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51. 发明授权

US2783243A Heaterocyclic hydrazinium chlorides 失效
标题翻译：重氮肼氯化物
公开(公告)号：US2783243A
公开(公告)日：1957-02-26
申请号：US55682456
申请日：1956-01-03
申请人： GRACE W R & CO
发明人： BERNARD RUDNER
IPC分类号： C07D233/06 , C07D233/10 , C07D233/12 , C07D233/14 , C07D233/16 , D06P1/66
CPC分类号： D06P1/66 , C07D233/06 , C07D233/10 , C07D233/12 , C07D233/14 , C07D233/16

52. 发明授权

US2400395A Composition of matter and process for preventing water-in-oil type emulsions resulting from acidization of calcareous oil-bearing strata 失效
标题翻译：用于防止石灰石含油层酸化引起的油包水型乳液的物质组成和方法
公开(公告)号：US2400395A
公开(公告)日：1946-05-14
申请号：US56822944
申请日：1944-12-14
申请人： PETROLITE CORP
发明人： DE GROOTE MELVIN , BERNHARD KEISER
IPC分类号： C07D233/14 , C07D233/16 , C09K8/60 , C10G33/04
CPC分类号： C07D233/16 , C07D233/14 , C09K8/602 , C09K8/74 , C10G33/04 , Y10S507/933 , Y10S507/934

53. 发明授权

US2400394A Process for breaking petroleum emulsions 失效
标题翻译：破碎石油乳液的方法
公开(公告)号：US2400394A
公开(公告)日：1946-05-14
申请号：US56822844
申请日：1944-12-14
申请人： PETROLITE CORP
发明人： DE GROOTE MELVIN , BERNHARD KEISER
IPC分类号： C07D233/14 , C07D233/16 , C10G33/04
CPC分类号： C07D233/16 , C07D233/14 , C10G33/04

54. 发明授权

US2386445A Composition of matter 失效
公开(公告)号：US2386445A
公开(公告)日：1945-10-09
申请号：US42822642
申请日：1942-01-26
申请人： PETROLITE CORP
发明人： DE GROOTE MELVIN , BERNHARD KEISER
IPC分类号： C07C309/17 , C07D213/20 , C07D233/14 , C07D233/16 , C10G33/04
CPC分类号： C07D213/20 , C07C309/17 , C07D233/14 , C07D233/16 , C10G33/04

55. 发明授权

US2267965A Hydroxyalkyl glyoxalidines 失效
标题翻译：羟烷基乙醛酸
公开(公告)号：US2267965A
公开(公告)日：1941-12-30
申请号：US28508139
申请日：1939-07-18
申请人： CARBIDE & CARBON CHEM CORP
发明人： WILSON ALEXANDER L
IPC分类号： C07D233/16
CPC分类号： C07D233/16

56. 发明授权

US2211001A Oxalkyl derivatives of imidazolines 失效
标题翻译：咪唑啉的烷基衍生物
公开(公告)号：US2211001A
公开(公告)日：1940-08-13
申请号：US19511838
申请日：1938-03-10
申请人： GEN ANILINE & FILM CORP
发明人： AUGUST CHWALA
IPC分类号： C07D233/14 , C07D233/16 , C07D233/22
CPC分类号： C07D233/16 , C07D233/14 , C07D233/22

57. 发明授权

US09932315B2 Persistent carbene adducts and related methods 有权
公开(公告)号：US09932315B2
公开(公告)日：2018-04-03
申请号：US15502678
申请日：2015-08-07
申请人： Massachusetts Institute of Technology
发明人： Jeremiah A. Johnson , Aleksandr V. Zhukhovitskiy
IPC分类号： C07D233/16
CPC分类号： C07D233/16
摘要： Persistent carbene adducts and methods of forming the same are generally described, as well as compositions comprising the persistent carbene adduct. In some embodiments, methods are provided comprising heating a persistent carbene to relatively high temperatures to convert the persistent carbene into a persistent carbene-carbodiimide adduct. In certain embodiments, the percent of the persistent carbene that is converted to the persistent carbene-carbodiimide adduct is relatively high (e.g., at least about 50%). In some embodiments, the persistent carbene-carbodiimide adducts formed via the methods described herein may be relatively stable. Compositions comprising the persistent carbene-carbodiimide adducts of the present invention may be useful for applications involving catalysis, organometallic chemistry, sensing, and surface functionalization, amongst others.

