专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明申请

US20070259823A1 Diketo acids with nucleobase scaffolds: anti-HIV replication inhibitors targeted at HIV integrase 失效
公开(公告)号：US20070259823A1
公开(公告)日：2007-11-08
申请号：US11820444
申请日：2007-06-19
申请人： Vasu Nair , Guochen Chi , Vinod Uchil
发明人： Vasu Nair , Guochen Chi , Vinod Uchil
IPC分类号： A61K31/513 , A61K31/52 , A61K31/522 , A61K31/7052 , A61P31/18 , C07D239/10 , C07D473/00
CPC分类号： C07D473/30 , C07D239/54 , C07D473/00 , C07F9/6512 , C07F9/65616
摘要： A new class of diketo acids constructed on nucleobase scaffolds, designed as inhibitors of HIV replication through inhibition of HIV integrase, is described. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS and ARC, either as the compounds, or as pharmaceutically acceptable salts, with pharmaceutically acceptable carriers, used alone or in combination with antivirals, immunomodulators, antibiotics, vaccines, and other therapeutic agents. Methods of treating AIDS and ARC and methods of treating or preventing infection by HIV are also described.

52. 发明授权

US07026156B1 Diagnostic and protective antigen gene sequences of ichthyophthirius 失效
标题翻译：鱼腥草的诊断和保护性抗原基因序列
公开(公告)号：US07026156B1
公开(公告)日：2006-04-11
申请号：US09497967
申请日：2000-02-04
申请人： Theodore G. Clark , Harry W. Dickerson, Jr. , Tian-Long Lin
发明人： Theodore G. Clark , Harry W. Dickerson, Jr. , Tian-Long Lin
IPC分类号： C12N1/20 , C12N15/00 , C12N5/00 , A61K31/70 , C07H21/02
CPC分类号： C07H21/02 , A61K39/002 , A61K2039/53 , A61K2039/542 , A61K2039/552 , C07K14/44
摘要： A novel i-antigen protein from Ichthyophthirius multifiliis is effective to induce a protective immune response in fish. The invention includes antigenic and membrane-targeting sequences of i-antigen proteins, nucleic acid molecules that encode antigenic or membrane-targeting portions of i-antigen proteins, DNA and protein subunit vaccines, methods of inducing an immune response in fish and methods for detection and characterization of I. multifiliis.
摘要翻译： Ichthyophthirius multifiliis的一种新型i-抗原蛋白有效诱导鱼类的保护性免疫反应。本发明包括i-抗原蛋白的抗原和膜靶向序列，编码i抗原蛋白的抗原性或膜靶向部分的核酸分子，DNA和蛋白质亚单位疫苗，诱导鱼类免疫应答的方法和检测方法和多形性的表征。

53. 发明申请

US20060073534A1 Method for cleaving and deglycosylating antibodies to promote ligand binding 审中-公开
标题翻译：用于切割和去糖基化抗体以促进配体结合的方法
公开(公告)号：US20060073534A1
公开(公告)日：2006-04-06
申请号：US10958566
申请日：2004-10-05
申请人： Lisa Kelly , J. Puett , J. Pierce
发明人： Lisa Kelly , J. Puett , J. Pierce
IPC分类号： G01N33/537
CPC分类号： G01N33/54306 , G01N33/76
摘要： The present invention details methods to detect glycoproteins in samples to identify a disease state. In particular, an improved sandwich assay is described, using both an antibody and an array of lectins. Methods for increasing the efficiency of interaction of an antibody with a ligand by cleaving the antibody to remove the carbohydrate moiety, and orienting the cleaved fragment on a matrix to enhance recognition of a ligand are also described. Methods of differentiating pregnancy-derived and disease derived samples are also described.
摘要翻译：本发明详述了检测样品中糖蛋白以识别疾病状态的方法。特别地，使用抗体和凝集素阵列描述了改进的夹心测定法。还描述了通过切割抗体以除去碳水化合物部分并且将切割的片段取向于基质以增强配体的识别来提高抗体与配体的相互作用效率的方法。还描述了区分妊娠衍生和疾病衍生样品的方法。

