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51. 发明授权

US08172765B2 Method of assessment of airway variability in airway hyperresponsiveness 有权
标题翻译：气道高反应性气道变异性评估方法
公开(公告)号：US08172765B2
公开(公告)日：2012-05-08
申请号：US11121031
申请日：2005-05-04
申请人： Geoffrey N. Maksym , Carolyn A. Lall
发明人： Geoffrey N. Maksym , Carolyn A. Lall
IPC分类号： A61B5/08
CPC分类号： A61B5/4884 , A61B5/085 , A61B5/087 , G06F19/00 , G06F19/3456
摘要： The invention relates to a method of assessing airway variability in airway responsiveness or asthma by measuring the variation of resistance (Rrs) by a forced oscillation technique utilizing either a single or a plurality of input frequencies during a plurality of respiratory cycles of a patient; calculating the statistical variability of the Rrs for the patient; and, correlating the statistical variability of the Rrs of the patient to a standard curve to quantify the degree of asthma of the patient. The invention also enables the effectiveness of a bronchoactive agent to be measured.
摘要翻译：本发明涉及通过在患者的多个呼吸周期期间利用单个或多个输入频率的强制振荡技术来测量电阻变化（Rrs）来评估气道反应性或哮喘中气道变异性的方法。计算患者Rrs的统计学变异性; 并且将患者的Rrs的统计变异性与标准曲线相关联，以量化患者的哮喘程度。本发明还能够测量支气管活性剂的有效性。

52. 发明授权

US08109269B2 Method of automatically controlling a respiration system and a corresponding respirator 有权
标题翻译：自动控制呼吸系统和相应的呼吸器的方法
公开(公告)号：US08109269B2
公开(公告)日：2012-02-07
申请号：US12264993
申请日：2008-11-05
申请人： Marcus Eger
发明人： Marcus Eger
IPC分类号： F16K31/02
CPC分类号： A61B5/08 , A61B5/037 , A61B5/0488 , A61B5/085 , A61B5/087 , A61B5/224 , A61B5/7203 , A61B5/7239 , A61M16/026 , A61M2016/0027 , A61M2016/0036 , A61M2230/60 , A61M2230/63
摘要： A method of automatically controlling a respiration system for proportional assist ventilation with a control device and with a ventilator. An electrical signal is recorded by electromyography with electrodes on the chest in order to obtain a signal uemg(t) representing the breathing activity. The respiratory muscle pressure pmus(t) is determined by calculating it in the control unit from measured values for the airway pressure and the volume flow Flow(t) as well as the patient's lung mechanical parameters. The breathing activity signal uemg(t) is transformed by means of a preset transformation rule into a pressure signal pemg(uemg)(t)) such that the mean deviation of the resulting transformed pressure signal pemg(t) from the respiratory muscle pressure pmus(t) is minimized. The respiratory effort pressure ppat(t) is determined as a weighted mean according to ppat(t)=a·pmus(t)+(1−a)·pemg(t), where a is a parameter selected under the boundary condition 0≦a≦1.
摘要翻译：一种通过控制装置和通风机自动控制比例辅助通气呼吸系统的方法。通过肌电图记录电信号，电极在胸部，以获得表示呼吸活动的信号uemg（t）。通过从气道压力和体积流量（t）的测量值以及患者的肺机械参数计算控制单元来确定呼吸肌肉压力pm（t）。将呼吸活动信号uemg（t）通过预设的变换规则转换成压力信号pemg（uemg）（t）），使得所得到的转化压力信号pemg（t）与呼吸肌肉压力的平均偏差（t）最小化。根据ppat（t）= a·pmus（t）+（1-a）·pemg（t），呼吸努力压力ppat（t）被确定为加权平均值，其中a是在边界条件0＆ ; a＆nlE; 1。

