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51. 发明授权

US6080786A Solid compositions suitable for oral administration comprising L-carnitine or alkanoyl-L-carnitine choline tartrate 失效
标题翻译：适用于口服给药的固体组合物，其包含L-肉毒碱或烷酰基-L-肉碱酒石酸胆碱
公开(公告)号：US6080786A
公开(公告)日：2000-06-27
申请号：US402650
申请日：1999-10-08
申请人： Mose Santaniello , Nazareno Scafetta , Maria Ornella Tinti
发明人： Mose Santaniello , Nazareno Scafetta , Maria Ornella Tinti
IPC分类号： A23L1/30 , A23K1/16 , A23L1/305 , A61K31/14 , A61K31/205 , A61P3/02 , C07C59/255 , C07C215/08 , C07C215/40 , C07C229/22
CPC分类号： C07C59/255 , A23K20/105 , A23K20/174 , A23L33/175 , C07C215/40 , C07C229/22
摘要： Stable and non-hygroscopic salts consisting of L-carnitine or alkanoyl-L-carnitine choline tartrate are disclosed. The salts are suitable for preparing solid compositions useful as dietary/nutritional supplements for human use and as fodder supplement for veterinary purposes.
摘要翻译： PCT No.PCT / IT98 / 00080 Sec。 371 1999年10月8日第 102（e）日期1999年10月8日PCT提交1998年4月4日PCT公布。公开号WO98 / 47857 日期：1998年10月29日公开了由左旋肉碱或烷酰基-L-肉碱酒石酸胆碱组成的稳定和非吸湿性盐。这些盐适用于制备用作人类膳食/营养补充剂的固体组合物，以及用作兽医用途的饲料补充剂。

52. 发明授权

US6066664A Method for decreasing the appetite in bulimic, overweight individuals 失效
标题翻译：减少贪食，超重人群食欲的方法
公开(公告)号：US6066664A
公开(公告)日：2000-05-23
申请号：US870299
申请日：1997-06-06
申请人： Claudio Cavazza
发明人： Claudio Cavazza
IPC分类号： A61K31/405 , A01N43/38
CPC分类号： A61K31/405
摘要： A method for controlling and decreasing the appetite in an overweight individual is disclosed which comprises administering to said individual 5-hydroxytryptophan and an alkanoyl L-carnitine wherein the alkanoyl group has 2-6 carbons atoms, preferably acetyl L-carnitine, or a pharmacologically acceptable salt thereof.
摘要翻译：公开了一种控制和降低超重人群食欲的方法，其包括向所述个体5-羟色氨酸和烷酰基L-肉毒碱施用，其中烷酰基具有2-6个碳原子，优选乙酰基左旋肉碱，或药理学上可接受的的盐。