54. 发明申请

US20050064386A1 Identification of toxin-binding protein involved in resistance to Cry1 toxins, and related screening methods 有权
标题翻译：鉴定涉及抗Cry1毒素的毒素结合蛋白，以及相关筛选方法
公开(公告)号：US20050064386A1
公开(公告)日：2005-03-24
申请号：US10897621
申请日：2004-07-23
申请人： Michael Adang , Rebecca McNall , Juan Fuentes
发明人： Michael Adang , Rebecca McNall , Juan Fuentes
IPC分类号： C12N9/00 , C12Q1/00 , C12Q1/42 , G01N33/50 , G01N33/573
CPC分类号： G01N33/573 , C12Q1/42 , G01N33/5085 , G01N2333/43552 , G01N2333/916 , Y10S435/832 , Y10S435/962 , Y10S435/967 , Y10S435/97
摘要： The subject invention relates in part to the surprising and unexpected discovery that insects that are resistant to Bacillus thuringiensis Cry toxins have measurably altered alkaline phosphatase (ALP) activity as compared to insects that are susceptible to Cry toxins. This and other surprising discoveries reported herein have broad implications in areas such as managing and monitoring the development of insect resistance to B.t. toxins. For example, the subject invention provides a simple and fast assay (enzymatic or otherwise) for detecting ALP activity levels and thereby monitoring the development of resistance by insects to crystal protein insect toxins. There was no prior motivation or suggestion to go about resistance monitoring using this simple and easy approach.
摘要翻译：本发明部分地涉及惊人的和意想不到的发现，与对于Cry毒素敏感的昆虫相比，对苏云金芽孢杆菌Cry毒素具有抗性的昆虫具有可测量的碱性磷酸酶（ALP）活性。这里报道的这个和其他惊人的发现在诸如管理和监测对B.t.的昆虫抗性的发展的领域具有广泛的影响。毒素例如，本发明提供了用于检测ALP活性水平的简单且快速的测定（酶或其它），从而监测昆虫对晶体蛋白质昆虫毒素的抗性的发展。没有事先的动机或建议，使用这种简单而简单的方法来进行阻力监测。

55. 发明申请

US20040038437A1 Resonant microcavity communication device 审中-公开
标题翻译：共振微腔通信装置
公开(公告)号：US20040038437A1
公开(公告)日：2004-02-26
申请号：US10651864
申请日：2003-08-29
申请人： The University of Georgia Research Foundation, Inc.
发明人： Steven M. Jaffe , Stuart M. Jacobson , Hergen Eilers , Michieal L. Jones
IPC分类号： H01L021/00
CPC分类号： H01J29/28 , G02F1/1336 , G02F1/133602 , G02F1/133621 , G02F2001/133521 , H01J61/42 , H01J63/06 , H01L51/5262 , H01L51/5265 , H05B33/12 , H05B33/22
摘要： A resonant microcavity display having microcavity with a substrate, a phosphor active region and front and rear reflectors. The front and rear reflectors may be spaced to create either a standing or traveling electromagnetic wave to enhance the efficiency of the light transmission.
摘要翻译：具有具有基板，荧光体活性区域和前后反射体的微腔的共振微腔显示器。前后反射器可以间隔开以形成立起或行进的电磁波，以提高光传输的效率。