53. 发明授权

US08100836B2 Augmented RIC model of respiratory systems 失效
标题翻译：增强RIC呼吸系统模型
公开(公告)号：US08100836B2
公开(公告)日：2012-01-24
申请号：US11634636
申请日：2006-12-06
申请人： Billy Ming Diong
发明人： Billy Ming Diong
IPC分类号： A61B5/08
CPC分类号： A61B5/085 , G09B23/288
摘要： The present invention generally relates to an apparatus and method analyzing the respiratory characteristics of a human respiratory system from impulse oscillometry data, through the use of a linear network of electrical components. The present invention offers an improved alternative to the RIC respiratory circuit model, with an addition of a peripheral resistance to account for the resistance presented by the respiratory system's small airways and of a capacitor to account for extrathoracic compliance. After air pressure and air flow measurements are obtained from the subject by performing Impulse Oscillometry System testing, a graphical representation of a mechanical impedance characteristic may be derived. This allows for the estimation and adjustment of parameter values of the linear network whose components correlate to the resistances, compliances and inertances inherent in the respiratory system. Additionally, the linear network of electrical components may be configured as a virtual network represented in graphical form wherein the parameter values are estimated and adjusted according to program instructions operating on a computer system. The linear network of electrical components serves to provide parametric means for detection, diagnosis and treatment of various pathologies in the human respiratory system.
摘要翻译：本发明一般涉及通过使用电气部件的线性网络从脉冲示波测量数据分析人类呼吸系统的呼吸特性的装置和方法。本发明提供了对RIC呼吸回路模型的改进的替代方案，其中增加了外围阻力以解决由呼吸系统的小气道和电容器呈现的抵抗胸外顺应性的电阻。通过执行脉冲示波测试系统测试，从受试者获得气压和气流测量值后，可以得出机械阻抗特性的图示。这允许对其分量与呼吸系统固有的电阻，一致性和惯性相关的线性网络的参数值进行估计和调整。此外，电气部件的线性网络可以被配置为以图形形式表示的虚拟网络，其中根据在计算机系统上操作的程序指令来估计和调整参数值。电气部件的线性网络用于提供用于人类呼吸系统中各种病理学的检测，诊断和治疗的参数手段。

54. 发明申请

US20110313307A1 MEASURING LUNG FUNCTION AND LUNG DISEASE PROGRESSION AT A LOBAR/SEGMENTAL LEVEL 有权
标题翻译：测量肺功能和肺功能障碍进展
公开(公告)号：US20110313307A1
公开(公告)日：2011-12-22
申请号：US12964515
申请日：2010-12-09
申请人： Srikanth Radhakrishnan , Surag Mantri , Ryan Olivera
发明人： Srikanth Radhakrishnan , Surag Mantri , Ryan Olivera
IPC分类号： A61B5/085
CPC分类号： A61B5/085 , A61B5/087 , A61B5/097 , A61B5/6853 , A61B5/7278 , A61B2562/0247
摘要： A method for determining lung function in a patient is disclosed, in which a multi-lumen catheter with an expandable occluding element at its end is used to isolate a targeted lung compartment, and respiratory characteristics at the targeted lung compartment are measured over multiple respiratory cycles. The relation between various characteristics of the respiratory cycle is used to determine compliance of lung tissue within the targeted lung compartment.
摘要翻译：公开了一种用于确定患者的肺功能的方法，其中使用其末端具有可扩张闭塞元件的多腔导管来分离靶向的肺隔室，并且在多个呼吸循环中测量目标肺隔室处的呼吸特征。呼吸周期的各种特征之间的关系用于确定目标肺隔室内肺组织的依从性。

55. 发明申请

US20110232643A1 SYSTEM AND METHOD FOR TREATING LUNG DISEASE USING POSITIVE PRESSURE AIRWAY SUPPORT 有权
标题翻译：使用正压气道支持治疗肺疾病的系统和方法
公开(公告)号：US20110232643A1
公开(公告)日：2011-09-29
申请号：US13131902
申请日：2009-11-21
申请人： Douglas Mechlenburg , Richard J. Coldren
发明人： Douglas Mechlenburg , Richard J. Coldren
IPC分类号： A61M16/00
CPC分类号： A61M16/026 , A61B5/085 , A61M11/00 , A61M15/00 , A61M16/0003 , A61M16/0006 , A61M16/0069 , A61M16/021 , A61M16/022 , A61M16/024 , A61M16/202 , A61M2016/0027 , A61M2016/003 , A61M2016/0039 , A61M2230/46
摘要： A method of treating lung disease, such as asthma or COPD, is provided that includes determining a parameter indicative of a patient's pulmonary mechanics (such as, without limitation, airway resistance or lung compliance), and delivering positive pressure support to the airway of the patient, wherein the pressure level (which may be constant or variable) of the positive pressure support during at least a portion of the inspiratory phase of the patient is determined based on the determined parameter.
摘要翻译：提供了治疗肺部疾病如哮喘或COPD的方法，其包括确定指示患者的肺动力学（例如但不限于气道阻力或肺顺应性）的参数，以及将正压力支持递送至患者，其中，基于所确定的参数确定在患者的吸气阶段的至少一部分期间所述正压力支持件的压力水平（其可以是恒定的或可变的）。