58. 发明申请

US20130210769A1 COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF CANNABINOID RECEPTOR 1 ACTIVITY 审中-公开
公开(公告)号：US20130210769A1
公开(公告)日：2013-08-15
申请号：US13840673
申请日：2013-03-15
申请人： Hong Liu , Xiaohui He , Dean Paul Phillips , Xuefeng Zhu , Kunyong Yang , Thomas Lau , Baogen Wu , Yongping Xie , Truc Ngoc Nguyen , Xing Wang
发明人： Hong Liu , Xiaohui He , Dean Paul Phillips , Xuefeng Zhu , Kunyong Yang , Thomas Lau , Baogen Wu , Yongping Xie , Truc Ngoc Nguyen , Xing Wang
IPC分类号： C07D265/32 , C07D263/20 , C07F7/18 , C07D233/74 , C07D233/32 , C07D207/26 , C07D233/38
CPC分类号： C07D265/32 , C07D207/26 , C07D207/40 , C07D233/12 , C07D233/16 , C07D233/32 , C07D233/38 , C07D233/42 , C07D233/46 , C07D233/50 , C07D233/52 , C07D233/74 , C07D263/20 , C07D263/22 , C07D285/06 , C07D403/04 , C07D403/06 , C07D403/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07F7/1804
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).

59. 发明授权

US08455663B2 Halosubstituted aryloxyalkylimidazolines for use as pesticides 失效
标题翻译：用作农药的卤代芳氧基烷基咪唑啉
公开(公告)号：US08455663B2
公开(公告)日：2013-06-04
申请号：US12677825
申请日：2008-09-09
申请人： Anthony Cornelius O'Sullivan , Thomas Pitterna , Jürgen Harry Schaetzer , Christoph Luethy
发明人： Anthony Cornelius O'Sullivan , Thomas Pitterna , Jürgen Harry Schaetzer , Christoph Luethy
IPC分类号： C07D233/22 , C07C255/13
CPC分类号： C07D233/16 , A01N43/50
摘要： The present invention relates to novel imidazoline derivatives and their use as insecticidal, acaricidal, molluscicidal and nematocidal agents. The invention also extends to insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising such imidazoline derivatives, and to methods of using such derivatives and/or compositions to combat and control insect, acarine, mollusc and nematode pests. A compound of formula (I) and salts and N-oxides thereof, wherein: R1 is C1-10 alkyl; R2 is chloro, bromo or iodo; R3 is C2-5 alkyl, C1-5 haloalkyl, C1-6 hydroxyalkyl, C1-5alkoxy-(C1-3)-alkyl, di-(C1-5 alkoxy)-(C1-3)-alkyl, C1-5alkylthio-(C1-3)-alkyl; C1-5 alkylsulfinyl-(C1-3)alkyl; C2-5 alkenyl, C1-5 haloalkenyl, C2-5 alkinyl, C3-6 cycloalkyl, C3-6 cycloalkenyl, hydroxy, C1-5 alkoxy, C1-5haloalkoxy, C1-5alkylthio, C1-5 haloalkylthio, formyl, cyano, bromo, or iodo; Z is hydrogen, hydroxy, nitro cyano, rhodano, formyl, G-, G-S—, G-S—S—, G-A-, R7R8N—, R7R8N—S—, R7R8N-A-, G-O-A-, G-S-A-, (R10O)(R11O)P(X)—, (R10O)(R11S)P(X)—, (R10O)(R11)P(X)—, (R10S)(R11S)P(X)—, (R10O)(R14R15N)P(X)—, (R11)(R14R15N)P(X)—, (R14R15N)(R16R17N)P(X)—, G-N═CH—, G-O—N═CH—, N≡C—N═CH—, or Z is a group of formula (II), wherein B is S—, S—S—, S(O)—, C(O)—, or (CH2)n—; n is an integer from 1 to 6; and R1, R2, and R3 are as defined above; and G is optionally substituted C1-10alkyl, optionally substituted C2-10 alkenyl, optionally substituted C2-10 alkynyl, optionally substituted C3-7 cycloalkyl, optionally substituted C3-7 cycloalkenyl, optionally substituted aryl, optionally substituted heteroaryl or optionally substituted heterocyclyl; A is S(O), SO2, C(O) or C(S).
摘要翻译：本发明涉及新的咪唑啉衍生物及其作为杀虫，杀螨，杀软体动物和杀线虫剂的用途。本发明还延伸到包含这种咪唑啉衍生物的杀虫，杀螨，杀软体动物和杀线虫组合物，以及使用这些衍生物和/或组合物来对抗和控制昆虫，螨虫，软体动物和线虫的害虫的方法。式（I）化合物及其盐和N-氧化物，其中：R1为C1-10烷基; R2是氯，溴或碘; R3是C2-5烷基，C1-5卤代烷基，C1-6羟基烷基，C1-5烷氧基 - （C1-3） - 烷基，二 - （C1-5烷氧基） - （C1-3） - 烷基，C1-5烷硫基 - （C 1-3） - 烷基; C 1-5烷基亚磺酰基 - （C 1-3）烷基; C2-5烯基，C1-5卤代烯基，C2-5炔基，C3-6环烷基，C3-6环烯基，羟基，C1-5烷氧基，C1-5卤代烷氧基，C1-5烷硫基，C1-5卤代烷硫基，甲酰基，氰基，溴，或碘; Z是氢，羟基，硝基氰基，罗丹明，甲酰基，G-，GS-，GSS-，GA-，R7R8N-，R7R8N-S-，R7R8N-A-，GOA-，GSA-，（R10O） P（X） - ，（R10O）（R11S）P（X） - ，（R10O）（R11）P（X） - ，（R10S）（R11S）P（X） - ，（R10O）（R14R15N） X） - ，（R11）（R14R15N）P（X） - ，（R14R15N）（R16R17N）P（X） - ，GN = CH-，GON = CH-，N = CN = CH-，或Z为基团其中B为S-，SS-，S（O） - ，C（O） - 或（CH 2）n - ）的式（II） n是1至6的整数; 并且R 1，R 2和R 3如上所定义; 任选取代的C 2-10炔基，任选取代的C 3-7环烷基，任选取代的C 3-7环烯基，任选取代的芳基，任选取代的杂芳基或任选取代的杂环基; A是S（O），SO 2，C（O）或C（S）。