56. 发明授权

US5808040A L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides 失效
标题翻译：掺入聚合物结构中的L-核苷用于寡核苷酸的稳定化
公开(公告)号：US5808040A
公开(公告)日：1998-09-15
申请号：US682623
申请日：1997-01-24
申请人： Chung K. Chu , Yung-Chi Cheng , Balakrishna S. Pai , Gang-Qing Yao
发明人： Chung K. Chu , Yung-Chi Cheng , Balakrishna S. Pai , Gang-Qing Yao
IPC分类号： C07H19/04 , C07H1/00 , C07H21/04
CPC分类号： C07H19/04
摘要： A method for stabilizing an oligonucleotide by including a .beta.-L-2'-deoxy-2'-fluoro-arabinofuranosyl nucleoside at the 5'-terminus, the 3'-terminus, or in the interior of the oligonucleotide. The oligonucleotide can be used in the modulation of gene expression through a process wherein a synthetic oligonucleotide is hybridized to a complementary nucleic acid sequence to inhibit transcription or replication of DNA or to inhibit translation or processing of RNA.
摘要翻译： PCT No.PCT / US95 / 01253 Sec。 371日期1997年1月24日 102（e）日期1997年1月24日PCT 1995年1月30日PCT PCT。公开号WO95 / 20595 日期1995年8月3日一种通过在寡核苷酸的5'端，3'端或内部包含β-2'-2'-脱氧-2'-氟 - 阿拉伯呋喃糖基核苷来稳定寡核苷酸的方法。寡核苷酸可以通过其中合成的寡核苷酸与互补核酸序列杂交以抑制DNA的转录或复制或抑制RNA的翻译或加工的方法用于调节基因表达。

57. 发明授权

US5196514A Method of detecting mycoplasma infection in poultry and compositions therefor 失效
标题翻译：家禽支原体感染检测方法及其组成
公开(公告)号：US5196514A
公开(公告)日：1993-03-23
申请号：US489011
申请日：1990-03-06
申请人： Alan P. Avakian , Stanley H. Kleven
发明人： Alan P. Avakian , Stanley H. Kleven
IPC分类号： A61K39/00 , C07K14/30 , C07K16/12
CPC分类号： C07K16/1253 , C07K14/30 , A61K39/00 , Y10S435/863
摘要： The present invention relates to the identification and purification of antigens from M. gallisepticum and M. synoviae and their use in serological assays. Cell proteins from these organisms that possess substantial immunoreactive responses with poultry antisera to the mycoplasma from which they are isolated in both the acute and convalescent stages of infection are identified. Of these immunogenic proteins, those that also lack immunogenic cross-reactivity with antisera to other poultry mycoplasmas and pathogens are identified. These species specific proteins are purified and incorporated into enzyme-linked immunosorbent assays (ELISAs). The resulting assays are able to detect sensitively and selectively both field or experimentally-induced M. gallisepticum or M. synoviae infection in poultry. A combination of these assays are incorporated into a diagnostic kit to allow the rapid, sensitive, and selective testing for and differentiation between M. gallisepticum and M. synoviae. This invention also provides anti-serum to these mycoplasma antigens and an immunoassay that employs this anti-serum to detect infection in poultry. Furthermore, a method to produce genetic clones that express the antigenic portions of the mycoplasma antigens is provided.
摘要翻译：本发明涉及鉴定和纯化来自烟曲霉和滑膜梭菌的抗原及其在血清学检测中的应用。鉴定出来自这些生物体的细胞蛋白质，其具有与家禽抗血清相当的免疫反应性对支原体的敏感性，从支原体分离其在感染的急性期和恢复期。在这些免疫原性蛋白质中，鉴定出与其他家禽支原体和病原体的抗血清也缺乏免疫原性交叉反应性的蛋白质。这些物种特异性蛋白质被纯化并并入酶联免疫吸附测定（ELISA）中。所得到的测定能够敏感地和有选择地检测野鸡或实验诱导的鸡只胆囊炎或家禽中的滑膜梭菌感染。将这些测定法的组合并入诊断试剂盒中，以允许快速，灵敏和选择性检测烟曲霉和滑膜梭菌之间的鉴定和分化。本发明还提供了对这些支原体抗原的抗血清和使用该抗血清检测家禽感染的免疫测定。此外，提供了产生表达支原体抗原的抗原部分的遗传克隆的方法。