56. 发明申请

US20110197888A1 METHOD AND SYSTEM FOR VENTILATION 有权
标题翻译：方法和系统通风
公开(公告)号：US20110197888A1
公开(公告)日：2011-08-18
申请号：US13124663
申请日：2009-10-22
申请人： Israel Deutsch , Shai Efrati
发明人： Israel Deutsch , Shai Efrati
IPC分类号： A61M16/00
CPC分类号： A61B5/085 , A61M16/0051 , A61M16/026 , A61M16/0434 , A61M16/044 , A61M16/0463 , A61M16/0479 , A61M16/0484 , A61M16/0486 , A61M2016/0027 , A61M2016/0036 , A61M2016/0413 , A61M2205/15 , A61M2205/3306 , A61M2205/3317 , A61M2205/3331 , A61M2205/3375 , A61M2209/02
摘要： A method of monitoring tracheal pressure of a subject is disclosed. The subject is ventilated with breathing gas flowing via an endotracheal tube having an inflatable cuff. The method comprises monitoring sealing of the trachea by the cuff using a close loop control, varying a ventilation pressure thereby varying flow level of the breathing gas, monitoring a response pressure within the cuff in response to the variation, and calculating the tracheal pressure using the ventilation pressure variations, the cuff response pressure and the flow level. In some embodiments, an under-pressure is applied for suctioning fluid carrying secretions, synchronously with variations in the tracheal pressure.
摘要翻译：公开了一种监测受检者气管压力的方法。受试者通气，呼吸气体通过具有充气袖带的气管内管流动。该方法包括使用闭环控制来监测通过袖带对气管的密封，改变通气压力从而改变呼吸气体的流量，响应于变化监测袖带内的应答压力，并使用该方法计算气管压力通气压力变化，袖带响应压力和流量水平。在一些实施方案中，与气管压力的变化同步地施加负压用于抽吸携带分泌物的流体。

57. 发明授权

US07993278B2 Method and system for non-invasively measuring pulmonary function 有权
标题翻译：非侵入性测量肺功能的方法和系统
公开(公告)号：US07993278B2
公开(公告)日：2011-08-09
申请号：US11485394
申请日：2006-07-13
申请人： Michael Sokoloff
发明人： Michael Sokoloff
IPC分类号： A61B5/08
CPC分类号： A61B5/085 , A61B5/0813 , A61B5/411
摘要： A method and system for measuring pulmonary function. The method comprises the following steps of: (1) providing or obtaining a measurement of a subject breathing an inert gas composition; (2) providing or obtaining a measurement of the subject breathing a replacement gas composition; and (3) extracting parameters from these two measurements. The system comprises: (a) a gas supply; (b) a subject interface; (c) an inert gas concentration measuring device, wherein the system; and (d) means for extracting parameters from the measurements by the inert gas concentration measuring device: (1) obtains a measurement with the measuring device through the subject interface of a subject breathing an inert gas composition supplied from the gas supply; (2) obtains a measurement with the measuring device through the subject interface of the subject breathing a replacement gas composition supplied from the gas supply; and (3) extracts parameters with the parameter extracting means from these two measurements.
摘要翻译：一种测量肺功能的方法和系统。该方法包括以下步骤：（1）提供或获得呼吸惰性气体组合物的对象的测量; （2）提供或获得呼吸替代气体组合物的对象的测量; 和（3）从这两个测量中提取参数。该系统包括：（a）气体供应; （b）主题界面; （c）惰性气体浓度测量装置，其中所述系统; （d）惰性气体浓度测量装置从测量中提取参数的装置：（1）通过从气体供给的惰性气体组合物的受试者接口的主体界面获得测量装置的测量值; （2）通过被检者的主体界面通过测量装置获得测量，呼吸由气体供应的置换气体组成; 和（3）从这两个测量中用参数提取装置提取参数。

58. 发明授权

US07988641B2 Apparatus and method for delivery of an aerosol 有权
标题翻译：用于输送气溶胶的装置和方法
公开(公告)号：US07988641B2
公开(公告)日：2011-08-02
申请号：US12771151
申请日：2010-04-30
申请人： Michael McCawley , Gary Gasner , Ian Christie , Tal Gottesman , James Dalton
发明人： Michael McCawley , Gary Gasner , Ian Christie , Tal Gottesman , James Dalton
IPC分类号： A61B5/08
CPC分类号： A61B5/085 , A61B5/0813
摘要： An apparatus for measuring lung ventilation, comprising: a pressure device to measure volume of air flow; an aerosol-generating device that provides aerosol particles to be released at a determined point in a breathing cycle; a mouthpiece with a detector that measures the concentration of aerosol particles for a given volume during the breathing cycle; and a computing device configured to provide lung ventilation data as a function of time constants.
摘要翻译：一种用于测量肺通气的装置，包括：用于测量空气流量的压力装置; 气溶胶发生装置，其提供将在呼吸循环中的确定点释放的气溶胶颗粒; 具有检测器的喉舌，其在呼吸循环期间测量给定体积的气溶胶颗粒的浓度; 以及被配置为提供肺通气数据作为时间常数的函数的计算设备。

