/55
CPC分类号： C07D213/69 , C07C229/44 , C07C57/03 , C07D209/08 , C07D215/12 , C07D215/14 , C07D215/18 , C07D223/16 , C07D225/06 , C07D231/12 , C07D233/16 , C07D241/38 , C07D241/42 , C07D241/46 , C07D261/18 , C07D263/32 , C07D265/36 , C07D333/76 , C07D405/14 , C07D455/04 , C07D487/04 , C07D495/04 , G06F17/30607 , Y02P20/55
摘要： Compounds of the formula and compounds of the formula ##STR1## or their salts have the potent ability to bind to retinoic acid receptors thus useful in treating psoriasis and rheumatoid arthritis.
摘要翻译：下式的化合物和下式化合物或其盐具有结合视黄酸受体的有效能力，因此可用于治疗牛皮癣和类风湿性关节炎。

57. 发明授权

US4731108A Derivatives of 4-((aryloxy)phenoxy)alkenols and their herbicidal uses 失效
公开(公告)号：US4731108A
公开(公告)日：1988-03-15
申请号：US837229
申请日：1986-03-07
申请人： James A. Turner , Wendy S. Jacks , Paul S. Zorner
发明人： James A. Turner , Wendy S. Jacks , Paul S. Zorner
IPC分类号： A01N43/40 , A01N43/42 , A01N43/54 , A01N43/60 , A01N43/74 , A01N43/90 , A01N47/12 , C07D213/64 , C07D213/643 , C07D215/22 , C07D239/34 , C07D241/46 , C07D513/04
CPC分类号： C07D213/643 , A01N43/40 , A01N43/42 , A01N43/54 , A01N43/60 , A01N43/74 , A01N43/90 , A01N47/12 , C07D215/22 , C07D239/34 , C07D241/46 , C07D513/04
摘要： Derivatives of 4-((aryloxy)phenoxy)alkenols, their preparation and use as active herbicides for the postemergent control of grassy weeds and especially the control of said weeds in the presence of corn plants are disclosed.

58. 发明授权

US4710570A Azine redox dyes and leuco azine dyes 失效
标题翻译： Azine氧化还原染料和无色吖嗪染料
公开(公告)号：US4710570A
公开(公告)日：1987-12-01
申请号：US781913
申请日：1985-09-30
申请人： Tran V. Thien
发明人： Tran V. Thien
IPC分类号： B41M5/136 , B41M5/323 , C07D241/46 , C07D265/36 , C07D279/20 , C07D413/04 , C07D417/12 , C07D513/04 , C09B17/00 , C09B17/02 , C09B19/00 , C09B21/00 , G03C1/498 , C07D265/38
CPC分类号： G03C1/49854 , B41M5/136 , B41M5/323 , C07D241/46 , C07D265/36 , C07D279/20 , C07D413/04 , C07D417/12 , C07D513/04 , C09B17/02 , C09B19/00 , C09B21/00
摘要： Azine redox dyes and their corresponding dyes of the formula: ##STR1## in which: X is O, S, NR.sup.2,Z completes a fused aromatic of heterocyclic ring system,n is 0 or 1 to allow one R.sup.1 ring substituent,Q represents CR.sup.4 R.sup.5 in which at least one of R.sup.4 and R.sup.5 is an electronegative group or R.sup.4 and R.sup.5 may complete a ring, orwhen X is S Q may represent NR.sup.3 in which R.sup.3 is an aromatic or heterocyclic group.The leuco dyes are useful as dye generators in pressure sensitive, thermographic or photothermographic imaging systems.
摘要翻译： Azine氧化还原染料及其相应的具有下式的染料：其中：X为O，S，NR 2，Z，完成杂环系统的稠合芳族化合物，n为0或1，以允许一个R 1 Q表示CR4R5，其中R4和R5中的至少一个是电负性基团，或者R4和R5可以完成环，或者当X是SQ时可以表示NR 3，其中R 3是芳族或杂环基。无色染料可用作压敏，热成像或光热成像系统中的染料发生器。

59. 发明授权

US4568675A Phenazine ACE inhibitor produced from streptomyces species 失效
标题翻译：由链霉菌种产生的吩嗪ACE抑制剂
公开(公告)号：US4568675A
公开(公告)日：1986-02-04
申请号：US562914
申请日：1983-12-19
申请人： Karen Bush , Dorothy S. Slusarchyk , Wen-Chih Liu
发明人： Karen Bush , Dorothy S. Slusarchyk , Wen-Chih Liu
IPC分类号： C07D241/46 , C12P17/12 , A61K31/495
CPC分类号： C12P17/12 , C07D241/46
摘要： 3,6-Dihydroxyphenazine-1-carboxylic acid, a hypotensive agent, and its production by culturing aerobically Streptomyces species A.T.C.C. No. 39460 are disclosed herein.
摘要翻译： 3,6-二羟基苯并嗪-1-羧酸，一种降血压药，其生产方法是培养有氧链霉菌属A.T.C.C. 本文公开了第39460号。

60. 发明授权

US3743584A Acid bright copper plating bath 失效
标题翻译：酸性明亮铜镀层
公开(公告)号：US3743584A
公开(公告)日：1973-07-03
申请号：US3743584D
申请日：1971-06-02
申请人： SCHERING AG
发明人： TODT H , CLAUSS W , DAHMS W
IPC分类号： C07D241/46 , C08G73/06 , C25D3/38 , C23B5/18
CPC分类号： C25D3/38 , C07D241/46 , C08G73/0694
摘要： Polymeric phenazonium compounds, their method of preparation and their use in acid electrolytes for the deposition of bright, leveling, copper coatings on surfaces.
摘要翻译：高分子苯扎嗪化合物，它们的制备方法及其在酸性电解质中的用途，用于在表面上沉积光亮，流平的铜涂层。

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