60. 发明申请

US20110142856A1 COMPOUND CONTAINING BASIC GROUP AND USE THEREOF 有权
标题翻译：包含基本组合的化合物及其用途
公开(公告)号：US20110142856A1
公开(公告)日：2011-06-16
申请号：US13027957
申请日：2011-02-15
申请人： Masaya KOKUBO , Yoshikazu Takaoka , Shiro Shibayama
发明人： Masaya KOKUBO , Yoshikazu Takaoka , Shiro Shibayama
IPC分类号： A61K31/4178 , C07D403/12 , C07D401/14 , C07D401/12 , C07D413/12 , C07D471/10 , C07D498/10 , C07D487/10 , A61K31/713 , A61K39/42 , A61K39/21 , A61K31/454 , A61K31/4725 , A61K31/4439 , A61K31/4709 , A61K31/5377 , A61K31/4184 , A61K31/438 , A61K31/537 , A61K31/55 , A61P35/00 , A61P31/18 , A61P37/02 , A61P35/04 , A61P29/00 , A61P19/02 , A61P27/02 , A61P11/00 , A61P37/06 , A61P43/00
CPC分类号： C07D471/10 , C07D233/16 , C07D233/84 , C07D233/90 , C07D401/14 , C07D403/12 , C07D403/14 , C07D487/10
摘要： The present invention relates to a compound represented by formula (I-0): wherein symbols in formula have the same meanings as described in the present specification, a salt thereof, an N-oxide thereof or a solvate thereof or a prodrug thereof, and medical use thereof.The compound of the present invention has an antagonistic activity against CXCR4 and is therefore useful as a preventive and/or therapeutic agent for CXCR4-mediated diseases, for example, inflammatory and immune diseases (for example, rheumatoidarthritis, arthritis, retinopathy, pulmonary fibrosis, transplanted organ rejection, etc.), allergic diseases, infections (for example, human immunodeficiency virus infection, acquired immunodeficiency syndrome, etc.), psychoneurotic diseases, cerebral diseases, cardiovascular disease, metabolic diseases, and cancerous diseases (for example, cancer, cancer metastasis, etc.), or an agent for regeneration therapy.
摘要翻译：本发明涉及由式（I-0）表示的化合物：其中式中的符号与本说明书中所述的相同含义，其盐，其N-氧化物或其溶剂合物或其前药，以及医疗用途。本发明的化合物对CXCR4具有拮抗作用，因此可用作CXCR4介导的疾病的预防和/或治疗剂，例如炎性和免疫疾病（例如类风湿关节炎，关节炎，视网膜病，肺纤维化，移植器官排斥反应等），过敏性疾病，感染（例如人类免疫缺陷病毒感染，获得性免疫缺陷综合征等），精神神经病，脑疾病，心血管疾病，代谢性疾病和癌性疾病（例如癌症，癌症转移等）或再生治疗剂。

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