59. 发明申请

US20110087122A1 MINIMALLY INVASIVE DETERMINATION OF COLLATERAL VENTILATION IN LUNGS 有权
标题翻译：最小限度地确定肺内通气通气
公开(公告)号：US20110087122A1
公开(公告)日：2011-04-14
申请号：US12972225
申请日：2010-12-17
申请人： Nikolai Aljuri , Anthony Wondka , George Surjan , Kirk Davis , Peter Soltesz , Rodney C. Perkins
发明人： Nikolai Aljuri , Anthony Wondka , George Surjan , Kirk Davis , Peter Soltesz , Rodney C. Perkins
IPC分类号： A61B5/087 , A61B5/091 , A61F2/04
CPC分类号： A61B5/085 , A61B5/055 , A61B5/08 , A61B5/0813 , A61B5/087 , A61B5/4836 , A61B5/4851 , A61B5/6853 , A61B5/7278 , A61M16/04 , A61M16/0404 , A61M16/0434 , A61M2016/0413
摘要： Minimally invasive methods, systems and devices are provided for qualitatively and quantitatively assessing collateral ventilation in the lungs. In particular, collateral ventilation of a target compartment within a lung of a patient is assessed by advancement of a catheter through the tracheobronchial tree to a feeding bronchus of the target compartment. The feeding bronchus is occluded by the catheter and a variety of measurements are taken with the use of the catheter in a manner which is of low risk to the patient. Examples of such measurements include but are not limited to flow rate, volume and pressure. These measurements are used to determine the presence of collateral ventilation and to quantify such collateral ventilation.
摘要翻译：提供了微创方法，系统和装置，用于定性和定量评估肺中的旁路通气。特别地，通过将导管穿过气管支气管树推进到目标隔室的进食支气管来评估患者的肺内的目标隔室的侧支通气。供血支气管被导管阻塞，并且以对患者的风险低的方式使用导管进行各种测量。这种测量的实例包括但不限于流量，体积和压力。这些测量用于确定侧支通气的存在并量化此类旁路通气。

60. 发明申请

US20110021941A1 SYSTEMS AND METHODS FOR RESPIRATION MONITORING 审中-公开
标题翻译：用于呼吸监测的系统和方法
公开(公告)号：US20110021941A1
公开(公告)日：2011-01-27
申请号：US12508172
申请日：2009-07-23
申请人： James N. Watson , Paul Stanley Addison , James Wolstencroft
发明人： James N. Watson , Paul Stanley Addison , James Wolstencroft
IPC分类号： A61B5/08
CPC分类号： A61B5/0205 , A61B5/02416 , A61B5/0816 , A61B5/085 , A61B5/113 , A61B5/14551 , A61B5/14552 , A61B5/6822 , A61B5/6823 , A61B5/684 , A61B5/7207 , A61B5/726 , A61B5/7278
摘要： According to embodiments, techniques for determining respiratory parameters are disclosed. More suitable probe locations for determining respiratory parameters, such as respiration rate and respiratory effort, may be identified. The most suitable probe location may be selected for probe placement. A scalogram may be generated from the detected signal at the more suitable location, resulting in an enhanced breathing band for determining respiratory parameters. Flexible probes that allow for a patient's natural movement due to respiration may also be used to enhance the breathing components of the detected signal. From the enhanced signal, more accurate and reliable respiratory parameters may be determined.
摘要翻译：根据实施例，公开了用于确定呼吸参数的技术。可以确定用于确定呼吸参数（例如呼吸速率和呼吸努力）的更合适的探针位置。可以选择最合适的探针位置用于探针放置。可以在更合适的位置处从检测到的信号产生标尺，导致用于确定呼吸参数的增强的呼吸频带。允许患者由于呼吸引起的自然运动的柔性探针也可用于增强检测到的信号的呼吸成分。从增强的信号，可以确定更准确和可靠的呼吸参数。

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