58. 发明授权

US5118502A Naturally attenuated Newcastle disease vaccine and method of using the same 失效
标题翻译：自然衰老的新药疫苗及其使用方法
公开(公告)号：US5118502A
公开(公告)日：1992-06-02
申请号：US369071
申请日：1989-06-20
申请人： John R. Glisson , Pedro Villegas
发明人： John R. Glisson , Pedro Villegas
IPC分类号： A61K39/17
CPC分类号： A61K39/17 , A61K39/12 , A61K2039/5254 , A61K2039/541 , A61K2039/542 , A61K2039/544 , A61K2039/552 , C12N2760/18134 , Y10S424/816
摘要： A Newcastle disease vaccine and method of using the vaccine for protecting a poultry animal from Newcastle disease is provided. The vaccine consists of a naturally attenuated live Newcastle disease virus which has the identifying characteristics of ATCC No. VR 2239. The vaccine is capable of conferring solid immunity against Newcastle disease and causes minimal respiratory or other undesirable reactions in inoculated animals.
摘要翻译：提供了一种新城疫疫苗和使用该疫苗保护家禽动物免受新城疫的方法。该疫苗由具有ATCC No.VR 2239的鉴定特征的天然减毒活新城疫病毒组成。该疫苗能够赋予新城疫的固体免疫，并且在接种动物中引起最小的呼吸或其它不期望的反应。

59. 发明授权

US4607452A Seedling detector and ferret 失效
标题翻译：幼苗探测器和雪貂
公开(公告)号：US4607452A
公开(公告)日：1986-08-26
申请号：US623399
申请日：1984-06-22
申请人： Bryan W. Maw , Harold L. Brewer
发明人： Bryan W. Maw , Harold L. Brewer
IPC分类号： A01C1/00 , A01G9/10
CPC分类号： A01G9/108 , A01C1/00
摘要： A device for detecting a seedling. A row of detectors determine the presence or absence of a seedling at positions in a two dimensional grid, one row at a time. A comb has teeth spaced to fit between rows of the seedlings. Each tooth carries a light source on one side and a light detector on the other. Each light detector receives light from the light source on the adjacent tooth. When a seedling is present, the light is interrupted. A memory stores the position of the present seedlings so that cells having no seedlings may be removed.
摘要翻译：用于检测幼苗的装置。一排检测器确定在二维网格中的位置存在或不存在，一次一行。梳子具有间隔开的齿以配合在幼苗的行之间。每颗牙齿一侧都装有一个光源，另一个是光检测器。每个光检测器从相邻牙齿上的光源接收光。当存在幼苗时，光线被中断。存储器存储当前幼苗的位置，使得可以除去不具有幼苗的细胞。

60. 发明授权

US09839213B2 Photochemical cross-linkable polymers, methods of making photochemical cross-linkable polymers, methods of using photochemical cross-linkable polymers, and methods of making articles containing photochemical cross-linkable polymers 有权
公开(公告)号：US09839213B2
公开(公告)日：2017-12-12
申请号：US14351348
申请日：2012-10-12
申请人： THE UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
发明人： Jason J. Locklin
IPC分类号： C08F2/46 , C08F2/50 , C08G61/04 , A01N35/04 , C09D179/02 , C08G73/02 , D06M10/04 , D06M15/61 , D06M16/00 , D06M23/08 , C09D5/14 , C08J7/12
CPC分类号： A01N35/04 , C08G73/0226 , C08J7/12 , C08J2479/02 , C09D5/14 , C09D179/02 , D06M10/04 , D06M15/61 , D06M16/00 , D06M23/08 , D06M2400/01 , Y10T428/249953 , Y10T428/2967 , Y10T428/31678 , Y10T442/2525
摘要： Embodiments of the present disclosure, in one aspect, relate to polymer compositions, methods of making polymer compositions, structures having the polymer composition covalently bonded to the surface of the structure, methods of attaching the polymer to the surface of the structure, methods of decreasing the amount of microorganisms formed on a structure, materials, methods of attaching materials, and the like.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式