53. 发明授权

US6037373A Use of L-acetylcarnitine, L-isovalerylcarnitine, L-propionylcarnitine for increasing the levels of IGF-1 失效
标题翻译：使用L-乙酰肉碱，L-异戊基肉毒碱，L-丙酰基肉碱来增加IGF-1的水平
公开(公告)号：US6037373A
公开(公告)日：2000-03-14
申请号：US147465
申请日：1999-01-04
申请人： Claudio De Simone
发明人： Claudio De Simone
IPC分类号： A61P3/04 , A61K31/14 , A61K31/221 , A61P5/06 , A61P19/00 , A61P19/02 , A61P19/10 , A61P21/04 , A61P25/02 , A61P37/02 , A61P43/00 , A61K31/205
CPC分类号： A61K31/221
摘要： A method is provided for increasing the levels of IGF-1 for the therapeutic treatment or prophylaxis of cytological disorders or diseases related to IGF-1 selected from the group consisting of neuropathies of the optic nerve and of the olfactory nerve, neuralgia of the trigeminal nerve, Bell's paralysis, amyotrophic lateral sclerosis, osteoporosis, arthropathy, arthritis, cervical spondylosis and hernia of the intervertebral discs, clinical syndromes of reduced height, cachexia and acute or chronic hepatic necrosis, Turner's syndrome, sarcopoenia, growth hormone insensitivity syndromes, obesity, asthenia, myasthenia and heart asthenia, immunodeficiencies and reperfusion injuries, and for the cicatrization of wounds, the healing of ulcers, the treatment of burns, tissue regeneration, cutaneous, intestinal and hepatic tissue regeneration and the formation of dentine, that includes administering, to a patient in need thereof, at least one selected from the group consisting of L-acetylcarnitine, L-isovalerylcarnitine, and L-propionylcarnitine or pharmacologically acceptable salts thereof.
摘要翻译： PCT No.PCT / IT97 / 00113 Sec。 371日期1999年1月4日 102（e）1999年1月4日PCT PCT 1997年5月15日PCT公布。公开号WO98 / 01128 日期1998年1月15日提供了用于增加IGF-1水平用于治疗性或预防与IGF-1有关的细胞学疾病或疾病的方法，所述IGF-1选自视神经和嗅觉神经的神经病变，三叉神经神经痛，贝尔麻痹，肌萎缩性侧索硬化，骨质疏松症，关节病，关节炎，椎间盘颈椎病和疝气，高度减低的临床综合征，恶病质和急性或慢性肝坏死，特纳综合征，肌肉松弛，生长激素不敏感综合征，肥胖症，虚弱症，重症肌无力和心脏虚弱，免疫缺陷和再灌注损伤，以及伤口愈合，溃疡愈合，烧伤治疗，组织再生，皮肤，肠和肝组织再生以及牙本质的形成，包括向有需要的患者施用选自组中的至少一种的L-乙酰肉碱，L-异戊酰肉碱和L-丙酰基肉毒碱或其药理学上可接受的盐。

54. 发明授权

US5861289A Heat-resistant .beta.-galactosyltransferase, its production process and its use 失效
标题翻译：耐热β-半乳糖转移酶，其生产工艺及其应用
公开(公告)号：US5861289A
公开(公告)日：1999-01-19
申请号：US55553
申请日：1993-05-03
申请人： Toru Nakayama , Yukiko Kodama , Norihide Amano , Masahiro Nakao , Yuji Shibano , Teruo Amachi
发明人： Toru Nakayama , Yukiko Kodama , Norihide Amano , Masahiro Nakao , Yuji Shibano , Teruo Amachi
IPC分类号： A23C9/12 , C12N9/10 , C12P19/18 , C12N9/38 , C12R1/01
CPC分类号： C12Y302/01023 , A23C9/1206 , C12N9/1051 , C12P19/18 , Y10S435/822
摘要： Described herein are a novel heat-resistant .beta.-galactosyltransferase, a production process of the enzyme and a utilization method of the enzyme. The enzyme is produced preferably by produced by a microorganism belonging to the family of Actinomycetaceae, which may be selected from fungi belonging to the genus Saccharopolyspora, the genus Thermomonospora or the genus Thermoactinomvces.
摘要翻译：本文描述了新型耐热β-半乳糖基转移酶，酶的生产方法和酶的利用方法。优选通过由属于放线菌科家族的微生物产生的酶，其可以选自属于Saccharopolyspora属，Thermomonospora属或Thermactinomvces属的真菌。

55. 发明授权

US5705662A 17-(3-imino-2-alkylpropenyl)-5.beta., 14.beta.-androstane derivatives active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing same 失效
标题翻译：对心血管系统有活性的17-（3-亚氨基-2-烷基丙烯基）-5β，14β-雄甾烷衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US5705662A
公开(公告)日：1998-01-06
申请号：US559291
申请日：1995-11-15
申请人： Alberto Cerri , Giuseppe Bianchi , Patrizia Ferrari , Piero Melloni , Maria Luisa Quadri
发明人： Alberto Cerri , Giuseppe Bianchi , Patrizia Ferrari , Piero Melloni , Maria Luisa Quadri
IPC分类号： A61K31/575 , A61K31/58 , A61P9/00 , C07J41/00 , C07J43/00 , C07J9/00 , A01N45/00
CPC分类号： C07J43/003 , C07J41/0055
摘要： New 17-�3-imino-2-alkyl propenyl!-14.beta.-hydroxy-5.beta.-androstane derivatives active on the cardiovascular system by inhibiting Na+,K+-ATPase, a process for their preparation, and to pharmaceutical compositions for the treatment of cardiovascular disorders, such as heart failure and hypertension.
摘要翻译：通过抑制Na +，K + -ATP酶，其制备方法和用于治疗的药物组合物，对心血管系统上活性的新的17- [3-亚氨基-2-烷基丙烯基]-14β-羟基-5β-雄甾烷衍生物的心血管疾病，如心力衰竭和高血压。

56. 发明授权

US5631288A Therapeutic method of treating patients suffering from AIDS and AIDS-related syndromes and asymptomatic HIV-seropositive patients. 失效
标题翻译：治疗艾滋病和艾滋病相关综合征患者和无症状HIV-血清阳性患者的治疗方法。
公开(公告)号：US5631288A
公开(公告)日：1997-05-20
申请号：US370357
申请日：1995-01-09
申请人： Claudio De Simone
发明人： Claudio De Simone
IPC分类号： A61K31/535 , A61K31/205 , A61K31/22 , A61K31/221 , A61K31/35
CPC分类号： A61K31/221 , A61K31/205 , A61K31/22
摘要： A novel therapeutical utilization of L-carnitine, acyl L-carnitines and the pharmacologically acceptable salts thereof is disclosed, for treating immune and metabolic alterations in patients suffering from AIDS and AIDS-related syndromes and in asymptomatic HIV-seropositive patients.The L-carnitine amount to be administered according to this novel use is about 6-8 grams daily, via the oral route or an equivalent amount of an acyl L-carnitine or a pharmacologically acceptable salt thereof, i.e. three-four times as much the dose usually administered for the already known therapeutic uses of L-carnitine.
摘要翻译：公开了用于治疗患有AIDS和AIDS相关综合征的患者和无症状的HIV-血清阳性患者中的免疫和代谢改变的新颖的L-肉碱，酰基L-肉毒碱及其药理学上可接受的盐的治疗用途。根据该新用途施用的L-肉碱量每天约6-8克，经由口服途径或等量的酰基L-肉毒碱或其药理学上可接受的盐，即三通常用于已知的左旋肉碱治疗用途的剂量。

57. 发明授权

US5599978A Process for manufacturing L-(-)-carnitine from a waste product having opposite configuration 失效
标题翻译：从具有相反构型的废物制造L-（ - ） - 肉碱的方法
公开(公告)号：US5599978A
公开(公告)日：1997-02-04
申请号：US367863
申请日：1995-01-03
申请人： Fabio Giannessi , Maria L. Bolognesi , Maria O. Tinti , Francesco De Angelis
发明人： Fabio Giannessi , Maria L. Bolognesi , Maria O. Tinti , Francesco De Angelis
IPC分类号： C07C227/30 , C07C227/32 , C07C229/22 , C07D305/12 , C07C229/10
CPC分类号： C07C227/32
摘要： The present invention relates to a proces for manufacturing L-(-)-carnitine from D-(+)-carnitine or a derivative thereof. D-(+)-carnitine is esterified in order to protect the carboxyl group and subsequently converted to an acyl derivative. The acyl derivative is then converted to a lactone of L-(-)-carnitine. Finally, the lactone is reopened to obtain L-(-)-carnitine.
摘要翻译：本发明涉及从D-（+） - 肉碱或其衍生物制造L-（ - ） - 肉碱的方法。 D - （+） - 肉碱被酯化以保护羧基并随后转化为酰基衍生物。然后将酰基衍生物转化为L - （ - ） - 肉碱的内酯。最后，内酯重新开放以获得L-（ - ） - 肉碱。

58. 发明授权

US5596110A Process for the preparation of 3 .beta., 14 .beta.-dihydroxyethianaldehyde 失效
标题翻译：制备3β，14β-二羟基乙醛的方法
公开(公告)号：US5596110A
公开(公告)日：1997-01-21
申请号：US405354
申请日：1995-03-16
申请人： Mauro Gobbini , Marco Torri
发明人： Mauro Gobbini , Marco Torri
IPC分类号： B01J23/46 , C07B61/00 , C07J3/00 , C07J5/00 , C07J15/00 , C07J19/00 , C07J71/00 , C07J75/00
CPC分类号： C07J71/0005 , C07J15/00 , C07J19/00 , C07J3/00 , C07J3/005 , C07J5/0015
摘要： An improvement in a process for producing 3.beta.,14.beta.-dihydroxyethianaldehyde is disclosed wherein the oxidation of the lactone ring of digitoxigenin-3-acetate is conducted with an alkaline periodate in the presence of a catalytic amount of ruthenium tetroxide obtained in situ by reacting RuO.sub.2 hydrate or RuCl.sub.3 with the alkaline periodate.
摘要翻译：公开了生产3β，14β-二羟基硫代乙醛的方法的改进，其中在碱催化量的四氧化钌存在下，用碱性高碘酸盐进行氧化氧代辛-3-乙酸内酯环，其原位通过使 RuO2水合物或RuCl3与碱性高碘酸盐。

59. 发明授权

US5538960A Hydrazono-5.beta., 14.beta.-androstane derivatives active on the cardiovascular system, and pharmaceutical compositions containing same 失效
标题翻译：对心血管系统有活性的肼基-5β，14β-雄甾烷衍生物和含有它们的药物组合物
公开(公告)号：US5538960A
公开(公告)日：1996-07-23
申请号：US106638
申请日：1993-08-16
申请人： Alberto Cerri , Luigi Bernardi , Giuseppe Bianchi , Patrizia Ferrari , Elena Folpini , Piero Melloni
发明人： Alberto Cerri , Luigi Bernardi , Giuseppe Bianchi , Patrizia Ferrari , Elena Folpini , Piero Melloni
IPC分类号： A61K31/565 , A61K31/58 , A61P9/00 , A61P9/12 , C07J31/00 , C07J41/00 , C07J43/00 , C07J75/00 , C07D43/00 , A61K31/57
CPC分类号： C07J41/0088 , C07J41/0005 , C07J41/0038 , C07J43/003
摘要： The present invention relates to new 17-hydrazonomethyl- and 17-hydrazono-14.beta.-hydroxy-5.beta.-androstane derivatives active on the cardiovascular system, to a process for their preparation and to pharmaceutical compositions containing same for the treatment of cardiovascular disorders, such as heart failure and hypertension.
摘要翻译：本发明涉及在心血管系统上活性的新的17-亚肼基甲基和17-亚肼基-14β-羟基-5β-雄甾烷衍生物，其制备方法以及含有其用于治疗心血管疾病的药物组合物，如心力衰竭和高血压。

60. 发明授权

US5525627A Esters of acyl carnitines with long-chain aliphatic alcohols and pharmaceutical compositions containing same having antimycotic activity 失效
公开(公告)号：US5525627A
公开(公告)日：1996-06-11
申请号：US409714
申请日：1995-03-24
申请人： Mose Santaniello , Maria O. Tinti , Domenico Misiti , Piero Foresta
发明人： Mose Santaniello , Maria O. Tinti , Domenico Misiti , Piero Foresta
IPC分类号： A61K31/22 , A61P31/04 , A61P31/10 , C07C229/22 , A61K31/275
CPC分类号： C07C229/22
摘要： Esters of acyl L-carnitines of general formula (I) ##STR1## wherein R is a straight or branched acyl group having 2 to 16 carbon atoms, in particular isobutyryl and isovaleryl;n is an integer comprised between 7 and 15, particularly 10; and,X- is the anion of a pharmacologically acceptable acid are endowed with potent antimycotic activity particularly against yeast like fungi, such as Candida albicans, the aetiologic agent of candidiasis and against filamentous fungi, such as Aspergillus fumigatus, the aetiologic agent of aspergillosis. Orally or parenterally administrable or topically applicable pharmaceutical compositions comprise an ester of formula (I) as active ingredient.

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